SIMILAR PATTERNS OF AMINO ACIDS FOR 3VRM_A_VD3A502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gn1 CCT-GAMMA

(Mus musculus)
PF00118
(Cpn60_TCP1)
5 ILE A 282
LEU A 304
ILE A 296
ALA A 300
PRO A 335
None
1.00A 3vrmA-1gn1A:
0.0
3vrmA-1gn1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi)
PF00710
(Asparaginase)
5 ILE A  16
LEU A  39
ILE A   9
ALA A  11
ILE A 156
None
1.00A 3vrmA-1hg0A:
0.0
3vrmA-1hg0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
5 PRO A 718
ILE A  97
LEU A  44
ILE A  86
ALA A  88
None
None
None
NAP  A1000 ( 4.2A)
None
1.05A 3vrmA-1j1wA:
0.0
3vrmA-1j1wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE


(Rabbit
hemorrhagic
disease virus)
PF00680
(RdRP_1)
5 ILE A 269
LEU A 324
LEU A 265
ILE A  88
ILE A 221
None
0.98A 3vrmA-1khwA:
0.0
3vrmA-1khwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis)
PF07992
(Pyr_redox_2)
5 ILE A 225
LEU A 230
ILE A 249
ILE A 196
LEU A 212
None
1.04A 3vrmA-1lqtA:
0.0
3vrmA-1lqtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE


(Helicobacter
pylori)
PF00633
(HHH)
PF00730
(HhH-GPD)
5 ILE A 104
LEU A  69
ILE A  72
ALA A  73
ILE A 129
None
1.06A 3vrmA-1pu7A:
0.0
3vrmA-1pu7A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 PRO A 294
ILE A 312
LEU A 282
ALA A 265
ILE A 332
None
1.05A 3vrmA-1pv9A:
0.0
3vrmA-1pv9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51


(Pyrococcus
furiosus)
PF08423
(Rad51)
PF14520
(HHH_5)
5 ILE A  62
LEU A  70
ILE A  76
ALA A  81
ILE A  37
None
1.07A 3vrmA-1pznA:
undetectable
3vrmA-1pznA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 PRO A  36
MET A   1
ILE A  63
ILE A 216
ILE A  58
None
1.00A 3vrmA-1vb3A:
undetectable
3vrmA-1vb3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 PRO A 297
ILE A 315
LEU A 285
ALA A 268
ILE A 335
None
0.98A 3vrmA-1wy2A:
undetectable
3vrmA-1wy2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1)
PF01547
(SBP_bac_1)
5 MET A  17
ILE A  15
ALA A  32
ILE A 319
LEU A 332
None
1.07A 3vrmA-1y3nA:
undetectable
3vrmA-1y3nA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B


(Homo sapiens)
PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C)
6 ILE B 398
LEU B  21
LEU B  32
ALA B 115
ILE B 405
LEU B 136
None
1.40A 3vrmA-1y8qB:
undetectable
3vrmA-1y8qB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5


(Mycobacterium
tuberculosis)
PF01039
(Carboxyl_trans)
5 ILE A 344
LEU A 450
LEU A 528
ILE A 424
LEU A 388
None
0.88A 3vrmA-2a7sA:
undetectable
3vrmA-2a7sA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE


(Bacillus firmus)
PF13091
(PLDc_2)
5 LEU A 285
ILE A 304
ALA A 303
ILE A 213
LEU A 205
None
1.03A 3vrmA-2c1lA:
undetectable
3vrmA-2c1lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
5 ILE A 178
ILE A 155
ALA A 154
PRO A 336
ILE A 339
None
ACY  A 903 (-3.5A)
None
None
None
0.98A 3vrmA-2g39A:
undetectable
3vrmA-2g39A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT


(Homo sapiens)
PF00503
(G-alpha)
5 ILE A 127
LEU A 159
ILE A 162
ALA A 163
ILE A  82
None
1.02A 3vrmA-2ik8A:
undetectable
3vrmA-2ik8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j48 TWO-COMPONENT SENSOR
KINASE


(Synechococcus
elongatus)
PF00072
(Response_reg)
5 LEU A 632
LEU A 689
ALA A 663
PRO A 672
ILE A 673
None
1.04A 3vrmA-2j48A:
undetectable
3vrmA-2j48A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk1 HYDROGENASE
TRANSCRIPTIONAL
REGULATORY PROTEIN
HUPR1


(Rhodobacter
capsulatus)
PF00072
(Response_reg)
5 ILE A  52
LEU A  44
ILE A  41
ALA A  40
ILE A 100
None
1.07A 3vrmA-2jk1A:
undetectable
3vrmA-2jk1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzj CYANOVIRIN-N HOMOLOG

(Ceratopteris
richardii)
PF08881
(CVNH)
5 ILE A  41
LEU A  48
ALA A  72
ILE A  35
LEU A  14
None
1.06A 3vrmA-2jzjA:
undetectable
3vrmA-2jzjA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4h HIV-2 MYRISTOYLATED
MATRIX PROTEIN


(Human
immunodeficiency
virus 2)
PF00540
(Gag_p17)
5 ILE A  85
LEU A  31
LEU A  51
ALA A  37
ILE A  19
MYR  A   1 ( 3.4A)
None
MYR  A   1 (-3.3A)
None
None
1.07A 3vrmA-2k4hA:
undetectable
3vrmA-2k4hA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL


(Homo sapiens)
PF08712
(Nfu_N)
5 ILE A  93
LEU A  33
LEU A  51
PRO A  28
ILE A  27
None
1.05A 3vrmA-2ltmA:
undetectable
3vrmA-2ltmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN


(Bacillus
megaterium)
PF13377
(Peripla_BP_3)
5 PRO G 240
LEU G 209
LEU G 172
ILE G 173
ILE G 216
None
1.07A 3vrmA-2nzuG:
undetectable
3vrmA-2nzuG:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0g SELENOPROTEIN
W-RELATED PROTEIN


(Vibrio cholerae)
PF10262
(Rdx)
5 ILE A  57
LEU A  79
ILE A  80
ILE A   8
LEU A  27
None
0.99A 3vrmA-2p0gA:
undetectable
3vrmA-2p0gA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q47 PROBABLE
TYROSINE-PROTEIN
PHOSPHATASE
AT1G05000


(Arabidopsis
thaliana)
PF03162
(Y_phosphatase2)
5 PRO A  72
ILE A 148
LEU A 111
LEU A  91
ALA A 134
None
1.03A 3vrmA-2q47A:
undetectable
3vrmA-2q47A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
None
1.03A 3vrmA-2quqA:
undetectable
3vrmA-2quqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus
halodurans)
PF00268
(Ribonuc_red_sm)
5 ILE A 183
LEU A 187
ALA A 288
ILE A 178
LEU A 295
None
1.05A 3vrmA-2rccA:
undetectable
3vrmA-2rccA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 ILE B  42
LEU B 122
LEU B 154
PRO B 100
ILE B 103
None
0.91A 3vrmA-2rhqB:
undetectable
3vrmA-2rhqB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE


(Escherichia
coli)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
6 PRO A 137
ILE A 112
LEU A 160
ALA A 193
PRO A 110
ILE A 146
None
1.43A 3vrmA-2tptA:
undetectable
3vrmA-2tptA:
23.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A  74
ILE A  76
LEU A 159
LEU A 226
ILE A 229
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
None
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
0.93A 3vrmA-2xkrA:
45.1
3vrmA-2xkrA:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 ILE A  96
LEU A 180
LEU A 240
ILE A 243
ALA A 244
HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
0.63A 3vrmA-2zbzA:
47.7
3vrmA-2zbzA:
37.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1


(Homo sapiens)
PF00179
(UQ_con)
5 ILE A 145
LEU A 132
LEU A 149
ILE A 152
PRO A 111
None
0.98A 3vrmA-3bzhA:
undetectable
3vrmA-3bzhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqy ANHYDRO-N-ACETYLMURA
MIC ACID KINASE


(Shewanella
oneidensis)
PF03702
(AnmK)
5 ILE A 168
LEU A 311
LEU A 304
ILE A 174
LEU A 292
None
0.99A 3vrmA-3cqyA:
undetectable
3vrmA-3cqyA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db1 STS-2 PROTEIN

(Mus musculus)
PF00300
(His_Phos_1)
5 ILE A 364
LEU A 583
ALA A 424
ILE A 545
LEU A 460
None
1.00A 3vrmA-3db1A:
undetectable
3vrmA-3db1A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz4 PUTATIVE ARSENATE
REDUCTASE


(Streptococcus
mutans)
PF03960
(ArsC)
5 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
None
None
None
FMT  A 205 (-4.6A)
None
1.01A 3vrmA-3fz4A:
undetectable
3vrmA-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec)
5 ILE A 220
LEU A 126
ILE A  14
ILE A  27
LEU A 123
None
0.89A 3vrmA-3javA:
undetectable
3vrmA-3javA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32)
5 ILE A 234
LEU A 242
ILE A 197
ALA A 199
ILE A 269
None
1.02A 3vrmA-3k1jA:
undetectable
3vrmA-3k1jA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4y ISOPENTENYL
PHOSPHATE KINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
5 ILE A  97
LEU A  26
ILE A  29
ALA A  30
ILE A 142
None
0.88A 3vrmA-3k4yA:
undetectable
3vrmA-3k4yA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE


(Tribolium
castaneum)
PF00078
(RVT_1)
PF12009
(Telomerase_RBD)
5 ILE A  48
LEU A 123
LEU A  78
ILE A  77
ILE A  55
None
0.99A 3vrmA-3kylA:
undetectable
3vrmA-3kylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN


(Thermus
thermophilus)
PF13458
(Peripla_BP_6)
5 ILE A 301
ILE A 320
ALA A 319
PRO A  77
ILE A  76
None
0.96A 3vrmA-3lkbA:
undetectable
3vrmA-3lkbA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkv PUTATIVE
AMIDOHYDROLASE


(unidentified)
PF01979
(Amidohydro_1)
5 LEU A 367
LEU A  59
ILE A  60
ALA A 353
PRO A  14
None
0.90A 3vrmA-3mkvA:
undetectable
3vrmA-3mkvA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf2 30S RIBOSOMAL
PROTEIN S8


(Aquifex
aeolicus)
PF00410
(Ribosomal_S8)
5 ILE A  96
LEU A  98
ILE A  18
ALA A  17
ILE A  36
None
0.82A 3vrmA-3rf2A:
undetectable
3vrmA-3rf2A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 LEU A 548
ILE A 536
ALA A 532
ILE A 410
LEU A 388
None
0.99A 3vrmA-3rimA:
undetectable
3vrmA-3rimA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA


(Bacillus
subtilis)
PF01343
(Peptidase_S49)
5 MET A 237
ILE A 231
ILE A 245
ALA A 246
ILE A 159
None
0.96A 3vrmA-3rstA:
undetectable
3vrmA-3rstA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI


(Mycobacterium
tuberculosis)
PF00425
(Chorismate_bind)
5 MET A  20
LEU A 164
ILE A 161
ALA A 160
LEU A  56
None
0.98A 3vrmA-3rv6A:
undetectable
3vrmA-3rv6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Escherichia
coli)
PF00275
(EPSP_synthase)
6 ILE A 244
MET A 306
LEU A 312
ALA A 379
ILE A 249
LEU A 406
None
1.50A 3vrmA-3swdA:
undetectable
3vrmA-3swdA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Entamoeba
histolytica)
PF01048
(PNP_UDP_1)
5 ILE A  90
LEU A 189
ILE A 192
ALA A 193
ILE A  17
None
0.70A 3vrmA-3tl6A:
undetectable
3vrmA-3tl6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 ILE A1476
LEU A1503
LEU A1512
ALA A1510
ILE A1469
None
1.01A 3vrmA-3u9wA:
undetectable
3vrmA-3u9wA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride)
PF01593
(Amino_oxidase)
5 LEU A 296
MET A 294
LEU A 288
ILE A 309
ALA A 308
None
FAD  A 601 (-4.9A)
None
None
None
1.00A 3vrmA-3x0vA:
undetectable
3vrmA-3x0vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi5 RESTRICTION
ENDONUCLEASE


(Bacillus firmus)
no annotation 5 LEU A 285
ILE A 304
ALA A 303
ILE A 213
LEU A 205
None
1.01A 3vrmA-3zi5A:
undetectable
3vrmA-3zi5A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION


(Staphylothermus
marinus)
PF00128
(Alpha-amylase)
5 ILE A 233
LEU A 308
ILE A 304
ILE A 282
LEU A 330
None
1.00A 3vrmA-4aeeA:
undetectable
3vrmA-4aeeA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N)
5 ILE A 459
LEU A 455
ALA A 410
ILE A 595
LEU A 538
None
0.85A 3vrmA-4bl3A:
undetectable
3vrmA-4bl3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8


(Schistosoma
mansoni)
PF00850
(Hist_deacetyl)
5 PRO A 275
LEU A 164
ILE A 161
ALA A 160
ILE A 326
None
0.71A 3vrmA-4bz7A:
undetectable
3vrmA-4bz7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
5 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
None
0.96A 3vrmA-4c90A:
undetectable
3vrmA-4c90A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 ILE A  76
LEU A 325
LEU A 328
ALA A  67
LEU A 320
None
1.05A 3vrmA-4c9mA:
41.0
3vrmA-4c9mA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
5 LEU A  61
LEU A 153
ALA A 151
ILE A  75
LEU A  58
None
1.04A 3vrmA-4ccwA:
undetectable
3vrmA-4ccwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddi UBIQUITIN-CONJUGATIN
G ENZYME E2 D2,
UBIQUITIN
THIOESTERASE OTUB1


(Homo sapiens)
PF00179
(UQ_con)
PF10275
(Peptidase_C65)
5 ILE A  99
LEU A  86
LEU A 103
ILE A 106
PRO A  65
None
1.02A 3vrmA-4ddiA:
undetectable
3vrmA-4ddiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Escherichia
coli)
PF04452
(Methyltrans_RNA)
5 PRO A 148
LEU A  82
ILE A 232
ALA A 228
ILE A 134
None
1.05A 3vrmA-4e8bA:
undetectable
3vrmA-4e8bA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN


(Plasmodium
falciparum)
PF00092
(VWA)
5 ILE A  76
LEU A  88
ALA A  90
ILE A 227
LEU A 160
None
0.95A 3vrmA-4f1kA:
undetectable
3vrmA-4f1kA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3r PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Coxiella
burnetii)
PF01467
(CTP_transf_like)
5 ILE A  85
LEU A  72
ALA A  77
PRO A   8
LEU A  69
None
1.06A 3vrmA-4f3rA:
undetectable
3vrmA-4f3rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE


(Caenorhabditis
elegans)
PF03372
(Exo_endo_phos)
5 LEU A 228
LEU A 190
ILE A 189
ALA A 188
ILE A 356
None
0.90A 3vrmA-4fvaA:
undetectable
3vrmA-4fvaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE


(Caenorhabditis
elegans)
PF03372
(Exo_endo_phos)
PF14555
(UBA_4)
5 LEU A 228
LEU A 190
ILE A 189
ALA A 188
ILE A 356
None
0.87A 3vrmA-4gewA:
undetectable
3vrmA-4gewA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5


(Saccharomyces
cerevisiae)
PF09084
(NMT1)
5 ILE A 224
LEU A  84
LEU A 269
ALA A  81
LEU A  61
None
0.99A 3vrmA-4h65A:
undetectable
3vrmA-4h65A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4


(Schizosaccharomyces
pombe)
PF00179
(UQ_con)
5 ILE C  99
LEU C  86
LEU C 103
ILE C 106
PRO C  65
None
0.96A 3vrmA-4ii2C:
undetectable
3vrmA-4ii2C:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8


(Homo sapiens)
PF12134
(PRP8_domainIV)
5 ILE B1953
LEU B1988
LEU B1983
ILE B1987
ALA B1942
None
1.06A 3vrmA-4jkgB:
undetectable
3vrmA-4jkgB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE


(Sulfurimonas
denitrificans)
PF01048
(PNP_UDP_1)
5 ILE A  90
LEU A 170
LEU A  84
ILE A  80
ILE A 190
None
ADE  A 305 (-4.7A)
None
None
None
1.01A 3vrmA-4jwtA:
undetectable
3vrmA-4jwtA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium)
PF00378
(ECH_1)
5 MET A  65
LEU A  30
ILE A  25
ALA A  24
LEU A   2
None
0.99A 3vrmA-4jylA:
undetectable
3vrmA-4jylA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG


(Schizosaccharomyces
pombe)
PF04388
(Hamartin)
6 PRO A 226
ILE A 254
LEU A 233
ALA A 238
ILE A 215
LEU A 208
None
1.26A 3vrmA-4kk1A:
undetectable
3vrmA-4kk1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum)
PF11894
(Nup192)
5 ILE A 245
LEU A 140
ILE A 139
ALA A 160
ILE A  46
None
0.95A 3vrmA-4knhA:
undetectable
3vrmA-4knhA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN


(Lactococcus
lactis)
PF00497
(SBP_bac_3)
5 MET A 324
LEU A 463
LEU A 290
ILE A 293
ALA A 294
None
0.80A 3vrmA-4kr5A:
undetectable
3vrmA-4kr5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA


(Bacillus
subtilis)
PF01343
(Peptidase_S49)
5 MET A 237
ILE A 231
ILE A 245
ALA A 246
ILE A 159
None
0.97A 3vrmA-4kwbA:
undetectable
3vrmA-4kwbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
PF16403
(DUF5011)
5 ILE A 122
LEU A 152
ILE A 150
PRO A  82
ILE A  81
None
None
None
None
PEG  A 604 (-3.9A)
1.06A 3vrmA-4mb5A:
undetectable
3vrmA-4mb5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Enterococcus
faecalis)
PF04095
(NAPRTase)
5 ILE A 148
LEU A 140
LEU A 319
ILE A 141
ALA A 178
None
1.04A 3vrmA-4mzyA:
undetectable
3vrmA-4mzyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 ILE B 519
LEU B 460
LEU B 453
ILE B 562
LEU B 423
None
0.92A 3vrmA-4ni2B:
undetectable
3vrmA-4ni2B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE


(Archaeoglobus
fulgidus)
PF01066
(CDP-OH_P_transf)
5 ILE A 250
LEU A 305
ILE A 207
ALA A 203
ILE A 323
None
1.07A 3vrmA-4o6mA:
undetectable
3vrmA-4o6mA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
6 LEU A 320
MET A 317
ILE A 258
ALA A 287
PRO A 269
ILE A 360
None
1.50A 3vrmA-4ovkA:
undetectable
3vrmA-4ovkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus)
PF03664
(Glyco_hydro_62)
5 ILE A 237
LEU A 319
ILE A 323
ILE A 234
LEU A 249
None
1.06A 3vrmA-4pviA:
undetectable
3vrmA-4pviA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmf KRR1 SMALL SUBUNIT
PROCESSOME COMPONENT


(Saccharomyces
cerevisiae)
no annotation 5 LEU D 103
MET D 174
LEU D 117
ALA D  97
ILE D  56
None
1.01A 3vrmA-4qmfD:
undetectable
3vrmA-4qmfD:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuy VACUOLAR MEMBRANE
PROTEIN PEP3


(Saccharomyces
cerevisiae)
PF05131
(Pep3_Vps18)
5 ILE A 261
LEU A 266
ILE A 271
ILE A 198
LEU A 314
None
1.07A 3vrmA-4uuyA:
undetectable
3vrmA-4uuyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
6 ILE A 122
LEU A 170
LEU A 152
ILE A 150
PRO A  82
ILE A  81
None
1.37A 3vrmA-4w5zA:
undetectable
3vrmA-4w5zA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
5 ILE A 270
LEU A  47
ILE A 276
ILE A 118
LEU A  93
None
1.05A 3vrmA-4wd9A:
undetectable
3vrmA-4wd9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax)
PF01979
(Amidohydro_1)
5 PRO A 423
LEU A  62
LEU A 389
ALA A 393
ILE A  58
None
0.95A 3vrmA-4wgxA:
undetectable
3vrmA-4wgxA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 ILE A 204
LEU A 115
LEU A 112
ALA A 231
ILE A  21
None
0.92A 3vrmA-4ynnA:
undetectable
3vrmA-4ynnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger)
PF01977
(UbiD)
5 ILE A 192
LEU A 182
LEU A 269
ALA A 296
ILE A 171
None
None
None
None
FZZ  A 602 ( 3.7A)
1.06A 3vrmA-4zaaA:
undetectable
3vrmA-4zaaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF13654
(AAA_32)
5 ILE A 234
LEU A 242
ILE A 197
ALA A 199
ILE A 269
None
1.02A 3vrmA-4zpxA:
undetectable
3vrmA-4zpxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN


(Thauera
aromatica)
PF01228
(Gly_radical)
PF02901
(PFL-like)
6 PRO A 299
LEU A 103
LEU A 318
ILE A 323
ALA A 322
ILE A 592
None
1.47A 3vrmA-5bwdA:
undetectable
3vrmA-5bwdA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum)
PF14011
(ESX-1_EspG)
5 ILE A 235
LEU A 147
LEU A 233
ILE A 271
ALA A 270
None
0.97A 3vrmA-5dlbA:
undetectable
3vrmA-5dlbA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 PRO A  83
ILE A  88
LEU A 232
ILE A 235
ALA A 236
PRO A 287
ILE A 288
LEU A 387
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.5A)
None
None
0.89A 3vrmA-5gnmA:
55.3
3vrmA-5gnmA:
99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 PRO A  83
MET A  86
ILE A  88
LEU A 232
ILE A 235
ALA A 236
PRO A 287
ILE A 288
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.5A)
None
0.75A 3vrmA-5gnmA:
55.3
3vrmA-5gnmA:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gve DNA TOPOISOMERASE
3-BETA-1


(Homo sapiens)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 LEU A  21
MET A 164
ILE A  17
ALA A  14
LEU A  26
None
1.07A 3vrmA-5gveA:
undetectable
3vrmA-5gveA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1)
no annotation 5 PRO G   6
ILE G 172
LEU G 154
ILE G  77
ALA G  74
None
1.02A 3vrmA-5h0rG:
undetectable
3vrmA-5h0rG:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A 239
ILE A 120
LEU A 169
ILE A 421
ALA A 420
None
1.05A 3vrmA-5i51A:
undetectable
3vrmA-5i51A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens)
PF01759
(NTR)
PF07677
(A2M_recep)
5 ILE C1472
LEU C1523
LEU C1556
ILE C1485
ALA C1484
None
0.99A 3vrmA-5jpnC:
undetectable
3vrmA-5jpnC:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
5 ILE A  85
LYS A 187
LEU A 238
ILE A 241
ALA A 242
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
0.66A 3vrmA-5l94A:
49.5
3vrmA-5l94A:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 ILE A 519
ILE A 542
ALA A 544
PRO A 247
ILE A 248
MET  A 807 ( 4.4A)
None
None
MET  A 807 ( 4.7A)
MET  A 807 (-4.8A)
0.97A 3vrmA-5nfhA:
undetectable
3vrmA-5nfhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL


(Homo sapiens)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 PRO A 809
LEU A 742
LEU A 800
PRO A 654
LEU A 658
None
1.04A 3vrmA-5o1pA:
undetectable
3vrmA-5o1pA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN


(Thermoactinomyces
vulgaris)
PF00668
(Condensation)
5 LEU A1225
ILE A1193
ALA A1047
ILE A1059
LEU A1052
None
0.99A 3vrmA-5t3eA:
undetectable
3vrmA-5t3eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN


(Thermoactinomyces
vulgaris)
PF00668
(Condensation)
5 LEU A1225
ILE A1193
PRO A1056
ILE A1059
LEU A1052
None
0.99A 3vrmA-5t3eA:
undetectable
3vrmA-5t3eA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN


(Bacteroides
dorei)
PF00144
(Beta-lactamase)
6 ILE A 228
LEU A 170
LYS A 165
MET A 163
ALA A  66
PRO A 178
None
1.44A 3vrmA-5tgfA:
undetectable
3vrmA-5tgfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Clostridium
perfringens)
PF00478
(IMPDH)
5 ILE A 345
LEU A 339
ALA A 335
PRO A  43
ILE A  42
None
1.03A 3vrmA-5uzeA:
undetectable
3vrmA-5uzeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A 235
ILE A 117
LEU A 166
ILE A 414
ALA A 413
None
1.03A 3vrmA-5vrbA:
undetectable
3vrmA-5vrbA:
22.40