SIMILAR PATTERNS OF AMINO ACIDS FOR 3VRM_A_VD3A502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gn1 | CCT-GAMMA (Mus musculus) |
PF00118(Cpn60_TCP1) | 5 | ILE A 282LEU A 304ILE A 296ALA A 300PRO A 335 | None | 1.00A | 3vrmA-1gn1A:0.0 | 3vrmA-1gn1A:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg0 | L-ASPARAGINASE (Dickeyachrysanthemi) |
PF00710(Asparaginase) | 5 | ILE A 16LEU A 39ILE A 9ALA A 11ILE A 156 | None | 1.00A | 3vrmA-1hg0A:0.0 | 3vrmA-1hg0A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 5 | PRO A 718ILE A 97LEU A 44ILE A 86ALA A 88 | NoneNoneNoneNAP A1000 ( 4.2A)None | 1.05A | 3vrmA-1j1wA:0.0 | 3vrmA-1j1wA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khw | RNA-DIRECTED RNAPOLYMERASE (Rabbithemorrhagicdisease virus) |
PF00680(RdRP_1) | 5 | ILE A 269LEU A 324LEU A 265ILE A 88ILE A 221 | None | 0.98A | 3vrmA-1khwA:0.0 | 3vrmA-1khwA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lqt | FPRA (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 5 | ILE A 225LEU A 230ILE A 249ILE A 196LEU A 212 | None | 1.04A | 3vrmA-1lqtA:0.0 | 3vrmA-1lqtA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pu7 | 3-METHYLADENINE DNAGLYCOSYLASE (Helicobacterpylori) |
PF00633(HHH)PF00730(HhH-GPD) | 5 | ILE A 104LEU A 69ILE A 72ALA A 73ILE A 129 | None | 1.06A | 3vrmA-1pu7A:0.0 | 3vrmA-1pu7A:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pv9 | XAA-PRO DIPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | PRO A 294ILE A 312LEU A 282ALA A 265ILE A 332 | None | 1.05A | 3vrmA-1pv9A:0.0 | 3vrmA-1pv9A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pzn | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD51 (Pyrococcusfuriosus) |
PF08423(Rad51)PF14520(HHH_5) | 5 | ILE A 62LEU A 70ILE A 76ALA A 81ILE A 37 | None | 1.07A | 3vrmA-1pznA:undetectable | 3vrmA-1pznA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb3 | THREONINE SYNTHASE (Escherichiacoli) |
PF00291(PALP)PF14821(Thr_synth_N) | 5 | PRO A 36MET A 1ILE A 63ILE A 216ILE A 58 | None | 1.00A | 3vrmA-1vb3A:undetectable | 3vrmA-1vb3A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy2 | XAA-PRO DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | PRO A 297ILE A 315LEU A 285ALA A 268ILE A 335 | None | 0.98A | 3vrmA-1wy2A:undetectable | 3vrmA-1wy2A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3n | ALGQ1 (Sphingomonassp. A1) |
PF01547(SBP_bac_1) | 5 | MET A 17ILE A 15ALA A 32ILE A 319LEU A 332 | None | 1.07A | 3vrmA-1y3nA:undetectable | 3vrmA-1y3nA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8q | UBIQUITIN-LIKE 2ACTIVATING ENZYMEE1B (Homo sapiens) |
PF00899(ThiF)PF14732(UAE_UbL)PF16195(UBA2_C) | 6 | ILE B 398LEU B 21LEU B 32ALA B 115ILE B 405LEU B 136 | None | 1.40A | 3vrmA-1y8qB:undetectable | 3vrmA-1y8qB:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7s | PROBABLEPROPIONYL-COACARBOXYLASE BETACHAIN 5 (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 5 | ILE A 344LEU A 450LEU A 528ILE A 424LEU A 388 | None | 0.88A | 3vrmA-2a7sA:undetectable | 3vrmA-2a7sA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1l | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
PF13091(PLDc_2) | 5 | LEU A 285ILE A 304ALA A 303ILE A 213LEU A 205 | None | 1.03A | 3vrmA-2c1lA:undetectable | 3vrmA-2c1lA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g39 | ACETYL-COA HYDROLASE (Pseudomonasaeruginosa) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | ILE A 178ILE A 155ALA A 154PRO A 336ILE A 339 | NoneACY A 903 (-3.5A)NoneNoneNone | 0.98A | 3vrmA-2g39A:undetectable | 3vrmA-2g39A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ik8 | GUANINENUCLEOTIDE-BINDINGPROTEIN G(I),ALPHA-1 SUBUNIT (Homo sapiens) |
PF00503(G-alpha) | 5 | ILE A 127LEU A 159ILE A 162ALA A 163ILE A 82 | None | 1.02A | 3vrmA-2ik8A:undetectable | 3vrmA-2ik8A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j48 | TWO-COMPONENT SENSORKINASE (Synechococcuselongatus) |
PF00072(Response_reg) | 5 | LEU A 632LEU A 689ALA A 663PRO A 672ILE A 673 | None | 1.04A | 3vrmA-2j48A:undetectable | 3vrmA-2j48A:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jk1 | HYDROGENASETRANSCRIPTIONALREGULATORY PROTEINHUPR1 (Rhodobactercapsulatus) |
PF00072(Response_reg) | 5 | ILE A 52LEU A 44ILE A 41ALA A 40ILE A 100 | None | 1.07A | 3vrmA-2jk1A:undetectable | 3vrmA-2jk1A:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzj | CYANOVIRIN-N HOMOLOG (Ceratopterisrichardii) |
PF08881(CVNH) | 5 | ILE A 41LEU A 48ALA A 72ILE A 35LEU A 14 | None | 1.06A | 3vrmA-2jzjA:undetectable | 3vrmA-2jzjA:14.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4h | HIV-2 MYRISTOYLATEDMATRIX PROTEIN (Humanimmunodeficiencyvirus 2) |
PF00540(Gag_p17) | 5 | ILE A 85LEU A 31LEU A 51ALA A 37ILE A 19 | MYR A 1 ( 3.4A)NoneMYR A 1 (-3.3A)NoneNone | 1.07A | 3vrmA-2k4hA:undetectable | 3vrmA-2k4hA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ltm | NFU1 IRON-SULFURCLUSTER SCAFFOLDHOMOLOG,MITOCHONDRIAL (Homo sapiens) |
PF08712(Nfu_N) | 5 | ILE A 93LEU A 33LEU A 51PRO A 28ILE A 27 | None | 1.05A | 3vrmA-2ltmA:undetectable | 3vrmA-2ltmA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzu | CATABOLITE CONTROLPROTEIN (Bacillusmegaterium) |
PF13377(Peripla_BP_3) | 5 | PRO G 240LEU G 209LEU G 172ILE G 173ILE G 216 | None | 1.07A | 3vrmA-2nzuG:undetectable | 3vrmA-2nzuG:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0g | SELENOPROTEINW-RELATED PROTEIN (Vibrio cholerae) |
PF10262(Rdx) | 5 | ILE A 57LEU A 79ILE A 80ILE A 8LEU A 27 | None | 0.99A | 3vrmA-2p0gA:undetectable | 3vrmA-2p0gA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q47 | PROBABLETYROSINE-PROTEINPHOSPHATASEAT1G05000 (Arabidopsisthaliana) |
PF03162(Y_phosphatase2) | 5 | PRO A 72ILE A 148LEU A 111LEU A 91ALA A 134 | None | 1.03A | 3vrmA-2q47A:undetectable | 3vrmA-2q47A:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quq | CENTROMEREDNA-BINDING PROTEINCOMPLEX CBF3 SUBUNITB (Saccharomycescerevisiae) |
PF16846(Cep3) | 5 | MET A 174ILE A 171LEU A 179ILE A 182LEU A 106 | None | 1.03A | 3vrmA-2quqA:undetectable | 3vrmA-2quqA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcc | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT BETA (Bacillushalodurans) |
PF00268(Ribonuc_red_sm) | 5 | ILE A 183LEU A 187ALA A 288ILE A 178LEU A 295 | None | 1.05A | 3vrmA-2rccA:undetectable | 3vrmA-2rccA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhq | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Staphylococcushaemolyticus) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 5 | ILE B 42LEU B 122LEU B 154PRO B 100ILE B 103 | None | 0.91A | 3vrmA-2rhqB:undetectable | 3vrmA-2rhqB:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tpt | THYMIDINEPHOSPHORYLASE (Escherichiacoli) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 6 | PRO A 137ILE A 112LEU A 160ALA A 193PRO A 110ILE A 146 | None | 1.43A | 3vrmA-2tptA:undetectable | 3vrmA-2tptA:23.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | MET A 74ILE A 76LEU A 159LEU A 226ILE A 229 | PG4 A1399 ( 4.4A)HEM A1400 (-4.1A)NoneHEM A1400 (-4.4A)PG4 A1399 ( 4.5A) | 0.93A | 3vrmA-2xkrA:45.1 | 3vrmA-2xkrA:36.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | ILE A 96LEU A 180LEU A 240ILE A 243ALA A 244 | HEM A 413 (-4.0A)VDX A 501 (-4.2A)HEM A 413 ( 4.5A)VDX A 501 (-4.2A)HEM A 413 (-3.5A) | 0.63A | 3vrmA-2zbzA:47.7 | 3vrmA-2zbzA:37.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bzh | UBIQUITIN-CONJUGATING ENZYME E2 E1 (Homo sapiens) |
PF00179(UQ_con) | 5 | ILE A 145LEU A 132LEU A 149ILE A 152PRO A 111 | None | 0.98A | 3vrmA-3bzhA:undetectable | 3vrmA-3bzhA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cqy | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Shewanellaoneidensis) |
PF03702(AnmK) | 5 | ILE A 168LEU A 311LEU A 304ILE A 174LEU A 292 | None | 0.99A | 3vrmA-3cqyA:undetectable | 3vrmA-3cqyA:24.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3db1 | STS-2 PROTEIN (Mus musculus) |
PF00300(His_Phos_1) | 5 | ILE A 364LEU A 583ALA A 424ILE A 545LEU A 460 | None | 1.00A | 3vrmA-3db1A:undetectable | 3vrmA-3db1A:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz4 | PUTATIVE ARSENATEREDUCTASE (Streptococcusmutans) |
PF03960(ArsC) | 5 | ILE A 92LEU A 51LEU A 96ILE A 103LEU A 46 | NoneNoneNoneFMT A 205 (-4.6A)None | 1.01A | 3vrmA-3fz4A:undetectable | 3vrmA-3fz4A:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jav | INOSITOL1,4,5-TRISPHOSPHATERECEPTOR TYPE 1 (Rattusnorvegicus) |
PF00520(Ion_trans)PF01365(RYDR_ITPR)PF02815(MIR)PF08454(RIH_assoc)PF08709(Ins145_P3_rec) | 5 | ILE A 220LEU A 126ILE A 14ILE A 27LEU A 123 | None | 0.89A | 3vrmA-3javA:undetectable | 3vrmA-3javA:9.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1j | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF05362(Lon_C)PF13654(AAA_32) | 5 | ILE A 234LEU A 242ILE A 197ALA A 199ILE A 269 | None | 1.02A | 3vrmA-3k1jA:undetectable | 3vrmA-3k1jA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4y | ISOPENTENYLPHOSPHATE KINASE (Methanocaldococcusjannaschii) |
PF00696(AA_kinase) | 5 | ILE A 97LEU A 26ILE A 29ALA A 30ILE A 142 | None | 0.88A | 3vrmA-3k4yA:undetectable | 3vrmA-3k4yA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyl | TELOMERASE REVERSETRANSCRIPTASE (Triboliumcastaneum) |
PF00078(RVT_1)PF12009(Telomerase_RBD) | 5 | ILE A 48LEU A 123LEU A 78ILE A 77ILE A 55 | None | 0.99A | 3vrmA-3kylA:undetectable | 3vrmA-3kylA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkb | PROBABLEBRANCHED-CHAIN AMINOACID ABCTRANSPORTER, AMINOACID BINDING PROTEIN (Thermusthermophilus) |
PF13458(Peripla_BP_6) | 5 | ILE A 301ILE A 320ALA A 319PRO A 77ILE A 76 | None | 0.96A | 3vrmA-3lkbA:undetectable | 3vrmA-3lkbA:27.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkv | PUTATIVEAMIDOHYDROLASE (unidentified) |
PF01979(Amidohydro_1) | 5 | LEU A 367LEU A 59ILE A 60ALA A 353PRO A 14 | None | 0.90A | 3vrmA-3mkvA:undetectable | 3vrmA-3mkvA:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rf2 | 30S RIBOSOMALPROTEIN S8 (Aquifexaeolicus) |
PF00410(Ribosomal_S8) | 5 | ILE A 96LEU A 98ILE A 18ALA A 17ILE A 36 | None | 0.82A | 3vrmA-3rf2A:undetectable | 3vrmA-3rf2A:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | LEU A 548ILE A 536ALA A 532ILE A 410LEU A 388 | None | 0.99A | 3vrmA-3rimA:undetectable | 3vrmA-3rimA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rst | SIGNAL PEPTIDEPEPTIDASE SPPA (Bacillussubtilis) |
PF01343(Peptidase_S49) | 5 | MET A 237ILE A 231ILE A 245ALA A 246ILE A 159 | None | 0.96A | 3vrmA-3rstA:undetectable | 3vrmA-3rstA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rv6 | ISOCHORISMATESYNTHASE/ISOCHORISMATE-PYRUVATE LYASEMBTI (Mycobacteriumtuberculosis) |
PF00425(Chorismate_bind) | 5 | MET A 20LEU A 164ILE A 161ALA A 160LEU A 56 | None | 0.98A | 3vrmA-3rv6A:undetectable | 3vrmA-3rv6A:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swd | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Escherichiacoli) |
PF00275(EPSP_synthase) | 6 | ILE A 244MET A 306LEU A 312ALA A 379ILE A 249LEU A 406 | None | 1.50A | 3vrmA-3swdA:undetectable | 3vrmA-3swdA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl6 | PURINE NUCLEOSIDEPHOSPHORYLASE (Entamoebahistolytica) |
PF01048(PNP_UDP_1) | 5 | ILE A 90LEU A 189ILE A 192ALA A 193ILE A 17 | None | 0.70A | 3vrmA-3tl6A:undetectable | 3vrmA-3tl6A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9w | LEUKOTRIENE A-4HYDROLASE (Homo sapiens) |
PF01433(Peptidase_M1)PF09127(Leuk-A4-hydro_C) | 5 | ILE A1476LEU A1503LEU A1512ALA A1510ILE A1469 | None | 1.01A | 3vrmA-3u9wA:undetectable | 3vrmA-3u9wA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0v | L-LYSINE OXIDASE (Trichodermaviride) |
PF01593(Amino_oxidase) | 5 | LEU A 296MET A 294LEU A 288ILE A 309ALA A 308 | NoneFAD A 601 (-4.9A)NoneNoneNone | 1.00A | 3vrmA-3x0vA:undetectable | 3vrmA-3x0vA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zi5 | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
no annotation | 5 | LEU A 285ILE A 304ALA A 303ILE A 213LEU A 205 | None | 1.01A | 3vrmA-3zi5A:undetectable | 3vrmA-3zi5A:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 5 | ILE A 233LEU A 308ILE A 304ILE A 282LEU A 330 | None | 1.00A | 3vrmA-4aeeA:undetectable | 3vrmA-4aeeA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bl3 | PENICILLIN BINDINGPROTEIN 2 PRIME (Staphylococcusaureus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF05223(MecA_N) | 5 | ILE A 459LEU A 455ALA A 410ILE A 595LEU A 538 | None | 0.85A | 3vrmA-4bl3A:undetectable | 3vrmA-4bl3A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bz7 | HISTONE DEACETYLASE8 (Schistosomamansoni) |
PF00850(Hist_deacetyl) | 5 | PRO A 275LEU A 164ILE A 161ALA A 160ILE A 326 | None | 0.71A | 3vrmA-4bz7A:undetectable | 3vrmA-4bz7A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c90 | ALPHA-GLUCURONIDASEGH115 (Bacteroidesovatus) |
PF15979(Glyco_hydro_115) | 5 | MET A 477ILE A 473LEU A 239ILE A 236LEU A 204 | None | 0.96A | 3vrmA-4c90A:undetectable | 3vrmA-4c90A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | ILE A 76LEU A 325LEU A 328ALA A 67LEU A 320 | None | 1.05A | 3vrmA-4c9mA:41.0 | 3vrmA-4c9mA:27.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccw | CARBOXYL ESTERASE NP (Bacillussubtilis) |
PF12697(Abhydrolase_6) | 5 | LEU A 61LEU A 153ALA A 151ILE A 75LEU A 58 | None | 1.04A | 3vrmA-4ccwA:undetectable | 3vrmA-4ccwA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ddi | UBIQUITIN-CONJUGATING ENZYME E2 D2,UBIQUITINTHIOESTERASE OTUB1 (Homo sapiens) |
PF00179(UQ_con)PF10275(Peptidase_C65) | 5 | ILE A 99LEU A 86LEU A 103ILE A 106PRO A 65 | None | 1.02A | 3vrmA-4ddiA:undetectable | 3vrmA-4ddiA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8b | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE E (Escherichiacoli) |
PF04452(Methyltrans_RNA) | 5 | PRO A 148LEU A 82ILE A 232ALA A 228ILE A 134 | None | 1.05A | 3vrmA-4e8bA:undetectable | 3vrmA-4e8bA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1k | THROMBOSPONDINRELATED ANONYMOUSPROTEIN (Plasmodiumfalciparum) |
PF00092(VWA) | 5 | ILE A 76LEU A 88ALA A 90ILE A 227LEU A 160 | None | 0.95A | 3vrmA-4f1kA:undetectable | 3vrmA-4f1kA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3r | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Coxiellaburnetii) |
PF01467(CTP_transf_like) | 5 | ILE A 85LEU A 72ALA A 77PRO A 8LEU A 69 | None | 1.06A | 3vrmA-4f3rA:undetectable | 3vrmA-4f3rA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fva | 5'-TYROSYL-DNAPHOSPHODIESTERASE (Caenorhabditiselegans) |
PF03372(Exo_endo_phos) | 5 | LEU A 228LEU A 190ILE A 189ALA A 188ILE A 356 | None | 0.90A | 3vrmA-4fvaA:undetectable | 3vrmA-4fvaA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gew | 5'-TYROSYL-DNAPHOSPHODIESTERASE (Caenorhabditiselegans) |
PF03372(Exo_endo_phos)PF14555(UBA_4) | 5 | LEU A 228LEU A 190ILE A 189ALA A 188ILE A 356 | None | 0.87A | 3vrmA-4gewA:undetectable | 3vrmA-4gewA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h65 | PYRIMIDINE PRECURSORBIOSYNTHESIS ENZYMETHI5 (Saccharomycescerevisiae) |
PF09084(NMT1) | 5 | ILE A 224LEU A 84LEU A 269ALA A 81LEU A 61 | None | 0.99A | 3vrmA-4h65A:undetectable | 3vrmA-4h65A:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ii2 | UBIQUITIN-CONJUGATING ENZYME E2 4 (Schizosaccharomycespombe) |
PF00179(UQ_con) | 5 | ILE C 99LEU C 86LEU C 103ILE C 106PRO C 65 | None | 0.96A | 3vrmA-4ii2C:undetectable | 3vrmA-4ii2C:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jkg | PRE-MRNA-PROCESSING-SPLICING FACTOR 8 (Homo sapiens) |
PF12134(PRP8_domainIV) | 5 | ILE B1953LEU B1988LEU B1983ILE B1987ALA B1942 | None | 1.06A | 3vrmA-4jkgB:undetectable | 3vrmA-4jkgB:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwt | METHYLTHIOADENOSINENUCLEOSIDASE (Sulfurimonasdenitrificans) |
PF01048(PNP_UDP_1) | 5 | ILE A 90LEU A 170LEU A 84ILE A 80ILE A 190 | NoneADE A 305 (-4.7A)NoneNoneNone | 1.01A | 3vrmA-4jwtA:undetectable | 3vrmA-4jwtA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jyl | ENOYL-COA HYDRATASE (Thermoplasmavolcanium) |
PF00378(ECH_1) | 5 | MET A 65LEU A 30ILE A 25ALA A 24LEU A 2 | None | 0.99A | 3vrmA-4jylA:undetectable | 3vrmA-4jylA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kk1 | TUBEROUS SCLEROSIS 1PROTEIN HOMOLOG (Schizosaccharomycespombe) |
PF04388(Hamartin) | 6 | PRO A 226ILE A 254LEU A 233ALA A 238ILE A 215LEU A 208 | None | 1.26A | 3vrmA-4kk1A:undetectable | 3vrmA-4kk1A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4knh | NUP192P (Chaetomiumthermophilum) |
PF11894(Nup192) | 5 | ILE A 245LEU A 140ILE A 139ALA A 160ILE A 46 | None | 0.95A | 3vrmA-4knhA:undetectable | 3vrmA-4knhA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kr5 | GLUTAMINE ABCTRANSPORTER PERMEASEAND SUBSTRATEBINDING PROTEINPROTEIN (Lactococcuslactis) |
PF00497(SBP_bac_3) | 5 | MET A 324LEU A 463LEU A 290ILE A 293ALA A 294 | None | 0.80A | 3vrmA-4kr5A:undetectable | 3vrmA-4kr5A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kwb | SIGNAL PEPTIDEPEPTIDASE SPPA (Bacillussubtilis) |
PF01343(Peptidase_S49) | 5 | MET A 237ILE A 231ILE A 245ALA A 246ILE A 159 | None | 0.97A | 3vrmA-4kwbA:undetectable | 3vrmA-4kwbA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mb5 | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18)PF16403(DUF5011) | 5 | ILE A 122LEU A 152ILE A 150PRO A 82ILE A 81 | NoneNoneNoneNonePEG A 604 (-3.9A) | 1.06A | 3vrmA-4mb5A:undetectable | 3vrmA-4mb5A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzy | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Enterococcusfaecalis) |
PF04095(NAPRTase) | 5 | ILE A 148LEU A 140LEU A 319ILE A 141ALA A 178 | None | 1.04A | 3vrmA-4mzyA:undetectable | 3vrmA-4mzyA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni2 | GUANYLATE CYCLASESOLUBLE SUBUNITBETA-1 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | ILE B 519LEU B 460LEU B 453ILE B 562LEU B 423 | None | 0.92A | 3vrmA-4ni2B:undetectable | 3vrmA-4ni2B:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6m | AF2299, ACDP-ALCOHOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) |
PF01066(CDP-OH_P_transf) | 5 | ILE A 250LEU A 305ILE A 207ALA A 203ILE A 323 | None | 1.07A | 3vrmA-4o6mA:undetectable | 3vrmA-4o6mA:24.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovk | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 6 | LEU A 320MET A 317ILE A 258ALA A 287PRO A 269ILE A 360 | None | 1.50A | 3vrmA-4ovkA:undetectable | 3vrmA-4ovkA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvi | GH62 HYDROLASE (Mycothermusthermophilus) |
PF03664(Glyco_hydro_62) | 5 | ILE A 237LEU A 319ILE A 323ILE A 234LEU A 249 | None | 1.06A | 3vrmA-4pviA:undetectable | 3vrmA-4pviA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmf | KRR1 SMALL SUBUNITPROCESSOME COMPONENT (Saccharomycescerevisiae) |
no annotation | 5 | LEU D 103MET D 174LEU D 117ALA D 97ILE D 56 | None | 1.01A | 3vrmA-4qmfD:undetectable | 3vrmA-4qmfD:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uuy | VACUOLAR MEMBRANEPROTEIN PEP3 (Saccharomycescerevisiae) |
PF05131(Pep3_Vps18) | 5 | ILE A 261LEU A 266ILE A 271ILE A 198LEU A 314 | None | 1.07A | 3vrmA-4uuyA:undetectable | 3vrmA-4uuyA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5z | CHITINASE 60 (Moritellamarina) |
PF00704(Glyco_hydro_18) | 6 | ILE A 122LEU A 170LEU A 152ILE A 150PRO A 82ILE A 81 | None | 1.37A | 3vrmA-4w5zA:undetectable | 3vrmA-4w5zA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 5 | ILE A 270LEU A 47ILE A 276ILE A 118LEU A 93 | None | 1.05A | 3vrmA-4wd9A:undetectable | 3vrmA-4wd9A:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | PRO A 423LEU A 62LEU A 389ALA A 393ILE A 58 | None | 0.95A | 3vrmA-4wgxA:undetectable | 3vrmA-4wgxA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ILE A 204LEU A 115LEU A 112ALA A 231ILE A 21 | None | 0.92A | 3vrmA-4ynnA:undetectable | 3vrmA-4ynnA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zaa | FDC1 (Aspergillusniger) |
PF01977(UbiD) | 5 | ILE A 192LEU A 182LEU A 269ALA A 296ILE A 171 | NoneNoneNoneNoneFZZ A 602 ( 3.7A) | 1.06A | 3vrmA-4zaaA:undetectable | 3vrmA-4zaaA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpx | ATP-DEPENDENTPROTEASE LON (Thermococcusonnurineus) |
PF01078(Mg_chelatase)PF13654(AAA_32) | 5 | ILE A 234LEU A 242ILE A 197ALA A 199ILE A 269 | None | 1.02A | 3vrmA-4zpxA:undetectable | 3vrmA-4zpxA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwd | BENZYLSUCCINATESYNTHASE ALPHA CHAIN (Thaueraaromatica) |
PF01228(Gly_radical)PF02901(PFL-like) | 6 | PRO A 299LEU A 103LEU A 318ILE A 323ALA A 322ILE A 592 | None | 1.47A | 3vrmA-5bwdA:undetectable | 3vrmA-5bwdA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlb | CHAPERONE ESPG3 (Mycobacteriummarinum) |
PF14011(ESX-1_EspG) | 5 | ILE A 235LEU A 147LEU A 233ILE A 271ALA A 270 | None | 0.97A | 3vrmA-5dlbA:undetectable | 3vrmA-5dlbA:22.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 8 | PRO A 83ILE A 88LEU A 232ILE A 235ALA A 236PRO A 287ILE A 288LEU A 387 | NoneHEM A 501 ( 4.4A)HEM A 501 ( 4.7A)NoneHEM A 501 (-3.6A)HEM A 501 (-3.5A)NoneNone | 0.89A | 3vrmA-5gnmA:55.3 | 3vrmA-5gnmA:99.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 8 | PRO A 83MET A 86ILE A 88LEU A 232ILE A 235ALA A 236PRO A 287ILE A 288 | NoneNoneHEM A 501 ( 4.4A)HEM A 501 ( 4.7A)NoneHEM A 501 (-3.6A)HEM A 501 (-3.5A)None | 0.75A | 3vrmA-5gnmA:55.3 | 3vrmA-5gnmA:99.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gve | DNA TOPOISOMERASE3-BETA-1 (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | LEU A 21MET A 164ILE A 17ALA A 14LEU A 26 | None | 1.07A | 3vrmA-5gveA:undetectable | 3vrmA-5gveA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h0r | VP4 PROTEIN (Cypovirus 1) |
no annotation | 5 | PRO G 6ILE G 172LEU G 154ILE G 77ALA G 74 | None | 1.02A | 3vrmA-5h0rG:undetectable | 3vrmA-5h0rG:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PRO A 239ILE A 120LEU A 169ILE A 421ALA A 420 | None | 1.05A | 3vrmA-5i51A:undetectable | 3vrmA-5i51A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpn | COMPLEMENT C4-A (Homo sapiens) |
PF01759(NTR)PF07677(A2M_recep) | 5 | ILE C1472LEU C1523LEU C1556ILE C1485ALA C1484 | None | 0.99A | 3vrmA-5jpnC:undetectable | 3vrmA-5jpnC:21.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 5 | ILE A 85LYS A 187LEU A 238ILE A 241ALA A 242 | HEM A 501 (-4.4A)NoneHEM A 501 (-4.4A)TES A 502 (-4.0A)HEM A 501 (-3.5A) | 0.66A | 3vrmA-5l94A:49.5 | 3vrmA-5l94A:34.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | ILE A 519ILE A 542ALA A 544PRO A 247ILE A 248 | MET A 807 ( 4.4A)NoneNoneMET A 807 ( 4.7A)MET A 807 (-4.8A) | 0.97A | 3vrmA-5nfhA:undetectable | 3vrmA-5nfhA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o1p | ALPHA-AMINOADIPICSEMIALDEHYDESYNTHASE,MITOCHONDRIAL (Homo sapiens) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | PRO A 809LEU A 742LEU A 800PRO A 654LEU A 658 | None | 1.04A | 3vrmA-5o1pA:undetectable | 3vrmA-5o1pA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t3e | BACILLAMIDESYNTHETASEHETEROCYCLIZATIONDOMAIN (Thermoactinomycesvulgaris) |
PF00668(Condensation) | 5 | LEU A1225ILE A1193ALA A1047ILE A1059LEU A1052 | None | 0.99A | 3vrmA-5t3eA:undetectable | 3vrmA-5t3eA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t3e | BACILLAMIDESYNTHETASEHETEROCYCLIZATIONDOMAIN (Thermoactinomycesvulgaris) |
PF00668(Condensation) | 5 | LEU A1225ILE A1193PRO A1056ILE A1059LEU A1052 | None | 0.99A | 3vrmA-5t3eA:undetectable | 3vrmA-5t3eA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tgf | UNCHARACTERIZEDPROTEIN (Bacteroidesdorei) |
PF00144(Beta-lactamase) | 6 | ILE A 228LEU A 170LYS A 165MET A 163ALA A 66PRO A 178 | None | 1.44A | 3vrmA-5tgfA:undetectable | 3vrmA-5tgfA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 5 | ILE A 345LEU A 339ALA A 335PRO A 43ILE A 42 | None | 1.03A | 3vrmA-5uzeA:undetectable | 3vrmA-5uzeA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vrb | TRANSKETOLASE (Neisseriagonorrhoeae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PRO A 235ILE A 117LEU A 166ILE A 414ALA A 413 | None | 1.03A | 3vrmA-5vrbA:undetectable | 3vrmA-5vrbA:22.40 |