SIMILAR PATTERNS OF AMINO ACIDS FOR 3VT7_A_VDXA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n SPLICEOSOMAL U2B''
U2A'

(Homo sapiens) 		PF00076
(RRM_1)
PF14580
(LRR_9) 		5 TYR B  31
LEU A  70
VAL A  71
ARG A  27
LEU A  37
 None
 1.30A 3vt7A-1a9nB:
undetectable		 3vt7A-1a9nB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n SPLICEOSOMAL U2B''
U2A'

(Homo sapiens) 		PF00076
(RRM_1)
PF14580
(LRR_9) 		5 TYR B  31
LEU A  70
VAL A  71
SER A  50
ARG A  27
 None
 1.47A 3vt7A-1a9nB:
undetectable		 3vt7A-1a9nB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		5 LEU A 205
VAL A 217
HIS A 215
LEU A 284
HIS A 181
 None
 1.47A 3vt7A-1fiuA:
0.0		 3vt7A-1fiuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 SER A 330
SER A 334
HIS A 384
LEU A 383
HIS A 348
 None
None
CU  A 666 (-3.4A)
None
CU  A 666 (-3.8A)
 1.46A 3vt7A-1hcyA:
0.0		 3vt7A-1hcyA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		5 LEU A 113
SER A 116
ARG A 383
SER A 382
LEU A 187
 None
 1.06A 3vt7A-1ihpA:
0.1		 3vt7A-1ihpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		5 LEU A 122
VAL A 123
SER A 186
ARG A 171
LEU A 127
 None
 1.48A 3vt7A-1kopA:
undetectable		 3vt7A-1kopA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs INTEGRAL MEMBRANE
PROTEIN SED5
SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1)
PF11416
(Syntaxin-5_N) 		5 VAL A 144
SER A 145
SER B  13
VAL A 156
LEU A 132
 None
 1.41A 3vt7A-1mqsA:
0.0		 3vt7A-1mqsA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2o PANTOTHENATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF02569
(Pantoate_ligase) 		5 LEU A  36
VAL A  37
SER A  65
VAL A 181
LEU A 165
 None
None
BAL  A 802 ( 4.9A)
None
None
 1.28A 3vt7A-1n2oA:
undetectable		 3vt7A-1n2oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpw PORCINE HEMOGLOBIN
(BETA SUBUNIT)

(Sus scrofa) 		PF00042
(Globin) 		5 TYR B 145
LEU B 141
VAL B 137
ARG B 104
VAL B  67
 None
HEM  B 750 (-4.9A)
None
None
HEM  B 750 ( 4.3A)
 1.23A 3vt7A-1qpwB:
undetectable		 3vt7A-1qpwB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 TYR A 372
LEU A 376
VAL A 541
SER A 542
VAL A 383
 None
 1.41A 3vt7A-1u2zA:
undetectable		 3vt7A-1u2zA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN B2 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		5 LEU D  39
VAL D  35
SER D 115
ARG D 118
VAL D  58
 None
 1.43A 3vt7A-1yhuD:
undetectable		 3vt7A-1yhuD:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ar1 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF01878
(EVE) 		5 TYR A  92
VAL A 143
SER A 142
SER A  18
VAL A 109
 GOL  A 301 (-4.7A)
None
None
GOL  A 301 (-3.6A)
None
 1.35A 3vt7A-2ar1A:
undetectable		 3vt7A-2ar1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 TYR A 276
VAL A 168
SER A 167
ARG A 171
LEU A 251
 None
 1.40A 3vt7A-2d7iA:
undetectable		 3vt7A-2d7iA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 288
VAL A 289
SER A 200
SER A 389
VAL A 281
 None
 1.31A 3vt7A-2dc0A:
undetectable		 3vt7A-2dc0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8m RIBOSE 5-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF06026
(Rib_5-P_isom_A) 		5 LEU A 108
VAL A 109
SER A 112
SER A  77
LEU A  70
 None
 1.28A 3vt7A-2f8mA:
undetectable		 3vt7A-2f8mA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
ARG A 134
SER A 141
VAL A 234
LEU A 219
 None
 1.03A 3vt7A-2h21A:
undetectable		 3vt7A-2h21A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 VAL A 110
SER A 113
SER A 141
VAL A 234
LEU A 219
 None
 1.13A 3vt7A-2h21A:
undetectable		 3vt7A-2h21A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		5 VAL A 227
SER A 223
SER A 103
VAL A 168
LEU A 165
 None
 1.50A 3vt7A-2hxrA:
undetectable		 3vt7A-2hxrA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1
TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens;
Mus musculus) 		PF04099
(Sybindin) 		5 LEU C  88
SER D 132
SER D 131
LEU D 170
HIS D 145
 None
 1.49A 3vt7A-2j3tC:
undetectable		 3vt7A-2j3tC:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		5 TYR A 226
VAL A 255
SER A 256
ARG A 258
VAL A 273
 None
 1.16A 3vt7A-2jk0A:
undetectable		 3vt7A-2jk0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		5 SER A  61
ARG A  86
VAL A 130
HIS A 131
HIS A 119
 None
 1.40A 3vt7A-2k1gA:
undetectable		 3vt7A-2k1gA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		5 LEU A 640
SER A 643
ARG A 724
SER A 725
LEU A 627
 None
 1.11A 3vt7A-2o1tA:
undetectable		 3vt7A-2o1tA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o4j VITAMIN D3 RECEPTOR

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		12 TYR A 143
TYR A 147
LEU A 229
VAL A 230
SER A 233
ARG A 270
SER A 271
SER A 274
VAL A 296
HIS A 301
LEU A 305
HIS A 393
 VD4  A 500 ( 4.7A)
VD4  A 500 ( 4.9A)
VD4  A 500 ( 4.8A)
VD4  A 500 ( 4.6A)
VD4  A 500 ( 2.8A)
VD4  A 500 ( 4.0A)
VD4  A 500 ( 3.9A)
VD4  A 500 ( 2.9A)
VD4  A 500 ( 4.4A)
VD4  A 500 ( 3.9A)
None
VD4  A 500 ( 3.9A)
 0.58A 3vt7A-2o4jA:
39.4		 3vt7A-2o4jA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 180
VAL A 179
SER A 194
VAL A 169
LEU A 154
 None
 1.39A 3vt7A-2pmiA:
undetectable		 3vt7A-2pmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 TYR A 206
LEU A  54
VAL A  59
SER A 256
HIS A  17
 None
 1.43A 3vt7A-2qneA:
undetectable		 3vt7A-2qneA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qww TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Listeria
monocytogenes) 		PF12802
(MarR_2) 		5 LEU A  83
VAL A  84
SER A 103
SER A 110
LEU A  64
 None
 1.15A 3vt7A-2qwwA:
undetectable		 3vt7A-2qwwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rii SULFIREDOXIN-1

(Homo sapiens) 		PF02195
(ParBc) 		5 VAL X  81
SER X  95
ARG X  51
VAL X  41
HIS X  42
 None
 1.49A 3vt7A-2riiX:
undetectable		 3vt7A-2riiX:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 TYR A  45
LEU A  91
SER A  39
SER A 106
HIS A 150
 None
None
None
FE  A 502 ( 4.1A)
None
 1.28A 3vt7A-2z4gA:
undetectable		 3vt7A-2z4gA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF13561
(adh_short_C2) 		5 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.35A 3vt7A-2zk7A:
undetectable		 3vt7A-2zk7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 SER A 272
SER A 231
SER A 198
HIS A 136
HIS A 134
 None
None
None
CU  A 701 (-3.2A)
CU  A 702 (-3.1A)
 1.28A 3vt7A-3abgA:
undetectable		 3vt7A-3abgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		5 VAL A 320
SER A 319
SER A  77
SER A  79
LEU A  93
 None
 1.42A 3vt7A-3bb7A:
undetectable		 3vt7A-3bb7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG A 213
SER A 210
SER A  45
HIS A 347
LEU A 349
 None
 1.30A 3vt7A-3e60A:
undetectable		 3vt7A-3e60A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 LEU A 716
SER A 714
SER A 607
HIS A1184
HIS A1163
 None
MD1  A1245 (-3.9A)
None
MD1  A1245 ( 4.6A)
MD1  A1245 (-3.4A)
 1.40A 3vt7A-3egwA:
undetectable		 3vt7A-3egwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 TYR A 575
LEU A 463
SER A 580
HIS A 637
LEU A 640
 None
 1.19A 3vt7A-3fedA:
undetectable		 3vt7A-3fedA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		5 TYR A 156
TYR A 211
SER A 205
VAL A 250
HIS A 253
 None
 1.42A 3vt7A-3hzrA:
undetectable		 3vt7A-3hzrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU F 209
VAL F 215
SER F 214
ARG F 217
VAL F 191
 None
 1.49A 3vt7A-3kfuF:
undetectable		 3vt7A-3kfuF:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		5 TYR A 194
LEU A 205
VAL A 204
VAL A 231
HIS A 234
 None
 1.41A 3vt7A-3na6A:
undetectable		 3vt7A-3na6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ARG A 153
SER A 373
VAL A 318
HIS A 317
HIS A 282
 None
None
None
KCX  A 195 ( 4.7A)
KCX  A 195 ( 4.6A)
 1.49A 3vt7A-3nwrA:
undetectable		 3vt7A-3nwrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 LEU A 464
VAL A 463
SER A 460
ARG A 457
VAL A 490
 None
None
None
None
EDO  A 605 ( 4.9A)
 1.43A 3vt7A-3vexA:
undetectable		 3vt7A-3vexA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 TYR A 143
LEU A 233
VAL A 234
SER A 237
ARG A 274
SER A 275
SER A 278
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.21A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wgp VITAMIN D3 RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 TYR A 143
TYR A 147
VAL A 234
SER A 237
ARG A 274
SER A 275
SER A 278
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
None
None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.60A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 380
VAL A 411
SER A 414
VAL A 349
LEU A 357
 None
 1.42A 3vt7A-4a3tA:
undetectable		 3vt7A-4a3tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn2 KINESIN-LIKE PROTEIN
KIF15

(Homo sapiens) 		PF00225
(Kinesin) 		5 LEU A 173
ARG A 311
VAL A 225
HIS A 223
LEU A 252
 None
 1.44A 3vt7A-4bn2A:
undetectable		 3vt7A-4bn2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn9 ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Chloroflexus
aurantiacus) 		PF03992
(ABM) 		5 LEU A  65
VAL A  68
SER A  67
HIS A  59
LEU A   4
 None
 1.47A 3vt7A-4dn9A:
undetectable		 3vt7A-4dn9A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  29
VAL A  31
ARG A  59
SER A  71
LEU A 103
 None
 1.12A 3vt7A-4je3A:
undetectable		 3vt7A-4je3A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  29
VAL A  31
ARG A  59
SER A  71
VAL A  98
 None
 1.47A 3vt7A-4je3A:
undetectable		 3vt7A-4je3A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		5 ARG A 237
SER A 208
VAL A 195
HIS A 196
LEU A 202
 None
 1.42A 3vt7A-4r40A:
undetectable		 3vt7A-4r40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuc ANKYRIN REPEAT AND
SOCS BOX PROTEIN 11

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 150
VAL A 149
SER A 143
SER A 141
LEU A  78
 None
 1.17A 3vt7A-4uucA:
undetectable		 3vt7A-4uucA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0b DOUBLE CLP-N MOTIF
PROTEIN

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 VAL A 221
SER A 224
SER A 124
VAL A 135
LEU A 115
 None
 1.35A 3vt7A-4y0bA:
undetectable		 3vt7A-4y0bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y13 TRANSCRIPTIONAL
REGULATOR OF FTSQAZ
GENE CLUSTER

(Escherichia
coli) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		5 TYR A  27
TYR A  42
LEU A 133
VAL A 158
SER A 161
 None
 1.44A 3vt7A-4y13A:
undetectable		 3vt7A-4y13A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 686
SER A 680
SER A 658
LEU A 674
HIS A 676
 None
 1.40A 3vt7A-4yhcA:
undetectable		 3vt7A-4yhcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 TYR B  74
TYR B 144
VAL B 157
LEU B  30
HIS B  24
 None
None
None
None
SO4  B 402 (-4.4A)
 1.48A 3vt7A-4yjfB:
undetectable		 3vt7A-4yjfB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 LEU A 291
VAL A 290
ARG A 286
VAL A  10
LEU A 142
 None
None
None
FAD  A 401 (-4.7A)
None
 1.45A 3vt7A-5eowA:
undetectable		 3vt7A-5eowA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		5 TYR A 172
TYR A 340
VAL A 302
SER A 320
LEU A 247
 None
 1.39A 3vt7A-5fa1A:
undetectable		 3vt7A-5fa1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 LEU B1070
SER B1065
VAL B1114
LEU B1052
HIS B1040
 None
 1.41A 3vt7A-5hb4B:
undetectable		 3vt7A-5hb4B:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.31A 3vt7A-5iz5B:
undetectable		 3vt7A-5iz5B:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jx3 URACIL-DNA
GLYCOSYLASE

(Vaccinia virus) 		no annotation 5 LEU A 170
VAL A 152
HIS A 151
LEU A  57
HIS A 147
 None
 1.19A 3vt7A-5jx3A:
undetectable		 3vt7A-5jx3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		5 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.23A 3vt7A-5mdxC:
undetectable		 3vt7A-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 TYR A1248
LEU A1241
VAL A1238
SER A1253
LEU A1198
 None
 1.37A 3vt7A-5me3A:
undetectable		 3vt7A-5me3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 LEU A 332
VAL A 333
SER A 335
VAL A 185
LEU A 187
 None
 1.30A 3vt7A-5obuA:
undetectable		 3vt7A-5obuA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obw CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 LEU A 332
VAL A 333
SER A 335
VAL A 185
LEU A 187
 None
 1.27A 3vt7A-5obwA:
undetectable		 3vt7A-5obwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh1 -

(-) 		no annotation 5 TYR A 538
LEU A 496
VAL A 489
HIS A 488
HIS A 483
 None
 1.31A 3vt7A-5yh1A:
undetectable		 3vt7A-5yh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 5 LEU A 315
SER A 436
VAL A 310
HIS A 309
LEU A 362
 None
None
None
NI  A 800 (-3.5A)
None
 1.35A 3vt7A-5yknA:
undetectable		 3vt7A-5yknA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 SER A 378
ARG A 374
VAL A 431
HIS A 430
LEU A 165
 None
 1.45A 3vt7A-5yl7A:
undetectable		 3vt7A-5yl7A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bms PALMITOYLTRANSFERASE

(Danio rerio) 		no annotation 5 VAL A 257
SER A 272
SER A 153
SER A  68
HIS A 218
 None
 1.49A 3vt7A-6bmsA:
undetectable		 3vt7A-6bmsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 VAL A 343
ARG A 216
SER A 171
HIS A 101
LEU A  92
 None
 1.48A 3vt7A-6etzA:
undetectable		 3vt7A-6etzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 5 LEU A 261
VAL A 262
SER A 303
LEU A 338
HIS A 333
 DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.8A)
None
DZW  A 501 (-3.9A)
 1.31A 3vt7A-6fobA:
36.5		 3vt7A-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 7 TYR A 175
LEU A 261
VAL A 262
SER A 265
ARG A 302
SER A 303
LEU A 338
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
None
 1.18A 3vt7A-6fobA:
36.5		 3vt7A-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 11 TYR A 175
LEU A 261
VAL A 262
SER A 265
ARG A 302
SER A 303
SER A 306
VAL A 328
HIS A 333
LEU A 337
HIS A 423
 None
DZW  A 501 ( 4.5A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
None
DZW  A 501 (-4.0A)
 0.26A 3vt7A-6fobA:
36.5		 3vt7A-6fobA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fob VITAMIN D3 RECEPTOR
A

(Danio rerio) 		no annotation 11 TYR A 175
TYR A 179
VAL A 262
SER A 265
ARG A 302
SER A 303
SER A 306
VAL A 328
HIS A 333
LEU A 337
HIS A 423
 None
DZW  A 501 ( 4.8A)
None
DZW  A 501 (-3.0A)
DZW  A 501 (-3.8A)
DZW  A 501 (-3.8A)
DZW  A 501 (-2.7A)
DZW  A 501 ( 4.3A)
DZW  A 501 (-3.9A)
None
DZW  A 501 (-4.0A)
 0.62A 3vt7A-6fobA:
36.5		 3vt7A-6fobA:
21.78