SIMILAR PATTERNS OF AMINO ACIDS FOR 3V81_A_NVPA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)


(Malus domestica)
PF00155
(Aminotran_1_2)
4 LEU A 114
VAL A 267
TYR A 269
LEU A 116
None
0.99A 3v81A-1b8gA:
0.2
3v81A-1b8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 4 LEU B 262
TYR B 407
TYR B 403
LEU B 394
None
1.00A 3v81A-1ej6B:
0.0
3v81A-1ej6B:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE


(Arthrobacter
globiformis)
PF00903
(Glyoxalase)
4 VAL A 116
TYR A  79
LEU A 173
TYR A  93
None
1.11A 3v81A-1f1uA:
0.0
3v81A-1f1uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma)
PF01593
(Amino_oxidase)
5 LEU A   7
LYS A 222
TYR A 180
TYR A 188
LEU A 161
None
1.48A 3v81A-1f8rA:
2.8
3v81A-1f8rA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1s P-SELECTIN

(Homo sapiens)
PF00008
(EGF)
PF00059
(Lectin_C)
4 VAL A  27
TYR A  49
TYR A   5
TYR A  37
MRD  A 807 ( 4.7A)
None
None
None
1.11A 3v81A-1g1sA:
undetectable
3v81A-1g1sA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 LEU A 574
TYR A 143
LEU A 151
TYR A 578
None
0.82A 3v81A-1g8kA:
0.0
3v81A-1g8kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Salmonella
enterica)
PF00155
(Aminotran_1_2)
4 LEU A 353
VAL A 292
TYR A 336
LEU A 315
None
1.09A 3v81A-1lc7A:
0.0
3v81A-1lc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lip LIPID TRANSFER
PROTEIN


(Hordeum vulgare)
PF00234
(Tryp_alpha_amyl)
4 LEU A  51
VAL A  17
LEU A  34
TYR A  79
None
1.01A 3v81A-1lipA:
undetectable
3v81A-1lipA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf2 PHOSPHATASE

(Thermotoga
maritima)
PF08282
(Hydrolase_3)
4 LEU A 198
VAL A   6
TYR A  36
LEU A  72
None
1.01A 3v81A-1nf2A:
2.2
3v81A-1nf2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana)
PF00307
(CH)
4 LEU A 424
VAL A 411
TYR A 398
LEU A 493
None
1.03A 3v81A-1pxyA:
2.4
3v81A-1pxyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
4 LEU A 403
VAL A 351
LEU A 394
TYR A 397
None
1.09A 3v81A-1r47A:
undetectable
3v81A-1r47A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries)
PF08543
(Phos_pyr_kin)
4 LEU A   8
VAL A  94
LEU A  69
TYR A  77
None
1.01A 3v81A-1rfvA:
undetectable
3v81A-1rfvA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)


(Salmonella
enterica)
PF00440
(TetR_N)
PF09209
(DUF1956)
4 LEU A 110
LYS A 183
VAL A 116
LEU A 177
None
1.08A 3v81A-1t33A:
undetectable
3v81A-1t33A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkh PUTATIVE SERINE
HYDROLASE


(Saccharomyces
cerevisiae)
PF07859
(Abhydrolase_3)
4 LEU A 159
TYR A 154
LEU A 214
TYR A 163
None
1.08A 3v81A-1vkhA:
2.4
3v81A-1vkhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 LEU A 291
LYS A  72
VAL A  23
LEU A 257
None
1.05A 3v81A-1vmaA:
2.3
3v81A-1vmaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040


(Bacillus
subtilis)
PF01476
(LysM)
PF03734
(YkuD)
4 LEU A 150
VAL A 160
TYR A  56
TYR A  79
None
1.03A 3v81A-1y7mA:
2.1
3v81A-1y7mA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1


(Rattus
norvegicus)
PF00995
(Sec1)
4 LEU A  22
LYS A  39
TYR A  43
LEU A  60
None
0.97A 3v81A-1y9jA:
undetectable
3v81A-1y9jA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf9 UBIQUITIN CARRIER
PROTEIN 4


(Leishmania
major)
PF00179
(UQ_con)
4 LEU A  63
LYS A  70
LEU A 107
TYR A  67
None
1.08A 3v81A-1yf9A:
undetectable
3v81A-1yf9A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl6 BOTULINUM NEUROTOXIN
TYPE E


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 LEU A 274
VAL A 318
TYR A 306
LEU A 330
None
0.86A 3v81A-1zl6A:
undetectable
3v81A-1zl6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE


(Bacillus
halodurans)
PF00294
(PfkB)
4 LEU A 129
LYS A 152
TYR A 144
LEU A 120
None
0.93A 3v81A-2abqA:
undetectable
3v81A-2abqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV


(Stenotrophomonas
maltophilia)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 LEU A 548
TYR A 728
LEU A 735
TYR A 553
None
1.03A 3v81A-2ecfA:
undetectable
3v81A-2ecfA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eef PROTEIN PHOSPHATASE
1, REGULATORY
(INHIBITOR) SUBUNIT
3B


(Homo sapiens)
PF03370
(CBM_21)
4 LEU A  31
VAL A 115
TYR A 117
TYR A 124
None
1.12A 3v81A-2eefA:
undetectable
3v81A-2eefA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE


(Thermus
thermophilus)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 LEU A 145
VAL A 256
TYR A 218
LEU A 179
None
1.03A 3v81A-2ef0A:
undetectable
3v81A-2ef0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
4 LEU A 204
VAL A  41
TYR A 165
LEU A 202
None
FAD  A 611 (-4.9A)
None
None
1.07A 3v81A-2gmhA:
2.0
3v81A-2gmhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1


(Caenorhabditis
elegans)
PF00883
(Peptidase_M17)
4 LEU A 289
VAL A 486
TYR A 483
LEU A 298
None
1.11A 3v81A-2hb6A:
1.0
3v81A-2hb6A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus)
no annotation 4 LEU A 133
VAL A  64
TYR A  79
LEU A 158
None
1.02A 3v81A-2hihA:
undetectable
3v81A-2hihA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H


(Human
immunodeficiency
virus 1)
PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb)
8 LEU A 100
LYS A 103
VAL A 179
TYR A 181
TYR A 188
TRP A 229
LEU A 234
TYR A 318
PC0  A 999 ( 3.9A)
None
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
0.80A 3v81A-2hnzA:
35.6
3v81A-2hnzA:
98.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE


(Thermotoga
maritima)
PF00480
(ROK)
4 LEU A 116
VAL A  82
LEU A 171
TYR A 120
None
0.97A 3v81A-2hoeA:
3.7
3v81A-2hoeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG


(Escherichia
coli)
PF00183
(HSP90)
PF02518
(HATPase_c)
4 LEU A 597
VAL A 526
TYR A 566
LEU A 601
None
1.10A 3v81A-2iopA:
undetectable
3v81A-2iopA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 LEU A 260
VAL A  90
TRP A 203
LEU A 215
None
1.10A 3v81A-2j2mA:
undetectable
3v81A-2j2mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ku7 MLL1 PHD3-CYP33 RRM
CHIMERIC PROTEIN


(Homo sapiens)
PF00076
(RRM_1)
PF00628
(PHD)
4 LEU A  27
VAL A  65
TYR A  67
LEU A  30
None
0.92A 3v81A-2ku7A:
undetectable
3v81A-2ku7A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1


(Homo sapiens)
PF00282
(Pyridoxal_deC)
4 LEU A 200
VAL A 121
TYR A 127
LEU A 195
None
1.07A 3v81A-2okjA:
undetectable
3v81A-2okjA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica)
PF00781
(DAGK_cat)
4 LEU A   8
VAL A  73
TYR A  49
LEU A  56
None
0.95A 3v81A-2p1rA:
undetectable
3v81A-2p1rA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70


(Saccharomyces
cerevisiae)
PF03081
(Exo70)
4 LEU A 260
TYR A 174
LEU A 202
TYR A 261
None
0.97A 3v81A-2pfvA:
undetectable
3v81A-2pfvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM


(Homo sapiens)
PF02985
(HEAT)
PF13646
(HEAT_2)
4 LEU A 373
VAL A 419
TYR A 426
LEU A 404
None
1.02A 3v81A-2pkgA:
undetectable
3v81A-2pkgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qik UPF0131 PROTEIN YKQA

(Bacillus
subtilis)
PF06094
(GGACT)
PF13772
(AIG2_2)
4 LEU A   5
VAL A  86
TYR A   8
LEU A  11
None
1.09A 3v81A-2qikA:
undetectable
3v81A-2qikA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN


(Cellvibrio
japonicus)
no annotation 4 LEU A  74
VAL A 142
TYR A  86
LEU A  82
None
1.01A 3v81A-2va0A:
undetectable
3v81A-2va0A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE


(Homo sapiens;
Plasmodium
falciparum)
PF00156
(Pribosyltran)
4 LEU A 130
VAL A  71
LEU A 157
TYR A 161
None
1.10A 3v81A-2vfaA:
undetectable
3v81A-2vfaA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN


(Homo sapiens)
PF07995
(GSDH)
4 LEU B 266
TYR B 303
LEU B 299
TYR B 265
None
0.91A 3v81A-2wfxB:
undetectable
3v81A-2wfxB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE


(Methylophaga
aminisulfidivorans)
PF00743
(FMO-like)
4 VAL A 164
TYR A 162
LEU A 347
TYR A 336
None
1.00A 3v81A-2xlrA:
undetectable
3v81A-2xlrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum)
PF02458
(Transferase)
4 LEU A 256
VAL A 345
TYR A 276
LEU A 453
None
0.90A 3v81A-2xr7A:
undetectable
3v81A-2xr7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5


(Homo sapiens)
PF16669
(TTC5_OB)
4 LEU A 391
VAL A 367
TYR A 365
LEU A 393
None
0.94A 3v81A-2xvsA:
undetectable
3v81A-2xvsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT


(Clostridium
scatologenes)
PF01228
(Gly_radical)
PF02901
(PFL-like)
4 TYR A 729
TYR A 726
LEU A 648
TYR A 571
None
1.05A 3v81A-2y8nA:
1.5
3v81A-2y8nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypf AVRBS3

(Xanthomonas
campestris)
PF03377
(TAL_effector)
4 LEU A 260
LYS A 262
VAL A 295
LEU A 241
None
1.06A 3v81A-2ypfA:
undetectable
3v81A-2ypfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica)
PF07221
(GlcNAc_2-epim)
4 LEU A 198
VAL A 178
TYR A 185
LEU A 263
None
1.07A 3v81A-2zblA:
undetectable
3v81A-2zblA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adg F21M12.9 PROTEIN

(Arabidopsis
thaliana)
PF00035
(dsrm)
4 LEU A  53
TYR A  27
LEU A  82
TYR A  58
None
1.12A 3v81A-3adgA:
undetectable
3v81A-3adgA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
4 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
0.98A 3v81A-3av6A:
undetectable
3v81A-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3


(Saccharomyces
cerevisiae)
PF00155
(Aminotran_1_2)
4 LEU A 440
VAL A 362
TRP A 391
LEU A 396
None
1.11A 3v81A-3b46A:
undetectable
3v81A-3b46A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byh FIMBRIN ABD2

(Homo sapiens)
PF00307
(CH)
4 LEU B 424
VAL B 411
TYR B 398
LEU B 493
None
1.03A 3v81A-3byhB:
undetectable
3v81A-3byhB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3m RESPONSE REGULATOR
RECEIVER PROTEIN


(Methanoculleus
marisnigri)
PF00072
(Response_reg)
4 LEU A  51
VAL A  19
TYR A  27
LEU A  49
None
1.11A 3v81A-3c3mA:
undetectable
3v81A-3c3mA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE


(Bacteroides
thetaiotaomicron)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
4 LEU A 219
VAL A 289
TYR A 265
TYR A 221
None
1.01A 3v81A-3cihA:
undetectable
3v81A-3cihA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycobacterium
avium)
PF00535
(Glycos_transf_2)
4 VAL A 278
TYR A 234
LEU A 123
TYR A 218
None
UDP  A 332 (-4.7A)
None
None
0.89A 3v81A-3cknA:
undetectable
3v81A-3cknA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens)
PF08543
(Phos_pyr_kin)
4 LEU A   8
VAL A  94
LEU A  69
TYR A  77
None
1.07A 3v81A-3fhxA:
undetectable
3v81A-3fhxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
4 LEU A 290
VAL A 336
TYR A 324
LEU A 348
None
0.85A 3v81A-3fiiA:
undetectable
3v81A-3fiiA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2


(Homo sapiens)
PF01852
(START)
4 VAL A 544
TYR A 546
LEU A 415
TYR A 570
None
1PE  A   2 (-4.0A)
None
None
1.11A 3v81A-3fo5A:
undetectable
3v81A-3fo5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis)
PF00069
(Pkinase)
4 LEU A  89
VAL A  29
TYR A  26
LEU A  87
None
1.07A 3v81A-3gbzA:
undetectable
3v81A-3gbzA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF13201
(PCMD)
4 LYS A 173
TYR A 119
TRP A 145
LEU A 178
None
1.06A 3v81A-3hbzA:
undetectable
3v81A-3hbzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A


(Doryteuthis
pealeii)
PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N)
4 LEU A  13
LYS A   1
TYR A 113
LEU A 136
None
1.03A 3v81A-3i5gA:
undetectable
3v81A-3i5gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus)
PF08337
(Plexin_cytopl)
4 LEU A1373
VAL A1824
LEU A1344
TYR A1379
None
1.05A 3v81A-3ig3A:
undetectable
3v81A-3ig3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyj MAJOR CAPSID PROTEIN
L1


(Deltapapillomavirus
4)
no annotation 4 LEU F 328
VAL F  98
TYR F 308
LEU F 153
None
1.10A 3v81A-3iyjF:
undetectable
3v81A-3iyjF:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz4 SSRA-BINDING PROTEIN

(Escherichia
coli)
PF01668
(SmpB)
4 LEU B  53
VAL B 115
TYR B  20
LEU B  86
None
0.98A 3v81A-3iz4B:
undetectable
3v81A-3iz4B:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A


(Saccharomyces
cerevisiae)
no annotation 4 VAL C 217
TYR C 342
LEU C 100
TYR C 105
None
1.06A 3v81A-3j9uC:
undetectable
3v81A-3j9uC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum)
PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910)
4 LEU A 115
VAL A 155
TYR A 153
LEU A 140
None
1.06A 3v81A-3k9tA:
undetectable
3v81A-3k9tA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776


(Streptococcus
mutans)
PF10672
(Methyltrans_SAM)
4 LEU A  21
VAL A  18
LEU A  38
TYR A  26
None
1.05A 3v81A-3ldfA:
undetectable
3v81A-3ldfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Saccharomyces
cerevisiae)
PF00443
(UCH)
PF02148
(zf-UBP)
4 LEU A 463
VAL A 455
LEU A 316
TYR A 465
None
1.10A 3v81A-3m99A:
undetectable
3v81A-3m99A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ni8 PFC0360W PROTEIN

(Plasmodium
falciparum)
PF08327
(AHSA1)
4 LEU A 114
TRP A 140
LEU A 145
TYR A  27
None
1.06A 3v81A-3ni8A:
2.6
3v81A-3ni8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns4 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 53


(Saccharomyces
cerevisiae)
PF16854
(VPS53_C)
4 LEU A 680
VAL A 619
LEU A 707
TYR A 686
None
0.97A 3v81A-3ns4A:
undetectable
3v81A-3ns4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE


(Wolinella
succinogenes)
PF01053
(Cys_Met_Meta_PP)
4 LEU A  94
VAL A 252
TRP A 226
LEU A 229
None
1.09A 3v81A-3ri6A:
undetectable
3v81A-3ri6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
4 LEU A 195
VAL A 128
LEU A  15
TYR A 199
None
0.96A 3v81A-3sllA:
undetectable
3v81A-3sllA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3


(Homo sapiens)
PF00856
(SET)
PF09273
(Rubis-subs-bind)
4 LEU A 186
VAL A  56
TYR A 243
TYR A 187
None
1.05A 3v81A-3smtA:
undetectable
3v81A-3smtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE


(Helicobacter
pylori)
PF01370
(Epimerase)
4 VAL A 253
TYR A 255
LEU A 307
TYR A   3
None
1.07A 3v81A-3sxpA:
undetectable
3v81A-3sxpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB


(Methanosarcina
barkeri)
PF04055
(Radical_SAM)
4 LEU A 166
LYS A 198
LEU A 155
TYR A 202
None
1.07A 3v81A-3t7vA:
undetectable
3v81A-3t7vA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B


(Bacillus
subtilis)
PF12705
(PDDEXK_1)
5 LEU B1144
LYS B1116
TYR B 975
LEU B 978
TYR B1113
None
1.49A 3v81A-3u44B:
undetectable
3v81A-3u44B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uor ABC TRANSPORTER
SUGAR BINDING
PROTEIN


(Xanthomonas
citri)
PF13416
(SBP_bac_8)
4 LEU A 322
VAL A  84
LEU A  45
TYR A 321
None
1.06A 3v81A-3uorA:
undetectable
3v81A-3uorA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE


(Pseudomonas
syringae group
genomosp. 3)
PF13419
(HAD_2)
4 LEU A  76
VAL A  41
TRP A  30
TYR A  81
None
1.12A 3v81A-3vayA:
undetectable
3v81A-3vayA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa)
PF01373
(Glyco_hydro_14)
4 VAL A  47
TYR A  59
TRP A  20
TYR A 147
None
1.05A 3v81A-3vocA:
undetectable
3v81A-3vocA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vot L-AMINO ACID LIGASE,
BL00235


(Bacillus
licheniformis)
PF13535
(ATP-grasp_4)
4 LEU A 144
VAL A 129
LEU A 170
TYR A 146
None
1.09A 3v81A-3votA:
undetectable
3v81A-3votA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus)
no annotation 4 LEU A  29
VAL A  59
TYR A  20
LEU A 348
None
0.99A 3v81A-3vu4A:
undetectable
3v81A-3vu4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcx SPHINGOMYELINASE C

(Streptomyces
griseocarneus)
PF03372
(Exo_endo_phos)
4 LEU A 104
VAL A  90
TYR A  56
LEU A  60
None
1.10A 3v81A-3wcxA:
undetectable
3v81A-3wcxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B


(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 LEU A 640
VAL A 604
TYR A 595
LEU A 600
None
1.05A 3v81A-4aipA:
undetectable
3v81A-4aipA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE


(Acinetobacter
baumannii)
no annotation 4 LEU A 319
LYS A 218
TRP A 232
LEU A 323
None
1.09A 3v81A-4bfcA:
undetectable
3v81A-4bfcA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni INTERLEUKIN-6

(Homo sapiens)
PF00489
(IL6)
4 LEU C  62
VAL C  96
TYR C 100
LEU C 165
None
1.11A 3v81A-4cniC:
undetectable
3v81A-4cniC:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN


(Rhodothermus
marinus)
PF08007
(Cupin_4)
4 VAL A 121
TYR A 123
TRP A  87
LEU A  57
None
UN9  A1391 ( 4.8A)
None
None
0.89A 3v81A-4cswA:
undetectable
3v81A-4cswA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE


(Pseudogluconobacter
saccharoketogenes)
PF13360
(PQQ_2)
4 LEU A 421
LYS A 426
TYR A 430
TYR A 461
None
0.91A 3v81A-4cvcA:
undetectable
3v81A-4cvcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora)
PF02435
(Glyco_hydro_68)
4 LEU A 276
TYR A   4
LEU A 327
TYR A 331
None
0.95A 3v81A-4d47A:
undetectable
3v81A-4d47A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE


(Pantoea
ananatis)
PF01593
(Amino_oxidase)
4 LEU A  20
VAL A 463
TYR A 461
LEU A 488
None
1.12A 3v81A-4dgkA:
undetectable
3v81A-4dgkA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE


(Drosophila
melanogaster)
PF07859
(Abhydrolase_3)
4 LEU A 167
VAL A 230
LEU A 259
TYR A 225
None
1.10A 3v81A-4e14A:
undetectable
3v81A-4e14A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE


(Drosophila
melanogaster)
PF07859
(Abhydrolase_3)
4 LEU A 259
TYR A 191
LEU A 167
TYR A 264
None
0.96A 3v81A-4e14A:
undetectable
3v81A-4e14A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE


(Clostridioides
difficile)
PF00590
(TP_methylase)
4 LEU A 230
VAL A 127
TYR A 125
LEU A 121
None
1.10A 3v81A-4e16A:
undetectable
3v81A-4e16A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 VAL A 636
TYR A 232
TYR A 624
LEU A 587
None
1.06A 3v81A-4epaA:
undetectable
3v81A-4epaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu)
PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C)
4 LYS A 197
VAL A 236
TRP A 185
LEU A 188
None
0.88A 3v81A-4fcyA:
2.3
3v81A-4fcyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgh CULLIN-5

(Homo sapiens)
PF00888
(Cullin)
4 LEU D 299
TYR D 230
TYR D 233
LEU D 238
None
1.07A 3v81A-4jghD:
undetectable
3v81A-4jghD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila)
PF10487
(Nup188)
4 LEU A 707
VAL A 698
TRP A 646
LEU A 664
None
0.91A 3v81A-4kf7A:
undetectable
3v81A-4kf7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksy STIMULATOR OF
INTERFERON GENES
PROTEIN


(Homo sapiens)
PF15009
(TMEM173)
4 LEU A 299
TYR A 163
TYR A 167
LEU A 172
None
None
1SY  A 500 (-3.9A)
None
1.06A 3v81A-4ksyA:
undetectable
3v81A-4ksyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq0 LAGLIDADG HOMING
ENDONUCLEASE


(Leptographium
truncatum)
PF00961
(LAGLIDADG_1)
4 LEU A 135
VAL A  41
TYR A  39
LEU A 145
None
1.09A 3v81A-4lq0A:
undetectable
3v81A-4lq0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE


(Yersinia pestis)
PF00248
(Aldo_ket_red)
4 LEU A  89
VAL A 127
TYR A  95
TYR A 118
None
1.07A 3v81A-4mhbA:
undetectable
3v81A-4mhbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkn TRIOSEPHOSPHATE
ISOMERASE


(Chlamydomonas
reinhardtii)
PF00121
(TIM)
4 LEU A 164
VAL A 186
TYR A 193
LEU A 206
None
MRD  A 304 ( 4.2A)
None
None
1.10A 3v81A-4mknA:
1.5
3v81A-4mknA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF08020
(DUF1706)
4 LEU A  57
VAL A  71
TRP A  89
LEU A  86
None
0.95A 3v81A-4n6cA:
undetectable
3v81A-4n6cA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzd INTERLEUKIN-21
RECEPTOR


(Homo sapiens)
PF09238
(IL4Ra_N)
4 LEU A 139
VAL A 107
LEU A 166
TYR A 141
None
1.03A 3v81A-4nzdA:
undetectable
3v81A-4nzdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN


(Helicobacter
pylori)
no annotation 4 LEU A 318
TYR A 336
LEU A 342
TYR A 315
None
1.00A 3v81A-4o5jA:
undetectable
3v81A-4o5jA:
22.05