SIMILAR PATTERNS OF AMINO ACIDS FOR 3V7P_A_BEZA430

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 142
SER A 141
PHE A 192
LEU A 190
 None
 0.89A 3v7pA-1a2vA:
0.2		 3v7pA-1a2vA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		4 ILE A 115
GLY A  38
SER A  37
SER A  36
 None
None
WO4  A 250 ( 2.7A)
None
 0.85A 3v7pA-1atgA:
0.0		 3v7pA-1atgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		5 ILE A 350
GLY A 351
SER A 384
PHE A 394
LEU A 431
 None
 1.46A 3v7pA-1clwA:
0.9		 3v7pA-1clwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		4 ILE A 182
GLY A 183
PHE A  18
PHE A  17
 None
 0.74A 3v7pA-1dqpA:
0.2		 3v7pA-1dqpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dut DUTP PYROPHOSPHATASE

(Feline
immunodeficiency
virus) 		PF00692
(dUTPase) 		4 ILE A  58
GLY A  59
SER A  60
SER A  57
 None
 0.90A 3v7pA-1dutA:
0.0		 3v7pA-1dutA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emy MYOGLOBIN

(Elephas maximus) 		PF00042
(Globin) 		4 ILE A  99
PHE A  29
PHE A  33
LEU A  32
 HEM  A 154 (-4.1A)
CYN  A 155 ( 4.9A)
None
None
 0.86A 3v7pA-1emyA:
undetectable		 3v7pA-1emyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		4 ILE C 196
SER C 198
PHE C  22
LEU C 158
 None
 0.74A 3v7pA-1g3nC:
undetectable		 3v7pA-1g3nC:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ILE B 179
PHE B 236
PHE B 242
LEU B 240
 None
 0.88A 3v7pA-1gl9B:
0.2		 3v7pA-1gl9B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20
CASPASE-7 SUBUNIT
P11

(Homo sapiens;
Homo sapiens) 		PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14) 		4 ILE B 258
PHE A 101
PHE A 106
LEU A 104
 None
 0.78A 3v7pA-1i51B:
undetectable		 3v7pA-1i51B:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ILE A 258
PHE A 101
PHE A 106
LEU A 104
 None
 0.79A 3v7pA-1k86A:
0.3		 3v7pA-1k86A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 999
PHE A 979
PHE A 984
LEU A1007
 None
 0.89A 3v7pA-1kcwA:
undetectable		 3v7pA-1kcwA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 ILE A  21
GLY A  18
SER A 233
PHE A 196
 None
 0.84A 3v7pA-1khoA:
undetectable		 3v7pA-1khoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 GLY A 228
PHE A 166
PHE A 190
LEU A 194
 None
 0.77A 3v7pA-1lgfA:
undetectable		 3v7pA-1lgfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdc INSECT FATTY ACID
BINDING PROTEIN

(Manduca sexta) 		PF00061
(Lipocalin) 		5 ILE A  73
GLY A  74
PHE A  18
PHE A  15
LEU A  19
 PLM  A 133 ( 4.9A)
PLM  A 133 ( 4.1A)
None
None
None
 1.11A 3v7pA-1mdcA:
undetectable		 3v7pA-1mdcA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		4 GLY A 282
SER A 281
SER A 252
PHE A 162
 None
 0.77A 3v7pA-1mzhA:
6.1		 3v7pA-1mzhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nln ADENAIN

(Human
mastadenovirus
C) 		PF00770
(Peptidase_C5) 		4 GLY A   2
SER A   3
PHE A 185
LEU A 124
 None
 0.79A 3v7pA-1nlnA:
undetectable		 3v7pA-1nlnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 339
GLY A 338
PHE A 383
LEU A 335
 None
 0.82A 3v7pA-1o5zA:
undetectable		 3v7pA-1o5zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6u SEC14-LIKE PROTEIN 2

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 ILE A 264
GLY A 110
SER A 114
LEU A 120
 None
 0.78A 3v7pA-1o6uA:
undetectable		 3v7pA-1o6uA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p33 PTERIDINE REDUCTASE
1

(Leishmania
tarentolae) 		PF13561
(adh_short_C2) 		5 ILE A  22
GLY A  19
SER A  20
SER A  21
LEU A  47
 None
 1.17A 3v7pA-1p33A:
2.9		 3v7pA-1p33A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 454
GLY A 455
SER A 456
PHE A 422
LEU A 418
 None
None
HEA  A 601 ( 4.3A)
None
None
 1.23A 3v7pA-1qleA:
undetectable		 3v7pA-1qleA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		5 ILE A 347
GLY A 348
SER A 350
PHE A 397
LEU A 393
 None
 1.19A 3v7pA-1r55A:
undetectable		 3v7pA-1r55A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		5 ILE A 347
GLY A 348
SER A 350
PHE A 397
PHE A 396
 None
 1.04A 3v7pA-1r55A:
undetectable		 3v7pA-1r55A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 ILE B 298
GLY B 325
SER B 273
PHE B 286
LEU B 331
 None
 1.33A 3v7pA-1tnuB:
undetectable		 3v7pA-1tnuB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttx ONCOMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A  51
PHE A  30
PHE A  31
LEU A  36
 None
 0.68A 3v7pA-1ttxA:
undetectable		 3v7pA-1ttxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		4 ILE A 396
GLY A 397
SER A 398
PHE A 390
 None
 0.81A 3v7pA-1w2dA:
undetectable		 3v7pA-1w2dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		4 ILE A 332
GLY A 331
PHE A 593
LEU A 580
 None
 0.90A 3v7pA-1w8jA:
undetectable		 3v7pA-1w8jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ww6 GALECTIN

(Agrocybe
cylindracea) 		PF00337
(Gal-bind_lectin) 		4 ILE A  97
GLY A  98
SER A  99
LEU A  36
 None
 0.90A 3v7pA-1ww6A:
undetectable		 3v7pA-1ww6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		4 ILE A 126
GLY A 123
PHE A  93
LEU A 160
 None
 0.80A 3v7pA-1xdnA:
undetectable		 3v7pA-1xdnA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 ILE A 461
GLY A 462
SER A 463
SER A 460
 None
 0.89A 3v7pA-1z45A:
undetectable		 3v7pA-1z45A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  35
GLY A  13
SER A  14
PHE A 107
LEU A  41
 None
FAD  A4750 (-3.4A)
FAD  A4750 ( 4.1A)
None
None
 1.42A 3v7pA-1zy8A:
undetectable		 3v7pA-1zy8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zz3 HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE

(Alcaligenaceae
bacterium FB188) 		PF00850
(Hist_deacetyl) 		5 ILE A  56
GLY A  54
SER A  53
PHE A  46
LEU A 322
 None
 1.10A 3v7pA-1zz3A:
undetectable		 3v7pA-1zz3A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 ILE A 873
GLY A 874
SER A 875
PHE A 867
 None
 0.82A 3v7pA-2aqxA:
undetectable		 3v7pA-2aqxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzg THIOPURINE
S-METHYLTRANSFERASE

(Homo sapiens) 		PF05724
(TPMT) 		4 GLY A 126
PHE A  99
PHE A 100
LEU A 105
 None
 0.75A 3v7pA-2bzgA:
undetectable		 3v7pA-2bzgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0d THIOREDOXIN
PEROXIDASE 2

(Plasmodium
falciparum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 ILE A  41
GLY A  33
PHE A  48
LEU A  89
 None
 0.75A 3v7pA-2c0dA:
undetectable		 3v7pA-2c0dA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 303
GLY A 304
SER A 301
LEU A 339
 None
 0.87A 3v7pA-2chrA:
6.4		 3v7pA-2chrA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A 200
GLY A 205
SER A 204
SER A 203
 None
 0.90A 3v7pA-2cvzA:
undetectable		 3v7pA-2cvzA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 GLY A  72
SER A 253
PHE A 309
LEU A  97
 None
None
None
GOL  A 503 (-4.5A)
 0.88A 3v7pA-2de2A:
undetectable		 3v7pA-2de2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		4 GLY A  11
SER A  10
SER A   7
LEU A  47
 None
 0.81A 3v7pA-2dg6A:
undetectable		 3v7pA-2dg6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLY A 185
PHE A 386
PHE A 437
LEU A 417
 None
 0.88A 3v7pA-2exrA:
undetectable		 3v7pA-2exrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		4 GLY A 121
PHE A  94
PHE A  95
LEU A 100
 None
 0.81A 3v7pA-2gb4A:
undetectable		 3v7pA-2gb4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 303
GLY A 304
SER A 301
LEU A 339
 None
 0.80A 3v7pA-2ggjA:
5.6		 3v7pA-2ggjA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		4 ILE A 145
GLY A 146
PHE A 259
LEU A 262
 None
 0.90A 3v7pA-2h39A:
undetectable		 3v7pA-2h39A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		4 GLY A  91
PHE A 190
PHE A 191
LEU A 196
 None
 0.74A 3v7pA-2i3fA:
undetectable		 3v7pA-2i3fA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kte UNCHARACTERIZED
PROTEIN YNDB

(Bacillus
subtilis) 		PF08327
(AHSA1) 		4 ILE A  35
GLY A  34
PHE A  98
LEU A 138
 None
 0.88A 3v7pA-2kteA:
undetectable		 3v7pA-2kteA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lte SPECIALIZED ACYL
CARRIER PROTEIN

(Pseudomonas
aeruginosa) 		PF00550
(PP-binding) 		4 GLY A  40
SER A  39
SER A  36
LEU A  55
 None
 0.87A 3v7pA-2lteA:
undetectable		 3v7pA-2lteA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1b TRANSCRIPTIONAL
REGULATORY PROTEIN,
C TERMINAL FAMILY
PROTEIN

(Chlamydia
trachomatis) 		PF00486
(Trans_reg_C) 		4 GLY A  36
SER A  35
SER A  33
LEU A  19
 None
 0.82A 3v7pA-2m1bA:
undetectable		 3v7pA-2m1bA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		4 GLY A 247
SER A 246
PHE A  87
LEU A  83
 None
 0.74A 3v7pA-2nq2A:
undetectable		 3v7pA-2nq2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		4 GLY A  50
PHE A 305
PHE A 323
LEU A 255
 CL  A 503 ( 3.8A)
None
None
None
 0.89A 3v7pA-2o6iA:
undetectable		 3v7pA-2o6iA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 SER X 134
SER X 131
PHE X 193
LEU X 290
 None
 0.80A 3v7pA-2p4hX:
2.8		 3v7pA-2p4hX:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdx FERREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A  41
PHE A  20
PHE A  22
LEU A  83
 None
 0.88A 3v7pA-2qdxA:
undetectable		 3v7pA-2qdxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 GLY A 192
PHE A 401
PHE A 452
LEU A 433
 None
 0.89A 3v7pA-2qpmA:
undetectable		 3v7pA-2qpmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 426
GLY A 427
PHE A 441
PHE A 440
 None
 0.68A 3v7pA-2r6fA:
undetectable		 3v7pA-2r6fA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLY A 265
PHE A 338
PHE A 337
LEU A 312
 None
 0.89A 3v7pA-2v55A:
undetectable		 3v7pA-2v55A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 681
GLY A 736
SER A 616
PHE A 713
 None
 0.88A 3v7pA-2v9yA:
undetectable		 3v7pA-2v9yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A 131
GLY A  74
PHE A 144
LEU A 148
 None
 0.84A 3v7pA-2vdcA:
2.7		 3v7pA-2vdcA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsk HEMAGGLUTININ-NEURAM
INIDASE

(Hendra
henipavirus) 		PF00423
(HN) 		4 ILE A 356
GLY A 355
SER A 354
PHE A 512
 None
 0.79A 3v7pA-2vskA:
undetectable		 3v7pA-2vskA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE

(Nipah
henipavirus) 		PF00423
(HN) 		4 ILE A 356
GLY A 355
SER A 354
PHE A 512
 None
 0.82A 3v7pA-2vsmA:
undetectable		 3v7pA-2vsmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		4 GLY A 453
SER A 313
PHE A 487
PHE A 488
 None
 0.73A 3v7pA-2xutA:
undetectable		 3v7pA-2xutA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 540
GLY A 544
PHE A 564
LEU A 578
 None
 0.85A 3v7pA-3a2fA:
undetectable		 3v7pA-3a2fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bro TRANSCRIPTIONAL
REGULATOR

(Oenococcus oeni) 		PF12802
(MarR_2) 		4 GLY A  83
SER A  82
SER A  86
LEU A  49
 None
 0.89A 3v7pA-3broA:
undetectable		 3v7pA-3broA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cky 2-HYDROXYMETHYL
GLUTARATE
DEHYDROGENASE

(Eubacterium
barkeri) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ILE A 209
GLY A 214
SER A 213
SER A 212
 None
 0.85A 3v7pA-3ckyA:
undetectable		 3v7pA-3ckyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 GLY A 441
SER A 440
PHE A 466
LEU A 140
 None
 0.88A 3v7pA-3ckzA:
undetectable		 3v7pA-3ckzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		4 ILE A  76
GLY A 106
PHE A  92
LEU A 103
 None
 0.75A 3v7pA-3d8uA:
undetectable		 3v7pA-3d8uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY B 133
SER B 134
PHE B 258
PHE B 241
 PO4  B 323 (-3.9A)
PO4  B 323 (-3.4A)
None
None
 0.83A 3v7pA-3dm9B:
undetectable		 3v7pA-3dm9B:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A 228
GLY A 229
PHE A 325
LEU A 301
 None
 0.87A 3v7pA-3eb0A:
undetectable		 3v7pA-3eb0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ILE A 865
GLY A 866
SER A 863
PHE A 960
LEU A 964
 None
 1.39A 3v7pA-3f2bA:
undetectable		 3v7pA-3f2bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 ILE A 219
GLY A 203
PHE A 237
LEU A 241
 None
None
ATP  A 407 ( 4.8A)
None
 0.89A 3v7pA-3fhxA:
2.7		 3v7pA-3fhxA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 556
SER A 559
PHE A 567
LEU A 564
 None
 0.90A 3v7pA-3fxiA:
undetectable		 3v7pA-3fxiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD
CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis;
Bacillus
anthracis) 		no annotation
no annotation 		4 ILE L 195
PHE S 375
PHE S 385
LEU L  88
 None
 0.85A 3v7pA-3g9kL:
undetectable		 3v7pA-3g9kL:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u CEMENTING PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 GLY H  12
SER H  10
SER H 120
PHE H  60
 None
 0.83A 3v7pA-3j4uH:
undetectable		 3v7pA-3j4uH:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jab GAFB DOMAIN OF
PHOSPHODIESTERASE 2A

(Bos taurus) 		PF01590
(GAF) 		4 ILE B 507
GLY B 545
SER B 541
LEU B 403
 None
 0.88A 3v7pA-3jabB:
undetectable		 3v7pA-3jabB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljl TRANSCRIPTIONAL
REGULATOR LUXT

(Vibrio
parahaemolyticus) 		PF00440
(TetR_N) 		4 ILE A  88
SER A  86
SER A  84
LEU A  74
 None
 0.89A 3v7pA-3ljlA:
undetectable		 3v7pA-3ljlA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 ILE A 160
GLY A 157
PHE A 193
LEU A 144
 None
 0.82A 3v7pA-3lk6A:
undetectable		 3v7pA-3lk6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		5 ILE A  34
GLY A  33
PHE A 270
PHE A 249
LEU A 231
 None
 1.16A 3v7pA-3n5lA:
undetectable		 3v7pA-3n5lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 ILE A 470
GLY A 443
PHE A 156
LEU A 428
 None
 0.81A 3v7pA-3n6xA:
undetectable		 3v7pA-3n6xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 4 ILE A 165
GLY A 166
SER A 139
PHE A 130
 None
 0.77A 3v7pA-3n6zA:
undetectable		 3v7pA-3n6zA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncp NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2)

(Archaeoglobus
fulgidus) 		PF00543
(P-II) 		4 ILE A  74
GLY A  75
PHE A  25
LEU A  20
 None
 0.88A 3v7pA-3ncpA:
undetectable		 3v7pA-3ncpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4y CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
vivax) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 GLY A  85
SER A  84
PHE A 112
LEU A  57
 None
 0.75A 3v7pA-3o4yA:
undetectable		 3v7pA-3o4yA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 248
GLY A 303
SER A 187
PHE A 280
 None
 0.89A 3v7pA-3p4eA:
undetectable		 3v7pA-3p4eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 ILE A 263
GLY A 264
SER A 217
LEU A 209
 None
 0.83A 3v7pA-3p8tA:
undetectable		 3v7pA-3p8tA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 989
GLY A 953
SER A 952
SER A 993
 None
 0.75A 3v7pA-3psfA:
undetectable		 3v7pA-3psfA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 ILE A 989
GLY A 953
SER A 952
SER A 993
 None
 0.87A 3v7pA-3psiA:
undetectable		 3v7pA-3psiA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 252
GLY A 307
SER A 186
PHE A 284
 None
 0.84A 3v7pA-3qtyA:
undetectable		 3v7pA-3qtyA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLY A 253
PHE A 268
PHE A 239
LEU A 235
 None
 0.89A 3v7pA-3rg1A:
undetectable		 3v7pA-3rg1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 230
GLY A 229
PHE A 247
LEU A 277
 None
 0.90A 3v7pA-3rj8A:
undetectable		 3v7pA-3rj8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Bacillus
anthracis) 		PF04321
(RmlD_sub_bind) 		4 ILE A 182
GLY A 183
SER A 184
SER A 214
 None
 0.74A 3v7pA-3sc6A:
2.4		 3v7pA-3sc6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 GLY A 159
SER A 156
PHE A 273
LEU A 274
 None
NAD  A 300 ( 3.9A)
None
None
 0.89A 3v7pA-3sx2A:
3.9		 3v7pA-3sx2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		5 GLY A  75
SER A  74
SER A  72
PHE A  67
LEU A  44
 None
 1.17A 3v7pA-3sy8A:
3.0		 3v7pA-3sy8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 GLY A 253
PHE A 268
PHE A 239
LEU A 235
 None
 0.68A 3v7pA-3t6qA:
undetectable		 3v7pA-3t6qA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		5 ILE A 119
GLY A  71
SER A  73
SER A  70
LEU A  61
 None
 1.28A 3v7pA-3v2iA:
undetectable		 3v7pA-3v2iA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		6 ILE A 143
GLY A 144
SER A 145
SER A 183
PHE A 224
PHE A 228
 BEZ  A 430 (-4.5A)
BEZ  A 430 ( 3.7A)
BEZ  A 430 (-2.7A)
BEZ  A 430 (-4.8A)
None
BEZ  A 430 ( 4.6A)
 1.40A 3v7pA-3v7pA:
75.4		 3v7pA-3v7pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		7 ILE A 143
GLY A 144
SER A 145
SER A 183
PHE A 227
PHE A 228
LEU A 232
 BEZ  A 430 (-4.5A)
BEZ  A 430 ( 3.7A)
BEZ  A 430 (-2.7A)
BEZ  A 430 (-4.8A)
BEZ  A 430 ( 4.8A)
BEZ  A 430 ( 4.6A)
BEZ  A 430 (-4.5A)
 0.02A 3v7pA-3v7pA:
75.4		 3v7pA-3v7pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6d LYSOZYME-LIKE
CHITINOLYTIC ENZYME

(Ralstonia sp.
A-471) 		no annotation 5 ILE A 196
GLY A 193
SER A 194
PHE A 130
LEU A 134
 NAG  A 302 ( 4.7A)
None
None
None
None
 1.42A 3v7pA-3w6dA:
undetectable		 3v7pA-3w6dA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY A 460
SER A 459
SER A 457
PHE A 567
 None
NAG  A 703 (-4.7A)
None
None
 0.86A 3v7pA-3wkyA:
undetectable		 3v7pA-3wkyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		4 ILE A  84
GLY A  83
PHE A 214
PHE A 210
 None
 0.71A 3v7pA-3wwpA:
undetectable		 3v7pA-3wwpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ILE A 238
GLY A 237
PHE A 221
LEU A 120
 None
 0.74A 3v7pA-4a5qA:
3.5		 3v7pA-4a5qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ILE A 376
GLY A 504
SER A 505
PHE A 450
LEU A 448
 None
 1.27A 3v7pA-4av6A:
undetectable		 3v7pA-4av6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 GLY A 440
SER A 439
PHE A 465
LEU A 140
 None
 0.90A 3v7pA-4b7jA:
undetectable		 3v7pA-4b7jA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 GLY A 389
SER A 388
SER A 385
LEU A 361
 None
 0.80A 3v7pA-4c1sA:
undetectable		 3v7pA-4c1sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7o SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ILE A 294
GLY A 256
PHE A 285
LEU A 247
 None
 0.82A 3v7pA-4c7oA:
undetectable		 3v7pA-4c7oA:
22.97