SIMILAR PATTERNS OF AMINO ACIDS FOR 3VHU_A_SNLA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 LEU A 527
LEU A 429
LEU A 332
THR A 480
PHE A 482
 None
 1.29A 3vhuA-1f3lA:
undetectable		 3vhuA-1f3lA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1)
PF00510
(COX3) 		5 LEU A 278
ALA A 251
GLN A 195
THR C  46
PHE A 263
 None
 1.32A 3vhuA-1fftA:
undetectable		 3vhuA-1fftA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		5 MET C 405
ARG C 746
LEU C 402
THR C 395
PHE C 356
 None
 1.46A 3vhuA-1h2tC:
undetectable		 3vhuA-1h2tC:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6g ALPHA-1 CATENIN

(Homo sapiens) 		PF01044
(Vinculin) 		5 LEU A 486
ASN A 483
ALA A 467
LEU A 401
LEU A 460
 None
 1.45A 3vhuA-1h6gA:
undetectable		 3vhuA-1h6gA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA A 166
GLN A 165
LEU A 172
LEU A 188
THR A 144
 None
 1.47A 3vhuA-1imvA:
undetectable		 3vhuA-1imvA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 GLN A 140
LEU A 345
LEU A 151
THR A 163
PHE A 165
 None
 1.42A 3vhuA-1iuqA:
undetectable		 3vhuA-1iuqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 135
GLN A 140
LEU A 345
THR A 163
PHE A 165
 None
 1.18A 3vhuA-1iuqA:
undetectable		 3vhuA-1iuqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 ALA A 906
GLN A 905
LEU A 901
LEU A  83
PHE A 917
 None
 1.48A 3vhuA-1jqoA:
undetectable		 3vhuA-1jqoA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		5 LEU A 274
ALA A 322
LEU A 157
ARG A 163
LEU A 333
 None
 1.46A 3vhuA-1o7xA:
undetectable		 3vhuA-1o7xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A 144
ASN A  94
ALA A  95
MET A  40
LEU A  53
 None
 1.44A 3vhuA-1quaA:
undetectable		 3vhuA-1quaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 334
ALA A 327
GLN A 323
LEU A 309
LEU A 133
 None
 1.47A 3vhuA-1uouA:
undetectable		 3vhuA-1uouA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 491
ALA A 458
LEU A 465
THR A 559
PHE A 500
 None
 0.88A 3vhuA-1w6jA:
undetectable		 3vhuA-1w6jA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A1147
ASN A1151
GLN A1156
ARG A1322
LEU A1184
 None
 1.47A 3vhuA-1wufA:
undetectable		 3vhuA-1wufA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 LEU A 472
ASN A 469
ALA A 497
LEU A  97
THR A 519
 None
 1.27A 3vhuA-1x87A:
undetectable		 3vhuA-1x87A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A 144
ASN A  94
ALA A  95
MET A  40
LEU A  53
 None
 1.49A 3vhuA-1yp1A:
undetectable		 3vhuA-1yp1A:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
ASN A 705
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
PHE A 891
 None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
None
 0.74A 3vhuA-2ax9A:
35.7		 3vhuA-2ax9A:
46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 ALA A 822
GLN A 296
MET A 302
LEU A 830
PHE A 797
 None
 1.46A 3vhuA-2dw4A:
undetectable		 3vhuA-2dw4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.40A 3vhuA-2gksA:
undetectable		 3vhuA-2gksA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ju1 ERYTHRONOLIDE
SYNTHASE

(Saccharopolyspora
erythraea) 		PF00550
(PP-binding) 		5 ALA A  66
LEU A   9
ARG A   6
LEU A  21
THR A  27
 None
 1.39A 3vhuA-2ju1A:
undetectable		 3vhuA-2ju1A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 663
ASN A 233
ALA A 236
LEU A 356
LEU A 256
 None
 1.26A 3vhuA-2nyaA:
undetectable		 3vhuA-2nyaA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 LEU A 143
ASN A 172
ALA A 173
LEU A 125
THR A 132
 None
 1.25A 3vhuA-2ozeA:
undetectable		 3vhuA-2ozeA:
24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
ASN A  33
ALA A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.31A 3vhuA-2q3yA:
39.0		 3vhuA-2q3yA:
64.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  29
ASN A  33
LEU A  90
CYH A 205
THR A 208
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.19A 3vhuA-2q3yA:
39.0		 3vhuA-2q3yA:
64.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 ASN A 217
ALA A 149
LEU A 317
THR A 128
PHE A 215
 NAP  A 701 (-3.8A)
NAP  A 701 ( 3.9A)
None
NAP  A 701 (-3.1A)
None
 1.35A 3vhuA-2y05A:
undetectable		 3vhuA-2y05A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		5 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.47A 3vhuA-2z3tA:
undetectable		 3vhuA-2z3tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 283
ASN A 286
ALA A 289
LEU A 471
LEU A 405
 None
 1.45A 3vhuA-3a74A:
undetectable		 3vhuA-3a74A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 ALA A1581
GLN A1559
LEU A1586
THR A1166
PHE A1180
 SAM  A   1 (-3.7A)
None
None
None
None
 1.43A 3vhuA-3av6A:
undetectable		 3vhuA-3av6A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		5 LEU B  40
LEU B  52
ARG B  47
LEU B   7
THR B  64
 None
 1.35A 3vhuA-3bn3B:
undetectable		 3vhuA-3bn3B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A  81
ALA A 221
LEU A 485
LEU A 377
THR A 399
 None
VD3  A 701 ( 3.8A)
None
None
None
 1.22A 3vhuA-3c6gA:
undetectable		 3vhuA-3c6gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		5 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.38A 3vhuA-3dmpA:
undetectable		 3vhuA-3dmpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 ALA A 451
LEU A 315
ARG A 354
LEU A 308
PHE A 419
 None
 1.27A 3vhuA-3e1sA:
undetectable		 3vhuA-3e1sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE

(Pseudomonas
putida) 		PF13489
(Methyltransf_23) 		5 ASN A 122
ALA A 121
LEU A 118
THR A  39
PHE A 123
 SAH  A 300 (-3.8A)
None
None
None
None
 1.40A 3vhuA-3e8sA:
undetectable		 3vhuA-3e8sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01678
(DAP_epimerase) 		5 ASN A  37
LEU A 261
MET A 297
CYH A  99
PHE A  39
 ZDR  A 500 (-3.4A)
None
None
ZDR  A 500 (-3.0A)
None
 1.46A 3vhuA-3ekmA:
undetectable		 3vhuA-3ekmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 ALA A 168
LEU A 189
ARG A 247
MET A 181
THR A 144
 None
None
None
None
GOL  A 360 (-2.8A)
 1.44A 3vhuA-3f0hA:
undetectable		 3vhuA-3f0hA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum) 		PF00082
(Peptidase_S8) 		5 ASN A 133
ALA A 159
LEU A 252
LEU A 236
THR A  79
 None
 1.45A 3vhuA-3f7oA:
undetectable		 3vhuA-3f7oA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		5 ASN A 485
ALA A 488
LEU A 274
LEU A 295
PHE A  46
 None
 1.45A 3vhuA-3hjbA:
undetectable		 3vhuA-3hjbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.36A 3vhuA-3irvA:
undetectable		 3vhuA-3irvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN
USHER SYNDROME
TYPE-1G PROTEIN

(Homo sapiens) 		PF00536
(SAM_1)
PF00595
(PDZ) 		5 LEU A 153
ALA B 442
LEU B 415
LEU B 396
THR A 156
 None
 1.46A 3vhuA-3k1rA:
undetectable		 3vhuA-3k1rA:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
MET A 756
LEU A 763
ARG A 766
LEU A 887
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.50A 3vhuA-3kbaA:
35.5		 3vhuA-3kbaA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
GLN A 725
MET A 756
LEU A 763
ARG A 766
LEU A 887
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.69A 3vhuA-3kbaA:
35.5		 3vhuA-3kbaA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
LEU A 776
CYH A 891
THR A 894
PHE A 905
 WOW  A   1 (-3.9A)
None
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.39A 3vhuA-3kbaA:
35.5		 3vhuA-3kbaA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		5 ALA A  24
LEU A  29
ARG A  32
MET A  84
LEU A  12
 None
 1.45A 3vhuA-3louA:
undetectable		 3vhuA-3louA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 LEU A 135
ASN A 353
ALA A 352
ARG A  61
THR A 237
 None
 1.45A 3vhuA-3nz4A:
undetectable		 3vhuA-3nz4A:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.30A 3vhuA-3ry9A:
37.7		 3vhuA-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  29
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.23A 3vhuA-3ry9A:
37.7		 3vhuA-3ry9A:
65.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  98
ALA A 110
LEU A  64
LEU A  74
PHE A  94
 None
 1.49A 3vhuA-3tkrA:
undetectable		 3vhuA-3tkrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
ALA A 329
GLN A 326
MET A 110
LEU A  52
 None
 1.39A 3vhuA-3ugvA:
undetectable		 3vhuA-3ugvA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A1222
ALA A1122
LEU A1214
LEU A1132
THR A1138
 None
 1.33A 3vhuA-3va7A:
undetectable		 3vhuA-3va7A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.43A 3vhuA-3zlbA:
undetectable		 3vhuA-3zlbA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 LEU A 396
LEU A 163
ARG A 166
MET A 409
LEU A 442
 None
 1.42A 3vhuA-4abyA:
undetectable		 3vhuA-4abyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9b PRE-MRNA-SPLICING
FACTOR CWC22 HOMOLOG

(Homo sapiens) 		PF02854
(MIF4G) 		5 LEU B 239
ALA B 256
GLN B 205
LEU B 263
LEU B 273
 None
 1.46A 3vhuA-4c9bB:
undetectable		 3vhuA-4c9bB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.39A 3vhuA-4dpgA:
undetectable		 3vhuA-4dpgA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2u PHO RADA INTEIN

(Pyrococcus
horikoshii) 		PF14890
(Intein_splicing) 		5 LEU A 170
ALA A 107
ARG A  99
LEU A  81
THR A   6
 None
 1.19A 3vhuA-4e2uA:
undetectable		 3vhuA-4e2uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 MET A 282
LEU A 247
LEU A 297
THR A 125
PHE A  18
 None
None
None
ALA  A 402 (-3.5A)
GLU  A 403 (-4.6A)
 1.33A 3vhuA-4gfiA:
undetectable		 3vhuA-4gfiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 317
GLN A 333
LEU A 323
THR A  23
PHE A 346
 None
 1.49A 3vhuA-4gisA:
undetectable		 3vhuA-4gisA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113

(Mycobacteroides
abscessus) 		PF06013
(WXG100) 		5 ALA B  41
GLN B  42
LEU A  62
THR A  68
PHE A  76
 None
 1.47A 3vhuA-4i0xB:
undetectable		 3vhuA-4i0xB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 5 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.40A 3vhuA-4iqgC:
undetectable		 3vhuA-4iqgC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 LEU A 117
ALA A  30
MET A  37
LEU A 133
THR A 119
 None
 1.38A 3vhuA-4l6uA:
undetectable		 3vhuA-4l6uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmp SIALIC ACID BINDING
PROTEIN

(Pasteurella
multocida) 		PF03480
(DctP) 		5 ASN A 126
ALA A 124
LEU A 219
THR A 193
PHE A 251
 None
 1.33A 3vhuA-4mmpA:
undetectable		 3vhuA-4mmpA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 ASN A  56
LEU A 260
MET A  90
LEU A 253
THR A  31
 None
 1.25A 3vhuA-4mniA:
undetectable		 3vhuA-4mniA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
ALA A 287
MET A 321
ARG A 331
MET A 358
PHE A 462
 None
 0.72A 3vhuA-4n1yA:
28.9		 3vhuA-4n1yA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		5 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.37A 3vhuA-4oc8A:
undetectable		 3vhuA-4oc8A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
GLN A 570
MET A 601
LEU A 608
ARG A 611
LEU A 732
CYH A 736
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 0.38A 3vhuA-4p6wA:
35.0		 3vhuA-4p6wA:
56.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 564
LEU A 621
CYH A 736
THR A 739
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
 1.14A 3vhuA-4p6wA:
35.0		 3vhuA-4p6wA:
56.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 ALA A 451
ARG A 501
LEU A  42
THR A  48
PHE A 173
 None
 1.43A 3vhuA-4payA:
undetectable		 3vhuA-4payA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		5 LEU A 680
ASN A 677
ALA A 672
LEU A 667
LEU A 641
 None
 1.50A 3vhuA-4s3pA:
undetectable		 3vhuA-4s3pA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 938
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.32A 3vhuA-4udbA:
37.4		 3vhuA-4udbA:
87.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 766
ASN A 770
LEU A 827
LEU A 938
CYH A 942
THR A 945
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.19A 3vhuA-4udbA:
37.4		 3vhuA-4udbA:
87.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00004
(AAA) 		5 LEU A 147
LEU A 167
CYH A 224
THR A 225
PHE A 229
 None
 1.32A 3vhuA-4w5wA:
undetectable		 3vhuA-4w5wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 293
GLN A 367
LEU A 338
THR A 296
PHE A 344
 None
 1.24A 3vhuA-4xhlA:
undetectable		 3vhuA-4xhlA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce5 TRIACYLGLYCEROL
LIPASE

(Geobacillus
thermocatenulatus) 		no annotation 5 LEU A 157
ASN A   7
ALA A 385
LEU A 380
LEU A 344
 None
 1.45A 3vhuA-5ce5A:
undetectable		 3vhuA-5ce5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnl IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Pyrococcus
furiosus) 		PF00475
(IGPD) 		5 LEU A  27
ALA A  33
LEU A 155
LEU A  62
THR A  22
 None
 1.33A 3vhuA-5dnlA:
undetectable		 3vhuA-5dnlA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz6 POLYKETIDE
BIOSYNTHESIS MALONYL
COA-ACYL CARRIER
PROTEIN TRANSACYLASE
PKSC

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		5 LEU A  51
ASN A  52
LEU A  88
ARG A 112
MET A  16
 None
 1.18A 3vhuA-5dz6A:
undetectable		 3vhuA-5dz6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ALA A 182
GLN A  48
LEU A  69
LEU A 165
PHE A  13
 None
 1.34A 3vhuA-5f7cA:
undetectable		 3vhuA-5f7cA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A1222
ALA A1122
LEU A1214
LEU A1132
THR A1138
 None
 1.32A 3vhuA-5i8iA:
undetectable		 3vhuA-5i8iA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		5 LEU A 314
ALA A 307
LEU A 270
MET A 331
PHE A 371
 None
 1.41A 3vhuA-5kkbA:
undetectable		 3vhuA-5kkbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 ALA A 822
GLN A 296
MET A 302
LEU A 830
PHE A 797
 None
 1.40A 3vhuA-5l3dA:
undetectable		 3vhuA-5l3dA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 12 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 845
LEU A 938
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.36A 3vhuA-5mwpA:
39.5		 3vhuA-5mwpA:
66.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 LEU A 766
ASN A 770
LEU A 827
CYH A 942
THR A 945
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.26A 3vhuA-5mwpA:
39.5		 3vhuA-5mwpA:
66.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.25A 3vhuA-5nfgA:
undetectable		 3vhuA-5nfgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A2247
ALA A2049
LEU A1956
THR A2083
PHE A2009
 None
 1.31A 3vhuA-5nnnA:
undetectable		 3vhuA-5nnnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 LEU A 680
LEU A 691
LEU A 594
THR A 672
PHE A 663
 None
 1.32A 3vhuA-5ubkA:
undetectable		 3vhuA-5ubkA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 ASN A 560
GLN A 566
MET A 597
LEU A 604
ARG A 607
 486  A 801 (-4.2A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.73A 3vhuA-5uc1A:
23.4		 3vhuA-5uc1A:
44.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
GLN A  39
LEU A  77
ARG A  80
MET A 108
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.04A 3vhuA-5ufsA:
36.7		 3vhuA-5ufsA:
59.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
LEU A 201
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.38A 3vhuA-5ufsA:
36.7		 3vhuA-5ufsA:
59.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
LEU A  90
CYH A 205
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 1.16A 3vhuA-5ufsA:
36.7		 3vhuA-5ufsA:
59.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 LEU A 111
ASN A  77
ALA A  72
LEU A  65
MET A  29
 None
 1.48A 3vhuA-5xnzA:
undetectable		 3vhuA-5xnzA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3b UNCHARACTERIZED
PROTEIN

(Streptomyces
cattleya) 		no annotation 5 LEU A 370
ALA A 380
LEU A 341
LEU A 306
CYH A 301
 None
 1.37A 3vhuA-6c3bA:
undetectable		 3vhuA-6c3bA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E

(Pyrococcus
furiosus) 		no annotation 5 LEU A  72
ALA A 162
GLN A 108
ARG A  55
THR A 119
 None
 1.48A 3vhuA-6cfwA:
undetectable		 3vhuA-6cfwA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 5 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.40A 3vhuA-6chdA:
undetectable		 3vhuA-6chdA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 5 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.40A 3vhuA-6eotA:
undetectable		 3vhuA-6eotA:
13.40