SIMILAR PATTERNS OF AMINO ACIDS FOR 3V81_A_NVPA901_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8g | PROTEIN(1-AMINOCYCLOPROPANE-1-CARBOXYLATESYNTHASE) (Malus domestica) |
PF00155(Aminotran_1_2) | 4 | LEU A 114VAL A 267TYR A 269LEU A 116 | None | 0.99A | 3v81A-1b8gA:0.2 | 3v81A-1b8gA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 4 | LEU B 262TYR B 407TYR B 403LEU B 394 | None | 1.00A | 3v81A-1ej6B:0.0 | 3v81A-1ej6B:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f1u | HOMOPROTOCATECHUATE2,3-DIOXYGENASE (Arthrobacterglobiformis) |
PF00903(Glyoxalase) | 4 | VAL A 116TYR A 79LEU A 173TYR A 93 | None | 1.11A | 3v81A-1f1uA:0.0 | 3v81A-1f1uA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f8r | L-AMINO ACID OXIDASE (Calloselasmarhodostoma) |
PF01593(Amino_oxidase) | 5 | LEU A 7LYS A 222TYR A 180TYR A 188LEU A 161 | None | 1.48A | 3v81A-1f8rA:2.8 | 3v81A-1f8rA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g1s | P-SELECTIN (Homo sapiens) |
PF00008(EGF)PF00059(Lectin_C) | 4 | VAL A 27TYR A 49TYR A 5TYR A 37 | MRD A 807 ( 4.7A)NoneNoneNone | 1.11A | 3v81A-1g1sA:undetectable | 3v81A-1g1sA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | LEU A 574TYR A 143LEU A 151TYR A 578 | None | 0.82A | 3v81A-1g8kA:0.0 | 3v81A-1g8kA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lc7 | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Salmonellaenterica) |
PF00155(Aminotran_1_2) | 4 | LEU A 353VAL A 292TYR A 336LEU A 315 | None | 1.09A | 3v81A-1lc7A:0.0 | 3v81A-1lc7A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lip | LIPID TRANSFERPROTEIN (Hordeum vulgare) |
PF00234(Tryp_alpha_amyl) | 4 | LEU A 51VAL A 17LEU A 34TYR A 79 | None | 1.01A | 3v81A-1lipA:undetectable | 3v81A-1lipA:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nf2 | PHOSPHATASE (Thermotogamaritima) |
PF08282(Hydrolase_3) | 4 | LEU A 198VAL A 6TYR A 36LEU A 72 | None | 1.01A | 3v81A-1nf2A:2.2 | 3v81A-1nf2A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxy | FIMBRIN-LIKE PROTEIN (Arabidopsisthaliana) |
PF00307(CH) | 4 | LEU A 424VAL A 411TYR A 398LEU A 493 | None | 1.03A | 3v81A-1pxyA:2.4 | 3v81A-1pxyA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r47 | ALPHA-GALACTOSIDASEA (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 4 | LEU A 403VAL A 351LEU A 394TYR A 397 | None | 1.09A | 3v81A-1r47A:undetectable | 3v81A-1r47A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rfv | PYRIDOXAL KINASE (Ovis aries) |
PF08543(Phos_pyr_kin) | 4 | LEU A 8VAL A 94LEU A 69TYR A 77 | None | 1.01A | 3v81A-1rfvA:undetectable | 3v81A-1rfvA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t33 | PUTATIVETRANSCRIPTIONALREPRESSOR (TETR/ACRRFAMILY) (Salmonellaenterica) |
PF00440(TetR_N)PF09209(DUF1956) | 4 | LEU A 110LYS A 183VAL A 116LEU A 177 | None | 1.08A | 3v81A-1t33A:undetectable | 3v81A-1t33A:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkh | PUTATIVE SERINEHYDROLASE (Saccharomycescerevisiae) |
PF07859(Abhydrolase_3) | 4 | LEU A 159TYR A 154LEU A 214TYR A 163 | None | 1.08A | 3v81A-1vkhA:2.4 | 3v81A-1vkhA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vma | CELL DIVISIONPROTEIN FTSY (Thermotogamaritima) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | LEU A 291LYS A 72VAL A 23LEU A 257 | None | 1.05A | 3v81A-1vmaA:2.3 | 3v81A-1vmaA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7m | HYPOTHETICAL PROTEINBSU14040 (Bacillussubtilis) |
PF01476(LysM)PF03734(YkuD) | 4 | LEU A 150VAL A 160TYR A 56TYR A 79 | None | 1.03A | 3v81A-1y7mA:2.1 | 3v81A-1y7mA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9j | SEC1 FAMILY DOMAINCONTAINING PROTEIN 1 (Rattusnorvegicus) |
PF00995(Sec1) | 4 | LEU A 22LYS A 39TYR A 43LEU A 60 | None | 0.97A | 3v81A-1y9jA:undetectable | 3v81A-1y9jA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yf9 | UBIQUITIN CARRIERPROTEIN 4 (Leishmaniamajor) |
PF00179(UQ_con) | 4 | LEU A 63LYS A 70LEU A 107TYR A 67 | None | 1.08A | 3v81A-1yf9A:undetectable | 3v81A-1yf9A:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zl6 | BOTULINUM NEUROTOXINTYPE E (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | LEU A 274VAL A 318TYR A 306LEU A 330 | None | 0.86A | 3v81A-1zl6A:undetectable | 3v81A-1zl6A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 4 | LEU A 129LYS A 152TYR A 144LEU A 120 | None | 0.93A | 3v81A-2abqA:undetectable | 3v81A-2abqA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | LEU A 548TYR A 728LEU A 735TYR A 553 | None | 1.03A | 3v81A-2ecfA:undetectable | 3v81A-2ecfA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eef | PROTEIN PHOSPHATASE1, REGULATORY(INHIBITOR) SUBUNIT3B (Homo sapiens) |
PF03370(CBM_21) | 4 | LEU A 31VAL A 115TYR A 117TYR A 124 | None | 1.12A | 3v81A-2eefA:undetectable | 3v81A-2eefA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef0 | ORNITHINECARBAMOYLTRANSFERASE (Thermusthermophilus) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | LEU A 145VAL A 256TYR A 218LEU A 179 | None | 1.03A | 3v81A-2ef0A:undetectable | 3v81A-2ef0A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 4 | LEU A 204VAL A 41TYR A 165LEU A 202 | NoneFAD A 611 (-4.9A)NoneNone | 1.07A | 3v81A-2gmhA:2.0 | 3v81A-2gmhA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hb6 | LEUCINEAMINOPEPTIDASE 1 (Caenorhabditiselegans) |
PF00883(Peptidase_M17) | 4 | LEU A 289VAL A 486TYR A 483LEU A 298 | None | 1.11A | 3v81A-2hb6A:1.0 | 3v81A-2hb6A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hih | LIPASE 46 KDA FORM (Staphylococcushyicus) |
no annotation | 4 | LEU A 133VAL A 64TYR A 79LEU A 158 | None | 1.02A | 3v81A-2hihA:undetectable | 3v81A-2hihA:20.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hnz | REVERSETRANSCRIPTASE/RIBONUCLEASE H (Humanimmunodeficiencyvirus 1) |
PF00075(RNase_H)PF00078(RVT_1)PF06815(RVT_connect)PF06817(RVT_thumb) | 8 | LEU A 100LYS A 103VAL A 179TYR A 181TYR A 188TRP A 229LEU A 234TYR A 318 | PC0 A 999 ( 3.9A)NonePC0 A 999 (-4.4A)PC0 A 999 (-3.9A)PC0 A 999 (-4.1A)PC0 A 999 ( 4.2A)PC0 A 999 (-4.2A)PC0 A 999 (-4.3A) | 0.80A | 3v81A-2hnzA:35.6 | 3v81A-2hnzA:98.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hoe | N-ACETYLGLUCOSAMINEKINASE (Thermotogamaritima) |
PF00480(ROK) | 4 | LEU A 116VAL A 82LEU A 171TYR A 120 | None | 0.97A | 3v81A-2hoeA:3.7 | 3v81A-2hoeA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iop | CHAPERONE PROTEINHTPG (Escherichiacoli) |
PF00183(HSP90)PF02518(HATPase_c) | 4 | LEU A 597VAL A 526TYR A 566LEU A 601 | None | 1.10A | 3v81A-2iopA:undetectable | 3v81A-2iopA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j2m | CATALASE (Exiguobacteriumoxidotolerans) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | LEU A 260VAL A 90TRP A 203LEU A 215 | None | 1.10A | 3v81A-2j2mA:undetectable | 3v81A-2j2mA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ku7 | MLL1 PHD3-CYP33 RRMCHIMERIC PROTEIN (Homo sapiens) |
PF00076(RRM_1)PF00628(PHD) | 4 | LEU A 27VAL A 65TYR A 67LEU A 30 | None | 0.92A | 3v81A-2ku7A:undetectable | 3v81A-2ku7A:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okj | GLUTAMATEDECARBOXYLASE 1 (Homo sapiens) |
PF00282(Pyridoxal_deC) | 4 | LEU A 200VAL A 121TYR A 127LEU A 195 | None | 1.07A | 3v81A-2okjA:undetectable | 3v81A-2okjA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p1r | LIPID KINASE YEGS (Salmonellaenterica) |
PF00781(DAGK_cat) | 4 | LEU A 8VAL A 73TYR A 49LEU A 56 | None | 0.95A | 3v81A-2p1rA:undetectable | 3v81A-2p1rA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfv | EXOCYST COMPLEXCOMPONENT EXO70 (Saccharomycescerevisiae) |
PF03081(Exo70) | 4 | LEU A 260TYR A 174LEU A 202TYR A 261 | None | 0.97A | 3v81A-2pfvA:undetectable | 3v81A-2pfvA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkg | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A65 KDA REGULATORYSUBUNIT A ALPHAISOFORM (Homo sapiens) |
PF02985(HEAT)PF13646(HEAT_2) | 4 | LEU A 373VAL A 419TYR A 426LEU A 404 | None | 1.02A | 3v81A-2pkgA:undetectable | 3v81A-2pkgA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qik | UPF0131 PROTEIN YKQA (Bacillussubtilis) |
PF06094(GGACT)PF13772(AIG2_2) | 4 | LEU A 5VAL A 86TYR A 8LEU A 11 | None | 1.09A | 3v81A-2qikA:undetectable | 3v81A-2qikA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2va0 | ABFSARABINOFURANOSIDASETWO COMPONENT SYSTEMSENSOR PROTEIN (Cellvibriojaponicus) |
no annotation | 4 | LEU A 74VAL A 142TYR A 86LEU A 82 | None | 1.01A | 3v81A-2va0A:undetectable | 3v81A-2va0A:13.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfa | HYPOXANTHINE-GUANINE-XANTHINEPHOSPHORIBOSYLTRANSFERASE,HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens;Plasmodiumfalciparum) |
PF00156(Pribosyltran) | 4 | LEU A 130VAL A 71LEU A 157TYR A 161 | None | 1.10A | 3v81A-2vfaA:undetectable | 3v81A-2vfaA:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfx | HEDGEHOG-INTERACTINGPROTEIN (Homo sapiens) |
PF07995(GSDH) | 4 | LEU B 266TYR B 303LEU B 299TYR B 265 | None | 0.91A | 3v81A-2wfxB:undetectable | 3v81A-2wfxB:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xlr | FLAVIN-CONTAININGMONOOXYGENASE (Methylophagaaminisulfidivorans) |
PF00743(FMO-like) | 4 | VAL A 164TYR A 162LEU A 347TYR A 336 | None | 1.00A | 3v81A-2xlrA:undetectable | 3v81A-2xlrA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr7 | MALONYLTRANSFERASE (Nicotianatabacum) |
PF02458(Transferase) | 4 | LEU A 256VAL A 345TYR A 276LEU A 453 | None | 0.90A | 3v81A-2xr7A:undetectable | 3v81A-2xr7A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvs | TETRATRICOPEPTIDEREPEAT PROTEIN 5 (Homo sapiens) |
PF16669(TTC5_OB) | 4 | LEU A 391VAL A 367TYR A 365LEU A 393 | None | 0.94A | 3v81A-2xvsA:undetectable | 3v81A-2xvsA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y8n | 4-HYDROXYPHENYLACETATE DECARBOXYLASELARGE SUBUNIT (Clostridiumscatologenes) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | TYR A 729TYR A 726LEU A 648TYR A 571 | None | 1.05A | 3v81A-2y8nA:1.5 | 3v81A-2y8nA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ypf | AVRBS3 (Xanthomonascampestris) |
PF03377(TAL_effector) | 4 | LEU A 260LYS A 262VAL A 295LEU A 241 | None | 1.06A | 3v81A-2ypfA:undetectable | 3v81A-2ypfA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbl | PUTATIVE ISOMERASE (Salmonellaenterica) |
PF07221(GlcNAc_2-epim) | 4 | LEU A 198VAL A 178TYR A 185LEU A 263 | None | 1.07A | 3v81A-2zblA:undetectable | 3v81A-2zblA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3adg | F21M12.9 PROTEIN (Arabidopsisthaliana) |
PF00035(dsrm) | 4 | LEU A 53TYR A 27LEU A 82TYR A 58 | None | 1.12A | 3v81A-3adgA:undetectable | 3v81A-3adgA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 4 | LEU A 819VAL A 837TYR A 839LEU A 898 | None | 0.98A | 3v81A-3av6A:undetectable | 3v81A-3av6A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b46 | AMINOTRANSFERASEBNA3 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 4 | LEU A 440VAL A 362TRP A 391LEU A 396 | None | 1.11A | 3v81A-3b46A:undetectable | 3v81A-3b46A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3byh | FIMBRIN ABD2 (Homo sapiens) |
PF00307(CH) | 4 | LEU B 424VAL B 411TYR B 398LEU B 493 | None | 1.03A | 3v81A-3byhB:undetectable | 3v81A-3byhB:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3m | RESPONSE REGULATORRECEIVER PROTEIN (Methanoculleusmarisnigri) |
PF00072(Response_reg) | 4 | LEU A 51VAL A 19TYR A 27LEU A 49 | None | 1.11A | 3v81A-3c3mA:undetectable | 3v81A-3c3mA:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cih | PUTATIVEALPHA-RHAMNOSIDASE (Bacteroidesthetaiotaomicron) |
PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 4 | LEU A 219VAL A 289TYR A 265TYR A 221 | None | 1.01A | 3v81A-3cihA:undetectable | 3v81A-3cihA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckn | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumavium) |
PF00535(Glycos_transf_2) | 4 | VAL A 278TYR A 234LEU A 123TYR A 218 | NoneUDP A 332 (-4.7A)NoneNone | 0.89A | 3v81A-3cknA:undetectable | 3v81A-3cknA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhx | PYRIDOXAL KINASE (Homo sapiens) |
PF08543(Phos_pyr_kin) | 4 | LEU A 8VAL A 94LEU A 69TYR A 77 | None | 1.07A | 3v81A-3fhxA:undetectable | 3v81A-3fhxA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fii | BOTULINUM NEUROTOXINTYPE F (Clostridiumbotulinum) |
PF01742(Peptidase_M27) | 4 | LEU A 290VAL A 336TYR A 324LEU A 348 | None | 0.85A | 3v81A-3fiiA:undetectable | 3v81A-3fiiA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fo5 | THIOESTERASE,ADIPOSE ASSOCIATED,ISOFORM BFIT2 (Homo sapiens) |
PF01852(START) | 4 | VAL A 544TYR A 546LEU A 415TYR A 570 | None1PE A 2 (-4.0A)NoneNone | 1.11A | 3v81A-3fo5A:undetectable | 3v81A-3fo5A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gbz | KINASE, CMGC CDK (Giardiaintestinalis) |
PF00069(Pkinase) | 4 | LEU A 89VAL A 29TYR A 26LEU A 87 | None | 1.07A | 3v81A-3gbzA:undetectable | 3v81A-3gbzA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbz | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesthetaiotaomicron) |
PF13201(PCMD) | 4 | LYS A 173TYR A 119TRP A 145LEU A 178 | None | 1.06A | 3v81A-3hbzA:undetectable | 3v81A-3hbzA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 4 | LEU A 13LYS A 1TYR A 113LEU A 136 | None | 1.03A | 3v81A-3i5gA:undetectable | 3v81A-3i5gA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ig3 | PLXNA3 PROTEIN (Mus musculus) |
PF08337(Plexin_cytopl) | 4 | LEU A1373VAL A1824LEU A1344TYR A1379 | None | 1.05A | 3v81A-3ig3A:undetectable | 3v81A-3ig3A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iyj | MAJOR CAPSID PROTEINL1 (Deltapapillomavirus4) |
no annotation | 4 | LEU F 328VAL F 98TYR F 308LEU F 153 | None | 1.10A | 3v81A-3iyjF:undetectable | 3v81A-3iyjF:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iz4 | SSRA-BINDING PROTEIN (Escherichiacoli) |
PF01668(SmpB) | 4 | LEU B 53VAL B 115TYR B 20LEU B 86 | None | 0.98A | 3v81A-3iz4B:undetectable | 3v81A-3iz4B:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9u | V-TYPE PROTON ATPASECATALYTIC SUBUNIT A (Saccharomycescerevisiae) |
no annotation | 4 | VAL C 217TYR C 342LEU C 100TYR C 105 | None | 1.06A | 3v81A-3j9uC:undetectable | 3v81A-3j9uC:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9t | PUTATIVE PEPTIDASE (Clostridiumacetobutylicum) |
PF09940(DUF2172)PF16221(HTH_47)PF16254(DUF4910) | 4 | LEU A 115VAL A 155TYR A 153LEU A 140 | None | 1.06A | 3v81A-3k9tA:undetectable | 3v81A-3k9tA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldf | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.776 (Streptococcusmutans) |
PF10672(Methyltrans_SAM) | 4 | LEU A 21VAL A 18LEU A 38TYR A 26 | None | 1.05A | 3v81A-3ldfA:undetectable | 3v81A-3ldfA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m99 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Saccharomycescerevisiae) |
PF00443(UCH)PF02148(zf-UBP) | 4 | LEU A 463VAL A 455LEU A 316TYR A 465 | None | 1.10A | 3v81A-3m99A:undetectable | 3v81A-3m99A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ni8 | PFC0360W PROTEIN (Plasmodiumfalciparum) |
PF08327(AHSA1) | 4 | LEU A 114TRP A 140LEU A 145TYR A 27 | None | 1.06A | 3v81A-3ni8A:2.6 | 3v81A-3ni8A:14.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ns4 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 53 (Saccharomycescerevisiae) |
PF16854(VPS53_C) | 4 | LEU A 680VAL A 619LEU A 707TYR A 686 | None | 0.97A | 3v81A-3ns4A:undetectable | 3v81A-3ns4A:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ri6 | O-ACETYLHOMOSERINESULFHYDRYLASE (Wolinellasuccinogenes) |
PF01053(Cys_Met_Meta_PP) | 4 | LEU A 94VAL A 252TRP A 226LEU A 229 | None | 1.09A | 3v81A-3ri6A:undetectable | 3v81A-3ri6A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sll | PROBABLE ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteroidesabscessus) |
PF00378(ECH_1) | 4 | LEU A 195VAL A 128LEU A 15TYR A 199 | None | 0.96A | 3v81A-3sllA:undetectable | 3v81A-3sllA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3smt | HISTONE-LYSINEN-METHYLTRANSFERASESETD3 (Homo sapiens) |
PF00856(SET)PF09273(Rubis-subs-bind) | 4 | LEU A 186VAL A 56TYR A 243TYR A 187 | None | 1.05A | 3v81A-3smtA:undetectable | 3v81A-3smtA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxp | ADP-L-GLYCERO-D-MANNOHEPTOSE-6-EPIMERASE (Helicobacterpylori) |
PF01370(Epimerase) | 4 | VAL A 253TYR A 255LEU A 307TYR A 3 | None | 1.07A | 3v81A-3sxpA:undetectable | 3v81A-3sxpA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7v | METHYLORNITHINESYNTHASE PYLB (Methanosarcinabarkeri) |
PF04055(Radical_SAM) | 4 | LEU A 166LYS A 198LEU A 155TYR A 202 | None | 1.07A | 3v81A-3t7vA:undetectable | 3v81A-3t7vA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 5 | LEU B1144LYS B1116TYR B 975LEU B 978TYR B1113 | None | 1.49A | 3v81A-3u44B:undetectable | 3v81A-3u44B:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uor | ABC TRANSPORTERSUGAR BINDINGPROTEIN (Xanthomonascitri) |
PF13416(SBP_bac_8) | 4 | LEU A 322VAL A 84LEU A 45TYR A 321 | None | 1.06A | 3v81A-3uorA:undetectable | 3v81A-3uorA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vay | HAD-SUPERFAMILYHYDROLASE (Pseudomonassyringae groupgenomosp. 3) |
PF13419(HAD_2) | 4 | LEU A 76VAL A 41TRP A 30TYR A 81 | None | 1.12A | 3v81A-3vayA:undetectable | 3v81A-3vayA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voc | BETA/ALPHA-AMYLASE (Paenibacilluspolymyxa) |
PF01373(Glyco_hydro_14) | 4 | VAL A 47TYR A 59TRP A 20TYR A 147 | None | 1.05A | 3v81A-3vocA:undetectable | 3v81A-3vocA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vot | L-AMINO ACID LIGASE,BL00235 (Bacilluslicheniformis) |
PF13535(ATP-grasp_4) | 4 | LEU A 144VAL A 129LEU A 170TYR A 146 | None | 1.09A | 3v81A-3votA:undetectable | 3v81A-3votA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu4 | KMHSV2 (Kluyveromycesmarxianus) |
no annotation | 4 | LEU A 29VAL A 59TYR A 20LEU A 348 | None | 0.99A | 3v81A-3vu4A:undetectable | 3v81A-3vu4A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcx | SPHINGOMYELINASE C (Streptomycesgriseocarneus) |
PF03372(Exo_endo_phos) | 4 | LEU A 104VAL A 90TYR A 56LEU A 60 | None | 1.10A | 3v81A-3wcxA:undetectable | 3v81A-3wcxA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aip | FE-REGULATED PROTEINB (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | LEU A 640VAL A 604TYR A 595LEU A 600 | None | 1.05A | 3v81A-4aipA:undetectable | 3v81A-4aipA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfc | 3-DEOXY-D-MANNO-OCTULOSONIC-ACIDTRANSFERASE (Acinetobacterbaumannii) |
no annotation | 4 | LEU A 319LYS A 218TRP A 232LEU A 323 | None | 1.09A | 3v81A-4bfcA:undetectable | 3v81A-4bfcA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cni | INTERLEUKIN-6 (Homo sapiens) |
PF00489(IL6) | 4 | LEU C 62VAL C 96TYR C 100LEU C 165 | None | 1.11A | 3v81A-4cniC:undetectable | 3v81A-4cniC:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4csw | CUPIN 4 FAMILYPROTEIN (Rhodothermusmarinus) |
PF08007(Cupin_4) | 4 | VAL A 121TYR A 123TRP A 87LEU A 57 | NoneUN9 A1391 ( 4.8A)NoneNone | 0.89A | 3v81A-4cswA:undetectable | 3v81A-4cswA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvc | ALCOHOLDEHYDROGENASE (Pseudogluconobactersaccharoketogenes) |
PF13360(PQQ_2) | 4 | LEU A 421LYS A 426TYR A 430TYR A 461 | None | 0.91A | 3v81A-4cvcA:undetectable | 3v81A-4cvcA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d47 | LEVANSUCRASE (Erwiniaamylovora) |
PF02435(Glyco_hydro_68) | 4 | LEU A 276TYR A 4LEU A 327TYR A 331 | None | 0.95A | 3v81A-4d47A:undetectable | 3v81A-4d47A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgk | PHYTOENEDEHYDROGENASE (Pantoeaananatis) |
PF01593(Amino_oxidase) | 4 | LEU A 20VAL A 463TYR A 461LEU A 488 | None | 1.12A | 3v81A-4dgkA:undetectable | 3v81A-4dgkA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e14 | KYNURENINEFORMAMIDASE (Drosophilamelanogaster) |
PF07859(Abhydrolase_3) | 4 | LEU A 167VAL A 230LEU A 259TYR A 225 | None | 1.10A | 3v81A-4e14A:undetectable | 3v81A-4e14A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e14 | KYNURENINEFORMAMIDASE (Drosophilamelanogaster) |
PF07859(Abhydrolase_3) | 4 | LEU A 259TYR A 191LEU A 167TYR A 264 | None | 0.96A | 3v81A-4e14A:undetectable | 3v81A-4e14A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e16 | PRECORRIN-4C(11)-METHYLTRANSFERASE (Clostridioidesdifficile) |
PF00590(TP_methylase) | 4 | LEU A 230VAL A 127TYR A 125LEU A 121 | None | 1.10A | 3v81A-4e16A:undetectable | 3v81A-4e16A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4epa | PESTICIN RECEPTOR (Yersinia pestis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | VAL A 636TYR A 232TYR A 624LEU A 587 | None | 1.06A | 3v81A-4epaA:undetectable | 3v81A-4epaA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcy | TRANSPOSASE (Escherichiavirus Mu) |
PF02316(HTH_Tnp_Mu_1)PF02914(DDE_2)PF09039(HTH_Tnp_Mu_2)PF09299(Mu-transpos_C) | 4 | LYS A 197VAL A 236TRP A 185LEU A 188 | None | 0.88A | 3v81A-4fcyA:2.3 | 3v81A-4fcyA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgh | CULLIN-5 (Homo sapiens) |
PF00888(Cullin) | 4 | LEU D 299TYR D 230TYR D 233LEU D 238 | None | 1.07A | 3v81A-4jghD:undetectable | 3v81A-4jghD:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf7 | NUP188 (Thermothelomycesthermophila) |
PF10487(Nup188) | 4 | LEU A 707VAL A 698TRP A 646LEU A 664 | None | 0.91A | 3v81A-4kf7A:undetectable | 3v81A-4kf7A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ksy | STIMULATOR OFINTERFERON GENESPROTEIN (Homo sapiens) |
PF15009(TMEM173) | 4 | LEU A 299TYR A 163TYR A 167LEU A 172 | NoneNone1SY A 500 (-3.9A)None | 1.06A | 3v81A-4ksyA:undetectable | 3v81A-4ksyA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lq0 | LAGLIDADG HOMINGENDONUCLEASE (Leptographiumtruncatum) |
PF00961(LAGLIDADG_1) | 4 | LEU A 135VAL A 41TYR A 39LEU A 145 | None | 1.09A | 3v81A-4lq0A:undetectable | 3v81A-4lq0A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhb | PUTATIVE ALDO/KETOREDUCTASE (Yersinia pestis) |
PF00248(Aldo_ket_red) | 4 | LEU A 89VAL A 127TYR A 95TYR A 118 | None | 1.07A | 3v81A-4mhbA:undetectable | 3v81A-4mhbA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkn | TRIOSEPHOSPHATEISOMERASE (Chlamydomonasreinhardtii) |
PF00121(TIM) | 4 | LEU A 164VAL A 186TYR A 193LEU A 206 | NoneMRD A 304 ( 4.2A)NoneNone | 1.10A | 3v81A-4mknA:1.5 | 3v81A-4mknA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6c | UNCHARACTERIZEDPROTEIN (Streptococcuspneumoniae) |
PF08020(DUF1706) | 4 | LEU A 57VAL A 71TRP A 89LEU A 86 | None | 0.95A | 3v81A-4n6cA:undetectable | 3v81A-4n6cA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzd | INTERLEUKIN-21RECEPTOR (Homo sapiens) |
PF09238(IL4Ra_N) | 4 | LEU A 139VAL A 107LEU A 166TYR A 141 | None | 1.03A | 3v81A-4nzdA:undetectable | 3v81A-4nzdA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5j | UNCHARACTERIZEDPROTEIN (Helicobacterpylori) |
no annotation | 4 | LEU A 318TYR A 336LEU A 342TYR A 315 | None | 1.00A | 3v81A-4o5jA:undetectable | 3v81A-4o5jA:22.05 |