SIMILAR PATTERNS OF AMINO ACIDS FOR 3VQR_B_ACTB1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum) 		PF00314
(Thaumatin) 		4 GLY A   2
VAL A   3
ASP A 199
THR A 198
 None
 1.24A 3vqrB-1aunA:
undetectable		 3vqrB-1aunA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 GLY A  52
VAL A  51
ASP A  49
THR A 183
 None
 1.26A 3vqrB-1d2iA:
undetectable		 3vqrB-1d2iA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 257
GLY A 261
ASP A 124
THR A 125
 None
 0.98A 3vqrB-1dgfA:
undetectable		 3vqrB-1dgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		4 ASP A  15
GLY A  46
ASP A  17
THR A  76
 None
 0.91A 3vqrB-1lwdA:
undetectable		 3vqrB-1lwdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 GLY B 112
VAL B 111
ASP B 110
THR B 408
 None
 1.04A 3vqrB-1mu2B:
undetectable		 3vqrB-1mu2B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A 178
GLY A 222
VAL A 221
ASP A 220
 None
 1.20A 3vqrB-1o0sA:
undetectable		 3vqrB-1o0sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osm OMPK36

(Klebsiella
pneumoniae) 		PF00267
(Porin_1) 		4 ASP A 113
GLY A 119
ASP A 121
THR A 122
 None
 1.03A 3vqrB-1osmA:
undetectable		 3vqrB-1osmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovy 50S RIBOSOMAL
PROTEIN L18

(Geobacillus
stearothermophilus) 		PF00861
(Ribosomal_L18p) 		4 ASP A  60
GLY A  78
VAL A  77
THR A  68
 None
 1.17A 3vqrB-1ovyA:
undetectable		 3vqrB-1ovyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP A 351
VAL A 312
ASP A 311
THR A 448
 None
 1.20A 3vqrB-1pd1A:
undetectable		 3vqrB-1pd1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk9 METHYL-CPG-BINDING
PROTEIN 2

(Homo sapiens) 		PF01429
(MBD) 		4 GLY A  70
VAL A  69
ASP A  71
THR A  72
 None
 1.25A 3vqrB-1qk9A:
undetectable		 3vqrB-1qk9A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu4 ORNITHINE
DECARBOXYLASE

(Trypanosoma
brucei) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 321
VAL A 322
ASP A 364
THR A 359
 None
 1.25A 3vqrB-1qu4A:
undetectable		 3vqrB-1qu4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 ASP A  47
GLY A 104
VAL A 100
THR A   8
 ADN  A1001 (-2.9A)
None
ADN  A1001 ( 4.4A)
None
 1.11A 3vqrB-1uayA:
5.3		 3vqrB-1uayA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 224
VAL A 226
ASP A 223
THR A 375
 None
 0.92A 3vqrB-1v59A:
13.0		 3vqrB-1v59A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 396
VAL A 397
ASP A 417
THR A 420
 None
 1.08A 3vqrB-1w93A:
undetectable		 3vqrB-1w93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ASP A 209
GLY A 198
VAL A 197
THR A 203
 None
 1.03A 3vqrB-1wx4A:
undetectable		 3vqrB-1wx4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		4 ASP A  16
GLY A  18
VAL A  19
ASP A  89
 None
GTP  A 301 (-2.6A)
GTP  A 301 (-4.2A)
None
 1.07A 3vqrB-1yhnA:
2.2		 3vqrB-1yhnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0a RAS-RELATED PROTEIN
RAB-2A

(Homo sapiens) 		PF00071
(Ras) 		4 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.16A 3vqrB-1z0aA:
2.3		 3vqrB-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zor ISOCITRATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.89A 3vqrB-1zorA:
undetectable		 3vqrB-1zorA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 422
VAL A 423
ASP A 392
THR A 446
 None
 1.12A 3vqrB-2ag1A:
undetectable		 3vqrB-2ag1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A 152
GLY A 196
VAL A 195
ASP A 194
 None
 1.19A 3vqrB-2aw5A:
undetectable		 3vqrB-2aw5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		4 ASP A 491
GLY A 489
VAL A 632
ASP A 631
 None
 1.18A 3vqrB-2c79A:
2.4		 3vqrB-2c79A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		4 ASP A  60
GLY A 117
VAL A 113
THR A   8
 NAD  A1251 (-3.4A)
None
NAD  A1251 ( 4.1A)
None
 1.15A 3vqrB-2cfcA:
6.2		 3vqrB-2cfcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 ASP A 243
GLY A 213
VAL A 212
THR A 232
 None
 1.00A 3vqrB-2d0jA:
undetectable		 3vqrB-2d0jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ASP X  52
GLY X 106
VAL X 102
THR X  11
 None
 1.08A 3vqrB-2fwmX:
6.3		 3vqrB-2fwmX:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd9 HYPOTHETICAL PROTEIN
YYAP

(Bacillus
subtilis) 		PF01872
(RibD_C) 		4 ASP A 120
GLY A 118
ASP A  48
THR A  49
 None
 1.26A 3vqrB-2gd9A:
undetectable		 3vqrB-2gd9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 ASP A 393
GLY A 414
VAL A 395
THR A 418
 None
 1.22A 3vqrB-2gsnA:
undetectable		 3vqrB-2gsnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlj HYPOTHETICAL PROTEIN

(Pseudomonas
putida) 		PF13279
(4HBT_2) 		4 ASP A  40
GLY A  53
ASP A  36
THR A  35
 None
GOL  A 157 (-4.2A)
GOL  A 157 (-3.7A)
GOL  A 157 (-3.8A)
 1.13A 3vqrB-2hljA:
undetectable		 3vqrB-2hljA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 GLY A 610
VAL A 616
ASP A 619
THR A 606
 None
 1.09A 3vqrB-2iceA:
undetectable		 3vqrB-2iceA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR

(Corynebacterium
glutamicum) 		PF00498
(FHA) 		4 GLY A 105
VAL A 104
ASP A 103
THR A 110
 None
 0.90A 3vqrB-2kb3A:
undetectable		 3vqrB-2kb3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkl UNCHARACTERIZED
PROTEIN MB1858

(Mycobacterium
bovis) 		PF00498
(FHA) 		4 GLY A 114
VAL A 113
ASP A 112
THR A 119
 None
 1.13A 3vqrB-2kklA:
undetectable		 3vqrB-2kklA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 228
GLY A 230
VAL A 231
THR A 263
 None
 1.11A 3vqrB-2oaeA:
undetectable		 3vqrB-2oaeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pes URICASE

(Aspergillus
flavus) 		PF01014
(Uricase) 		4 ASP A 183
GLY A 148
ASP A 181
THR A 180
 None
 1.09A 3vqrB-2pesA:
undetectable		 3vqrB-2pesA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		4 GLY A 229
VAL A 228
ASP A 261
THR A 353
 None
 1.08A 3vqrB-2ra8A:
undetectable		 3vqrB-2ra8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLY A 171
VAL A 172
ASP A 150
THR A 148
 None
 1.24A 3vqrB-2v4iA:
undetectable		 3vqrB-2v4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 ASP A 105
GLY A 111
ASP A 113
THR A 114
 SO4  A1349 ( 4.3A)
None
None
None
 1.04A 3vqrB-2xe5A:
undetectable		 3vqrB-2xe5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 ASP A  41
GLY A  39
ASP A  42
THR A  51
 None
 1.23A 3vqrB-2xfgA:
undetectable		 3vqrB-2xfgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq0 ORF 73

(Human
gammaherpesvirus
8) 		no annotation 4 ASP A1049
GLY A1046
ASP A1045
THR A1111
 None
 0.86A 3vqrB-2yq0A:
undetectable		 3vqrB-2yq0A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 ASP A 231
GLY A 245
VAL A 246
THR A 229
 None
 0.81A 3vqrB-2yy5A:
undetectable		 3vqrB-2yy5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 ASP A 359
GLY A  16
ASP A  17
THR A  27
 None
 1.14A 3vqrB-2zktA:
undetectable		 3vqrB-2zktA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 ASP A 486
VAL A 482
ASP A 483
THR A 516
 None
 1.21A 3vqrB-3azqA:
undetectable		 3vqrB-3azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		4 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.16A 3vqrB-3bc1A:
undetectable		 3vqrB-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		4 GLY A  95
VAL A  94
ASP A  93
THR A  45
 None
 1.05A 3vqrB-3bl2A:
undetectable		 3vqrB-3bl2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 GLY A 592
VAL A 598
ASP A 601
THR A 588
 None
 1.03A 3vqrB-3hs0A:
undetectable		 3vqrB-3hs0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 GLY A 431
VAL A 432
ASP A 380
THR A 381
 None
 1.13A 3vqrB-3j4jA:
undetectable		 3vqrB-3j4jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtw DIHYDROFOLATE
REDUCTASE

(Pediococcus
pentosaceus) 		PF01872
(RibD_C) 		4 ASP A 111
GLY A 109
ASP A  48
THR A  49
 None
 1.23A 3vqrB-3jtwA:
undetectable		 3vqrB-3jtwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhi PUTATIVE
6-PHOSPHOGLUCONOLACT
ONASE

(Neisseria
gonorrhoeae) 		PF01182
(Glucosamine_iso) 		4 ASP A 155
GLY A 159
ASP A 180
THR A 178
 None
 0.95A 3vqrB-3lhiA:
undetectable		 3vqrB-3lhiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		4 ASP A 297
GLY A  52
ASP A 305
THR A  50
 None
 1.11A 3vqrB-3lw2A:
undetectable		 3vqrB-3lw2A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ASP D  77
GLY D  47
VAL D  46
THR D  49
 None
 1.23A 3vqrB-3nogD:
undetectable		 3vqrB-3nogD:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 GLY B 614
VAL B 620
ASP B 623
THR B 610
 None
 1.05A 3vqrB-3prxB:
undetectable		 3vqrB-3prxB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ASP A  75
GLY A 127
VAL A 123
THR A  12
 NAD  A 284 (-3.7A)
None
NAD  A 284 (-4.0A)
None
 1.09A 3vqrB-3pxxA:
4.1		 3vqrB-3pxxA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ASP A  76
GLY A 131
VAL A 127
THR A  13
 NAD  A 279 (-3.2A)
None
NAD  A 279 (-4.0A)
None
 1.11A 3vqrB-3t7cA:
5.5		 3vqrB-3t7cA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		4 ASP B  16
GLY B  18
VAL B  19
ASP B  89
 None
 1.19A 3vqrB-3tw8B:
undetectable		 3vqrB-3tw8B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ASP A  62
GLY A 116
VAL A 112
THR A  10
 None
 1.18A 3vqrB-3u5tA:
6.0		 3vqrB-3u5tA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 216
VAL A 218
ASP A 215
THR A 365
 None
 0.94A 3vqrB-3urhA:
12.5		 3vqrB-3urhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.93A 3vqrB-3us8A:
undetectable		 3vqrB-3us8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 ASP A 297
GLY A  52
ASP A 305
THR A  50
 None
 1.17A 3vqrB-3ut3A:
undetectable		 3vqrB-3ut3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		4 GLY A 379
VAL A 376
ASP A 375
THR A 317
 None
 1.26A 3vqrB-3v94A:
undetectable		 3vqrB-3v94A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ASP A 413
GLY A 439
VAL A 440
THR A 411
 None
 1.08A 3vqrB-3vi3A:
undetectable		 3vqrB-3vi3A:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		5 ASP A  43
GLY A 231
VAL A 232
ASP A 353
THR A 376
 ACT  A1002 ( 3.1A)
ACT  A1002 (-3.3A)
ACT  A1002 ( 3.3A)
EDO  A1003 ( 2.9A)
FAD  A1001 ( 3.2A)
 0.08A 3vqrB-3vqrA:
68.7		 3vqrB-3vqrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 ASP A  53
GLY A 107
VAL A 103
THR A  12
 None
 1.11A 3vqrB-3vtzA:
5.7		 3vqrB-3vtzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 GLY A 121
VAL A 120
ASP A  58
THR A 256
 None
 1.26A 3vqrB-3vv3A:
undetectable		 3vqrB-3vv3A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ASP A 270
GLY A 268
ASP A 352
THR A 350
 None
 1.16A 3vqrB-3zusA:
undetectable		 3vqrB-3zusA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj NETRIN-G1

(Homo sapiens) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 GLY B 282
VAL B 281
ASP B 168
THR B 190
 None
 0.90A 3vqrB-3zyjB:
undetectable		 3vqrB-3zyjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 ASP A  13
GLY A  44
ASP A  15
THR A  74
 None
None
None
NAP  A1403 (-4.4A)
 0.87A 3vqrB-4aovA:
undetectable		 3vqrB-4aovA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoy ISOCITRATE
DEHYDROGENASE [NADP]

(Ruminiclostridium
thermocellum) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.92A 3vqrB-4aoyA:
undetectable		 3vqrB-4aoyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqk ANTIBODY CR8059
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP E 101
VAL E  96
ASP E  95
THR E  35
 None
 1.24A 3vqrB-4fqkE:
undetectable		 3vqrB-4fqkE:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ASP A  17
GLY A  48
ASP A  19
THR A  78
 None
None
None
NDP  A 502 (-3.9A)
 0.92A 3vqrB-4hcxA:
undetectable		 3vqrB-4hcxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas;
Pseudomonas) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 ASP A 116
GLY A 111
VAL A 112
THR B 155
 None
 1.24A 3vqrB-4hstA:
undetectable		 3vqrB-4hstA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 ASP A 151
GLY A 117
VAL A 107
THR A 132
 None
 1.06A 3vqrB-4l1yA:
undetectable		 3vqrB-4l1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		4 ASP A  56
GLY A  54
ASP A  58
THR A  60
 None
 1.20A 3vqrB-4n4kA:
undetectable		 3vqrB-4n4kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 ASP A 187
GLY A 185
VAL A 213
THR A  14
 None
 1.10A 3vqrB-4p7cA:
undetectable		 3vqrB-4p7cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 GLY A  53
VAL A  54
ASP A  52
THR A  50
 None
 1.22A 3vqrB-4pj1A:
undetectable		 3vqrB-4pj1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6b CONSERVED
HYPOTHETICAL
LIPOPROTEIN

(Zobellia
galactanivorans) 		PF04616
(Glyco_hydro_43) 		4 ASP A 245
GLY A 237
ASP A 243
THR A 247
 None
 1.25A 3vqrB-4u6bA:
undetectable		 3vqrB-4u6bA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		4 ASP A  57
GLY A 114
VAL A 110
THR A  11
 NAD  A 300 (-3.5A)
None
NAD  A 300 ( 4.1A)
None
 1.13A 3vqrB-4xgnA:
5.4		 3vqrB-4xgnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A1183
VAL A1182
ASP A1181
THR A 963
 None
 1.23A 3vqrB-4yswA:
undetectable		 3vqrB-4yswA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ASP A 118
GLY A 121
VAL A 123
ASP A 120
 S4M  A 301 (-3.0A)
None
S4M  A 301 (-4.3A)
None
 1.02A 3vqrB-4yv2A:
3.4		 3vqrB-4yv2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 GLY C  33
VAL C  32
ASP A  33
THR A  27
 None
 1.23A 3vqrB-5aa5C:
undetectable		 3vqrB-5aa5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 321
VAL A 322
ASP A 364
THR A 359
 None
 1.12A 3vqrB-5bwaA:
undetectable		 3vqrB-5bwaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 GLY A  23
VAL A  22
ASP A  89
THR A  65
 None
 1.26A 3vqrB-5bwyA:
undetectable		 3vqrB-5bwyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		4 GLY A 414
VAL A 495
ASP A 496
THR A 501
 None
 0.87A 3vqrB-5da8A:
undetectable		 3vqrB-5da8A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 ASP A 370
GLY A 374
ASP A 377
THR A 376
 None
 1.26A 3vqrB-5dxxA:
undetectable		 3vqrB-5dxxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A1267
VAL A1090
ASP A1093
THR A1261
 None
MTE  A3003 (-4.3A)
None
None
 1.16A 3vqrB-5epgA:
undetectable		 3vqrB-5epgA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ASP A 314
GLY A 219
VAL A 205
ASP A 220
 CU  A 601 (-2.0A)
None
None
None
 1.15A 3vqrB-5f75A:
undetectable		 3vqrB-5f75A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A 247
VAL A 245
ASP A 235
THR A 240
 None
 1.23A 3vqrB-5gkxA:
2.4		 3vqrB-5gkxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ASP A  63
GLY A 109
VAL A 105
THR A  11
 NAD  A 302 (-3.6A)
None
NAD  A 302 (-3.9A)
None
 1.09A 3vqrB-5ilgA:
2.6		 3vqrB-5ilgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 ASP A 416
GLY A 496
VAL A 495
THR A 499
 None
 1.12A 3vqrB-5jozA:
undetectable		 3vqrB-5jozA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 4 ASP A 251
GLY A 247
ASP A 252
THR A 348
 CA  A 502 ( 4.2A)
None
None
None
 1.19A 3vqrB-5minA:
undetectable		 3vqrB-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ASP A 586
GLY A 542
VAL A 511
ASP A 512
 None
 1.22A 3vqrB-5ny0A:
undetectable		 3vqrB-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 ASP C 106
GLY C 112
ASP C 114
THR C 115
 None
 0.99A 3vqrB-5o9cC:
undetectable		 3vqrB-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 ASP A 314
GLY A 219
VAL A 205
ASP A 220
 CU  A 601 (-2.1A)
None
None
None
 1.18A 3vqrB-5oexA:
undetectable		 3vqrB-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 GLY A 257
VAL A 255
ASP A 281
THR A 282
 None
None
DMS  A 521 ( 4.9A)
None
 1.21A 3vqrB-5sytA:
undetectable		 3vqrB-5sytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 LIGHT CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L  32
GLY L  30
VAL L  29
THR L  51
 None
 1.01A 3vqrB-5te6L:
undetectable		 3vqrB-5te6L:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		4 GLY A 108
VAL A 107
ASP A 106
THR A  86
 None
 1.03A 3vqrB-5uscA:
4.8		 3vqrB-5uscA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0s 60 KDA CHAPERONIN

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 GLY A  53
VAL A  54
ASP A  52
THR A  50
 None
 1.26A 3vqrB-5w0sA:
undetectable		 3vqrB-5w0sA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 108
GLY A  38
VAL A  37
ASP A 106
 None
 1.07A 3vqrB-5w5bA:
undetectable		 3vqrB-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 4 ASP A  21
GLY A  23
VAL A  24
ASP A  94
 None
GNP  A 301 (-3.4A)
GNP  A 301 (-4.1A)
None
 1.17A 3vqrB-5xr6A:
undetectable		 3vqrB-5xr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 ASP B 182
GLY B 185
ASP B  53
THR B  52
 None
 1.16A 3vqrB-6cxhB:
undetectable		 3vqrB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 ASP A 136
GLY A 138
VAL A 139
THR A 134
 None
 1.19A 3vqrB-6eslA:
undetectable		 3vqrB-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 GLY A 981
VAL A 989
ASP A 890
THR A 891
 None
 1.14A 3vqrB-6etzA:
undetectable		 3vqrB-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 501
GLY B 682
VAL B 684
THR B 471
 None
 1.22A 3vqrB-6f42B:
undetectable		 3vqrB-6f42B:
undetectable