SIMILAR PATTERNS OF AMINO ACIDS FOR 3VFJ_A_ACTA410_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTERCELLULAR
ADHESION MOLECULE-3

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LYS B  42
ALA B  35
GLU B  37
LEU B  36
 None
None
MG  A 901 (-2.6A)
None
 1.22A 3vfjA-1t0pB:
undetectable		 3vfjA-1t0pB:
10.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.66A 3vfjA-3csgA:
54.5		 3vfjA-3csgA:
82.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.64A 3vfjA-3mq9A:
57.7		 3vfjA-3mq9A:
81.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpf MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT

(Helicobacter
pylori) 		PF02391
(MoaE) 		4 LYS A   3
ALA A  17
GLU A  13
LEU A  14
 None
 1.35A 3vfjA-3rpfA:
undetectable		 3vfjA-3rpfA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 LYS A  16
ALA A  64
GLU A 112
LEU A 263
 CEY  A 400 (-2.9A)
CEY  A 400 (-3.6A)
CEY  A 400 (-3.0A)
None
 0.85A 3vfjA-4gizA:
56.3		 3vfjA-4gizA:
96.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 LYS A 273
ALA A 331
GLU A 280
LEU A 332
 None
 1.42A 3vfjA-4ka8A:
undetectable		 3vfjA-4ka8A:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.35A 3vfjA-4kegA:
59.7		 3vfjA-4kegA:
77.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LYS A  17
ALA A  65
GLU A 113
LEU A 264
 None
 0.46A 3vfjA-4logA:
45.5		 3vfjA-4logA:
75.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		4 LYS A  16
ALA A  64
GLU A 112
LEU A 263
 None
 0.39A 3vfjA-4o2xA:
54.3		 3vfjA-4o2xA:
85.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.79A 3vfjA-4r0yA:
54.0		 3vfjA-4r0yA:
75.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 LYS A 215
ALA A 164
GLU A 637
LEU A 163
 None
 1.45A 3vfjA-4zm6A:
undetectable		 3vfjA-4zm6A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 LYS A  15
ALA A  63
GLU A 111
LEU A1262
 None
 0.76A 3vfjA-5k94A:
50.0		 3vfjA-5k94A:
71.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 SER  A1205 (-3.1A)
SER  A1205 (-3.2A)
SER  A1205 ( 4.5A)
SER  A1205 (-3.9A)
 0.59A 3vfjA-5vawA:
51.6		 3vfjA-5vawA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LYS A  15
ALA A  63
GLU A 111
LEU A 262
 None
 0.72A 3vfjA-6apxA:
57.5		 3vfjA-6apxA:
83.86