SIMILAR PATTERNS OF AMINO ACIDS FOR 3VET_A_TOYA604_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		5 TYR A 171
PHE A 207
GLU A 204
ASP A  46
TYR A  49
 None
 1.28A 3vetA-1uddA:
0.4		 3vetA-1uddA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		5 ASP A  24
TYR A 278
GLU A 184
ASP A 242
ASP A  56
 None
ACY  A 750 (-4.6A)
ACY  A 750 ( 3.8A)
None
None
 1.48A 3vetA-1yhtA:
0.0		 3vetA-1yhtA:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		8 ASP A  12
TYR A  42
PHE A 169
GLU A 172
GLU A 176
ASP A 183
ASP A 228
TYR A 230
 None
None
None
CA0  A 602 (-3.3A)
None
None
None
None
 0.42A 3vetA-3vexA:
64.3		 3vetA-3vexA:
99.65