SIMILAR PATTERNS OF AMINO ACIDS FOR 3VM4_A_IZPA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		4 LEU A 408
PHE A 407
ARG A 511
PRO A 406
 None
 1.32A 3vm4A-1advA:
0.0		 3vm4A-1advA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		4 LEU L 265
ARG L 337
PRO L 334
ALA L 336
 None
 1.44A 3vm4A-1cc1L:
0.0		 3vm4A-1cc1L:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 LEU A 385
ARG A 382
PRO A 411
ALA A 412
 None
 1.41A 3vm4A-1ex0A:
0.0		 3vm4A-1ex0A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		4 LEU A  78
ARG A 242
PRO A 243
ALA A 246
 PAM  A 601 ( 4.7A)
PAM  A 601 (-3.7A)
PAM  A 601 (-3.9A)
PAM  A 601 (-3.9A)
 0.31A 3vm4A-1izoA:
59.0		 3vm4A-1izoA:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		4 LEU A2502
PHE A2521
PRO A2510
ALA A2516
 None
 1.41A 3vm4A-1mjeA:
0.0		 3vm4A-1mjeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 LEU A 300
PHE A 310
PRO A 189
ALA A 154
 None
 1.45A 3vm4A-1mnnA:
0.0		 3vm4A-1mnnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 LEU A 408
PHE A 404
PRO A 337
ALA A 340
 None
 1.03A 3vm4A-1mqsA:
0.0		 3vm4A-1mqsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 LEU A 387
ARG A 485
PRO A 486
ALA A 490
 None
 1.43A 3vm4A-1tf0A:
3.0		 3vm4A-1tf0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk9 VALYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		4 LEU A 331
PHE A 325
PRO A 217
ALA A 321
 None
 1.47A 3vm4A-1wk9A:
0.0		 3vm4A-1wk9A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		4 LEU A 262
PHE A 260
ARG A 302
ALA A   4
 None
 1.47A 3vm4A-1xcrA:
undetectable		 3vm4A-1xcrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 LEU A  11
PHE A 245
PRO A 249
ALA A 251
 None
 1.24A 3vm4A-1yxmA:
undetectable		 3vm4A-1yxmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 LEU A 540
ARG A 555
PRO A 553
ALA A 554
 None
 1.37A 3vm4A-2c4mA:
undetectable		 3vm4A-2c4mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.40A 3vm4A-2csdA:
undetectable		 3vm4A-2csdA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9b GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		4 LEU A  95
PHE A  94
PRO A  93
ALA A  53
 None
 1.18A 3vm4A-2d9bA:
undetectable		 3vm4A-2d9bA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3l TRANSCRIPTION FACTOR
GTF2IRD2 BETA

(Homo sapiens) 		PF02946
(GTF2I) 		4 LEU A  85
PHE A  84
PRO A  83
ALA A  43
 None
 1.35A 3vm4A-2e3lA:
undetectable		 3vm4A-2e3lA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcj SMALL TOPRIM DOMAIN
PROTEIN

(Geobacillus
stearothermophilus) 		PF01751
(Toprim) 		4 LEU A  41
PHE A  74
PRO A  75
ALA A  77
 None
 1.46A 3vm4A-2fcjA:
undetectable		 3vm4A-2fcjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		4 LEU A 139
PHE A 148
PRO A 147
ALA A 252
 None
 1.36A 3vm4A-2fefA:
undetectable		 3vm4A-2fefA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 LEU A  51
ARG A  35
PRO A  20
ALA A  23
 None
 1.49A 3vm4A-2gd2A:
undetectable		 3vm4A-2gd2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 LEU A  83
ARG A  79
PRO A 577
ALA A 578
 None
 1.40A 3vm4A-2h4tA:
undetectable		 3vm4A-2h4tA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 330
PHE A 324
PRO A 315
ALA A 316
 None
None
None
GOL  A5489 (-3.4A)
 1.37A 3vm4A-2isaA:
undetectable		 3vm4A-2isaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 LEU A 202
PHE A 171
ARG A 175
PRO A 170
 None
 0.96A 3vm4A-2lnlA:
undetectable		 3vm4A-2lnlA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  63
ARG A 267
PRO A  53
ALA A  57
 None
 1.31A 3vm4A-2obyA:
undetectable		 3vm4A-2obyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 LEU A 298
PHE A 281
PRO A 278
ALA A 156
 None
 1.49A 3vm4A-2owzA:
undetectable		 3vm4A-2owzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 LEU A 294
PHE A 288
PRO A 286
ALA A 287
 None
None
CL  A 402 ( 3.9A)
CL  A 402 (-3.5A)
 1.41A 3vm4A-2qw5A:
undetectable		 3vm4A-2qw5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A1216
ARG A1182
PRO A1181
ALA A1186
 None
 1.47A 3vm4A-2vz9A:
undetectable		 3vm4A-2vz9A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 LEU A 320
ARG A 415
PRO A 412
ALA A 414
 None
 1.41A 3vm4A-3ayxA:
undetectable		 3vm4A-3ayxA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 LEU A 443
ARG A 299
PRO A 298
ALA A 300
 None
 1.16A 3vm4A-3fdhA:
undetectable		 3vm4A-3fdhA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfh TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		4 LEU A 802
ARG A 826
PRO A 825
ALA A 829
 None
None
MLY  A 828 ( 4.4A)
MLY  A 828 ( 3.7A)
 1.49A 3vm4A-3hfhA:
undetectable		 3vm4A-3hfhA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		4 LEU A 307
ARG A  36
PRO A 316
ALA A  37
 None
None
None
MPD  A 508 ( 4.8A)
 1.48A 3vm4A-3hi0A:
undetectable		 3vm4A-3hi0A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		4 LEU A 233
ARG A 290
PRO A 264
ALA A 265
 None
 1.33A 3vm4A-3i32A:
undetectable		 3vm4A-3i32A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq E-CADHERIN
PLAKOGLOBIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		4 LEU C 677
ARG C 630
PRO A 496
ALA A 500
 None
 1.11A 3vm4A-3ifqC:
undetectable		 3vm4A-3ifqC:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 351
PHE A 367
PRO A 287
ALA A 280
 None
 1.35A 3vm4A-3ledA:
undetectable		 3vm4A-3ledA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.38A 3vm4A-3m7dA:
undetectable		 3vm4A-3m7dA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		4 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.46A 3vm4A-3m7gA:
undetectable		 3vm4A-3m7gA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 LEU C 282
PHE C 271
PRO C 264
ALA C 267
 None
 1.45A 3vm4A-3mc6C:
undetectable		 3vm4A-3mc6C:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na2 UNCHARACTERIZED
PROTEIN

(Leptospirillum
rubarum) 		no annotation 4 LEU A  14
PHE A  17
ARG A  18
ALA A  40
 None
None
None
ACY  A 151 (-4.4A)
 0.93A 3vm4A-3na2A:
undetectable		 3vm4A-3na2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		4 LEU A 494
PHE A 460
PRO A 464
ALA A 466
 None
 1.40A 3vm4A-3nawA:
undetectable		 3vm4A-3nawA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 LEU A 380
PHE A 379
PRO A 351
ALA A 354
 None
 0.97A 3vm4A-3ox4A:
undetectable		 3vm4A-3ox4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 LEU A 154
PHE A 151
PRO A 149
ALA A 147
 None
 1.46A 3vm4A-3pduA:
undetectable		 3vm4A-3pduA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpi CHLORITE DISMUTASE

(Nitrobacter
winogradskyi) 		PF06778
(Chlor_dismutase) 		4 LEU A  17
ARG A  84
PRO A 149
ALA A 152
 None
 1.12A 3vm4A-3qpiA:
undetectable		 3vm4A-3qpiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 LEU A  86
PHE A 143
PRO A 142
ALA A 136
 None
 1.18A 3vm4A-3qz4A:
undetectable		 3vm4A-3qz4A:
22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		4 LEU A  77
PHE A 169
ARG A 241
PRO A 242
 None
None
None
HEM  A 501 (-4.2A)
 0.29A 3vm4A-3vooA:
69.3		 3vm4A-3vooA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zd0 P7 PROTEIN

(Hepacivirus C) 		no annotation 4 LEU A  42
PHE A  41
PRO A  57
ALA A  60
 None
 1.34A 3vm4A-3zd0A:
undetectable		 3vm4A-3zd0A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 LEU A 749
PHE A 559
PRO A 753
ALA A 563
 None
 1.21A 3vm4A-4a01A:
0.0		 3vm4A-4a01A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3w ARCHAEMETZINCIN

(Archaeoglobus
fulgidus) 		PF07998
(Peptidase_M54) 		4 LEU A  56
ARG A  91
PRO A  61
ALA A  90
 None
 1.23A 3vm4A-4a3wA:
undetectable		 3vm4A-4a3wA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		4 LEU A 351
ARG A 353
PRO A 308
ALA A 357
 None
 1.40A 3vm4A-4ak5A:
undetectable		 3vm4A-4ak5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 LEU A 315
PHE A 319
PRO A 321
ALA A 324
 None
 1.07A 3vm4A-4aoaA:
undetectable		 3vm4A-4aoaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 LEU A 321
ARG A 418
PRO A 415
ALA A 417
 None
 1.40A 3vm4A-4c3oA:
undetectable		 3vm4A-4c3oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		4 LEU A 276
ARG A 278
PRO A 481
ALA A 247
 None
 1.20A 3vm4A-4gf8A:
undetectable		 3vm4A-4gf8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.42A 3vm4A-4gfjA:
undetectable		 3vm4A-4gfjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A 181
PHE A 136
PRO A 134
ALA A 135
 None
 1.36A 3vm4A-4hj2A:
undetectable		 3vm4A-4hj2A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 LEU A 373
ARG A 317
PRO A 360
ALA A 361
 None
 1.34A 3vm4A-4ix3A:
undetectable		 3vm4A-4ix3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j07 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
leprae) 		PF00885
(DMRL_synthase) 		4 LEU A  36
ARG A  40
PRO A  51
ALA A  43
 None
 1.45A 3vm4A-4j07A:
undetectable		 3vm4A-4j07A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		4 LEU A 326
PHE A 250
ARG A 128
ALA A 132
 PLP  A 500 (-4.1A)
None
PLP  A 500 (-2.7A)
None
 0.99A 3vm4A-4k6nA:
undetectable		 3vm4A-4k6nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr3 PROTEIN YFBU

(Escherichia
coli) 		PF03887
(YfbU) 		4 LEU A 110
PHE A 133
ARG A 114
ALA A 128
 None
 1.05A 3vm4A-4lr3A:
undetectable		 3vm4A-4lr3A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 LEU A 248
PHE A 246
ARG A 259
PRO A 452
 GOL  A 502 (-3.8A)
None
GOL  A 502 (-3.6A)
None
 1.31A 3vm4A-4oetA:
undetectable		 3vm4A-4oetA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 LEU A 448
ARG A 452
PRO A 464
ALA A 428
 None
 1.23A 3vm4A-4ogcA:
undetectable		 3vm4A-4ogcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN

(Vibrio cholerae) 		no annotation 4 LEU E 138
ARG E 226
PRO E 223
ALA E 225
 None
 1.43A 3vm4A-4p9uE:
undetectable		 3vm4A-4p9uE:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 LEU A 387
ARG A 485
PRO A 486
ALA A 490
 NPS  A 601 ( 4.7A)
None
None
None
 1.20A 3vm4A-4po0A:
undetectable		 3vm4A-4po0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 LEU A 144
PHE A 142
ARG A 366
PRO A 365
 None
 1.30A 3vm4A-4pxdA:
undetectable		 3vm4A-4pxdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7s SURFACE ANTIGEN
PROTEIN 2

(Candida
albicans) 		PF05730
(CFEM) 		4 LEU A 138
PHE A 110
ARG A 111
ALA A 114
 None
 1.43A 3vm4A-4y7sA:
undetectable		 3vm4A-4y7sA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 LEU C 307
ARG C 310
PRO C 424
ALA C 304
 None
 1.30A 3vm4A-4yfaC:
undetectable		 3vm4A-4yfaC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 LEU A 359
ARG A 204
PRO A 205
ALA A 203
 None
 1.49A 3vm4A-4zc0A:
undetectable		 3vm4A-4zc0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 848
ARG A 736
PRO A 822
ALA A 820
 None
 1.28A 3vm4A-5b7iA:
undetectable		 3vm4A-5b7iA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 LEU A 509
ARG A 512
PRO A 626
ALA A 506
 None
 1.29A 3vm4A-5c9iA:
undetectable		 3vm4A-5c9iA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 662
ARG A 152
PRO A 475
ALA A 471
 None
 1.21A 3vm4A-5chcA:
undetectable		 3vm4A-5chcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 PHE A 275
ARG A 271
PRO A 273
ALA A 274
 None
 1.37A 3vm4A-5d4kA:
undetectable		 3vm4A-5d4kA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		4 LEU B  85
PHE B  86
PRO B  88
ALA B 198
 None
 1.46A 3vm4A-5ej1B:
undetectable		 3vm4A-5ej1B:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		4 LEU A 215
PHE A 204
PRO A 197
ALA A 200
 None
 1.49A 3vm4A-5eueA:
undetectable		 3vm4A-5eueA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flw EXO-BETA-1,3-GALACTA
NASE

(Bifidobacterium
bifidum) 		PF04616
(Glyco_hydro_43) 		4 LEU A  66
PHE A 123
PRO A 122
ALA A 116
 None
 1.16A 3vm4A-5flwA:
undetectable		 3vm4A-5flwA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 PHE A 597
ARG A  35
PRO A  36
ALA A  38
 None
 1.11A 3vm4A-5fwjA:
undetectable		 3vm4A-5fwjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		4 LEU A 599
ARG A 606
PRO A 576
ALA A 609
 U  B   1 ( 4.8A)
None
None
None
 1.34A 3vm4A-5guhA:
undetectable		 3vm4A-5guhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.37A 3vm4A-5hm5A:
undetectable		 3vm4A-5hm5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		4 LEU A  33
PHE A  32
PRO A 195
ALA A 198
 None
 0.73A 3vm4A-5i2cA:
undetectable		 3vm4A-5i2cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 275
ARG A 279
PRO A 436
ALA A 438
 None
 1.31A 3vm4A-5i68A:
undetectable		 3vm4A-5i68A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 LEU A 520
PHE A 464
PRO A 466
ALA A 450
 None
 1.38A 3vm4A-5l2rA:
undetectable		 3vm4A-5l2rA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m0o TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE

(Jeotgalicoccus
sp. ATCC 8456) 		PF00067
(p450) 		4 LEU A  78
ARG A 245
PRO A 246
ALA A 249
 None
EPA  A 502 (-3.8A)
EPA  A 502 ( 3.7A)
HEM  A 501 (-3.9A)
 0.38A 3vm4A-5m0oA:
55.7		 3vm4A-5m0oA:
37.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlq CDPS

(Nocardia
brasiliensis) 		no annotation 4 LEU A 208
ARG A 204
PRO A 137
ALA A 141
 None
 1.27A 3vm4A-5mlqA:
undetectable		 3vm4A-5mlqA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 LEU A 862
PHE A 865
PRO A 867
ALA A 869
 None
 1.33A 3vm4A-5wu3A:
undetectable		 3vm4A-5wu3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases) 		4 LEU D 253
ARG D 315
PRO D 312
ALA D 314
 None
 1.46A 3vm4A-5xfaD:
undetectable		 3vm4A-5xfaD:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 4 LEU F 129
PHE F 134
PRO F 107
ALA F 108
 None
 1.43A 3vm4A-5y81F:
undetectable		 3vm4A-5y81F:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhj CYTOCHROME P450

(Exiguobacterium
sp. AT1b) 		no annotation 5 LEU A  78
PHE A 167
ARG A 239
PRO A 240
ALA A 243
 None
None
MYR  A 502 (-4.2A)
MYR  A 502 ( 3.7A)
MYR  A 502 (-3.7A)
 0.49A 3vm4A-5yhjA:
58.4		 3vm4A-5yhjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9z SULFATE TRANSPORTER
CYSZ

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		no annotation 4 LEU F 138
PHE F 141
PRO F 143
ALA F 145
 None
 1.16A 3vm4A-6d9zF:
undetectable		 3vm4A-6d9zF:
11.93