SIMILAR PATTERNS OF AMINO ACIDS FOR 3VT7_A_VDXA500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		4 LEU A 224
ILE A  92
TYR A 196
TYR A 108
 None
 0.90A 3vt7A-1ecxA:
0.0		 3vt7A-1ecxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0k PROFILIN

(Saccharomyces
cerevisiae) 		PF00235
(Profilin) 		4 LEU A  35
ILE A  77
TYR A 100
TYR A  21
 None
 1.44A 3vt7A-1k0kA:
undetectable		 3vt7A-1k0kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5p CIRCADIAN
OSCILLATION
REGULATOR

(Nostoc sp. PCC
7120) 		PF07689
(KaiB) 		4 LEU A  93
ILE A  77
TYR A  40
TYR A  13
 None
 1.40A 3vt7A-1r5pA:
undetectable		 3vt7A-1r5pA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 335
ILE A 389
TYR A 362
TYR A 380
 None
 1.27A 3vt7A-1tz7A:
0.0		 3vt7A-1tz7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 LEU A 166
ILE A   7
TYR A 162
TYR A 177
 None
MXA  A 187 (-4.5A)
None
None
 1.36A 3vt7A-1u71A:
undetectable		 3vt7A-1u71A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		4 LEU A  21
ILE A   8
TYR A 212
TYR A  68
 None
 1.14A 3vt7A-1uf3A:
undetectable		 3vt7A-1uf3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		4 LEU A 334
ILE A 398
TYR A 403
TYR A 387
 None
 1.22A 3vt7A-1vrgA:
0.0		 3vt7A-1vrgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A2208
ILE A2421
TYR A2466
TYR A2457
 None
 1.48A 3vt7A-1wchA:
undetectable		 3vt7A-1wchA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwy THIOREDOXIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF06201
(PITH) 		4 LEU A  12
ILE A 116
TYR A 148
TYR A  64
 None
 1.27A 3vt7A-1wwyA:
undetectable		 3vt7A-1wwyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		4 LEU A  29
ILE A 127
TYR A 119
TYR A 142
 GOL  A 202 (-3.8A)
None
None
None
 1.43A 3vt7A-1xwwA:
undetectable		 3vt7A-1xwwA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 LEU A 177
ILE A 182
TYR A 190
TYR A 122
 None
 1.34A 3vt7A-1z26A:
undetectable		 3vt7A-1z26A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axo HYPOTHETICAL PROTEIN
ATU2684

(Agrobacterium
fabrum) 		PF06764
(DUF1223) 		4 LEU A 120
ILE A  68
TYR A  78
TYR A 135
 None
 1.45A 3vt7A-2axoA:
undetectable		 3vt7A-2axoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 LEU A 132
ILE A 165
TYR A 229
TYR A 105
 None
 1.09A 3vt7A-2bhmA:
0.4		 3vt7A-2bhmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 255
ILE A 402
TYR A  37
TYR A  26
 None
 1.39A 3vt7A-2ct8A:
undetectable		 3vt7A-2ct8A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 LEU A 133
ILE A 320
TYR A 167
TYR A 326
 None
 1.42A 3vt7A-2e1mA:
undetectable		 3vt7A-2e1mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A  51
ILE A 765
TYR A 753
TYR A 380
 None
 1.43A 3vt7A-2eaeA:
undetectable		 3vt7A-2eaeA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6i ATP-DEPENDENT CLP
PROTEASE, PUTATIVE

(Plasmodium
falciparum) 		PF00574
(CLP_protease) 		4 LEU A 189
ILE A 226
TYR A 198
TYR A 217
 None
 1.09A 3vt7A-2f6iA:
undetectable		 3vt7A-2f6iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 352
ILE A 281
TYR A 333
TYR A 294
 None
 1.36A 3vt7A-2f7lA:
undetectable		 3vt7A-2f7lA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A  54
ILE A 145
TYR A  59
TYR A 241
 None
 1.29A 3vt7A-2fk7A:
undetectable		 3vt7A-2fk7A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		4 LEU A 223
ILE A 267
TYR A 291
TYR A 397
 None
VD4  A 500 ( 4.7A)
None
None
 0.12A 3vt7A-2o4jA:
39.4		 3vt7A-2o4jA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4u ACID PHOSPHATASE 1

(Mus musculus) 		PF01451
(LMWPc) 		4 LEU A  30
ILE A 128
TYR A 120
TYR A 143
 None
 1.34A 3vt7A-2p4uA:
undetectable		 3vt7A-2p4uA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		4 LEU A 182
ILE A 279
TYR A 236
TYR A 247
 None
 1.47A 3vt7A-2pbeA:
undetectable		 3vt7A-2pbeA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 LEU A 276
ILE A 479
TYR A 494
TYR A 393
 None
 1.40A 3vt7A-2qveA:
1.4		 3vt7A-2qveA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 4 LEU A  91
ILE A 134
TYR A 104
TYR A  83
 None
 1.50A 3vt7A-2wjfA:
undetectable		 3vt7A-2wjfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		4 LEU A 300
ILE A 271
TYR A 405
TYR A 324
 None
None
NAG  A 469 (-4.8A)
None
 1.33A 3vt7A-2wwdA:
undetectable		 3vt7A-2wwdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylf PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		4 LEU A 156
ILE A  53
TYR A 134
TYR A 217
 None
 1.43A 3vt7A-2ylfA:
undetectable		 3vt7A-2ylfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		4 LEU A 320
ILE A 203
TYR A 265
TYR A 357
 None
 1.27A 3vt7A-3hbzA:
undetectable		 3vt7A-3hbzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		4 LEU A  16
ILE A  83
TYR A 106
TYR A  46
 None
 1.45A 3vt7A-3iwgA:
undetectable		 3vt7A-3iwgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		4 LEU B 366
ILE B 430
TYR B 435
TYR B 419
 None
 1.46A 3vt7A-3n6rB:
undetectable		 3vt7A-3n6rB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nj2 DUF269-CONTAINING
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF03270
(DUF269) 		4 LEU A  87
ILE A  62
TYR A  92
TYR A  53
 None
 1.50A 3vt7A-3nj2A:
undetectable		 3vt7A-3nj2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on7 OXIDOREDUCTASE,
IRON/ASCORBATE
FAMILY

(Shewanella
oneidensis) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 150
ILE A 245
TYR A 108
TYR A  88
 None
 1.14A 3vt7A-3on7A:
undetectable		 3vt7A-3on7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prc PHOTOSYNTHETIC
REACTION CENTER

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		4 LEU L   3
ILE L 107
TYR L  29
TYR L   9
 None
 1.39A 3vt7A-3prcL:
undetectable		 3vt7A-3prcL:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		4 LEU A 156
ILE A  53
TYR A 134
TYR A 217
 None
 1.49A 3vt7A-3r7gA:
undetectable		 3vt7A-3r7gA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 227
ILE A 271
TYR A 295
TYR A 401
 None
ED9  A 501 (-4.5A)
None
None
 0.39A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		4 LEU E 587
ILE E 624
TYR E 604
TYR E 558
 None
 1.16A 3vt7A-3winE:
undetectable		 3vt7A-3winE:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		4 LEU A 480
ILE A 380
TYR A 476
TYR A 431
 None
GLC  A1519 ( 3.9A)
XYS  A1524 (-3.9A)
None
 1.35A 3vt7A-3zmrA:
undetectable		 3vt7A-3zmrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 LEU A  53
ILE A 116
TYR A  65
TYR A 159
 None
 1.32A 3vt7A-3zx2A:
undetectable		 3vt7A-3zx2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		4 LEU A 432
ILE A 484
TYR A 295
TYR A 498
 None
 1.36A 3vt7A-4acoA:
undetectable		 3vt7A-4acoA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		4 LEU A 132
ILE A 165
TYR A 229
TYR A 105
 None
 1.10A 3vt7A-4akzA:
undetectable		 3vt7A-4akzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5a UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11589
(DUF3244) 		4 LEU A  45
ILE A  83
TYR A 107
TYR A  92
 None
 1.07A 3vt7A-4g5aA:
undetectable		 3vt7A-4g5aA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhx TOXIN COREGULATED
PILUS BIOSYNTHESIS
PROTEIN E

(Vibrio cholerae) 		PF00482
(T2SSF) 		4 LEU A  66
ILE A  33
TYR A  27
TYR A  13
 None
 1.20A 3vt7A-4hhxA:
undetectable		 3vt7A-4hhxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes) 		PF02618
(YceG) 		4 LEU A 230
ILE A 129
TYR A 271
TYR A 184
 None
 1.45A 3vt7A-4iiwA:
undetectable		 3vt7A-4iiwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 LEU A 255
ILE A 617
TYR A 309
TYR A 518
 None
 1.18A 3vt7A-4jc8A:
undetectable		 3vt7A-4jc8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kso CIRCADIAN CLOCK
PROTEIN KAIB

(Synechococcus
elongatus) 		no annotation 4 LEU C  92
ILE C  76
TYR C  39
TYR C  12
 None
 1.17A 3vt7A-4ksoC:
undetectable		 3vt7A-4ksoC:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kz1 VIRB8 PROTEIN

(Bartonella
grahamii) 		PF04335
(VirB8) 		4 LEU A  66
ILE A 107
TYR A 165
TYR A  43
 None
 1.12A 3vt7A-4kz1A:
undetectable		 3vt7A-4kz1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		4 LEU A  89
ILE A 285
TYR A 314
TYR A 227
 1X8  A 401 (-4.0A)
None
None
1X8  A 401 (-3.6A)
 1.41A 3vt7A-4lh7A:
1.3		 3vt7A-4lh7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lso TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Bartonella
quintana) 		PF04335
(VirB8) 		4 LEU A 131
ILE A 165
TYR A 226
TYR A 104
 None
 1.11A 3vt7A-4lsoA:
undetectable		 3vt7A-4lsoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw4 LIPOPROTEIN S-LAYER
PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 LEU A 138
ILE A 126
TYR A 254
TYR A  90
 GOL  A 409 (-4.8A)
None
None
None
 1.30A 3vt7A-4nw4A:
undetectable		 3vt7A-4nw4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		4 LEU A 280
ILE A 250
TYR A 243
TYR A 273
 None
 1.36A 3vt7A-4r7bA:
undetectable		 3vt7A-4r7bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A  37
ILE A 669
TYR A 657
TYR A 338
 None
 1.43A 3vt7A-4ufcA:
undetectable		 3vt7A-4ufcA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 LEU A  66
ILE A  77
TYR A  50
TYR A  94
 None
 1.36A 3vt7A-4wd3A:
undetectable		 3vt7A-4wd3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		4 LEU B 326
ILE B 292
TYR B 298
TYR B 359
 None
 1.40A 3vt7A-4xmmB:
undetectable		 3vt7A-4xmmB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		4 LEU A 299
ILE A 344
TYR A 565
TYR A 328
 None
None
None
ACT  A 702 (-3.4A)
 1.46A 3vt7A-4y4rA:
undetectable		 3vt7A-4y4rA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		4 LEU A  80
ILE A 278
TYR A 120
TYR A  83
 None
 1.43A 3vt7A-4y4vA:
undetectable		 3vt7A-4y4vA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z45 ODORANT-BINDING
PROTEIN NRIBOBP3

(Nasonovia
ribisnigri) 		PF01395
(PBP_GOBP) 		4 LEU A  51
ILE A  10
TYR A 105
TYR A  70
 None
 1.12A 3vt7A-4z45A:
undetectable		 3vt7A-4z45A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en6 SMU-1

(Caenorhabditis
elegans) 		no annotation 4 LEU A  85
ILE A 145
TYR A 133
TYR A  78
 None
 1.39A 3vt7A-5en6A:
undetectable		 3vt7A-5en6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 LEU A  82
ILE A 277
TYR A 306
TYR A 219
 None
 1.31A 3vt7A-5fprA:
1.3		 3vt7A-5fprA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		4 LEU A 206
ILE A 222
TYR A 213
TYR A 184
 None
 1.38A 3vt7A-5fqeA:
undetectable		 3vt7A-5fqeA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 LEU A 349
ILE A 413
TYR A 418
TYR A 402
 None
 1.32A 3vt7A-5infA:
undetectable		 3vt7A-5infA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 297
ILE A 379
TYR A 353
TYR A 411
 None
 1.23A 3vt7A-5jo7A:
undetectable		 3vt7A-5jo7A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		4 LEU A 263
ILE A 217
TYR A 222
TYR A 319
 None
CMP  A 501 ( 4.9A)
None
CMP  A 501 (-3.6A)
 1.37A 3vt7A-5kbfA:
undetectable		 3vt7A-5kbfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		4 LEU A 138
ILE A 536
TYR A 130
TYR A 171
 None
 1.00A 3vt7A-5nnpA:
undetectable		 3vt7A-5nnpA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 LEU 0 476
ILE 0 491
TYR 0 564
TYR 0 472
 None
 1.42A 3vt7A-5oa30:
undetectable		 3vt7A-5oa30:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 196
ILE A 483
TYR A 193
TYR A 538
 None
 1.04A 3vt7A-5uv2A:
undetectable		 3vt7A-5uv2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wru PROBABLE INORGANIC
PYROPHOSPHATASE

(Plasmodium
falciparum) 		no annotation 4 LEU A 212
ILE A 148
TYR A 168
TYR A  66
 None
 1.40A 3vt7A-5wruA:
undetectable		 3vt7A-5wruA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 LEU A 690
ILE A 446
TYR A 522
TYR A 535
 None
 1.44A 3vt7A-5ydjA:
undetectable		 3vt7A-5ydjA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 LEU P 189
ILE P 414
TYR P 169
TYR P 406
 None
 1.41A 3vt7A-6c1dP:
undetectable		 3vt7A-6c1dP:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 4 LEU B 143
ILE B 223
TYR B 344
TYR B 191
 None
 1.49A 3vt7A-6d6uB:
undetectable		 3vt7A-6d6uB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eua ANGIOPOIETIN-RELATED
PROTEIN 3

(Homo sapiens) 		no annotation 4 LEU A 450
ILE A 262
TYR A 329
TYR A 273
 None
 1.26A 3vt7A-6euaA:
undetectable		 3vt7A-6euaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 LEU A 893
ILE A 859
TYR A 973
TYR A 846
 None
 1.33A 3vt7A-6fj4A:
undetectable		 3vt7A-6fj4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 4 LEU A 255
ILE A 299
TYR A 323
TYR A 427
 None
DZW  A 501 (-4.7A)
DZW  A 501 (-3.6A)
DZW  A 501 (-4.9A)
 0.42A 3vt7A-6fobA:
36.5		 3vt7A-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 LEU E 432
ILE E 484
TYR E 295
TYR E 498
 None
 1.36A 3vt7A-6gsaE:
undetectable		 3vt7A-6gsaE:
undetectable