SIMILAR PATTERNS OF AMINO ACIDS FOR 3VW1_B_CVIB301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqy | PLASMINOGENACTIVATOR (Trimeresurusstejnegeri) |
PF00089(Trypsin) | 5 | LEU A 105ILE A 212ILE A 242PHE A 209LEU A 123 | None | 1.40A | 3vw1B-1bqyA:undetectable | 3vw1B-1bqyA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3h | GUANOSINEPENTAPHOSPHATESYNTHETASE (Streptomycesantibioticus) |
PF00013(KH_1)PF01138(RNase_PH)PF03726(PNPase) | 5 | LEU A 106SER A 153ILE A 102ALA A 122LEU A 246 | None | 1.43A | 3vw1B-1e3hA:0.0 | 3vw1B-1e3hA:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f1u | HOMOPROTOCATECHUATE2,3-DIOXYGENASE (Arthrobacterglobiformis) |
PF00903(Glyoxalase) | 5 | LEU A 64THR A 219SER A 55ILE A 23LEU A 256 | None | 1.45A | 3vw1B-1f1uA:0.0 | 3vw1B-1f1uA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzh | TUMOR SUPPRESSORP53-BINDING PROTEIN1 (Homo sapiens) |
no annotation | 5 | LEU B1840TYR B1732PHE B1734LEU B1803LEU B1736 | None | 1.24A | 3vw1B-1gzhB:undetectable | 3vw1B-1gzhB:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i60 | IOLI PROTEIN (Bacillussubtilis) |
PF01261(AP_endonuc_2) | 5 | ILE A 198SER A 244TYR A 199PHE A 239LEU A 234 | None | 0.99A | 3vw1B-1i60A:undetectable | 3vw1B-1i60A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9g | HYPOTHETICAL PROTEINRV2118C (Mycobacteriumtuberculosis) |
PF08704(GCD14)PF14801(GCD14_N) | 5 | ILE A 97ALA A 253LEU A 117LEU A 255LEU A 199 | None | 1.06A | 3vw1B-1i9gA:0.0 | 3vw1B-1i9gA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j7j | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Salmonellaenterica) |
PF00156(Pribosyltran) | 5 | LEU A 86THR A 107ILE A 90LEU A 41LEU A 123 | None | 1.38A | 3vw1B-1j7jA:0.0 | 3vw1B-1j7jA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jny | ELONGATION FACTOR1-ALPHA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | LEU A 222ALA A 108LEU A 215PHE A 79LEU A 27 | None | 1.38A | 3vw1B-1jnyA:0.0 | 3vw1B-1jnyA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k8g | TELOMERE-BINDINGPROTEIN ALPHASUBUNIT (Sterkiella nova) |
PF02765(POT1) | 5 | LEU A 189TYR A 55ILE A 181ALA A 179LEU A 100 | NoneNoneNoneSO4 A 322 ( 4.3A)None | 1.12A | 3vw1B-1k8gA:undetectable | 3vw1B-1k8gA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwc | 2,3-DIHYDROXYBIPHENYL DIOXYGENASE (Pseudomonas sp.KKS102) |
PF00903(Glyoxalase) | 5 | LEU B 8ILE B 143ALA B 42LEU B 212LEU B 227 | None | 1.03A | 3vw1B-1kwcB:0.0 | 3vw1B-1kwcB:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwc | 2,3-DIHYDROXYBIPHENYL DIOXYGENASE (Pseudomonas sp.KKS102) |
PF00903(Glyoxalase) | 5 | LEU B 8ILE B 257ILE B 143ALA B 42LEU B 212 | None | 1.08A | 3vw1B-1kwcB:0.0 | 3vw1B-1kwcB:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr0 | ACTIN INTERACTINGPROTEIN 1 (Caenorhabditiselegans) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 5 | LEU A 330ILE A 353ILE A 327LEU A 590PHE A 10 | None | 1.44A | 3vw1B-1nr0A:undetectable | 3vw1B-1nr0A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 5 | ILE A 169ALA A 317LEU A 152PHE A 484LEU A 455 | None | 1.00A | 3vw1B-1nr6A:0.8 | 3vw1B-1nr6A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ph5 | TELOMERE-BINDINGPROTEIN ALPHASUBUNIT (Sterkiella nova) |
PF02765(POT1) | 5 | LEU A 189TYR A 55ILE A 181ALA A 179LEU A 100 | None | 1.10A | 3vw1B-1ph5A:undetectable | 3vw1B-1ph5A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s58 | B19 PARVOVIRUSCAPSID (Primateerythroparvovirus1) |
PF00740(Parvo_coat) | 5 | LEU A 97TYR A 422ALA A 29LEU A 426LEU A 242 | None | 1.34A | 3vw1B-1s58A:undetectable | 3vw1B-1s58A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tyd | TYROSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00579(tRNA-synt_1b) | 5 | SER E 43ILE E 120ALA E 118PHE E 108LEU E 305 | None | 1.29A | 3vw1B-1tydE:0.0 | 3vw1B-1tydE:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wox | HEME OXYGENASE 2 (Synechocystissp. PCC 6803) |
PF01126(Heme_oxygenase) | 5 | TYR A 104ILE A 65ALA A 198LEU A 56LEU A 178 | None | 1.03A | 3vw1B-1woxA:1.8 | 3vw1B-1woxA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzz | INOSITOL1,4,5-TRISPHOSPHATERECEPTOR TYPE 1 (Mus musculus) |
PF08709(Ins145_P3_rec) | 5 | LEU A 184ILE A 27ILE A 163LEU A 60LEU A 126 | None | 1.45A | 3vw1B-1xzzA:undetectable | 3vw1B-1xzzA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z34 | PURINE NUCLEOSIDEPHOSPHORYLASE (Trichomonasvaginalis) |
PF01048(PNP_UDP_1) | 5 | LEU A 229ILE A 199ILE A 57ALA A 13LEU A 185 | None | 1.27A | 3vw1B-1z34A:undetectable | 3vw1B-1z34A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6g | GUANYLATE KINASE (Plasmodiumfalciparum) |
PF00625(Guanylate_kin) | 5 | ILE A 191TYR A 190PHE A 32LEU A 7LEU A 25 | None | 1.35A | 3vw1B-1z6gA:undetectable | 3vw1B-1z6gA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | ILE A 158ILE A 96PHE A 135LEU A 114LEU A 138 | NoneNoneNoneNoneFAD A 600 (-3.9A) | 1.29A | 3vw1B-2bvgA:undetectable | 3vw1B-2bvgA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elj | TRANSCRIPTIONALADAPTER 2 (Saccharomycescerevisiae) |
PF04433(SWIRM) | 5 | ILE A 78ILE A 14ALA A 17LEU A 44LEU A 23 | None | 1.14A | 3vw1B-2eljA:undetectable | 3vw1B-2eljA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 5 | LEU A 168THR A 156TYR A 161PHE A 180LEU A 183 | None | 1.21A | 3vw1B-2fuqA:undetectable | 3vw1B-2fuqA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g4b | SPLICING FACTOR U2AF65 KDA SUBUNIT (Homo sapiens) |
PF00076(RRM_1) | 5 | LEU A 224THR A 161ILE A 160ILE A 226LEU A 200 | None | 1.24A | 3vw1B-2g4bA:undetectable | 3vw1B-2g4bA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glj | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Clostridiumacetobutylicum) |
PF02127(Peptidase_M18) | 5 | LEU A 225ILE A 151ILE A 221ALA A 125LEU A 127 | None | 1.40A | 3vw1B-2gljA:undetectable | 3vw1B-2gljA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jig | PROLYL-4 HYDROXYLASE (Chlamydomonasreinhardtii) |
PF13640(2OG-FeII_Oxy_3) | 5 | LEU A 129THR A 119ILE A 66PHE A 57LEU A 58 | None | 1.12A | 3vw1B-2jigA:undetectable | 3vw1B-2jigA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | LEU A 296THR A 359ILE A 256ALA A 258LEU A 324 | None | 1.37A | 3vw1B-2okcA:undetectable | 3vw1B-2okcA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkg | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A65 KDA REGULATORYSUBUNIT A ALPHAISOFORM (Homo sapiens) |
PF02985(HEAT)PF13646(HEAT_2) | 5 | THR A 481ILE A 482ILE A 424ALA A 412PHE A 439 | None | 1.19A | 3vw1B-2pkgA:undetectable | 3vw1B-2pkgA:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v8j | PECTATE LYASE (Yersiniaenterocolitica) |
PF06917(Pectate_lyase_2) | 5 | LEU A 214TYR A 210ALA A 505LEU A 314LEU A 508 | None | 1.03A | 3vw1B-2v8jA:undetectable | 3vw1B-2v8jA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb7 | PT26-6P (Thermococcussp. 26-2) |
no annotation | 5 | THR A 415ILE A 283ALA A 286PHE A 453LEU A 485 | None | 1.32A | 3vw1B-2wb7A:2.1 | 3vw1B-2wb7A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtk | SERINE/THREONINE-PROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU C 182THR C 249ILE C 248ILE C 192LEU C 285 | None | 1.07A | 3vw1B-2wtkC:undetectable | 3vw1B-2wtkC:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8c | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Plasmodiumfalciparum) |
PF00692(dUTPase) | 5 | LEU A 3SER A 141ILE A 5LEU A 31LEU A 101 | None | 1.24A | 3vw1B-2y8cA:undetectable | 3vw1B-2y8cA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zr2 | SERYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | TYR A 186LEU A 166ILE A 443ILE A 296LEU A 434 | None | 1.15A | 3vw1B-2zr2A:undetectable | 3vw1B-2zr2A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2d | CD180 ANTIGEN (Homo sapiens) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | LEU A 140ILE A 185ALA A 172LEU A 196LEU A 227 | None | 1.20A | 3vw1B-3b2dA:undetectable | 3vw1B-3b2dA:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brc | CONSERVED PROTEIN OFUNKNOWN FUNCTION (Methanothermobacterthermautotrophicus) |
PF11576(DUF3236) | 5 | LEU A 96SER A 35ILE A 98PHE A 154LEU A 149 | None | 1.00A | 3vw1B-3brcA:undetectable | 3vw1B-3brcA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3can | PYRUVATE-FORMATELYASE-ACTIVATINGENZYME (Bacteroidesvulgatus) |
PF04055(Radical_SAM) | 5 | TYR A 98LEU A 65ILE A 88ALA A 92LEU A 174 | None | 0.90A | 3vw1B-3canA:undetectable | 3vw1B-3canA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3can | PYRUVATE-FORMATELYASE-ACTIVATINGENZYME (Bacteroidesvulgatus) |
PF04055(Radical_SAM) | 5 | TYR A 98LEU A 65ILE A 115ILE A 88LEU A 174 | None | 1.17A | 3vw1B-3canA:undetectable | 3vw1B-3canA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3l | ARACHIDONATE12-LIPOXYGENASE,12S-TYPE (Homo sapiens) |
PF00305(Lipoxygenase) | 5 | LEU A 389THR A 503ILE A 502PHE A 519LEU A 525 | None | 1.09A | 3vw1B-3d3lA:undetectable | 3vw1B-3d3lA:15.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eh0 | UDP-3-O-[3-HYDROXYMYRISTOYL] GLUCOSAMINEN-ACYLTRANSFERASE (Escherichiacoli) |
PF00132(Hexapep)PF04613(LpxD)PF14602(Hexapep_2) | 5 | LEU A 130ILE A 166SER A 146ILE A 118ALA A 97 | None | 1.46A | 3vw1B-3eh0A:undetectable | 3vw1B-3eh0A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fvq | FE(3+) IONS IMPORTATP-BINDING PROTEINFBPC (Neisseriagonorrhoeae) |
PF00005(ABC_tran) | 5 | LEU A 185ILE A 160ALA A 152PHE A 166LEU A 169 | None | 1.09A | 3vw1B-3fvqA:undetectable | 3vw1B-3fvqA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8z | PROTEIN OF UNKNOWNFUNCTION WITHCYSTATIN-LIKE FOLD (Xanthomonascampestris) |
PF12680(SnoaL_2) | 5 | TYR A 73LEU A 103ILE A 26ILE A 82ALA A 70 | NoneNoneNoneNone CL A 131 (-4.3A) | 1.09A | 3vw1B-3g8zA:undetectable | 3vw1B-3g8zA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkb | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 5 | LEU A 9THR A 107LEU A 42PHE A 122LEU A 65 | None | 1.15A | 3vw1B-3gkbA:undetectable | 3vw1B-3gkbA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjn | THYMIDYLATE KINASE (Thermotogamaritima) |
PF02223(Thymidylate_kin) | 5 | SER A 94TYR A 97ALA A 135PHE A 150LEU A 151 | TYD A 401 (-2.7A)TYD A 401 (-3.8A)NoneNoneNone | 1.34A | 3vw1B-3hjnA:undetectable | 3vw1B-3hjnA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv9 | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Neisseriameningitidis) |
PF03466(LysR_substrate) | 5 | LEU A 105THR A 129ILE A 98LEU A 95LEU A 136 | None CL A 307 (-4.2A)NoneNoneNone | 1.38A | 3vw1B-3jv9A:undetectable | 3vw1B-3jv9A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7d | GLUTAMATE-AMMONIA-LIGASEADENYLYLTRANSFERASE (Escherichiacoli) |
PF03710(GlnE)PF08335(GlnD_UR_UTase) | 5 | LEU A 532ILE A 556ILE A 535LEU A 576LEU A 585 | None | 1.10A | 3vw1B-3k7dA:undetectable | 3vw1B-3k7dA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lf2 | SHORT CHAINOXIDOREDUCTASEQ9HYA2 (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 5 | SER A 17ILE A 239ALA A 243LEU A 28LEU A 85 | NDP A 301 (-2.7A)NoneNoneNoneNone | 0.99A | 3vw1B-3lf2A:undetectable | 3vw1B-3lf2A:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mil | ISOAMYLACETATE-HYDROLYZINGESTERASE (Saccharomycescerevisiae) |
PF13472(Lipase_GDSL_2) | 5 | ILE A 207ALA A 17LEU A 204PHE A 6LEU A 8 | None | 1.00A | 3vw1B-3milA:undetectable | 3vw1B-3milA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mwt | NUCLEOPROTEIN (Lassamammarenavirus) |
PF00843(Arena_nucleocap)PF17290(Arena_ncap_C) | 5 | LEU A 470ILE A 479ILE A 390ALA A 530LEU A 380 | None | 1.50A | 3vw1B-3mwtA:undetectable | 3vw1B-3mwtA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 5 | LEU A 615ILE A 711ILE A 611LEU A 719LEU A 744 | None | 1.05A | 3vw1B-3nawA:undetectable | 3vw1B-3nawA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3naw | SECRETED EFFECTORPROTEIN (Escherichiacoli) |
PF00805(Pentapeptide)PF13979(SopA_C)PF13981(SopA) | 5 | LEU A 615ILE A 711TYR A 715ILE A 611LEU A 719 | None | 1.34A | 3vw1B-3nawA:undetectable | 3vw1B-3nawA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q7b | NUCLEOPROTEIN (Lassamammarenavirus) |
PF17290(Arena_ncap_C) | 5 | LEU A 470ILE A 479ILE A 390ALA A 530LEU A 380 | None | 1.44A | 3vw1B-3q7bA:undetectable | 3vw1B-3q7bA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q88 | GLUCOSE-6-PHOSPHATEISOMERASE (Francisellatularensis) |
PF00342(PGI) | 5 | LEU A 53TYR A 43PHE A 41LEU A 34LEU A 479 | None | 1.05A | 3vw1B-3q88A:undetectable | 3vw1B-3q88A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qp5 | CVIR TRANSCRIPTIONALREGULATOR (Chromobacteriumviolaceum) |
PF00196(GerE)PF03472(Autoind_bind) | 5 | TYR A 88LEU A 57ALA A 94LEU A 72LEU A 63 | HLC A 266 (-4.5A)HLC A 266 (-4.7A)NoneNoneNone | 1.34A | 3vw1B-3qp5A:undetectable | 3vw1B-3qp5A:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sdq | ALPHA-BISABOLENESYNTHASE (Abies grandis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | LEU A 140ILE A 159LEU A 197PHE A 183LEU A 207 | None | 1.45A | 3vw1B-3sdqA:2.0 | 3vw1B-3sdqA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3suc | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 5 | LEU A 149ILE A 229ILE A 128LEU A 219PHE A 195 | None | 1.39A | 3vw1B-3sucA:undetectable | 3vw1B-3sucA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voc | BETA/ALPHA-AMYLASE (Paenibacilluspolymyxa) |
PF01373(Glyco_hydro_14) | 5 | TYR A 137ILE A 260ALA A 264PHE A 312LEU A 317 | None | 1.49A | 3vw1B-3vocA:undetectable | 3vw1B-3vocA:18.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vw1 | PUTATIVE REGULATORYPROTEIN (Salmonellaenterica) |
PF00440(TetR_N) | 9 | TYR A 59LEU A 66THR A 85ILE A 88SER A 91TYR A 92ILE A 106ALA A 110LEU A 130 | None | 0.66A | 3vw1B-3vw1A:28.7 | 3vw1B-3vw1A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vw1 | PUTATIVE REGULATORYPROTEIN (Salmonellaenterica) |
PF00440(TetR_N) | 9 | TYR A 59LEU A 66THR A 85ILE A 88SER A 91TYR A 92ILE A 106LEU A 130PHE A 155 | None | 0.70A | 3vw1B-3vw1A:28.7 | 3vw1B-3vw1A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vw1 | PUTATIVE REGULATORYPROTEIN (Salmonellaenterica) |
PF00440(TetR_N) | 9 | TYR A 59LEU A 66THR A 85SER A 91TYR A 92ILE A 106ALA A 110LEU A 130LEU A 188 | None | 0.68A | 3vw1B-3vw1A:28.7 | 3vw1B-3vw1A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vw1 | PUTATIVE REGULATORYPROTEIN (Salmonellaenterica) |
PF00440(TetR_N) | 9 | TYR A 59LEU A 66THR A 85SER A 91TYR A 92ILE A 106LEU A 130PHE A 155LEU A 188 | None | 0.68A | 3vw1B-3vw1A:28.7 | 3vw1B-3vw1A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vw1 | PUTATIVE REGULATORYPROTEIN (Salmonellaenterica) |
PF00440(TetR_N) | 9 | TYR A 59LEU A 66THR A 85SER A 91TYR A 92ILE A 106PHE A 155LEU A 156LEU A 188 | None | 0.68A | 3vw1B-3vw1A:28.7 | 3vw1B-3vw1A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5q | CHI1 (Yersiniaentomophaga) |
PF00704(Glyco_hydro_18) | 5 | TYR A 80SER A 211TYR A 115PHE A 196LEU A 199 | None | 1.39A | 3vw1B-4a5qA:undetectable | 3vw1B-4a5qA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpz | ENDO-1,3-BETA-GLUCANASE, FAMILY GH16 (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 5 | LEU A 329SER A 317TYR A 316ILE A 306LEU A 231 | None | 1.39A | 3vw1B-4bpzA:undetectable | 3vw1B-4bpzA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d53 | BB0689 (Borreliellaburgdorferi) |
PF00188(CAP) | 5 | ILE A 16SER A 19TYR A 18ALA A 43LEU A 89 | None | 0.96A | 3vw1B-4d53A:undetectable | 3vw1B-4d53A:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4db3 | N-ACETYL-D-GLUCOSAMINE KINASE (Vibriovulnificus) |
PF00480(ROK) | 5 | TYR A 262ILE A 240ILE A 261PHE A 134LEU A 130 | None | 1.10A | 3vw1B-4db3A:undetectable | 3vw1B-4db3A:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de8 | CPS2A (Streptococcuspneumoniae) |
PF02916(DNA_PPF)PF03816(LytR_cpsA_psr) | 5 | LEU A 405SER A 317ILE A 401ALA A 394LEU A 325 | None | 1.17A | 3vw1B-4de8A:undetectable | 3vw1B-4de8A:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4du6 | GTP CYCLOHYDROLASE 1 (Yersinia pestis) |
PF01227(GTP_cyclohydroI) | 5 | LEU A 161ILE A 85ILE A 157ALA A 144PHE A 82 | None | 1.37A | 3vw1B-4du6A:undetectable | 3vw1B-4du6A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egx | KINESIN-LIKE PROTEINKIF1A (Homo sapiens) |
PF00498(FHA)PF16183(Kinesin_assoc) | 5 | LEU A 531ILE A 585SER A 589ILE A 529LEU A 494 | None | 1.48A | 3vw1B-4egxA:undetectable | 3vw1B-4egxA:24.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ese | FMN-DEPENDENTNADH-AZOREDUCTASE (Yersinia pestis) |
PF02525(Flavodoxin_2) | 5 | THR A 118ILE A 137ALA A 94LEU A 84PHE A 160 | None | 1.20A | 3vw1B-4eseA:undetectable | 3vw1B-4eseA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 212THR A 185ALA A 360LEU A 207PHE A 178 | None | 1.47A | 3vw1B-4h7uA:undetectable | 3vw1B-4h7uA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 13 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | LEU M 233SER M 318ALA M 86LEU M 327LEU M 357 | None | 1.45A | 3vw1B-4heaM:2.4 | 3vw1B-4heaM:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hqf | THROMBOSPONDIN-RELATED ANONYMOUSPROTEIN, TRAP (Plasmodiumfalciparum) |
PF00092(VWA) | 5 | LEU A 122ILE A 118LEU A 160LEU A 88LEU A 156 | None | 1.22A | 3vw1B-4hqfA:undetectable | 3vw1B-4hqfA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4krf | PROTEIN ARGONAUTE-1 (Homo sapiens) |
PF02170(PAZ)PF02171(Piwi)PF08699(ArgoL1)PF16486(ArgoN)PF16487(ArgoMid)PF16488(ArgoL2) | 5 | LEU A 213ILE A 397TYR A 386ILE A 215LEU A 160 | None | 1.29A | 3vw1B-4krfA:undetectable | 3vw1B-4krfA:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlo | TCP PILUS VIRULENCEREGULATORY PROTEIN (Vibrio cholerae) |
PF00165(HTH_AraC) | 5 | ILE A 58SER A 56ILE A 79LEU A 71LEU A 114 | NoneNoneNonePAM A 304 ( 4.9A)None | 1.33A | 3vw1B-4mloA:3.5 | 3vw1B-4mloA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n18 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASE FAMILYPROTEIN (Klebsiellapneumoniae) |
PF02826(2-Hacid_dh_C) | 5 | LEU A 196ILE A 205LEU A 142PHE A 185LEU A 182 | None | 1.49A | 3vw1B-4n18A:undetectable | 3vw1B-4n18A:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 374THR A 268ILE A 440ILE A 12ALA A 103 | None | 1.42A | 3vw1B-4na3A:undetectable | 3vw1B-4na3A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rh7 | GREEN FLUORESCENTPROTEIN/CYTOPLASMICDYNEIN 2 HEAVY CHAIN1 (Homo sapiens;syntheticconstruct) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | LEU A4183ILE A4217ILE A4072LEU A4170LEU A4163 | None | 0.97A | 3vw1B-4rh7A:undetectable | 3vw1B-4rh7A:4.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 5 | LEU P 204ILE P 239TYR P 225ILE P 218LEU P 163 | None | 1.19A | 3vw1B-4s2tP:undetectable | 3vw1B-4s2tP:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9e | DEOXYGUANOSINETRIPHOSPHATETRIPHOSPHOHYDROLASE (Escherichiacoli) |
PF01966(HD) | 5 | LEU A 356ILE A 263ILE A 4PHE A 106LEU A 99 | None | 1.23A | 3vw1B-4x9eA:undetectable | 3vw1B-4x9eA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zyj | DNMZ (Streptomycespeucetius) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 93ILE A 178LEU A 40LEU A 67LEU A 32 | None | 0.96A | 3vw1B-4zyjA:3.1 | 3vw1B-4zyjA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bop | NANOBODYOCTARELLIN V.1 (Lama glama;syntheticconstruct) |
PF07686(V-set)no annotation | 5 | LEU A 102THR A 54ILE B 5ALA B 110LEU B 49 | None | 1.45A | 3vw1B-5bopA:undetectable | 3vw1B-5bopA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dil | NON-STRUCTURALPROTEIN 1 (Influenza Bvirus) |
PF02942(Flu_B_NS1) | 5 | ILE A 239ILE A 255ALA A 257LEU A 173LEU A 265 | None | 1.13A | 3vw1B-5dilA:undetectable | 3vw1B-5dilA:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esy | SAL1 PHOSPHATASE (Arabidopsisthaliana) |
PF00459(Inositol_P) | 5 | LEU A 275SER A 241ILE A 273ALA A 225LEU A 248 | None | 1.28A | 3vw1B-5esyA:undetectable | 3vw1B-5esyA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fn4 | GAMMA-SECRETASESUBUNIT APH-1A (Homo sapiens) |
PF06105(Aph-1) | 5 | ILE C 168SER C 129ILE C 137ALA C 141PHE C 14 | None | 1.21A | 3vw1B-5fn4C:3.8 | 3vw1B-5fn4C:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irr | SEPTIN-LIKE PROTEIN (Chlamydomonasreinhardtii) |
PF00735(Septin) | 5 | LEU A 373TYR A 175ILE A 376LEU A 113LEU A 126 | None | 1.28A | 3vw1B-5irrA:undetectable | 3vw1B-5irrA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l09 | QUORUM-SENSINGTRANSCRIPTIONALACTIVATOR (Yersiniaenterocolitica) |
PF03472(Autoind_bind) | 5 | TYR A 50LEU A 29SER A 139PHE A 112LEU A 124 | 482 A 201 (-4.5A)NoneNoneNoneNone | 1.41A | 3vw1B-5l09A:undetectable | 3vw1B-5l09A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u94 | SERINE/THREONINE-PROTEIN KINASE PKNB (Mycobacteriumtuberculosis) |
no annotation | 5 | LEU A 202THR A 179ILE A 119ALA A 115LEU A 100 | NoneGOL A 304 (-3.6A)NoneNoneNone | 1.33A | 3vw1B-5u94A:undetectable | 3vw1B-5u94A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vtg | TRANSLOCATION ANDASSEMBLY MODULESUBUNIT TAMB (Escherichiacoli) |
no annotation | 5 | LEU A1045ILE A 991ALA A1125LEU A1089LEU A1053 | None | 1.42A | 3vw1B-5vtgA:undetectable | 3vw1B-5vtgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 5 | TYR C3013THR C2949ILE C2952SER C2955ALA C3017 | None | 1.26A | 3vw1B-5y3rC:undetectable | 3vw1B-5y3rC:4.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yfg | RAN GUANINENUCLEOTIDE RELEASEFACTOR (Homo sapiens) |
no annotation | 5 | THR A 4ILE A 17SER A 15ALA A 102LEU A 93 | None | 1.43A | 3vw1B-5yfgA:undetectable | 3vw1B-5yfgA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhp | COLD ACTIVE PROLINEIMINOPEPTIDASE (Glaciozymaantarctica) |
no annotation | 5 | LEU A 131ILE A 136ALA A 123LEU A 280LEU A 139 | None | 1.23A | 3vw1B-5yhpA:undetectable | 3vw1B-5yhpA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b8s | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Helicobacterpylori) |
no annotation | 5 | LEU A 169TYR A 175ALA A 125PHE A 177LEU A 146 | None | 1.45A | 3vw1B-6b8sA:undetectable | 3vw1B-6b8sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cf8 | LYTICTRANSGLYCOSYLASE (Campylobacterjejuni) |
no annotation | 5 | TYR A 283ILE A 531ILE A 282LEU A 457LEU A 474 | None | 1.19A | 3vw1B-6cf8A:undetectable | 3vw1B-6cf8A:undetectable |