SIMILAR PATTERNS OF AMINO ACIDS FOR 3VLN_A_ACTA908

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wta 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Aeropyrum
pernix) 		PF01048
(PNP_UDP_1) 		4 MET A 247
SER A 153
LEU A 150
VAL A 251
 None
 1.26A 3vlnA-1wtaA:
0.4		 3vlnA-1wtaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zaw 50S RIBOSOMAL
PROTEIN L10

(Thermotoga
maritima) 		PF00466
(Ribosomal_L10) 		4 MET A  14
SER A  15
LEU A  61
VAL A  11
 None
 1.46A 3vlnA-1zawA:
0.0		 3vlnA-1zawA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 MET A 151
SER A 181
LEU A 209
VAL A 185
 None
SO4  A1003 ( 4.7A)
None
None
 1.40A 3vlnA-2aeuA:
0.0		 3vlnA-2aeuA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		4 MET A 260
SER A 263
LEU A 258
VAL A 274
 None
 1.41A 3vlnA-2iq1A:
0.0		 3vlnA-2iq1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q62 ARSH

(Sinorhizobium
meliloti) 		PF03358
(FMN_red) 		4 MET A 142
SER A 173
LEU A  53
VAL A 175
 None
 1.49A 3vlnA-2q62A:
0.8		 3vlnA-2q62A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		4 MET A  44
SER A  48
LEU A 102
VAL A 110
 None
 1.31A 3vlnA-3b5oA:
0.1		 3vlnA-3b5oA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 MET A 245
SER A 246
LEU A 213
VAL A 232
 None
 1.29A 3vlnA-3e02A:
0.0		 3vlnA-3e02A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		4 MET A 178
SER A 174
LEU A 233
VAL A 237
 None
 1.45A 3vlnA-3ez6A:
0.0		 3vlnA-3ez6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 MET A 114
SER A 105
LEU A 164
VAL A 110
 None
 1.28A 3vlnA-3i7aA:
1.0		 3vlnA-3i7aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb3 PROTEIN PHOSPHATASE
2C 16

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 MET B 396
SER B 399
LEU B 394
VAL B 409
 None
 1.46A 3vlnA-3kb3B:
undetectable		 3vlnA-3kb3B:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 MET A  67
SER A  65
LEU A  28
VAL A 186
 None
 1.25A 3vlnA-3kl9A:
0.6		 3vlnA-3kl9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		4 MET A  67
SER A 209
LEU A  28
VAL A 186
 None
 1.19A 3vlnA-3kl9A:
0.6		 3vlnA-3kl9A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 MET A  87
SER A  86
LEU A 115
VAL A 124
 None
 1.35A 3vlnA-3ntvA:
undetectable		 3vlnA-3ntvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ANTIDOTE OF
EPSILON-ZETA
POSTSEGREGATIONAL
KILLING SYSTEM

(Streptococcus
pyogenes) 		PF08998
(Epsilon_antitox) 		4 MET A  76
SER A  80
LEU A  50
VAL A  21
 None
 0.86A 3vlnA-3q8xA:
3.5		 3vlnA-3q8xA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 MET A  53
SER A 118
LEU A  78
VAL A  56
 None
 1.49A 3vlnA-3vgoA:
2.0		 3vlnA-3vgoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggp TRANS-2-ENOYL-COA
REDUCTASE

(Treponema
denticola) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 MET A 353
SER A 293
LEU A 289
VAL A 356
 None
 1.44A 3vlnA-4ggpA:
undetectable		 3vlnA-4ggpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 MET A 688
SER A 683
LEU A 661
VAL A 681
 None
 1.39A 3vlnA-4p2kA:
0.4		 3vlnA-4p2kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		4 MET A 270
SER A 273
LEU A 268
VAL A 283
 None
 1.45A 3vlnA-5gwoA:
0.4		 3vlnA-5gwoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 MET G 267
SER G 263
LEU G 253
VAL G 216
 None
 1.50A 3vlnA-6criG:
1.4		 3vlnA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv6 3-DEHYDROQUINATE
DEHYDRATASE

(Paraburkholderia
phymatum) 		no annotation 4 MET A   6
SER A  48
LEU A  35
VAL A  46
 None
 1.44A 3vlnA-6cv6A:
1.6		 3vlnA-6cv6A:
undetectable