SIMILAR PATTERNS OF AMINO ACIDS FOR 3V5W_A_8PRA701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  62
GLY A  65
GLY A  68
VAL A  70
ALA A  83
LYS A  85
 None
 0.78A 3v5wA-1gngA:
8.9		 3v5wA-1gngA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 161
GLY A 164
VAL A 166
ALA A 179
LYS A 181
LEU A 183
 None
 0.63A 3v5wA-1gzkA:
10.2		 3v5wA-1gzkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 414
VAL A 416
ALA A 428
VAL A 458
LEU A 528
SER A 538
ASP A 539
 None
 1.02A 3v5wA-1k2pA:
8.3		 3v5wA-1k2pA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
LYS A 222
VAL A 249
LEU A 321
 None
 1.23A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.25A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
LYS A 222
VAL A 249
ASP A 332
 None
 1.04A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.33A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 580
GLY A 583
GLY A 586
VAL A 588
ALA A 606
LYS A 608
 None
 0.71A 3v5wA-1lufA:
7.9		 3v5wA-1lufA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ILE A 211
GLY A 214
GLY A 217
VAL A 219
ALA A 230
LYS A 232
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.95A 3v5wA-1py5A:
6.8		 3v5wA-1py5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
ASP A 169
 None
 0.80A 3v5wA-1u5qA:
10.3		 3v5wA-1u5qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A  16
VAL A  18
ALA A  30
VAL A  63
LEU A 132
ASP A 143
 None
 0.80A 3v5wA-1v0bA:
9.2		 3v5wA-1v0bA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
VAL A  68
LEU A 137
SER A 147
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.79A 3v5wA-1zltA:
8.2		 3v5wA-1zltA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		7 ILE A  18
GLY A  21
GLY A  24
ALA A  39
LYS A  41
LEU A 138
ASP A 154
 CKI  A 300 (-4.1A)
None
None
CKI  A 300 (-3.6A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 0.77A 3v5wA-2csnA:
24.3		 3v5wA-2csnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  20
GLY X  23
VAL X  25
ALA X  37
LYS X  39
ASP X 148
 None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-3.6A)
 0.70A 3v5wA-2dq7X:
8.4		 3v5wA-2dq7X:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  20
GLY X  23
VAL X  25
ALA X  37
LYS X  39
VAL X  67
 None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
 0.69A 3v5wA-2dq7X:
8.4		 3v5wA-2dq7X:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
ASP A 169
 STU  A 400 (-4.2A)
None
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-3.6A)
 0.64A 3v5wA-2gcdA:
11.1		 3v5wA-2gcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
 STU  A 400 (-4.2A)
None
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
 0.67A 3v5wA-2gcdA:
11.1		 3v5wA-2gcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  30
ALA A  43
LYS A  45
VAL A  77
ASP A 157
 None
 0.83A 3v5wA-2h34A:
10.8		 3v5wA-2h34A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
 None
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
 0.69A 3v5wA-2h8hA:
7.2		 3v5wA-2h8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ASP A 404
 None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 1.02A 3v5wA-2hckA:
8.6		 3v5wA-2hckA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
GLY A 254
VAL A 256
ALA A 269
LYS A 271
VAL A 299
LEU A 370
 None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
 0.97A 3v5wA-2hz0A:
6.3		 3v5wA-2hz0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
VAL A 484
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
 0.81A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
VAL A 484
LEU A 553
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.4A)
 1.07A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
VAL A 399
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 0.91A 3v5wA-2ozoA:
8.3		 3v5wA-2ozoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
VAL B  98
LEU B 171
 None
 1.08A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
 None
 0.72A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
ANP  A1480 ( 3.8A)
None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
 0.82A 3v5wA-2v55A:
10.9		 3v5wA-2v55A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 ILE A 490
GLY A 493
GLY A 496
VAL A 498
ALA A 509
LYS A 511
ASP A 687
 None
None
None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
IOD  A1799 (-4.0A)
 0.60A 3v5wA-2vuwA:
17.1		 3v5wA-2vuwA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  58
GLY C  61
VAL C  63
ALA C  76
LEU C 183
SER C 193
 ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.73A 3v5wA-2wtkC:
10.3		 3v5wA-2wtkC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
GLY A 630
GLY A 633
VAL A 635
ALA A 651
LYS A 653
 None
None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
 0.57A 3v5wA-2xyuA:
21.8		 3v5wA-2xyuA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  30
GLY A  33
VAL A  38
ALA A  51
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
None
None
B49  A1294 (-3.2A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 1.05A 3v5wA-2y7jA:
10.9		 3v5wA-2y7jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 100
GLY A 103
VAL A 105
ALA A 121
LEU A 125
VAL A 156
 None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
 0.75A 3v5wA-3a62A:
11.6		 3v5wA-3a62A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 490
GLY A 493
VAL A 495
ALA A 515
LEU A 633
ASP A 644
 M33  A1996 (-3.0A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.86A 3v5wA-3b2tA:
25.9		 3v5wA-3b2tA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
LYS A 222
VAL A 249
LEU A 321
 None
 1.23A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.25A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
LYS A 222
VAL A 249
ASP A 332
 None
 1.04A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.33A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 155
 DRK  A   1 (-4.2A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
 0.58A 3v5wA-3f3zA:
10.8		 3v5wA-3f3zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 209
GLY A 212
GLY A 215
VAL A 217
ALA A 228
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.6A)
None
 1.06A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 209
GLY A 212
VAL A 217
ALA A 228
LYS A 230
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-4.6A)
 0.70A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 104
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 160
 GMG  A   1 (-4.3A)
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
None
 0.78A 3v5wA-3hdnA:
10.9		 3v5wA-3hdnA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  16
GLY A  19
GLY A  22
VAL A  24
ALA A  37
LYS A  39
 ANP  A 329 ( 4.2A)
ANP  A 329 (-3.3A)
None
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
 0.68A 3v5wA-3hkoA:
9.6		 3v5wA-3hkoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 205
 ANP  A 610 (-2.9A)
ANP  A 610 (-4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
None
 0.77A 3v5wA-3igoA:
10.7		 3v5wA-3igoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 683
VAL A 689
ALA A 700
LYS A 702
LEU A 804
SER A 827
 ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.4A)
ADP  A2101 ( 4.4A)
 0.82A 3v5wA-3lj0A:
7.8		 3v5wA-3lj0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 GLY A 561
GLY A 564
VAL A 566
ALA A 579
LYS A 581
VAL A 614
LEU A 684
 ANP  A 877 (-3.3A)
ANP  A 877 (-3.9A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.94A 3v5wA-3lltA:
8.0		 3v5wA-3lltA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LEU A 723
LEU A 820
ASP A 831
 None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
None
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
 1.13A 3v5wA-3lzbA:
7.5		 3v5wA-3lzbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LYS A 721
LEU A 723
ASP A 831
 None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
None
ITI  A   1 ( 4.6A)
 1.11A 3v5wA-3lzbA:
7.5		 3v5wA-3lzbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
ASP A 184
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.85A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
VAL A 104
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.79A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  36
GLY A  39
GLY A  42
VAL A  44
ALA A  57
LYS A  59
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.0A)
ANP  A 430 (-3.9A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 (-4.4A)
 0.91A 3v5wA-3nieA:
7.4		 3v5wA-3nieA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 GLY A  32
GLY A  35
VAL A  37
ALA A  49
LYS A  51
VAL A  82
LEU A 151
 ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 (-4.6A)
 0.90A 3v5wA-3nizA:
27.3		 3v5wA-3nizA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 GLY A 196
GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
ASP A 329
 None
None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.0A)
 1.25A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
LEU A 318
 None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.89A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		6 GLY A 159
GLY A 162
VAL A 164
ALA A 177
LYS A 179
LEU A 181
 GLY  A 159 ( 0.0A)
GLY  A 162 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
 0.58A 3v5wA-3o96A:
29.3		 3v5wA-3o96A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A1088
GLY A1091
GLY A1094
VAL A1096
ALA A1112
ASP A1226
 ANP  A1358 (-4.3A)
ANP  A1358 (-3.4A)
None
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
MG  A   1 ( 3.2A)
 0.79A 3v5wA-3plsA:
7.2		 3v5wA-3plsA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
GLY A 560
GLY A 563
ALA A 576
LYS A 578
VAL A 609
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.99A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 580
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
 0.71A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.94A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
 0.81A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
ASP A 218
 None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
EDO  A 417 (-3.7A)
 0.80A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 364
GLY A 367
VAL A 369
ALA A 382
LYS A 384
LEU A 386
 None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.84A 3v5wA-3txoA:
5.6		 3v5wA-3txoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
ASP A 143
 None
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.77A 3v5wA-3zduA:
7.8		 3v5wA-3zduA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
VAL A  64
 D15  A 500 (-4.2A)
D15  A 500 (-3.6A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
 0.82A 3v5wA-4aguA:
11.0		 3v5wA-4aguA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  16
VAL A  18
ALA A  31
LYS A  33
VAL A  64
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.5A)
 1.09A 3v5wA-4aguA:
11.0		 3v5wA-4aguA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
GLY A  86
GLY A  89
VAL A  91
ALA A 104
LYS A 106
LEU A 108
ASP A 219
 None
None
None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-4.2A)
None
 0.65A 3v5wA-4aw2A:
11.1		 3v5wA-4aw2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  64
GLY A  67
VAL A  69
ALA A  82
LYS A  84
LEU A 189
 None
None
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.5A)
 0.85A 3v5wA-4b99A:
25.7		 3v5wA-4b99A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 220
VAL A 222
ALA A 233
LYS A 235
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 3v5wA-4c02A:
7.5		 3v5wA-4c02A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 666
GLY A 669
ALA A 684
LYS A 686
LEU A 688
VAL A 721
ASP A 800
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 ( 3.3A)
 0.99A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
LEU A 688
VAL A 721
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.90A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
GLY A 573
VAL A 575
ALA A 588
LYS A 590
ASP A 701
 GUI  A 901 (-4.0A)
None
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 ( 4.1A)
 0.79A 3v5wA-4e93A:
8.0		 3v5wA-4e93A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
GLY A  67
VAL A  72
ALA A  88
LYS A  90
ASP A 196
 None
ADP  A 601 (-3.7A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
MG  A 602 ( 3.1A)
 0.61A 3v5wA-4f99A:
7.4		 3v5wA-4f99A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
VAL A  72
ALA A  88
LYS A  90
LEU A  92
ASP A 196
 None
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
MG  A 602 ( 3.1A)
 0.76A 3v5wA-4f99A:
7.4		 3v5wA-4f99A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  34
ALA A  47
LYS A  49
VAL A  79
LEU A 148
SER A 161
 ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
ATP  A 401 (-2.8A)
 0.77A 3v5wA-4fg8A:
9.1		 3v5wA-4fg8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		9 GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
VAL A 379
LEU A 447
SER A 457
ASP A 458
 ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.86A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		8 ILE A 327
GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
SER A 457
ASP A 458
 None
ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.85A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 GLY A 380
GLY A 383
VAL A 385
ALA A 400
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.78A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 383
VAL A 385
ALA A 400
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.82A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 1.04A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.93A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
LYS A  52
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.70A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
VAL A  84
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.79A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 159
GLY A 162
VAL A 164
ALA A 177
LYS A 179
LEU A 181
ASP A 292
 0XZ  A 501 (-4.1A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-4.9A)
0XZ  A 501 ( 3.4A)
 0.71A 3v5wA-4gv1A:
12.4		 3v5wA-4gv1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 831
GLY A 834
VAL A 836
ALA A 853
LYS A 855
VAL A 884
 19S  A1201 ( 4.3A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
 0.77A 3v5wA-4hviA:
7.4		 3v5wA-4hviA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 135
GLY A 138
VAL A 140
ALA A 156
LYS A 158
LEU A 259
 None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.6A)
 0.79A 3v5wA-4id7A:
24.1		 3v5wA-4id7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
VAL A 323
ASP A 404
 None
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 (-3.1A)
 0.95A 3v5wA-4k11A:
7.2		 3v5wA-4k11A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
VAL A 323
LEU A 393
ASP A 404
 None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 1.09A 3v5wA-4k11A:
7.2		 3v5wA-4k11A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 416
GLY A 419
VAL A 421
ALA A 434
VAL A 465
LEU A 533
SER A 543
ASP A 544
 None
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.95A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 416
VAL A 421
ALA A 434
LYS A 436
VAL A 465
LEU A 533
SER A 543
 None
None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.92A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
GLY A 416
GLY A 419
VAL A 421
ALA A 434
SER A 543
ASP A 544
 B49  A 701 (-4.2A)
None
None
None
B49  A 701 (-3.2A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.83A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 413
GLY A 416
VAL A 421
ALA A 434
LYS A 436
SER A 543
 B49  A 701 (-4.2A)
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.0A)
 0.84A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		11 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
LEU A 324
SER A 334
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 ( 4.3A)
 0.47A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		11 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
SER A 334
ASP A 335
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
29X  A 702 ( 4.3A)
 0.61A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
GLY A 203
VAL A 205
ALA A 218
VAL A 255
SER A 334
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 1.26A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  81
GLY A  84
VAL A  86
ALA A  99
LYS A 101
VAL A 130
 STU  A 601 (-3.9A)
None
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
 0.83A 3v5wA-4mvfA:
22.6		 3v5wA-4mvfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
LEU B 151
 ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
 0.65A 3v5wA-4o27B:
10.1		 3v5wA-4o27B:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		7 ILE A  19
GLY A  22
GLY A  25
VAL A  27
ALA A  40
LYS A  42
ASP A 159
 None
 0.80A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 ILE A  19
GLY A  25
VAL A  27
ALA A  40
LEU A  44
ASP A 159
 None
 0.84A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 392
VAL A 394
ALA A 407
LYS A 409
LEU A 411
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.83A 3v5wA-4q9zA:
37.4		 3v5wA-4q9zA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ILE A  27
GLY A  30
GLY A  33
VAL A  35
ALA A  49
LYS A  51
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.4A)
None
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-4.6A)
 0.92A 3v5wA-4qnyA:
7.9		 3v5wA-4qnyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  48
GLY A  54
VAL A  56
ALA A  69
LYS A  71
LEU A 173
 38Z  A 418 ( 4.4A)
None
None
38Z  A 418 (-3.4A)
38Z  A 418 (-2.9A)
38Z  A 418 (-4.4A)
 0.86A 3v5wA-4qtbA:
8.7		 3v5wA-4qtbA:
22.16