SIMILAR PATTERNS OF AMINO ACIDS FOR 3V8V_A_SAMA802

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 PHE A 220
ASP A 241
MET A 242
TYR A 246
PRO A  32
 SAM  A 500 (-4.6A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.6A)
SAM  A 500 (-4.4A)
None
 0.50A 3v8vA-1g60A:
3.9		 3v8vA-1g60A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		5 PHE A 220
MET A 242
TYR A 246
CYH A  12
PRO A  32
 SAM  A 500 (-4.6A)
SAM  A 500 (-3.6A)
SAM  A 500 (-4.4A)
SAM  A 500 (-3.4A)
None
 1.29A 3v8vA-1g60A:
3.9		 3v8vA-1g60A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		5 PHE A 225
TYR A 227
ASP A 247
SER A 249
PRO A 298
 None
 0.61A 3v8vA-2as0A:
26.9		 3v8vA-2as0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		6 PHE A 140
TYR A 142
ASP A 161
SER A 163
ASP A 190
PRO A 213
 SAM  A1001 (-4.4A)
FMT  A1013 ( 4.7A)
SAM  A1001 (-2.9A)
ACY  A1008 ( 2.6A)
SAM  A1001 (-3.7A)
SAM  A1001 (-3.2A)
 0.63A 3v8vA-2igtA:
20.1		 3v8vA-2igtA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 PHE A 228
TYR A 230
ASP A 250
SER A 252
ASP A 279
 None
 0.42A 3v8vA-3c0kA:
27.5		 3v8vA-3c0kA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		5 PHE A 220
TYR A 222
ASP A 242
ASP A 271
PRO A 294
 SAH  A 401 (-4.6A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.2A)
SAH  A 401 ( 4.0A)
 0.62A 3v8vA-3ldfA:
28.9		 3v8vA-3ldfA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 PHE A 546
TYR A 548
ASP A 568
CYH A 598
PRO A 616
 SAM  A 802 (-4.5A)
SAM  A 802 (-4.7A)
SAM  A 802 (-2.9A)
SAM  A 802 (-3.3A)
None
 1.39A 3v8vA-3v8vA:
62.9		 3v8vA-3v8vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		9 PHE A 546
TYR A 548
ASP A 568
MET A 569
SER A 570
TYR A 573
ASP A 597
CYH A 598
PRO A 617
 SAM  A 802 (-4.5A)
SAM  A 802 (-4.7A)
SAM  A 802 (-2.9A)
SAM  A 802 (-3.2A)
None
SAM  A 802 (-4.6A)
SAM  A 802 (-3.5A)
SAM  A 802 (-3.3A)
SAM  A 802 ( 4.6A)
 0.01A 3v8vA-3v8vA:
62.9		 3v8vA-3v8vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		5 PHE A 222
TYR A 224
ASP A 243
ASP A 272
PRO A 295
 SAH  A 401 (-4.3A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.2A)
 0.51A 3v8vA-3vseA:
15.9		 3v8vA-3vseA:
20.85