SIMILAR PATTERNS OF AMINO ACIDS FOR 3V8V_B_SAMB801_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dct | PROTEIN(MODIFICATIONMETHYLASE HAEIII) (Haemophilusinfluenzae) |
PF00145(DNA_methylase) | 5 | GLY A 9ASP A 31ASP A 50PRO A 70LEU A 90 | None | 0.99A | 3v8vB-1dctA:8.3 | 3v8vB-1dctA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dus | MJ0882 (Methanocaldococcusjannaschii) |
PF05175(MTS) | 5 | GLY A 65ASP A 84ASP A 113ASN A 129PRO A 131 | None | 0.74A | 3v8vB-1dusA:11.9 | 3v8vB-1dusA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ne2 | HYPOTHETICAL PROTEINTA1320 (Thermoplasmaacidophilum) |
PF06325(PrmA) | 6 | GLY A 58ASP A 78ASP A 80ASP A 100VAL A 101ASN A 114 | None | 0.64A | 3v8vB-1ne2A:12.1 | 3v8vB-1ne2A:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1okg | POSSIBLE3-MERCAPTOPYRUVATESULFURTRANSFERASE (Leishmaniamajor) |
PF00581(Rhodanese)PF09122(DUF1930) | 5 | MET A 92GLY A 94ASP A 123VAL A 31LEU A 113 | None | 1.18A | 3v8vB-1okgA:0.6 | 3v8vB-1okgA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5d | P450 EPOXIDASE (Sorangiumcellulosum) |
PF00067(p450) | 5 | MET A 287GLY A 285VAL A 379ASN A 289LEU A 270 | None | 1.19A | 3v8vB-1q5dA:0.0 | 3v8vB-1q5dA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy7 | HYPOTHETICAL PROTEINPH1948 (Pyrococcushorikoshii) |
PF05175(MTS) | 6 | GLY A 59ASP A 81ASP A 105VAL A 106ASN A 119PRO A 121 | SAH A1001 (-3.3A)NoneSAH A1001 (-3.2A)SAH A1001 (-3.9A)SAH A1001 (-4.6A)None | 0.73A | 3v8vB-1wy7A:10.9 | 3v8vB-1wy7A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 5 | GLY A 253ASP A 233VAL A 202PRO A 243LEU A 214 | None | 1.25A | 3v8vB-1wytA:2.0 | 3v8vB-1wytA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq9 | PROBABLEDIMETHYLADENOSINETRANSFERASE (Homo sapiens) |
PF00398(RrnaAD) | 5 | ASP A 87ASP A 113VAL A 114ASN A 128PRO A 130 | NoneSAM A4000 (-3.8A)SAM A4000 (-3.9A)SAM A4000 (-2.7A)SAM A4000 (-4.1A) | 1.16A | 3v8vB-1zq9A:10.9 | 3v8vB-1zq9A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq9 | PROBABLEDIMETHYLADENOSINETRANSFERASE (Homo sapiens) |
PF00398(RrnaAD) | 5 | GLY A 66ASP A 87VAL A 114ASN A 128PRO A 130 | SAM A4000 (-3.2A)NoneSAM A4000 (-3.9A)SAM A4000 (-2.7A)SAM A4000 (-4.1A) | 0.92A | 3v8vB-1zq9A:10.9 | 3v8vB-1zq9A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3t | PROTEINMETHYLTRANSFERASEHEMK (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY A 119ASP A 140ASP A 167ASN A 183PRO A 185 | SAH A 300 (-3.5A)SAH A 300 (-3.1A)SAH A 300 (-3.0A)SAH A 300 (-3.9A)SAH A 300 ( 3.9A) | 0.74A | 3v8vB-2b3tA:15.9 | 3v8vB-2b3tA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus;Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD)PF06345(Drf_DAD) | 5 | MET B 6GLY B 4ASP B 7ASN A 218LEU A 253 | None | 1.17A | 3v8vB-2f31B:undetectable | 3v8vB-2f31B:3.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8l | HYPOTHETICAL PROTEINLMO1582 (Listeriamonocytogenes) |
PF02384(N6_Mtase) | 5 | GLY A 128ASP A 154ASP A 156ASP A 180PRO A 198 | SAM A 400 (-3.3A)SAM A 400 (-2.7A)NoneSAM A 400 (-3.4A)SAM A 400 (-3.8A) | 0.56A | 3v8vB-2f8lA:10.3 | 3v8vB-2f8lA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gu2 | ASPA PROTEIN (Rattusnorvegicus) |
PF04952(AstE_AspA) | 5 | ASP A 248VAL A 260PRO A 279TYR A 222LEU A 254 | None | 1.20A | 3v8vB-2gu2A:undetectable | 3v8vB-2gu2A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8x | XENOBIOTIC REDUCTASEA (Pseudomonasputida) |
PF00724(Oxidored_FMN) | 5 | GLY A 239ASP A 241VAL A 267ASN A 275PRO A 277 | None | 1.22A | 3v8vB-2h8xA:undetectable | 3v8vB-2h8xA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hf0 | BILE SALT HYDROLASE (Bifidobacteriumlongum) |
PF02275(CBAH) | 5 | GLY A 74SER A 114ASP A 113ASP A 116ASN A 12 | None | 0.97A | 3v8vB-2hf0A:undetectable | 3v8vB-2hf0A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 5 | GLY A 20ASP A 42ASP A 60PRO A 80LEU A 100 | SAH A 328 (-3.3A)NoneSAH A 328 (-3.6A)SAH A 328 (-4.0A)SAH A 328 ( 4.9A) | 0.94A | 3v8vB-2i9kA:9.9 | 3v8vB-2i9kA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kny | LRP-1, LINKER, APO-E (Homo sapiens) |
PF00057(Ldl_recept_a) | 5 | GLY A 16ASP A 35ASP A 38VAL A 21LEU A 2 | NoneNone CA A 81 (-3.2A)NoneNone | 1.21A | 3v8vB-2knyA:undetectable | 3v8vB-2knyA:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mpo | MIC2-ASSOCIATEDPROTEIN (Toxoplasmagondii) |
no annotation | 5 | GLY A 48SER A 52ASP A 50ASN A 173LEU A 178 | None | 1.21A | 3v8vB-2mpoA:undetectable | 3v8vB-2mpoA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okc | TYPE I RESTRICTIONENZYME STYSJI MPROTEIN (Bacteroidesthetaiotaomicron) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | GLY A 180ASP A 214ASP A 243ASN A 259PRO A 261 | SAM A 500 (-3.2A)SAM A 500 (-2.9A)SAM A 500 (-3.3A)SAM A 500 (-3.9A)SAM A 500 (-4.1A) | 0.75A | 3v8vB-2okcA:undetectable | 3v8vB-2okcA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p35 | TRANS-ACONITATE2-METHYLTRANSFERASE (Agrobacteriumfabrum) |
PF13489(Methyltransf_23) | 5 | GLY A 40ASP A 61SER A 62ASP A 63ASP A 83 | SAH A 301 (-3.3A)SAH A 301 (-2.7A)SAH A 301 (-3.3A)NoneSAH A 301 (-3.2A) | 0.60A | 3v8vB-2p35A:9.6 | 3v8vB-2p35A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjd | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASE C (Escherichiacoli) |
PF05175(MTS)PF08468(MTS_N) | 5 | GLY A 206ASP A 227VAL A 254ASN A 268PRO A 270 | None | 0.90A | 3v8vB-2pjdA:12.7 | 3v8vB-2pjdA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pxx | UNCHARACTERIZEDPROTEIN MGC2408 (Homo sapiens) |
PF08241(Methyltransf_11) | 5 | GLY A 68ASP A 88ASP A 113VAL A 114LEU A 136 | SAH A 301 ( 3.2A)SAH A 301 (-2.9A)SAH A 301 (-3.1A)SAH A 301 (-3.6A)None | 0.96A | 3v8vB-2pxxA:11.5 | 3v8vB-2pxxA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qe6 | UNCHARACTERIZEDPROTEIN TFU_2867 (Thermobifidafusca) |
PF04672(Methyltransf_19) | 5 | GLY A 86ASP A 110ASP A 112ASP A 135VAL A 136 | SAM A 400 ( 3.2A)SAM A 400 (-2.7A)NoneSAM A 400 (-3.4A)SAM A 400 (-3.8A) | 0.86A | 3v8vB-2qe6A:10.1 | 3v8vB-2qe6A:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 5 | MET A 9GLY A 93ASP A 92SER A 831LEU A 346 | None | 1.24A | 3v8vB-2vz9A:undetectable | 3v8vB-2vz9A:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | ASP A 291ASP A 293ASP A 318PRO A 339LEU A 367 | SFG A5748 (-2.9A)NoneSFG A5748 (-3.7A)SFG A5748 (-4.0A)None | 1.19A | 3v8vB-2yxlA:13.4 | 3v8vB-2yxlA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxl | 450AA LONGHYPOTHETICAL FMUPROTEIN (Pyrococcushorikoshii) |
PF01189(Methyltr_RsmB-F)PF17125(Methyltr_RsmF_N) | 5 | ASP A 291ASP A 293ASP A 318PRO A 339LEU A 371 | SFG A5748 (-2.9A)NoneSFG A5748 (-3.7A)SFG A5748 (-4.0A)None | 1.10A | 3v8vB-2yxlA:13.4 | 3v8vB-2yxlA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z87 | CHONDROITIN SYNTHASE (Escherichiacoli) |
PF00535(Glycos_transf_2) | 5 | VAL A 183ASN A 337PRO A 244TYR A 385LEU A 172 | None | 1.22A | 3v8vB-2z87A:2.1 | 3v8vB-2z87A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwv | PROBABLE RIBOSOMALRNA SMALL SUBUNITMETHYLTRANSFERASE (Thermusthermophilus) |
PF05175(MTS) | 6 | GLY A 243ASP A 264ASP A 288VAL A 289ASN A 305PRO A 307 | SAH A 376 (-3.4A)NoneSAH A 376 (-4.1A)SAH A 376 (-4.0A)SAH A 376 (-4.4A)SAH A 376 ( 4.3A) | 0.65A | 3v8vB-2zwvA:12.7 | 3v8vB-2zwvA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay0 | UNCHARACTERIZEDPROTEIN MJ0883 (Methanocaldococcusjannaschii) |
PF02475(Met_10) | 5 | GLY A 205ASP A 223ASP A 251VAL A 252ASN A 265 | ADN A 401 ( 4.0A)ADN A 401 (-2.6A)ADN A 401 (-3.8A)ADN A 401 (-3.9A)ADN A 401 (-4.9A) | 0.92A | 3v8vB-3ay0A:18.6 | 3v8vB-3ay0A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b89 | 16S RRNA METHYLASE (Escherichiacoli) |
PF07091(FmrO) | 5 | GLY A 113ASP A 131ASP A 157VAL A 158LEU A 179 | 5GP A 500 ( 4.5A)5GP A 500 (-3.1A)5GP A 500 (-2.7A)5GP A 500 (-3.6A)None | 0.77A | 3v8vB-3b89A:5.2 | 3v8vB-3b89A:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgg | SAM-DEPENDENTMETHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13649(Methyltransf_25) | 5 | GLY A 55ASP A 74ASP A 76ASP A 96LEU A 120 | NoneNHE A 195 (-3.6A)NoneNHE A 195 (-4.3A)EDO A 197 (-4.0A) | 0.83A | 3v8vB-3cggA:5.9 | 3v8vB-3cggA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egi | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 5 | GLY A 700ASP A 719ASP A 721ASP A 747PRO A 765 | ADP A 3 (-3.5A)ADP A 3 (-2.9A)NoneADP A 3 (-3.4A)ADP A 3 (-3.3A) | 0.59A | 3v8vB-3egiA:14.6 | 3v8vB-3egiA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ekm | DIAMINOPIMELATEEPIMERASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01678(DAP_epimerase) | 5 | GLY A 68SER A 91ASP A 70ASP A 92ASN A 64 | None | 1.18A | 3v8vB-3ekmA:undetectable | 3v8vB-3ekmA:17.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fyd | PROBABLEDIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 5 | GLY A 40ASP A 61ASN A 101PRO A 103TYR A 104 | None | 0.87A | 3v8vB-3fydA:11.5 | 3v8vB-3fydA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7u | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Escherichiacoli) |
PF00145(DNA_methylase) | 5 | GLY A 9ASP A 31ASP A 51VAL A 52PRO A 78 | None | 1.07A | 3v8vB-3g7uA:5.4 | 3v8vB-3g7uA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdh | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 5 | GLY A 700ASP A 719ASP A 721ASP A 747PRO A 765 | SAH A 854 (-3.3A)SAH A 854 (-2.9A)NoneSAH A 854 (-3.6A)SAH A 854 (-3.8A) | 0.66A | 3v8vB-3gdhA:15.3 | 3v8vB-3gdhA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ged | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Ruminiclostridiumthermocellum) |
PF13561(adh_short_C2) | 5 | GLY A 11ASP A 33ASP A 35ASP A 55VAL A 56 | None | 0.85A | 3v8vB-3gedA:7.0 | 3v8vB-3gedA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvc | PROBABLE SHORT-CHAINTYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | GLY A 38ASP A 60ASP A 62ASP A 83VAL A 84 | None | 0.85A | 3v8vB-3gvcA:6.8 | 3v8vB-3gvcA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h09 | IMMUNOGLOBULIN A1PROTEASE (Haemophilusinfluenzae) |
PF02395(Peptidase_S6)PF03212(Pertactin) | 5 | GLY A 458SER A 504ASP A 476VAL A 506LEU A 472 | None | 1.18A | 3v8vB-3h09A:undetectable | 3v8vB-3h09A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icf | SERINE/THREONINE-PROTEIN PHOSPHATASE T (Saccharomycescerevisiae) |
PF00149(Metallophos)PF08321(PPP5) | 5 | GLY A 248ASP A 249ASP A 281VAL A 280ASN A 307 | None FE A 602 (-3.1A)NoneNoneNone | 1.27A | 3v8vB-3icfA:undetectable | 3v8vB-3icfA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0b | PREDICTEDN6-ADENINE-SPECIFICDNA METHYLASE (Listeriamonocytogenes) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 200ASP A 259ASP A 261VAL A 288LEU A 319 | None | 0.72A | 3v8vB-3k0bA:36.0 | 3v8vB-3k0bA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0b | PREDICTEDN6-ADENINE-SPECIFICDNA METHYLASE (Listeriamonocytogenes) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 200ASP A 259VAL A 288ASN A 303LEU A 319 | None | 0.98A | 3v8vB-3k0bA:36.0 | 3v8vB-3k0bA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0b | PREDICTEDN6-ADENINE-SPECIFICDNA METHYLASE (Listeriamonocytogenes) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 200ASP A 259VAL A 288PRO A 304LEU A 319 | None | 1.20A | 3v8vB-3k0bA:36.0 | 3v8vB-3k0bA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k50 | PUTATIVE S41PROTEASE (Bacteroidesfragilis) |
PF03572(Peptidase_S41) | 5 | GLY A 325ASP A 262ASN A 332TYR A 374LEU A 297 | None | 1.20A | 3v8vB-3k50A:undetectable | 3v8vB-3k50A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | GLY A 253SER A 290ASP A 317ASN A 335PRO A 337 | None | 0.77A | 3v8vB-3khkA:8.9 | 3v8vB-3khkA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l86 | ACETYLGLUTAMATEKINASE (Streptococcusmutans) |
PF00696(AA_kinase) | 5 | ASP A 69SER A 66ASP A 68VAL A 64PRO A 55 | None | 1.27A | 3v8vB-3l86A:4.6 | 3v8vB-3l86A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldg | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.472 (Streptococcusmutans) |
PF01170(UPF0020)PF02926(THUMP) | 6 | GLY A 204ASP A 263ASP A 265ASN A 307PRO A 309LEU A 323 | SAH A 385 (-3.4A)SAH A 385 (-2.8A)NoneSAH A 385 (-4.3A)SAH A 385 (-4.2A)None | 0.46A | 3v8vB-3ldgA:37.2 | 3v8vB-3ldgA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 8 | MET A 200GLY A 202ASP A 261ASP A 263ASP A 289ASN A 305PRO A 307LEU A 321 | GTP A 383 (-4.5A)GTP A 383 (-2.6A)GTP A 383 (-3.0A)NoneGTP A 383 ( 3.8A)GTP A 383 (-4.2A)GTP A 383 (-3.7A)None | 0.61A | 3v8vB-3lduA:37.4 | 3v8vB-3lduA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 6 | MET A 200GLY A 202ASP A 261ASP A 289ASN A 305LEU A 325 | GTP A 383 (-4.5A)GTP A 383 (-2.6A)GTP A 383 (-3.0A)GTP A 383 ( 3.8A)GTP A 383 (-4.2A)None | 1.16A | 3v8vB-3lduA:37.4 | 3v8vB-3lduA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkd | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLTRANSFERASESUBUNIT (Streptococcusthermophilus) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | GLY A 231ASP A 284ASN A 304PRO A 306TYR A 307 | None | 1.25A | 3v8vB-3lkdA:10.1 | 3v8vB-3lkdA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lku | UPF0363 PROTEINYOR164C (Saccharomycescerevisiae) |
PF04190(DUF410) | 5 | GLY A 160ASP A 163ASP A 170VAL A 169ASN A 203 | None | 1.25A | 3v8vB-3lkuA:undetectable | 3v8vB-3lkuA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lku | UPF0363 PROTEINYOR164C (Saccharomycescerevisiae) |
PF04190(DUF410) | 5 | MET A 165GLY A 160ASP A 170VAL A 169ASN A 203 | None | 1.26A | 3v8vB-3lkuA:undetectable | 3v8vB-3lkuA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lyk | STRINGENT STARVATIONPROTEIN A HOMOLOG (Haemophilusinfluenzae) |
PF00043(GST_C)PF02798(GST_N) | 5 | SER A 195ASP A 194VAL A 28PRO A 86LEU A 88 | None | 0.82A | 3v8vB-3lykA:undetectable | 3v8vB-3lykA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyi | FAT ACID-BINDINGPROTEIN (Eubacteriumventriosum) |
PF02645(DegV) | 5 | GLY A 199ASP A 200VAL A 180ASN A 124LEU A 171 | NoneNoneNoneSTE A 301 (-4.2A)None | 1.14A | 3v8vB-3nyiA:undetectable | 3v8vB-3nyiA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 5 | ASP A 483VAL A 487ASN A 556PRO A 558LEU A 560 | None | 1.25A | 3v8vB-3nzqA:2.5 | 3v8vB-3nzqA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocj | PUTATIVE EXPORTEDPROTEIN (Bordetellaparapertussis) |
PF13847(Methyltransf_31) | 5 | GLY A 125ASP A 147ASP A 149ASP A 175ASN A 191 | NoneNoneNoneNonePLM A 305 ( 4.3A) | 0.73A | 3v8vB-3ocjA:13.1 | 3v8vB-3ocjA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1s | RESTRICTIONENDONUCLEASE BPUSI (Bacilluspumilus) |
PF02384(N6_Mtase)PF15516(BpuSI_N) | 7 | GLY A 331ASP A 355ASP A 388VAL A 389ASN A 406PRO A 408TYR A 409 | SAH A 900 (-3.2A)SAH A 900 (-2.8A)SAH A 900 (-4.1A)SAH A 900 (-3.8A)SAH A 900 (-4.5A)SAH A 900 (-4.0A)None | 1.08A | 3v8vB-3s1sA:9.5 | 3v8vB-3s1sA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sx2 | PUTATIVE3-KETOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | GLY A 172SER A 165ASP A 167VAL A 163ASN A 127 | NoneNoneNoneNoneNAD A 300 ( 4.6A) | 1.21A | 3v8vB-3sx2A:3.4 | 3v8vB-3sx2A:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | MET A 225GLY A 227ASP A 276ASN A 293PRO A 295LEU A 309 | SFG A 401 (-3.9A)SFG A 401 ( 3.7A)SFG A 401 (-3.4A)SFG A 401 (-4.4A)SFG A 401 ( 4.4A)None | 0.59A | 3v8vB-3tm5A:27.7 | 3v8vB-3tm5A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | GLY A 194ASP A 216ASP A 218ASN A 260PRO A 262LEU A 276 | None | 0.53A | 3v8vB-3tmaA:26.4 | 3v8vB-3tmaA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 6 | GLY A 194ASP A 216ASP A 243ASN A 260PRO A 262LEU A 276 | None | 0.62A | 3v8vB-3tmaA:26.4 | 3v8vB-3tmaA:19.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v8v | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE L (Escherichiacoli) |
PF01170(UPF0020)PF02926(THUMP)PF10672(Methyltrans_SAM) | 11 | MET A 197GLY A 199ASP A 262SER A 263ASP A 264ASP A 290VAL A 291ASN A 309PRO A 311TYR A 312LEU A 325 | SAM A 801 (-4.5A)SAM A 801 (-3.2A)SAM A 801 (-2.9A)SAM A 801 (-3.5A)NoneSAM A 801 (-3.0A)SAM A 801 (-3.8A)SAM A 801 (-4.5A)SAM A 801 ( 4.1A)NoneSAM A 801 ( 4.8A) | 0.34A | 3v8vB-3v8vA:51.5 | 3v8vB-3v8vA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cql | ESTRADIOL17-BETA-DEHYDROGENASE 8 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | GLY A 20ASP A 42ASP A 44ASP A 75VAL A 76 | NAD A 301 ( 3.9A)NAD A 301 (-2.4A)NoneNAD A 301 (-3.4A)NAD A 301 (-3.6A) | 0.86A | 3v8vB-4cqlA:6.2 | 3v8vB-4cqlA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3q | TRANSCRIPTIONALREGULATORY PROTEINCBU_1566 (Coxiellaburnetii) |
PF01709(Transcrip_reg) | 5 | GLY A 89SER A 235VAL A 207PRO A 92LEU A 209 | None | 1.16A | 3v8vB-4f3qA:undetectable | 3v8vB-4f3qA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gc5 | DIMETHYLADENOSINETRANSFERASE 1,MITOCHONDRIAL (Mus musculus) |
PF00398(RrnaAD) | 6 | GLY A 65ASP A 87ASP A 111VAL A 112ASN A 141PRO A 143 | NoneNoneNoneNoneNoneACT A 402 ( 4.9A) | 1.00A | 3v8vB-4gc5A:10.7 | 3v8vB-4gc5A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inf | METAL-DEPENDENTHYDROLASE (Novosphingobiumaromaticivorans) |
PF04909(Amidohydro_2) | 5 | MET A 34GLY A 38ASP A 37VAL A 30LEU A 97 | None | 1.08A | 3v8vB-4infA:undetectable | 3v8vB-4infA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4itu | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | GLY A 16ASP A 38ASP A 40ASP A 64VAL A 65 | NAI A 301 ( 4.6A)NAI A 301 (-2.8A)NoneNAI A 301 (-3.6A)NAI A 301 (-3.5A) | 0.75A | 3v8vB-4ituA:5.9 | 3v8vB-4ituA:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv8 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumknowlesi) |
PF08241(Methyltransf_11) | 5 | GLY A 63ASP A 83ASP A 108TYR A 158LEU A 131 | SAM A 301 ( 3.9A)SAM A 301 (-2.7A)SAM A 301 (-3.5A)NoneNone | 1.00A | 3v8vB-4iv8A:12.2 | 3v8vB-4iv8A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l0o | CYSTATHIONINEGAMMA-SYNTHASE (Helicobacterpylori) |
no annotation | 5 | GLY H 64ASP H 61PRO H 176TYR H 178LEU H 197 | None | 1.22A | 3v8vB-4l0oH:undetectable | 3v8vB-4l0oH:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwz | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE,PUTATIVE (Plasmodiumvivax) |
PF13649(Methyltransf_25) | 5 | GLY A 62ASP A 82ASP A 107TYR A 157LEU A 130 | SAM A 301 ( 3.8A)SAM A 301 (-2.8A)SAM A 301 (-3.5A)PO4 A 302 (-4.5A)None | 0.73A | 3v8vB-4mwzA:11.8 | 3v8vB-4mwzA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6v | OXIDOREDUCTASE,SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY (Brucella suis) |
PF13561(adh_short_C2) | 5 | GLY A 54ASP A 67VAL A 66ASN A 56LEU A 116 | None | 1.08A | 3v8vB-4o6vA:6.5 | 3v8vB-4o6vA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r04 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80)PF12918(TcdB_N)PF12919(TcdA_TcdB)PF12920(TcdA_TcdB_pore) | 5 | GLY A1100ASP A1150ASP A1151VAL A1147PRO A1302 | None | 1.00A | 3v8vB-4r04A:undetectable | 3v8vB-4r04A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6w | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE (Plasmodiumfalciparum) |
PF13649(Methyltransf_25) | 5 | GLY A 65ASP A 85ASP A 110TYR A 160LEU A 133 | SAH A 302 (-3.6A)SAH A 302 (-2.6A)SAH A 302 (-3.6A) PC A 301 (-4.4A)None | 0.82A | 3v8vB-4r6wA:12.0 | 3v8vB-4r6wA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u7t | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00145(DNA_methylase) | 5 | GLY A 642ASP A 686VAL A 687PRO A 709LEU A 730 | SAH A1004 (-3.3A)SAH A1004 (-3.0A)SAH A1004 (-3.7A)SAH A1004 ( 3.9A)SAH A1004 ( 4.9A) | 0.91A | 3v8vB-4u7tA:7.4 | 3v8vB-4u7tA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wep | PUTATIVEOSMOPROTECTANTUPTAKE SYSTEMSUBSTRATE-BINDINGPROTEIN OSMF (Escherichiacoli) |
PF04069(OpuAC) | 5 | GLY A 30ASP A 77VAL A 47PRO A 247LEU A 264 | None | 1.08A | 3v8vB-4wepA:undetectable | 3v8vB-4wepA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjg | HAPTOGLOBIN (Homo sapiens) |
no annotation | 5 | GLY C 281ASP C 350ASP C 374VAL C 295ASN C 283 | None | 1.23A | 3v8vB-4wjgC:undetectable | 3v8vB-4wjgC:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9w | ASPARTIC ACIDENDOPEPTIDASE SAPP2 (Candidaparapsilosis) |
PF00026(Asp) | 5 | GLY A 207SER A 184ASP A 185PRO A 296TYR A 218 | None | 1.26A | 3v8vB-4y9wA:undetectable | 3v8vB-4y9wA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5df0 | AC-CHIA (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF00704(Glyco_hydro_18)PF08329(ChitinaseA_N) | 5 | ASP A 533ASP A 536ASP A 505VAL A 432ASN A 173 | None | 1.26A | 3v8vB-5df0A:undetectable | 3v8vB-5df0A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 189ASP A 208ASP A 235PRO A 256LEU A 271 | SAM A 400 (-3.3A)SAM A 400 (-2.8A)SAM A 400 (-3.4A)SAM A 400 (-4.2A)None | 0.70A | 3v8vB-5e72A:17.0 | 3v8vB-5e72A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5en4 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) |
PF13561(adh_short_C2) | 5 | GLY A 18ASP A 40ASP A 42ASN A 89LEU A 113 | NAD A 301 ( 4.2A)NAD A 301 (-2.8A)NoneNAD A 301 (-3.4A)NAD A 301 (-4.5A) | 1.20A | 3v8vB-5en4A:7.0 | 3v8vB-5en4A:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5en4 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE 14 (Homo sapiens) |
PF13561(adh_short_C2) | 6 | GLY A 18ASP A 40ASP A 42ASP A 62VAL A 63LEU A 113 | NAD A 301 ( 4.2A)NAD A 301 (-2.8A)NoneNAD A 301 (-3.4A)NAD A 301 (-3.7A)NAD A 301 (-4.5A) | 0.72A | 3v8vB-5en4A:7.0 | 3v8vB-5en4A:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 5 | GLY A 321ASP A 327VAL A 328ASN A 318LEU A 451 | NoneNoneNoneDQR A 544 (-3.1A)None | 1.14A | 3v8vB-5g5zA:undetectable | 3v8vB-5g5zA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjn | LYSINE/ORNITHINEDECARBOXYLASE (Selenomonasruminantium) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | MET A 50GLY A 257VAL A 71ASN A 53LEU A 80 | NoneGOL A 401 ( 3.1A)NoneNoneNone | 1.12A | 3v8vB-5gjnA:undetectable | 3v8vB-5gjnA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ha5 | BRUCELLA OVISOXIDOREDUCTASE (Brucella ovis) |
PF13561(adh_short_C2) | 5 | GLY A 23ASP A 45ASP A 47ASP A 71VAL A 72 | None | 0.79A | 3v8vB-5ha5A:4.4 | 3v8vB-5ha5A:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig2 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Paraburkholderiaphymatum) |
PF00106(adh_short) | 5 | GLY A 15ASP A 37ASP A 39ASP A 63ASN A 90 | NAD A 301 ( 4.2A)NAD A 301 (-2.9A)NoneNAD A 301 (-3.7A)NAD A 301 (-3.3A) | 1.26A | 3v8vB-5ig2A:7.5 | 3v8vB-5ig2A:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig2 | SHORT-CHAINDEHYDROGENASE/REDUCTASE SDR (Paraburkholderiaphymatum) |
PF00106(adh_short) | 5 | GLY A 15ASP A 37ASP A 39ASP A 63VAL A 64 | NAD A 301 ( 4.2A)NAD A 301 (-2.9A)NoneNAD A 301 (-3.7A)NAD A 301 (-3.5A) | 0.78A | 3v8vB-5ig2A:7.5 | 3v8vB-5ig2A:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip7 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB3 (Saccharomycescerevisiae) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 5 | GLY C 68ASP C 60VAL C 51TYR C 114LEU C 153 | None | 1.27A | 3v8vB-5ip7C:undetectable | 3v8vB-5ip7C:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jla | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Paraburkholderiaxenovorans) |
PF13561(adh_short_C2) | 5 | GLY A 18ASP A 40ASP A 42ASP A 61VAL A 62 | NAD A 401 ( 4.0A)NAD A 401 (-2.9A)NoneNAD A 401 (-3.7A)NAD A 401 (-3.6A) | 0.77A | 3v8vB-5jlaA:7.1 | 3v8vB-5jlaA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kh0 | SMALL GTP-BINDINGPROTEIN (Thermosiphomelanesiensis) |
PF01926(MMR_HSR1) | 5 | GLY A 321ASP A 288VAL A 292ASN A 318LEU A 326 | None | 1.27A | 3v8vB-5kh0A:undetectable | 3v8vB-5kh0A:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7z | MATERNAL PROTEINEXUPERANTIA (Drosophilamelanogaster) |
no annotation | 5 | GLY A 44VAL A 83PRO A 69TYR A 70LEU A 94 | None | 1.25A | 3v8vB-5l7zA:undetectable | 3v8vB-5l7zA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l80 | MATERNAL PROTEINEXUPERANTIA,MATERNALPROTEIN EXUPERANTIA (Drosophilamelanogaster) |
no annotation | 5 | GLY A 44VAL A 83PRO A 69TYR A 70LEU A 94 | None | 1.27A | 3v8vB-5l80A:undetectable | 3v8vB-5l80A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5my0 | FATTY ACID SYNTHASE (Mus musculus) |
no annotation | 5 | MET B 9GLY B 93ASP B 92SER B 831LEU B 346 | None | 1.21A | 3v8vB-5my0B:2.5 | 3v8vB-5my0B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT B (Methanothermococcusthermolithotrophicus) |
PF02754(CCG) | 5 | GLY B 17SER B 278VAL B 284PRO B 272LEU B 288 | None | 1.16A | 3v8vB-5odrB:undetectable | 3v8vB-5odrB:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj3 | ALKALINE PHOSPHATASEPAFA (Elizabethkingiameningoseptica) |
PF01663(Phosphodiest) | 5 | GLY A 289ASP A 295SER A 154PRO A 29LEU A 527 | ZN A 604 ( 4.9A) ZN A 604 (-2.4A)NoneNoneNone | 1.24A | 3v8vB-5tj3A:undetectable | 3v8vB-5tj3A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4t | PUTATIVE GENTAMICINMETHYLTRANSFERASE (Micromonosporaechinospora) |
no annotation | 5 | GLY A 133ASP A 152ASP A 179ASN A 194PRO A 196 | SAH A 414 (-2.8A)SAH A 414 (-2.1A)SAH A 414 (-2.9A)TRS A 415 ( 2.3A)SAH A 414 ( 3.2A) | 0.64A | 3v8vB-5u4tA:14.4 | 3v8vB-5u4tA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ukh | UNCHARACTERIZEDPROTEIN (Streptococcusintermedius) |
no annotation | 5 | GLY A 435ASP A 439ASP A 537VAL A 538LEU A 514 | None | 1.14A | 3v8vB-5ukhA:undetectable | 3v8vB-5ukhA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 63ASP A 82ASP A 107VAL A 108LEU A 132 | SAH A 701 (-3.5A)SAH A 701 (-2.9A)SAH A 701 (-3.2A)SAH A 701 (-3.6A)None | 0.88A | 3v8vB-5wp4A:13.3 | 3v8vB-5wp4A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 63ASP A 82ASP A 107VAL A 108LEU A 132 | SAH A 502 (-3.5A)SAH A 502 (-2.9A)SAH A 502 (-3.2A)SAH A 502 (-3.6A)None | 0.90A | 3v8vB-5wp5A:13.2 | 3v8vB-5wp5A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brr | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
no annotation | 5 | GLY A 642ASP A 686VAL A 687PRO A 709LEU A 730 | SAH A1001 (-3.4A)SAH A1001 (-3.0A)SAH A1001 (-3.7A)SAH A1001 (-3.7A)SAH A1001 (-4.8A) | 0.87A | 3v8vB-6brrA:7.2 | 3v8vB-6brrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILYCRISPR-ASSOCIATEDHELICASE, CAS3FAMILY (Thermobifidafusca;Thermobifidafusca) |
no annotationno annotation | 5 | GLY G 503ASP G 804ASP G 802ASN A 87PRO A 85 | None | 1.24A | 3v8vB-6c66G:undetectable | 3v8vB-6c66G:undetectable |