SIMILAR PATTERNS OF AMINO ACIDS FOR 3VQR_A_ACTA1002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 257
GLY A 261
ASP A 124
THR A 125
 None
 1.02A 3vqrA-1dgfA:
undetectable		 3vqrA-1dgfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ASP B 269
GLY B 267
ASP B 351
THR B 349
 None
 1.25A 3vqrA-1e1hB:
undetectable		 3vqrA-1e1hB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		4 ASP A  15
GLY A  46
ASP A  17
THR A  76
 None
 0.89A 3vqrA-1lwdA:
undetectable		 3vqrA-1lwdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 GLY B 112
VAL B 111
ASP B 110
THR B 408
 None
 1.04A 3vqrA-1mu2B:
undetectable		 3vqrA-1mu2B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A 178
GLY A 222
VAL A 221
ASP A 220
 None
 1.21A 3vqrA-1o0sA:
undetectable		 3vqrA-1o0sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osm OMPK36

(Klebsiella
pneumoniae) 		PF00267
(Porin_1) 		4 ASP A 113
GLY A 119
ASP A 121
THR A 122
 None
 1.00A 3vqrA-1osmA:
undetectable		 3vqrA-1osmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovy 50S RIBOSOMAL
PROTEIN L18

(Geobacillus
stearothermophilus) 		PF00861
(Ribosomal_L18p) 		4 ASP A  60
GLY A  78
VAL A  77
THR A  68
 None
 1.19A 3vqrA-1ovyA:
undetectable		 3vqrA-1ovyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ASP A 351
VAL A 312
ASP A 311
THR A 448
 None
 1.19A 3vqrA-1pd1A:
undetectable		 3vqrA-1pd1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk9 METHYL-CPG-BINDING
PROTEIN 2

(Homo sapiens) 		PF01429
(MBD) 		4 GLY A  70
VAL A  69
ASP A  71
THR A  72
 None
 1.23A 3vqrA-1qk9A:
undetectable		 3vqrA-1qk9A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 GLY A 309
TRP A 326
ASP A 310
THR A  41
 None
 1.15A 3vqrA-1qnrA:
undetectable		 3vqrA-1qnrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 ASP A 328
GLY A 352
VAL A 353
TRP A 144
 None
 0.94A 3vqrA-1r6vA:
undetectable		 3vqrA-1r6vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uay TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 ASP A  47
GLY A 104
VAL A 100
THR A   8
 ADN  A1001 (-2.9A)
None
ADN  A1001 ( 4.4A)
None
 1.10A 3vqrA-1uayA:
3.6		 3vqrA-1uayA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 224
VAL A 226
ASP A 223
THR A 375
 None
 0.94A 3vqrA-1v59A:
11.1		 3vqrA-1v59A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 396
VAL A 397
ASP A 417
THR A 420
 None
 1.07A 3vqrA-1w93A:
undetectable		 3vqrA-1w93A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 ASP A 209
GLY A 198
VAL A 197
THR A 203
 None
 1.03A 3vqrA-1wx4A:
undetectable		 3vqrA-1wx4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLY A  28
TRP A 346
ASP A 485
THR A 405
 None
 1.14A 3vqrA-1y9gA:
undetectable		 3vqrA-1y9gA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		4 ASP A  16
GLY A  18
VAL A  19
ASP A  89
 None
GTP  A 301 (-2.6A)
GTP  A 301 (-4.2A)
None
 1.06A 3vqrA-1yhnA:
undetectable		 3vqrA-1yhnA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		4 GLY A 226
VAL A 227
TRP A 215
THR A 184
 None
 1.22A 3vqrA-1ym0A:
undetectable		 3vqrA-1ym0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0a RAS-RELATED PROTEIN
RAB-2A

(Homo sapiens) 		PF00071
(Ras) 		4 ASP A  14
GLY A  16
VAL A  17
ASP A  87
 None
GDP  A1200 (-3.3A)
GDP  A1200 (-4.1A)
None
 1.15A 3vqrA-1z0aA:
undetectable		 3vqrA-1z0aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zor ISOCITRATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.88A 3vqrA-1zorA:
undetectable		 3vqrA-1zorA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 422
VAL A 423
ASP A 392
THR A 446
 None
 1.13A 3vqrA-2ag1A:
undetectable		 3vqrA-2ag1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASP A 152
GLY A 196
VAL A 195
ASP A 194
 None
 1.20A 3vqrA-2aw5A:
undetectable		 3vqrA-2aw5A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		4 ASP A 491
GLY A 489
VAL A 632
ASP A 631
 None
 1.16A 3vqrA-2c79A:
2.0		 3vqrA-2c79A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		4 ASP A  60
GLY A 117
VAL A 113
THR A   8
 NAD  A1251 (-3.4A)
None
NAD  A1251 ( 4.1A)
None
 1.13A 3vqrA-2cfcA:
4.3		 3vqrA-2cfcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 ASP A 243
GLY A 213
VAL A 212
THR A 232
 None
 1.03A 3vqrA-2d0jA:
undetectable		 3vqrA-2d0jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 GLY A 304
VAL A 303
TRP A 307
ASP A 302
 None
 1.10A 3vqrA-2e3jA:
undetectable		 3vqrA-2e3jA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ASP X  52
GLY X 106
VAL X 102
THR X  11
 None
 1.07A 3vqrA-2fwmX:
4.4		 3vqrA-2fwmX:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 ASP A 393
GLY A 414
VAL A 395
THR A 418
 None
 1.23A 3vqrA-2gsnA:
undetectable		 3vqrA-2gsnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlj HYPOTHETICAL PROTEIN

(Pseudomonas
putida) 		PF13279
(4HBT_2) 		4 ASP A  40
GLY A  53
ASP A  36
THR A  35
 None
GOL  A 157 (-4.2A)
GOL  A 157 (-3.7A)
GOL  A 157 (-3.8A)
 1.10A 3vqrA-2hljA:
undetectable		 3vqrA-2hljA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 GLY A 610
VAL A 616
ASP A 619
THR A 606
 None
 1.09A 3vqrA-2iceA:
undetectable		 3vqrA-2iceA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 ASP A 105
GLY A 111
ASP A 113
THR A 114
 None
 1.01A 3vqrA-2j1nA:
undetectable		 3vqrA-2j1nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb3 OXOGLUTARATE
DEHYDROGENASE
INHIBITOR

(Corynebacterium
glutamicum) 		PF00498
(FHA) 		4 GLY A 105
VAL A 104
ASP A 103
THR A 110
 None
 0.90A 3vqrA-2kb3A:
undetectable		 3vqrA-2kb3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkl UNCHARACTERIZED
PROTEIN MB1858

(Mycobacterium
bovis) 		PF00498
(FHA) 		4 GLY A 114
VAL A 113
ASP A 112
THR A 119
 None
 1.15A 3vqrA-2kklA:
undetectable		 3vqrA-2kklA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 228
GLY A 230
VAL A 231
THR A 263
 None
 1.12A 3vqrA-2oaeA:
undetectable		 3vqrA-2oaeA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pes URICASE

(Aspergillus
flavus) 		PF01014
(Uricase) 		4 ASP A 183
GLY A 148
ASP A 181
THR A 180
 None
 1.10A 3vqrA-2pesA:
undetectable		 3vqrA-2pesA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra8 UNCHARACTERIZED
PROTEIN Q64V53_BACFR

(Bacteroides
fragilis) 		PF05406
(WGR) 		4 GLY A 229
VAL A 228
ASP A 261
THR A 353
 None
 1.08A 3vqrA-2ra8A:
undetectable		 3vqrA-2ra8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLY A 171
VAL A 172
ASP A 150
THR A 148
 None
 1.24A 3vqrA-2v4iA:
undetectable		 3vqrA-2v4iA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		4 GLY A 102
VAL A 293
TRP A 288
ASP A 101
 None
 1.18A 3vqrA-2vdjA:
undetectable		 3vqrA-2vdjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 ASP A 105
GLY A 111
ASP A 113
THR A 114
 SO4  A1349 ( 4.3A)
None
None
None
 1.02A 3vqrA-2xe5A:
undetectable		 3vqrA-2xe5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 ASP A  41
GLY A  39
ASP A  42
THR A  51
 None
 1.23A 3vqrA-2xfgA:
undetectable		 3vqrA-2xfgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq0 ORF 73

(Human
gammaherpesvirus
8) 		no annotation 4 ASP A1049
GLY A1046
ASP A1045
THR A1111
 None
 0.85A 3vqrA-2yq0A:
undetectable		 3vqrA-2yq0A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 ASP A 231
GLY A 245
VAL A 246
THR A 229
 None
 0.80A 3vqrA-2yy5A:
undetectable		 3vqrA-2yy5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 ASP A 286
GLY A 305
VAL A 306
TRP A  88
 None
 1.24A 3vqrA-2z2zA:
undetectable		 3vqrA-2z2zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 ASP A 359
GLY A  16
ASP A  17
THR A  27
 None
 1.13A 3vqrA-2zktA:
undetectable		 3vqrA-2zktA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 ASP A 486
VAL A 482
ASP A 483
THR A 516
 None
 1.21A 3vqrA-3azqA:
undetectable		 3vqrA-3azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		4 ASP A  17
GLY A  19
VAL A  20
ASP A 100
 None
GNP  A 195 (-3.7A)
GNP  A 195 ( 4.1A)
None
 1.15A 3vqrA-3bc1A:
undetectable		 3vqrA-3bc1A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		4 GLY A  95
VAL A  94
ASP A  93
THR A  45
 None
 1.04A 3vqrA-3bl2A:
undetectable		 3vqrA-3bl2A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 ASP A 251
TRP A 258
ASP A 255
THR A 225
 None
 1.21A 3vqrA-3ed3A:
undetectable		 3vqrA-3ed3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd8 XYLANASE INHIBITOR

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 GLY A 141
VAL A 142
TRP A  38
THR A  19
 None
 1.24A 3vqrA-3hd8A:
undetectable		 3vqrA-3hd8A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		4 GLY A 431
VAL A 432
ASP A 380
THR A 381
 None
 1.13A 3vqrA-3j4jA:
undetectable		 3vqrA-3j4jA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ASP D  77
GLY D  47
VAL D  46
THR D  49
 None
 1.22A 3vqrA-3nogD:
undetectable		 3vqrA-3nogD:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 GLY B 614
VAL B 620
ASP B 623
THR B 610
 None
 1.03A 3vqrA-3prxB:
undetectable		 3vqrA-3prxB:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		4 ASP B  16
GLY B  18
VAL B  19
ASP B  89
 None
 1.18A 3vqrA-3tw8B:
undetectable		 3vqrA-3tw8B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 ASP A  62
GLY A 116
VAL A 112
THR A  10
 None
 1.17A 3vqrA-3u5tA:
3.2		 3vqrA-3u5tA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 216
VAL A 218
ASP A 215
THR A 365
 None
 0.94A 3vqrA-3urhA:
11.7		 3vqrA-3urhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.92A 3vqrA-3us8A:
undetectable		 3vqrA-3us8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 ASP A 297
GLY A  52
ASP A 305
THR A  50
 None
 1.17A 3vqrA-3ut3A:
undetectable		 3vqrA-3ut3A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		6 ASP A  43
GLY A 231
VAL A 232
TRP A 233
ASP A 353
THR A 376
 ACT  A1002 ( 3.1A)
ACT  A1002 (-3.3A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
EDO  A1003 ( 2.9A)
FAD  A1001 ( 3.2A)
 0.00A 3vqrA-3vqrA:
70.6		 3vqrA-3vqrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ASP A 270
GLY A 268
ASP A 352
THR A 350
 None
 1.13A 3vqrA-3zusA:
undetectable		 3vqrA-3zusA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj NETRIN-G1

(Homo sapiens) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		4 GLY B 282
VAL B 281
ASP B 168
THR B 190
 None
 0.92A 3vqrA-3zyjB:
undetectable		 3vqrA-3zyjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 ASP A  13
GLY A  44
ASP A  15
THR A  74
 None
None
None
NAP  A1403 (-4.4A)
 0.85A 3vqrA-4aovA:
undetectable		 3vqrA-4aovA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoy ISOCITRATE
DEHYDROGENASE [NADP]

(Ruminiclostridium
thermocellum) 		PF00180
(Iso_dh) 		4 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.90A 3vqrA-4aoyA:
undetectable		 3vqrA-4aoyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		4 GLY A 344
VAL A 345
TRP A 330
ASP A 346
 None
 1.23A 3vqrA-4ecnA:
undetectable		 3vqrA-4ecnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqk ANTIBODY CR8059
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP E 101
VAL E  96
ASP E  95
THR E  35
 None
 1.22A 3vqrA-4fqkE:
undetectable		 3vqrA-4fqkE:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 ASP A  17
GLY A  48
ASP A  19
THR A  78
 None
None
None
NDP  A 502 (-3.9A)
 0.90A 3vqrA-4hcxA:
undetectable		 3vqrA-4hcxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		4 GLY A  57
TRP A  11
ASP A  56
THR A  54
 None
 1.23A 3vqrA-4kv3A:
undetectable		 3vqrA-4kv3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius) 		no annotation 4 ASP A 151
GLY A 117
VAL A 107
THR A 132
 None
 1.05A 3vqrA-4l1yA:
undetectable		 3vqrA-4l1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		4 ASP A  56
GLY A  54
ASP A  58
THR A  60
 None
 1.18A 3vqrA-4n4kA:
undetectable		 3vqrA-4n4kA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 ASP A 187
GLY A 185
VAL A 213
THR A  14
 None
 1.09A 3vqrA-4p7cA:
undetectable		 3vqrA-4p7cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		4 GLY A  53
VAL A  54
ASP A  52
THR A  50
 None
 1.22A 3vqrA-4pj1A:
undetectable		 3vqrA-4pj1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 GLY A 320
TRP A 715
ASP A 159
THR A 193
 None
 1.04A 3vqrA-4wgkA:
undetectable		 3vqrA-4wgkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		4 ASP A  57
GLY A 114
VAL A 110
THR A  11
 NAD  A 300 (-3.5A)
None
NAD  A 300 ( 4.1A)
None
 1.12A 3vqrA-4xgnA:
3.8		 3vqrA-4xgnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 GLY C  33
VAL C  32
ASP A  33
THR A  27
 None
 1.23A 3vqrA-5aa5C:
undetectable		 3vqrA-5aa5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwy PLASMEPSIN-2

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 GLY A  23
VAL A  22
ASP A  89
THR A  65
 None
 1.24A 3vqrA-5bwyA:
undetectable		 3vqrA-5bwyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		4 GLY A 414
VAL A 495
ASP A 496
THR A 501
 None
 0.86A 3vqrA-5da8A:
undetectable		 3vqrA-5da8A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A1267
VAL A1090
ASP A1093
THR A1261
 None
MTE  A3003 (-4.3A)
None
None
 1.16A 3vqrA-5epgA:
undetectable		 3vqrA-5epgA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 4 ASP A 314
GLY A 219
VAL A 205
ASP A 220
 CU  A 601 (-2.0A)
None
None
None
 1.16A 3vqrA-5f75A:
undetectable		 3vqrA-5f75A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvn OMPC PORIN

(Enterobacter
cloacae) 		PF00267
(Porin_1) 		4 ASP A 105
GLY A 111
ASP A 113
THR A 114
 None
C8E  A 407 ( 4.9A)
C8E  A 407 (-3.3A)
None
 0.99A 3vqrA-5fvnA:
undetectable		 3vqrA-5fvnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A 247
VAL A 245
ASP A 235
THR A 240
 None
 1.22A 3vqrA-5gkxA:
undetectable		 3vqrA-5gkxA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ASP A  63
GLY A 109
VAL A 105
THR A  11
 NAD  A 302 (-3.6A)
None
NAD  A 302 (-3.9A)
None
 1.07A 3vqrA-5ilgA:
undetectable		 3vqrA-5ilgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 ASP A 416
GLY A 496
VAL A 495
THR A 499
 None
 1.15A 3vqrA-5jozA:
undetectable		 3vqrA-5jozA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 4 ASP A 251
GLY A 247
ASP A 252
THR A 348
 CA  A 502 ( 4.2A)
None
None
None
 1.17A 3vqrA-5minA:
undetectable		 3vqrA-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ASP A 586
GLY A 542
VAL A 511
ASP A 512
 None
 1.22A 3vqrA-5ny0A:
undetectable		 3vqrA-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 4 ASP C 106
GLY C 112
ASP C 114
THR C 115
 None
 0.97A 3vqrA-5o9cC:
undetectable		 3vqrA-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 4 ASP A 314
GLY A 219
VAL A 205
ASP A 220
 CU  A 601 (-2.1A)
None
None
None
 1.19A 3vqrA-5oexA:
undetectable		 3vqrA-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 GLY A 257
VAL A 255
ASP A 281
THR A 282
 None
None
DMS  A 521 ( 4.9A)
None
 1.20A 3vqrA-5sytA:
undetectable		 3vqrA-5sytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te6 LIGHT CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP L  32
GLY L  30
VAL L  29
THR L  51
 None
 1.00A 3vqrA-5te6L:
undetectable		 3vqrA-5te6L:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		4 GLY A 108
VAL A 107
ASP A 106
THR A  86
 None
 1.04A 3vqrA-5uscA:
3.7		 3vqrA-5uscA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuj ALKZ

(Streptomyces
sahachiroi) 		PF06224
(HTH_42) 		4 GLY A 255
VAL A 253
TRP A   5
ASP A 252
 None
 1.14A 3vqrA-5uujA:
undetectable		 3vqrA-5uujA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5b HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CMR

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 108
GLY A  38
VAL A  37
ASP A 106
 None
 1.09A 3vqrA-5w5bA:
undetectable		 3vqrA-5w5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 4 ASP A  21
GLY A  23
VAL A  24
ASP A  94
 None
GNP  A 301 (-3.4A)
GNP  A 301 (-4.1A)
None
 1.16A 3vqrA-5xr6A:
undetectable		 3vqrA-5xr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 ASP B 182
GLY B 185
ASP B  53
THR B  52
 None
 1.14A 3vqrA-6cxhB:
undetectable		 3vqrA-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 ASP A 136
GLY A 138
VAL A 139
THR A 134
 None
 1.19A 3vqrA-6eslA:
undetectable		 3vqrA-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 GLY A 981
VAL A 989
ASP A 890
THR A 891
 None
 1.15A 3vqrA-6etzA:
undetectable		 3vqrA-6etzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 ASP A  21
GLY A  66
TRP A  27
ASP A  63
 None
 1.19A 3vqrA-6f0qA:
undetectable		 3vqrA-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 ASP A 105
GLY A 150
TRP A 111
ASP A 147
 None
 1.23A 3vqrA-6f0qA:
undetectable		 3vqrA-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 ASP A 147
GLY A 192
TRP A 153
ASP A 189
 None
 1.18A 3vqrA-6f0qA:
undetectable		 3vqrA-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 ASP A 231
GLY A  24
TRP A 237
ASP A  21
 None
 1.23A 3vqrA-6f0qA:
undetectable		 3vqrA-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 4 GLY A 108
VAL A 104
TRP A  69
ASP A 105
 None
 0.98A 3vqrA-6f0qA:
undetectable		 3vqrA-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 501
GLY B 682
VAL B 684
THR B 471
 None
 1.21A 3vqrA-6f42B:
undetectable		 3vqrA-6f42B:
undetectable