SIMILAR PATTERNS OF AMINO ACIDS FOR 3VAW_A_FK5A114_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aso | ASCORBATE OXIDASE (Cucurbita pepo) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ASP A 253ARG A 322PHE A 326VAL A 238ILE A 231 | None | 1.37A | 3vawA-1asoA:undetectable | 3vawA-1asoA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fd9 | PROTEIN (MACROPHAGEINFECTIVITYPOTENTIATOR PROTEIN) (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 6 | PHE A 153ILE A 159TRP A 162TYR A 185ILE A 194PHE A 202 | None | 1.14A | 3vawA-1fd9A:17.5 | 3vawA-1fd9A:29.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fd9 | PROTEIN (MACROPHAGEINFECTIVITYPOTENTIATOR PROTEIN) (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 8 | TYR A 131ASP A 142VAL A 158ILE A 159TRP A 162TYR A 185ILE A 194PHE A 202 | None | 0.59A | 3vawA-1fd9A:17.5 | 3vawA-1fd9A:29.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fkk | FK506 BINDINGPROTEIN (Bos taurus) |
PF00254(FKBP_C) | 10 | TYR A 26ASP A 37ARG A 42PHE A 46VAL A 55ILE A 56TRP A 59TYR A 82ILE A 91PHE A 99 | None | 0.50A | 3vawA-1fkkA:18.0 | 3vawA-1fkkA:32.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxj | BETA-GLUCOSIDASE (Zea mays) |
PF00232(Glyco_hydro_1) | 5 | TYR A 163PHE A 151VAL A 140TRP A 96PHE A 166 | None | 1.33A | 3vawA-1hxjA:undetectable | 3vawA-1hxjA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i4s | RIBONUCLEASE III (Aquifexaeolicus) |
PF14622(Ribonucleas_3_3) | 5 | ASP A 138PHE A 109VAL A 47ILE A 51PHE A 79 | None | 1.42A | 3vawA-1i4sA:undetectable | 3vawA-1i4sA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 6 | PHE A 114ILE A 120TRP A 123TYR A 146ILE A 155PHE A 163 | None | 1.01A | 3vawA-1jvwA:16.2 | 3vawA-1jvwA:27.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 8 | TYR A 92ARG A 108VAL A 119ILE A 120TRP A 123TYR A 146ILE A 155PHE A 163 | None | 0.45A | 3vawA-1jvwA:16.2 | 3vawA-1jvwA:27.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvw | MACROPHAGEINFECTIVITYPOTENTIATOR (Trypanosomacruzi) |
PF00254(FKBP_C) | 8 | TYR A 92ASP A 103ARG A 108ILE A 120TRP A 123TYR A 146ILE A 155PHE A 163 | None | 0.67A | 3vawA-1jvwA:16.2 | 3vawA-1jvwA:27.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k1x | 4-ALPHA-GLUCANOTRANSFERASE (Thermococcuslitoralis) |
PF03065(Glyco_hydro_57)PF09094(DUF1925)PF09095(DUF1926) | 5 | TYR A 356PHE A 317ILE A 93ARG A 338ILE A 347 | None | 1.39A | 3vawA-1k1xA:undetectable | 3vawA-1k1xA:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt1 | FK506-BINDINGPROTEIN FKBP51 (Saimiriboliviensis) |
PF00254(FKBP_C)PF00515(TPR_1)PF13181(TPR_8) | 7 | TYR A 57PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113PHE A 130 | None | 0.81A | 3vawA-1kt1A:15.4 | 3vawA-1kt1A:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | ASP A 101ARG A 8PHE A 106VAL A 188ILE A 140 | None | 1.30A | 3vawA-1lnlA:undetectable | 3vawA-1lnlA:20.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n1a | FKBP52 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.58A | 3vawA-1n1aA:18.4 | 3vawA-1n1aA:35.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pbk | FKBP25 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 135ASP A 146VAL A 171ILE A 172TRP A 175TYR A 198ILE A 208PHE A 216 | RAP A 225 (-3.9A)RAP A 225 (-3.0A)RAP A 225 (-3.5A)RAP A 225 (-3.9A)RAP A 225 (-3.4A)RAP A 225 (-4.6A)RAP A 225 ( 4.9A)None | 0.32A | 3vawA-1pbkA:17.4 | 3vawA-1pbkA:26.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q6h | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKPA (Escherichiacoli) |
PF00254(FKBP_C)PF01346(FKBP_N) | 6 | PHE A 168ILE A 174TRP A 177TYR A 200ILE A 208PHE A 216 | None | 1.28A | 3vawA-1q6hA:18.0 | 3vawA-1q6hA:34.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q6h | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKPA (Escherichiacoli) |
PF00254(FKBP_C)PF01346(FKBP_N) | 9 | TYR A 146ASP A 157ARG A 162VAL A 173ILE A 174TRP A 177TYR A 200ILE A 208PHE A 216 | None | 0.54A | 3vawA-1q6hA:18.0 | 3vawA-1q6hA:34.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r9h | FK506 BINDINGPROTEIN FAMILY (Caenorhabditiselegans) |
PF00254(FKBP_C) | 10 | TYR A 40ASP A 51ARG A 56PHE A 60VAL A 69ILE A 70TRP A 73TYR A 96ILE A 105PHE A 113 | None | 0.61A | 3vawA-1r9hA:19.5 | 3vawA-1r9hA:31.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rc7 | RIBONUCLEASE III (Aquifexaeolicus) |
PF00035(dsrm)PF14622(Ribonucleas_3_3) | 5 | ASP A 138PHE A 109VAL A 47ILE A 51PHE A 79 | None | 1.36A | 3vawA-1rc7A:undetectable | 3vawA-1rc7A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ry2 | ACETYL-COENZYME ASYNTHETASE 1 (Saccharomycescerevisiae) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | PHE A 349VAL A 466ILE A 465TYR A 454ILE A 458 | None | 1.07A | 3vawA-1ry2A:undetectable | 3vawA-1ry2A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sa3 | TYPE II RESTRICTIONENZYME MSPI (Moraxella sp.) |
PF09208(Endonuc-MspI) | 5 | TYR A 214ASP A 216ILE A 38ILE A 219PHE A 207 | None | 1.40A | 3vawA-1sa3A:undetectable | 3vawA-1sa3A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u79 | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE3 (Arabidopsisthaliana) |
PF00254(FKBP_C) | 8 | TYR A 37ASP A 48VAL A 66ILE A 67TRP A 70TYR A 99ILE A 113PHE A 121 | None | 0.47A | 3vawA-1u79A:19.7 | 3vawA-1u79A:29.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3w | PEPTIDE:N-GLYCANASE (Saccharomycescerevisiae) |
PF03835(Rad4) | 5 | ASP A 242ARG A 230VAL A 212TYR A 247ILE A 246 | NoneNoneNoneNoneSUC A1002 (-4.5A) | 1.38A | 3vawA-1x3wA:undetectable | 3vawA-1x3wA:16.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1yat | FK506 BINDINGPROTEIN (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 10 | TYR A 26ASP A 37ARG A 42PHE A 46VAL A 55ILE A 56TRP A 59TYR A 82ILE A 91PHE A 99 | FK5 A 108 ( 4.0A)FK5 A 108 ( 3.3A)FK5 A 108 (-3.7A)FK5 A 108 ( 4.0A)FK5 A 108 ( 3.4A)FK5 A 108 ( 3.7A)FK5 A 108 ( 3.6A)FK5 A 108 ( 4.7A)NoneNone | 0.26A | 3vawA-1yatA:20.1 | 3vawA-1yatA:34.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxe | RIBULOSEBISPHOSPHATECARBOXYLASE (Pyrococcushorikoshii) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | VAL A 249ILE A 225TYR A 207ARG A 210PHE A 199 | None | 1.23A | 3vawA-2cxeA:undetectable | 3vawA-2cxeA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh4 | PUTATIVE GLYCOSYLHYDROLASE YTER (Bacillussubtilis) |
PF07470(Glyco_hydro_88) | 5 | TYR A 285ASP A 224ARG A 52TYR A 295ILE A 226 | None | 1.29A | 3vawA-2gh4A:undetectable | 3vawA-2gh4A:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2lpv | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Aedes aegypti) |
PF00254(FKBP_C) | 5 | TYR A 27PHE A 47ILE A 57TRP A 60ILE A 92 | None | 1.03A | 3vawA-2lpvA:14.3 | 3vawA-2lpvA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2lpv | FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Aedes aegypti) |
PF00254(FKBP_C) | 5 | TYR A 27VAL A 56ILE A 57TRP A 60ILE A 92 | None | 0.98A | 3vawA-2lpvA:14.3 | 3vawA-2lpvA:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pbc | FK506-BINDINGPROTEIN 2 (Homo sapiens) |
PF00254(FKBP_C) | 6 | PHE A 78ILE A 86TRP A 89TYR A 112ILE A 121PHE A 129 | NonePEG A 201 (-3.8A)PEG A 201 (-3.7A)NoneNoneNone | 1.47A | 3vawA-2pbcA:15.8 | 3vawA-2pbcA:33.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pbc | FK506-BINDINGPROTEIN 2 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 56ASP A 67PHE A 76VAL A 85ILE A 86TRP A 89TYR A 112ILE A 121PHE A 129 | PEG A 201 (-4.4A)NonePEG A 201 ( 3.9A)PEG A 201 (-3.6A)PEG A 201 (-3.8A)PEG A 201 (-3.7A)NoneNoneNone | 0.77A | 3vawA-2pbcA:15.8 | 3vawA-2pbcA:33.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcd | OUTER MEMBRANEPROTEIN MIP (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 5 | ASP A 66VAL A 82ILE A 83TRP A 86PHE A 126 | RAP A 138 (-2.7A)RAP A 138 (-3.2A)RAP A 138 (-3.6A)RAP A 138 (-2.3A)RAP A 138 ( 4.7A) | 0.76A | 3vawA-2vcdA:15.0 | 3vawA-2vcdA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcd | OUTER MEMBRANEPROTEIN MIP (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 5 | TYR A 55ASP A 66VAL A 82ILE A 83TRP A 86 | RAP A 138 (-2.6A)RAP A 138 (-2.7A)RAP A 138 (-3.2A)RAP A 138 (-3.6A)RAP A 138 (-2.3A) | 0.74A | 3vawA-2vcdA:15.0 | 3vawA-2vcdA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcd | OUTER MEMBRANEPROTEIN MIP (Legionellapneumophila) |
PF00254(FKBP_C)PF01346(FKBP_N) | 5 | TYR A 55VAL A 82ILE A 83TRP A 86TYR A 109 | RAP A 138 (-2.6A)RAP A 138 (-3.2A)RAP A 138 (-3.6A)RAP A 138 (-2.3A)RAP A 138 (-3.8A) | 0.62A | 3vawA-2vcdA:15.0 | 3vawA-2vcdA:26.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn1 | 70 KDAPEPTIDYLPROLYLISOMERASE (Plasmodiumfalciparum) |
PF00254(FKBP_C) | 10 | TYR A 44ASP A 56ARG A 61PHE A 65VAL A 74ILE A 75TRP A 78TYR A 101ILE A 110PHE A 118 | FK5 A 501 (-4.1A)FK5 A 501 (-3.4A)FK5 A 501 (-3.9A)FK5 A 501 (-4.1A)FK5 A 501 (-3.5A)FK5 A 501 (-4.3A)FK5 A 501 (-3.3A)FK5 A 501 (-4.7A)NoneFK5 A 501 (-4.8A) | 0.28A | 3vawA-2vn1A:19.5 | 3vawA-2vn1A:29.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 9 | TYR A 33ARG A 49PHE A 53VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | None | 0.48A | 3vawA-2y78A:22.1 | 3vawA-2y78A:59.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y78 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 9 | TYR A 33ASP A 44ARG A 49PHE A 53ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | None | 0.64A | 3vawA-2y78A:22.1 | 3vawA-2y78A:59.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b05 | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Sulfolobusshibatae) |
PF01070(FMN_dh) | 5 | ASP A 150ARG A 114VAL A 64ILE A 191PHE A 53 | None | 1.33A | 3vawA-3b05A:undetectable | 3vawA-3b05A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7x | FK506-BINDINGPROTEIN 6 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 61ASP A 73TYR A 118ILE A 127PHE A 135 | None | 0.99A | 3vawA-3b7xA:15.5 | 3vawA-3b7xA:24.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clo | TRANSCRIPTIONALREGULATOR (Bacteroidesthetaiotaomicron) |
PF00196(GerE) | 5 | ASP A 82PHE A 106VAL A 142TYR A 160ILE A 86 | None | 1.35A | 3vawA-3cloA:undetectable | 3vawA-3cloA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3foc | TRYPTOPHANYL-TRNASYNTHETASE (Giardiaintestinalis) |
PF00579(tRNA-synt_1b) | 5 | ASP A 208ARG A 214PHE A 212VAL A 106TYR A 155 | None | 1.24A | 3vawA-3focA:undetectable | 3vawA-3focA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i9f | PUTATIVE TYPE 11METHYLTRANSFERASE (Sulfolobussolfataricus) |
PF08241(Methyltransf_11) | 5 | TYR A 147ASP A 126PHE A 151VAL A 122ILE A 123 | None | 1.32A | 3vawA-3i9fA:undetectable | 3vawA-3i9fA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibp | CHROMOSOME PARTITIONPROTEIN MUKB (Escherichiacoli) |
PF16330(MukB_hinge) | 5 | TYR A 690ASP A 746PHE A 778ILE A 737PHE A 744 | None | 1.41A | 3vawA-3ibpA:undetectable | 3vawA-3ibpA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ARG A 685VAL A 712ILE A 701TYR A 745ILE A 674 | None | 1.33A | 3vawA-3j9dA:undetectable | 3vawA-3j9dA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ASP A 679VAL A 712ILE A 701TYR A 745ILE A 674 | None | 1.39A | 3vawA-3j9dA:undetectable | 3vawA-3j9dA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Archaeoglobusfulgidus) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | ILE A 347TRP A 348ARG A 379ILE A 309PHE A 212 | None | 1.39A | 3vawA-3mm5A:undetectable | 3vawA-3mm5A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mm5 | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Archaeoglobusfulgidus) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | TYR A 199ILE A 347TRP A 348ARG A 379ILE A 309 | None | 1.45A | 3vawA-3mm5A:undetectable | 3vawA-3mm5A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n11 | CHITINASE A (Bacillus cereus) |
PF00704(Glyco_hydro_18) | 5 | TYR A 82PHE A 88VAL A 64ILE A 62TRP A 40 | None | 1.43A | 3vawA-3n11A:undetectable | 3vawA-3n11A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o5d | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.82A | 3vawA-3o5dA:15.4 | 3vawA-3o5dA:24.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5e | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57ASP A 68PHE A 77VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.80A | 3vawA-3o5eA:18.9 | 3vawA-3o5eA:31.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o5e | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 8 | TYR A 57PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.79A | 3vawA-3o5eA:18.9 | 3vawA-3o5eA:31.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pa7 | 70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE (Plasmodiumvivax) |
PF00254(FKBP_C) | 9 | TYR A 43ARG A 60PHE A 64VAL A 73ILE A 74TRP A 77TYR A 100ILE A 109PHE A 117 | None | 0.46A | 3vawA-3pa7A:19.5 | 3vawA-3pa7A:28.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pa7 | 70 KDAPEPTIDYLPROLYLISOMERASE, PUTATIVE (Plasmodiumvivax) |
PF00254(FKBP_C) | 9 | TYR A 43ASP A 55ARG A 60PHE A 64VAL A 73ILE A 74TRP A 77ILE A 109PHE A 117 | None | 0.63A | 3vawA-3pa7A:19.5 | 3vawA-3pa7A:28.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqw | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ASP A 343VAL A 498ILE A 497TYR A 460ILE A 464 | None | 1.04A | 3vawA-3sqwA:undetectable | 3vawA-3sqwA:15.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | TYR A 569VAL A 210ILE A 224TYR A 226ILE A 200 | None | 1.27A | 3vawA-3um6A:undetectable | 3vawA-3um6A:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 7 | ASP A 324VAL A 341ILE A 342TRP A 345TYR A 368ILE A 376PHE A 384 | None | 0.76A | 3vawA-4bf8A:17.9 | 3vawA-4bf8A:28.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 6 | TYR A 313ASP A 324PHE A 332ILE A 342TRP A 345PHE A 384 | None | 0.96A | 3vawA-4bf8A:17.9 | 3vawA-4bf8A:28.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf8 | FPR4 (Saccharomycescerevisiae) |
PF00254(FKBP_C) | 7 | TYR A 313ASP A 324VAL A 341ILE A 342TRP A 345TYR A 368PHE A 384 | None | 0.78A | 3vawA-4bf8A:17.9 | 3vawA-4bf8A:28.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckm | SAS-6 (Leishmaniamajor) |
PF16531(SAS-6_N) | 5 | TYR A 196PHE A 209VAL A 173ILE A 263PHE A 199 | None | 1.34A | 3vawA-4ckmA:undetectable | 3vawA-4ckmA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4db4 | ATP-DEPENDENT RNAHELICASE MSS116,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00271(Helicase_C) | 5 | ASP A 343VAL A 498ILE A 497TYR A 460ILE A 464 | None | 1.08A | 3vawA-4db4A:undetectable | 3vawA-4db4A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dip | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C) | 5 | TYR A 52TRP A 88TYR A 111ILE A 119PHE A 127 | None | 0.63A | 3vawA-4dipA:17.2 | 3vawA-4dipA:28.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dz3 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei) |
PF00254(FKBP_C) | 10 | TYR A 33ASP A 44ARG A 49PHE A 53VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | FK5 A 201 ( 3.9A)FK5 A 201 (-3.5A)FK5 A 201 ( 3.7A)FK5 A 201 (-4.1A)FK5 A 201 ( 3.6A)FK5 A 201 (-3.8A)FK5 A 201 (-3.4A)FK5 A 201 (-4.7A)NoneFK5 A 201 (-4.8A) | 0.24A | 3vawA-4dz3A:22.8 | 3vawA-4dz3A:98.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h09 | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Eubacteriumventriosum) |
PF13306(LRR_5) | 5 | PHE A 337VAL A 346ILE A 369ILE A 375PHE A 383 | None | 1.32A | 3vawA-4h09A:undetectable | 3vawA-4h09A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hl7 | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Vibrio cholerae) |
PF04095(NAPRTase) | 5 | ASP A 303ARG A 342PHE A 321ILE A 273TRP A 301 | None | 1.44A | 3vawA-4hl7A:undetectable | 3vawA-4hl7A:18.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 26ASP A 37ARG A 42ILE A 56TYR A 82ILE A 91PHE A 99 | None | 0.77A | 3vawA-4iqcA:17.5 | 3vawA-4iqcA:30.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iqc | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1B (Homo sapiens) |
PF00254(FKBP_C) | 7 | TYR A 26PHE A 46VAL A 55ILE A 56TYR A 82ILE A 91PHE A 99 | None | 0.77A | 3vawA-4iqcA:17.5 | 3vawA-4iqcA:30.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyk | UNCHARACTERIZEDPROTEIN (Bacteroidesuniformis) |
PF12866(DUF3823) | 5 | VAL A 111ILE A 30TYR A 76ILE A 53PHE A 103 | None | 1.37A | 3vawA-4iykA:undetectable | 3vawA-4iykA:23.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ARG A 73PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | NoneNoneNoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)DMS A 304 ( 4.0A)NoneNoneDMS A 304 (-4.3A) | 0.76A | 3vawA-4lawA:15.7 | 3vawA-4lawA:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4law | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP4 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ASP A 68ARG A 73PHE A 77VAL A 86ILE A 87TRP A 90ILE A 122PHE A 130 | NoneNoneNoneNoneDMS A 304 (-3.5A)DMS A 304 (-3.8A)DMS A 304 ( 4.0A)NoneDMS A 304 (-4.3A) | 0.83A | 3vawA-4lawA:15.7 | 3vawA-4lawA:24.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4msp | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP14 (Homo sapiens) |
PF00254(FKBP_C)PF13499(EF-hand_7) | 5 | TYR A 33TRP A 69TYR A 92ILE A 100PHE A 108 | None | 0.57A | 3vawA-4mspA:17.9 | 3vawA-4mspA:26.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nnr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP2 (Homo sapiens) |
PF00254(FKBP_C) | 10 | TYR A 56ASP A 67PHE A 76VAL A 85ILE A 86TRP A 89TYR A 112ARG A 115ILE A 121PHE A 129 | FK5 A 201 (-4.1A)FK5 A 201 (-3.4A)FK5 A 201 (-4.0A)FK5 A 201 (-3.4A)FK5 A 201 (-3.8A)FK5 A 201 (-3.5A)FK5 A 201 (-4.5A)FK5 A 201 (-4.2A)NoneFK5 A 201 (-4.9A) | 0.60A | 3vawA-4nnrA:13.2 | 3vawA-4nnrA:34.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odm | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD (Thermusthermophilus) |
PF00254(FKBP_C) | 5 | TYR A 13ASP A 23ILE A 37TYR A 63PHE A 128 | None | 0.52A | 3vawA-4odmA:11.0 | 3vawA-4odmA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4odr | PEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A CHIMERA (Homo sapiens;Thermusthermophilus) |
PF00254(FKBP_C) | 6 | TYR A 13ASP A 23ILE A 37TYR A 63ILE A 72PHE A 80 | FK5 A 201 ( 3.6A)FK5 A 201 (-3.6A)FK5 A 201 (-3.9A)FK5 A 201 (-4.4A)NoneFK5 A 201 ( 4.8A) | 0.43A | 3vawA-4odrA:11.5 | 3vawA-4odrA:18.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r0x | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ARG A 73PHE A 77VAL A 86ILE A 87TRP A 90TYR A 113ILE A 122PHE A 130 | None | 0.78A | 3vawA-4r0xA:19.7 | 3vawA-4r0xA:31.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r0x | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP5 (Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 57ASP A 68ARG A 73PHE A 77VAL A 86ILE A 87TYR A 113ILE A 122PHE A 130 | None | 0.88A | 3vawA-4r0xA:19.7 | 3vawA-4r0xA:31.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4sli | INTRAMOLECULARTRANS-SIALIDASE (Macrobdelladecora) |
PF02973(Sialidase)PF13088(BNR_2) | 5 | VAL A 526ILE A 525TYR A 457ILE A 434PHE A 409 | None | 1.42A | 3vawA-4sliA:undetectable | 3vawA-4sliA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ukd | URIDYLMONOPHOSPHATE/CYTIDYLMONOPHOSPHATEKINASE (Dictyosteliumdiscoideum) |
PF00406(ADK) | 5 | ASP A 184ARG A 176PHE A 117ILE A 26ARG A 28 | None | 1.35A | 3vawA-4ukdA:undetectable | 3vawA-4ukdA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7l | CAS6B (Methanococcusmaripaludis) |
PF17262(DUF5328) | 5 | TYR A 31ILE A 63TYR A 10ILE A 94PHE A 27 | None | 1.30A | 3vawA-4z7lA:undetectable | 3vawA-4z7lA:25.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmh | UNCHARACTERIZEDPROTEIN (Saccharophagusdegradans) |
PF15979(Glyco_hydro_115) | 5 | ASP A 944PHE A 845ILE A 840TYR A 459ARG A 417 | None | 1.00A | 3vawA-4zmhA:undetectable | 3vawA-4zmhA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmh | UNCHARACTERIZEDPROTEIN (Saccharophagusdegradans) |
PF15979(Glyco_hydro_115) | 5 | ASP A 944PHE A 845ILE A 840TYR A 459ILE A 883 | None | 1.05A | 3vawA-4zmhA:undetectable | 3vawA-4zmhA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2o | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Francisellatularensis) |
no annotation | 5 | PHE A1576VAL A1561ILE A1547TYR A1549ILE A1611 | None | 1.25A | 3vawA-5b2oA:undetectable | 3vawA-5b2oA:9.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b8i | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Coccidioidesimmitis) |
PF00254(FKBP_C) | 10 | TYR C 36ASP C 56ARG C 61PHE C 64VAL C 73ILE C 74TRP C 77TYR C 100ILE C 109PHE C 117 | FK5 C 201 (-4.1A)FK5 C 201 ( 3.8A)FK5 C 201 (-3.8A)FK5 C 201 (-3.8A)FK5 C 201 (-3.5A)FK5 C 201 (-3.8A)FK5 C 201 (-3.4A)FK5 C 201 (-4.5A)NoneFK5 C 201 (-4.7A) | 0.45A | 3vawA-5b8iC:17.0 | 3vawA-5b8iC:28.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i7p | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPEPEPTIDYL-PROLYLCIS-TRANS ISOMERASESLYD,PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 26ASP A 37ARG A 42PHE A 46VAL A 55ILE A 56TRP A 59TYR A 82PHE A 146 | None | 0.60A | 3vawA-5i7pA:16.3 | 3vawA-5i7pA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i7q | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEFKBP1A,FKBP-TYPE 16KDA PEPTIDYL-PROLYLCIS-TRANSISOMERASE,PEPTIDYL-PROLYL CIS-TRANSISOMERASE FKBP1A (Escherichiacoli;Homo sapiens) |
PF00254(FKBP_C) | 9 | TYR A 26ASP A 37ARG A 42PHE A 46VAL A 55ILE A 56TRP A 59TYR A 82PHE A 147 | None | 0.56A | 3vawA-5i7qA:16.6 | 3vawA-5i7qA:26.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 7 | ASP A 41ARG A 46PHE A 50VAL A 59ILE A 60TYR A 97ILE A 102 | None | 1.42A | 3vawA-5i98A:17.3 | 3vawA-5i98A:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i98 | FK506-BINDINGPROTEIN 1 (Candidaalbicans) |
PF00254(FKBP_C) | 10 | TYR A 30ASP A 41ARG A 46PHE A 50VAL A 59ILE A 60TRP A 63TYR A 97ILE A 106PHE A 114 | None | 0.61A | 3vawA-5i98A:17.3 | 3vawA-5i98A:30.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5j6e | FK506-BINDINGPROTEIN 1A (Aspergillusfumigatus) |
PF00254(FKBP_C) | 10 | TYR A 27ASP A 38ARG A 43PHE A 47VAL A 56ILE A 57TRP A 60TYR A 83ILE A 92PHE A 100 | None | 0.62A | 3vawA-5j6eA:18.4 | 3vawA-5j6eA:31.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcv | LMO2181 PROTEIN (Listeriamonocytogenes) |
PF04203(Sortase) | 5 | ASP A 125VAL A 75ILE A 89TYR A 161ILE A 221 | None | 1.04A | 3vawA-5jcvA:undetectable | 3vawA-5jcvA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvk | UNCHARACTERIZEDPROTEIN (Bacteroidescellulosilyticus) |
no annotation | 5 | ASP A 162VAL A 134ILE A 159ILE A 197PHE A 184 | GOL A 654 (-2.9A)NoneNoneNoneNone | 1.43A | 3vawA-5jvkA:undetectable | 3vawA-5jvkA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l1b | GLUTAMATE RECEPTOR2,GLUTAMATE RECEPTOR2 (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | ASP A 138ARG A 141VAL A 205TYR A 177ILE A 168 | None | 1.43A | 3vawA-5l1bA:undetectable | 3vawA-5l1bA:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m99 | ALPHA-AMYLASE (Thermotogapetrophila) |
PF00128(Alpha-amylase) | 5 | ASP B 213VAL B 195ILE B 198TYR B 88ILE B 85 | EDO B 616 ( 2.8A)NoneNoneNoneNone | 1.29A | 3vawA-5m99B:undetectable | 3vawA-5m99B:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msz | THERMOBIA DOMESTICADOMESTICA AA15 (Thermobiadomestica) |
no annotation | 5 | ASP A 84VAL A 72ILE A 190TYR A 75ILE A 81 | None | 1.12A | 3vawA-5mszA:undetectable | 3vawA-5mszA:16.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5v8t | UBIQUITIN-LIKEPROTEINSMT3,PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Burkholderiapseudomallei;Saccharomycescerevisiae) |
no annotation | 10 | TYR A 33ASP A 44ARG A 49PHE A 53VAL A 62ILE A 63TRP A 66TYR A 89ILE A 98PHE A 106 | 8ZV A 201 (-3.8A)8ZV A 201 (-3.9A)8ZV A 201 (-3.6A)8ZV A 201 (-3.9A)8ZV A 201 (-3.6A)8ZV A 201 (-4.0A)8ZV A 201 (-3.3A)8ZV A 201 (-4.6A)8ZV A 201 ( 4.8A)8ZV A 201 (-4.6A) | 0.37A | 3vawA-5v8tA:27.6 | 3vawA-5v8tA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf3 | MAJOR CAPSID PROTEIN (Escherichiavirus T4) |
PF07068(Gp23) | 5 | TYR A 424ASP A 110VAL A 307ILE A 310PHE A 375 | None | 1.40A | 3vawA-5vf3A:undetectable | 3vawA-5vf3A:19.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 6 | PHE A 166ILE A 172TRP A 175TYR A 198ILE A 207PHE A 215 | TLA A 301 ( 4.6A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)NoneNoneNone | 1.16A | 3vawA-5xb0A:15.7 | 3vawA-5xb0A:32.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xb0 | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Pseudomonassyringae groupgenomosp. 3) |
PF00254(FKBP_C) | 8 | TYR A 147ASP A 158VAL A 171ILE A 172TRP A 175TYR A 198ILE A 207PHE A 215 | TLA A 301 ( 4.4A)TLA A 301 (-3.7A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)TLA A 301 (-3.4A)NoneNoneNone | 0.74A | 3vawA-5xb0A:15.7 | 3vawA-5xb0A:32.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xhw | PUTATIVE6-DEOXY-D-MANNOHEPTOSE PATHWAY PROTEIN (Yersiniapseudotuberculosis) |
no annotation | 5 | TYR A 207VAL A 132ILE A 165TYR A 140ILE A 213 | None | 1.40A | 3vawA-5xhwA:undetectable | 3vawA-5xhwA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y31 | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 22 (Homo sapiens) |
no annotation | 5 | PHE A 330VAL A 270ILE A 285TYR A 277ILE A 378 | None | 1.23A | 3vawA-5y31A:undetectable | 3vawA-5y31A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0y | SERINEHYDROXYMETHYLTRANSFERASE (Komagataellaphaffii) |
no annotation | 5 | TYR A 339ASP A 418VAL A 393ILE A 395PHE A 334 | None | 1.29A | 3vawA-5z0yA:undetectable | 3vawA-5z0yA:21.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6b4p | PEPTIDYLPROLYLISOMERASE (Naegleriafowleri) |
no annotation | 10 | TYR A 38ASP A 49ARG A 54PHE A 58VAL A 67ILE A 68TRP A 71TYR A 94ILE A 103PHE A 111 | None | 0.61A | 3vawA-6b4pA:19.1 | 3vawA-6b4pA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bsz | METABOTROPICGLUTAMATE RECEPTOR 8 (Homo sapiens) |
no annotation | 5 | TYR A 344ASP A 84ARG A 355VAL A 402ILE A 406 | None | 1.23A | 3vawA-6bszA:undetectable | 3vawA-6bszA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ez4 | RNA POLYMERASEII-ASSOCIATEDPROTEIN 3 (Homo sapiens) |
no annotation | 5 | VAL A 595ILE A 594TYR A 578ILE A 573PHE A 556 | None | 1.36A | 3vawA-6ez4A:undetectable | 3vawA-6ez4A:16.50 |