SIMILAR PATTERNS OF AMINO ACIDS FOR 3VHU_A_SNLA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 168
LEU A 167
LEU A 228
MET A 205
 None
 0.78A 3vhuA-1d2fA:
0.1		 3vhuA-1d2fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 LEU A  80
LEU A  83
LEU A 126
SER A 127
 None
 0.67A 3vhuA-1lkiA:
0.3		 3vhuA-1lkiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 LEU A 454
LEU A 453
LEU A 438
SER A 437
 None
None
None
PLD  A2005 (-3.1A)
 1.02A 3vhuA-1lshA:
0.0		 3vhuA-1lshA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhd SMAD3

(Homo sapiens) 		PF03165
(MH1) 		4 LEU A  16
LEU A  15
LEU A  38
SER A  37
 None
 1.00A 3vhuA-1mhdA:
0.0		 3vhuA-1mhdA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		4 LEU A  12
LEU A  11
LEU A  24
SER A  25
 None
 0.82A 3vhuA-1ogqA:
undetectable		 3vhuA-1ogqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvh LEUKEMIA INHIBITORY
FACTOR

(Homo sapiens) 		PF01291
(LIF_OSM) 		4 LEU B  80
LEU B  83
LEU B 126
SER B 127
 None
 0.78A 3vhuA-1pvhB:
undetectable		 3vhuA-1pvhB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sur PAPS REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		4 LEU A 100
LEU A  98
LEU A  49
SER A  50
 None
 1.02A 3vhuA-1surA:
undetectable		 3vhuA-1surA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 LEU A  51
LEU A  75
SER A  74
MET A  32
 None
 0.99A 3vhuA-1ta3A:
undetectable		 3vhuA-1ta3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhn CALCINEURIN B-LIKE
PROTEIN 2

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 LEU A 198
LEU A 199
LEU A 193
SER A 190
 None
 0.89A 3vhuA-1uhnA:
0.9		 3vhuA-1uhnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  56
LEU A  55
LEU A 205
SER A 203
 None
 0.95A 3vhuA-1v59A:
0.0		 3vhuA-1v59A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf6 MAGUK P55 SUBFAMILY
MEMBER 5
PALS1-ASSOCIATED
TIGHT JUNCTION
PROTEIN

(Homo sapiens;
Mus musculus) 		PF09045
(L27_2)
PF09060
(L27_N) 		4 LEU A  19
LEU A  16
LEU C 149
SER C 148
 None
 1.02A 3vhuA-1vf6A:
undetectable		 3vhuA-1vf6A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 LEU A 130
LEU A 134
LEU A 250
MET A 100
 None
 0.99A 3vhuA-1w27A:
1.7		 3vhuA-1w27A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		4 LEU A 347
LEU A 348
LEU A 251
SER A 252
 None
 0.92A 3vhuA-1yisA:
undetectable		 3vhuA-1yisA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yln HYPOTHETICAL PROTEIN
VCA0042

(Vibrio cholerae) 		PF07238
(PilZ)
PF12945
(YcgR_2) 		4 LEU A  44
LEU A  42
SER A 125
MET A 112
 None
 0.93A 3vhuA-1ylnA:
undetectable		 3vhuA-1ylnA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Saccharomyces
cerevisiae) 		PF00977
(His_biosynth) 		4 LEU A 193
LEU A 192
LEU A 227
SER A 228
 None
 0.81A 3vhuA-2agkA:
undetectable		 3vhuA-2agkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A 212
LEU A 208
LEU A 113
MET A 103
 None
 1.02A 3vhuA-2b2cA:
undetectable		 3vhuA-2b2cA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 LEU A 891
LEU A 894
LEU A 950
SER A 949
 None
 0.82A 3vhuA-2fgeA:
undetectable		 3vhuA-2fgeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 464
LEU A 467
LEU A 539
SER A 538
 None
 1.01A 3vhuA-2hajA:
undetectable		 3vhuA-2hajA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2na1 POLYCOMB COMPLEX
PROTEIN BMI-1,
POLYHOMEOTIC-LIKE 2

(Homo sapiens;
Mus musculus) 		PF16207
(RAWUL) 		4 LEU A 223
LEU A 175
LEU A 164
SER A 132
 None
 1.00A 3vhuA-2na1A:
undetectable		 3vhuA-2na1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		4 LEU A  77
LEU A  73
LEU A  31
SER A  27
 None
 0.95A 3vhuA-2owzA:
undetectable		 3vhuA-2owzA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paf LACTOSE OPERON
REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A 115
LEU A 114
LEU A  63
SER A 120
 None
 0.85A 3vhuA-2pafA:
undetectable		 3vhuA-2pafA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 LEU A 105
LEU A 109
LEU A 121
SER A 122
 None
 1.04A 3vhuA-2qbyA:
undetectable		 3vhuA-2qbyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A 328
LEU A 332
LEU A 648
SER A 649
 None
 0.98A 3vhuA-2rdyA:
undetectable		 3vhuA-2rdyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 LEU A 200
LEU A 177
LEU A 224
SER A 225
 None
 0.95A 3vhuA-2w9mA:
undetectable		 3vhuA-2w9mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqy SUCCINATE
DEHYDROGENASE
CYTOCHROME B, SMALL
SUBUNIT

(Gallus gallus) 		PF05328
(CybS) 		4 LEU D  43
LEU D  39
LEU D  19
SER D  17
 None
 1.03A 3vhuA-2wqyD:
undetectable		 3vhuA-2wqyD:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		4 LEU A 285
LEU A 284
LEU A 255
SER A 251
 None
 1.01A 3vhuA-2zbzA:
undetectable		 3vhuA-2zbzA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfd CALCINEURIN B-LIKE
PROTEIN 2

(Arabidopsis
thaliana) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 LEU A 198
LEU A 199
LEU A 193
SER A 190
 None
 0.91A 3vhuA-2zfdA:
undetectable		 3vhuA-2zfdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0b CENTROMERE PROTEIN S

(Gallus gallus) 		no annotation 4 LEU B  82
LEU B  81
LEU B  90
SER B  86
 None
 0.84A 3vhuA-3b0bB:
undetectable		 3vhuA-3b0bB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 LEU A 236
LEU A 233
LEU A 178
SER A 179
 None
 0.96A 3vhuA-3b40A:
undetectable		 3vhuA-3b40A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 LEU A1327
LEU A1328
LEU A1045
SER A1046
 None
 0.99A 3vhuA-3cmvA:
undetectable		 3vhuA-3cmvA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6m MARR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria
pomeroyi) 		PF01047
(MarR) 		4 LEU A  48
LEU A  43
LEU A 124
SER A 122
 None
 1.01A 3vhuA-3e6mA:
undetectable		 3vhuA-3e6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7q TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 LEU A 170
LEU A 173
LEU A 105
SER A 101
 None
 0.97A 3vhuA-3e7qA:
undetectable		 3vhuA-3e7qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN

(Homo sapiens) 		PF08324
(PUL) 		4 LEU A 749
LEU A 745
LEU A 728
SER A 727
 None
 1.03A 3vhuA-3ebbA:
undetectable		 3vhuA-3ebbA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		4 LEU A 556
LEU A 557
LEU A 487
SER A 486
 None
 1.03A 3vhuA-3edyA:
undetectable		 3vhuA-3edyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 LEU A 134
LEU A 133
LEU A 140
SER A 142
 None
 1.00A 3vhuA-3g5iA:
undetectable		 3vhuA-3g5iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 855
LEU A 854
LEU A 859
SER A 860
 None
 1.03A 3vhuA-3iu6A:
undetectable		 3vhuA-3iu6A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro NUCLEOPORIN NUP84

(Saccharomyces
cerevisiae) 		PF04121
(Nup84_Nup100) 		4 LEU C  81
LEU C  82
LEU C 355
SER C 354
 None
 0.95A 3vhuA-3jroC:
undetectable		 3vhuA-3jroC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 709
LEU A 731
LEU A 702
SER A 703
 None
 0.81A 3vhuA-3juxA:
undetectable		 3vhuA-3juxA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 LEU A  10
LEU A  49
LEU A 405
MET A 355
 None
 0.86A 3vhuA-3mduA:
undetectable		 3vhuA-3mduA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A  43
LEU A  46
LEU A 105
SER A 101
 None
 0.94A 3vhuA-3mvuA:
2.3		 3vhuA-3mvuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 LEU A 198
LEU A 177
LEU A 141
SER A 142
 None
 1.02A 3vhuA-3pjaA:
undetectable		 3vhuA-3pjaA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A1325
LEU A1328
LEU A1407
SER A1408
 None
 0.95A 3vhuA-3q2eA:
undetectable		 3vhuA-3q2eA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 LEU N  79
LEU N  82
LEU N 338
SER N 336
 LFA  N 488 ( 4.8A)
None
None
None
 1.03A 3vhuA-3rkoN:
1.4		 3vhuA-3rkoN:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		4 LEU A  19
LEU A  16
LEU A 107
SER A 106
 None
 1.00A 3vhuA-3uitA:
undetectable		 3vhuA-3uitA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 LEU B 838
LEU B 840
LEU B1005
SER B1004
 None
 1.01A 3vhuA-3v0aB:
undetectable		 3vhuA-3v0aB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v42 FOLLICULIN

(Homo sapiens) 		PF16692
(Folliculin_C) 		4 LEU A 356
LEU A 364
LEU A 349
SER A 348
 None
 1.00A 3vhuA-3v42A:
undetectable		 3vhuA-3v42A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 AGRIN

(Rattus
norvegicus) 		PF00054
(Laminin_G_1) 		4 LEU A1810
LEU A1824
LEU A1800
SER A1799
 None
 1.01A 3vhuA-3v65A:
undetectable		 3vhuA-3v65A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A 333
LEU A 332
LEU A 340
SER A 341
 VPX  A2001 (-4.9A)
OLC  A2007 (-4.6A)
VPX  A2001 ( 4.7A)
None
 0.71A 3vhuA-3vw7A:
undetectable		 3vhuA-3vw7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus) 		PF01273
(LBP_BPI_CETP) 		4 LEU A  65
LEU A  92
LEU A  25
SER A  26
 None
 1.02A 3vhuA-3zpmA:
undetectable		 3vhuA-3zpmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aaj N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE

(Pyrococcus
furiosus) 		PF00697
(PRAI) 		4 LEU A 118
LEU A 119
LEU A 149
SER A 148
 None
 1.03A 3vhuA-4aajA:
undetectable		 3vhuA-4aajA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 LEU B 299
LEU B 292
SER B 291
MET B 227
 None
 1.01A 3vhuA-4cakB:
undetectable		 3vhuA-4cakB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL15
MRPL4

(Sus scrofa) 		PF00573
(Ribosomal_L4)
PF00828
(Ribosomal_L27A) 		4 LEU F  93
LEU F  96
LEU P  24
SER P  23
 None
None
U  A 611 ( 4.2A)
U  A 611 ( 4.0A)
 0.90A 3vhuA-4ce4F:
undetectable		 3vhuA-4ce4F:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 198
LEU A 201
LEU A 240
SER A 241
 None
 0.90A 3vhuA-4fxbA:
undetectable		 3vhuA-4fxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 LEU C  18
LEU C   6
SER C   7
MET C  14
 None
 0.93A 3vhuA-4fzwC:
undetectable		 3vhuA-4fzwC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU M 730
LEU M 734
LEU M 798
SER M 799
 None
 0.94A 3vhuA-4gq2M:
undetectable		 3vhuA-4gq2M:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		4 LEU A 111
LEU A 112
LEU A  99
MET A 183
 None
 0.94A 3vhuA-4hyjA:
undetectable		 3vhuA-4hyjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 522
LEU A 525
LEU A 484
SER A 485
 None
 0.91A 3vhuA-4i7iA:
undetectable		 3vhuA-4i7iA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i96 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR) 		4 LEU A 522
LEU A 525
LEU A 484
SER A 485
 None
 0.70A 3vhuA-4i96A:
undetectable		 3vhuA-4i96A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		4 LEU A  23
LEU A  26
LEU A 155
SER A 154
 None
 0.97A 3vhuA-4ir8A:
undetectable		 3vhuA-4ir8A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgv NUCLEAR RECEPTOR
SUBFAMILY 4 GROUP A
MEMBER 1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 562
LEU A 559
LEU A 506
SER A 507
 None
T94  A 601 ( 4.0A)
T94  A 601 ( 4.2A)
None
 0.76A 3vhuA-4jgvA:
20.4		 3vhuA-4jgvA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A3882
LEU A3879
LEU A3929
SER A3928
 None
 0.88A 3vhuA-4kc5A:
undetectable		 3vhuA-4kc5A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 LEU A 116
LEU A 133
LEU A 158
SER A 157
 None
 0.98A 3vhuA-4l6uA:
undetectable		 3vhuA-4l6uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx1 UNCONVENTIONAL
MYOSIN-VA

(Homo sapiens) 		PF01843
(DIL) 		4 LEU A1600
LEU A1603
LEU A1556
SER A1557
 None
 0.94A 3vhuA-4lx1A:
undetectable		 3vhuA-4lx1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 LEU A 136
LEU A 132
LEU A 222
MET A 348
 None
 0.86A 3vhuA-4mruA:
undetectable		 3vhuA-4mruA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne5 CENTROMERE PROTEIN S

(Homo sapiens) 		PF15630
(CENP-S) 		4 LEU A  85
LEU A  84
LEU A  93
SER A  89
 None
 0.98A 3vhuA-4ne5A:
undetectable		 3vhuA-4ne5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 112
LEU A 115
LEU A 146
SER A 143
 None
 1.00A 3vhuA-4nrhA:
undetectable		 3vhuA-4nrhA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 112
LEU A 115
LEU A 146
SER A 143
 None
 0.92A 3vhuA-4p3zA:
undetectable		 3vhuA-4p3zA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2s PDC1 GE1 DOMAIN

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A1059
LEU A1041
LEU A1005
SER A1006
 None
 0.99A 3vhuA-4q2sA:
undetectable		 3vhuA-4q2sA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		4 LEU G 153
LEU G 167
LEU G 138
SER G 137
 None
 0.87A 3vhuA-4rerG:
undetectable		 3vhuA-4rerG:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 LEU A 226
LEU A 309
LEU A 260
SER A 261
 None
 0.91A 3vhuA-4rg8A:
undetectable		 3vhuA-4rg8A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8h CRYPTOCHROME-2
PERIOD CIRCADIAN
PROTEIN HOMOLOG 2

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
PF12114
(Period_C) 		4 LEU A 213
LEU A 216
LEU B1134
SER A  64
 None
 1.04A 3vhuA-4u8hA:
undetectable		 3vhuA-4u8hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 269
LEU A 268
LEU A 257
SER A 258
 None
 0.99A 3vhuA-4uadA:
undetectable		 3vhuA-4uadA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 769
LEU A 772
LEU A 810
SER A 811
 CV7  A1987 (-4.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-4.0A)
None
 0.18A 3vhuA-4udbA:
37.4		 3vhuA-4udbA:
87.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 LEU A 522
LEU A 525
LEU A 484
SER A 485
 None
 0.88A 3vhuA-4uwaA:
undetectable		 3vhuA-4uwaA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 LEU A 838
LEU A 833
LEU A 805
SER A 804
 None
 1.04A 3vhuA-5csaA:
undetectable		 3vhuA-5csaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 LEU A 286
LEU A 289
LEU A 254
SER A 253
 None
 0.91A 3vhuA-5ddbA:
undetectable		 3vhuA-5ddbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 LEU B 706
LEU B 707
LEU B 690
SER B 688
 None
 0.97A 3vhuA-5dlqB:
undetectable		 3vhuA-5dlqB:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft1 GP37

(Pseudomonas
virus phiKZ) 		no annotation 4 LEU A  18
LEU A  15
LEU A  75
SER A  76
 None
 0.95A 3vhuA-5ft1A:
undetectable		 3vhuA-5ft1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF09427
(DUF2014) 		4 LEU A 744
LEU A 747
LEU A 799
SER A 795
 None
 0.87A 3vhuA-5gpdA:
undetectable		 3vhuA-5gpdA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 349
LEU A 352
LEU A 385
SER A 383
 None
 1.03A 3vhuA-5jbgA:
undetectable		 3vhuA-5jbgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A2128
LEU A2103
LEU A2057
SER A2056
 None
 0.91A 3vhuA-5m5pA:
undetectable		 3vhuA-5m5pA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		4 LEU A 278
LEU A 275
LEU A 180
MET A 315
 None
 0.93A 3vhuA-5m95A:
undetectable		 3vhuA-5m95A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mil DUTPASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF08761
(dUTPase_2) 		4 LEU A  72
LEU A  68
LEU A 128
SER A 127
 None
 0.93A 3vhuA-5milA:
undetectable		 3vhuA-5milA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 LEU A 769
LEU A 772
SER A 811
MET A 852
 ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.0A)
ECV  A1101 (-3.7A)
 0.97A 3vhuA-5mwpA:
39.5		 3vhuA-5mwpA:
66.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 113
LEU A 293
LEU A 327
SER A 328
 None
 1.01A 3vhuA-5nccA:
undetectable		 3vhuA-5nccA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 LEU A  26
LEU A  68
LEU A  48
SER A  47
 None
 0.86A 3vhuA-5nn7A:
undetectable		 3vhuA-5nn7A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 LEU A 349
LEU A 350
LEU A 363
MET A 164
 None
 1.02A 3vhuA-5oglA:
undetectable		 3vhuA-5oglA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol1 DNA POLYMERASE III
SUBUNIT ALPHA,DNA
POLYMERASE III
SUBUNIT ALPHA

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU A 117
LEU A 137
LEU A  27
SER A  74
 None
 0.94A 3vhuA-5ol1A:
undetectable		 3vhuA-5ol1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8

(Homo sapiens) 		PF00004
(AAA) 		4 LEU d 103
LEU d 107
LEU d 139
SER d 138
 None
 0.93A 3vhuA-5vhid:
undetectable		 3vhuA-5vhid:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES

(Drosophila
melanogaster) 		no annotation 4 LEU A1147
LEU A1148
LEU A1218
SER A1215
 None
 1.01A 3vhuA-5vjcA:
undetectable		 3vhuA-5vjcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd8 LEM22

(Legionella
pneumophila) 		no annotation 4 LEU A  14
LEU A  17
LEU A  76
SER A  75
 None
 0.96A 3vhuA-5wd8A:
undetectable		 3vhuA-5wd8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 LEU D 948
LEU D 945
LEU D 905
SER D 906
 None
 0.91A 3vhuA-5xbkD:
undetectable		 3vhuA-5xbkD:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygk -

(-) 		no annotation 4 LEU A  48
LEU A   4
LEU A   7
MET A  29
 None
None
DST  A 301 (-4.1A)
DST  A 302 ( 4.4A)
 1.04A 3vhuA-5ygkA:
undetectable		 3vhuA-5ygkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 4 LEU A 297
LEU A 296
LEU A 267
SER A 263
 None
 0.86A 3vhuA-5ysmA:
undetectable		 3vhuA-5ysmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 LEU A 296
LEU A 295
LEU A 282
SER A 284
 None
 0.95A 3vhuA-5z5kA:
undetectable		 3vhuA-5z5kA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 167
LEU A 246
SER A 245
MET A 174
 None
 0.98A 3vhuA-6amnA:
undetectable		 3vhuA-6amnA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 LEU A 154
LEU A 158
LEU A 133
SER A 134
 None
 1.00A 3vhuA-6cwoA:
2.8		 3vhuA-6cwoA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 LEU A 154
LEU A 158
LEU A 133
SER A 134
 None
 0.90A 3vhuA-6cwpA:
2.8		 3vhuA-6cwpA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 LEU B  64
LEU B  83
LEU B 163
SER B 164
 None
 1.01A 3vhuA-6eysB:
undetectable		 3vhuA-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 727
LEU B 725
LEU B 461
SER B 462
 None
 0.88A 3vhuA-6f42B:
undetectable		 3vhuA-6f42B:
15.09