SIMILAR PATTERNS OF AMINO ACIDS FOR 3V5W_A_8PRA701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  62
GLY A  65
GLY A  68
VAL A  70
ALA A  83
LYS A  85
 None
 0.78A 3v5wA-1gngA:
8.9		 3v5wA-1gngA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 161
GLY A 164
VAL A 166
ALA A 179
LYS A 181
LEU A 183
 None
 0.63A 3v5wA-1gzkA:
10.2		 3v5wA-1gzkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 414
VAL A 416
ALA A 428
VAL A 458
LEU A 528
SER A 538
ASP A 539
 None
 1.02A 3v5wA-1k2pA:
8.3		 3v5wA-1k2pA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
LYS A 222
VAL A 249
LEU A 321
 None
 1.23A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.25A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
LYS A 222
VAL A 249
ASP A 332
 None
 1.04A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.33A 3v5wA-1k9aA:
8.3		 3v5wA-1k9aA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 580
GLY A 583
GLY A 586
VAL A 588
ALA A 606
LYS A 608
 None
 0.71A 3v5wA-1lufA:
7.9		 3v5wA-1lufA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ILE A 211
GLY A 214
GLY A 217
VAL A 219
ALA A 230
LYS A 232
LEU A 340
ASP A 351
 PY1  A 700 (-3.6A)
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.95A 3v5wA-1py5A:
6.8		 3v5wA-1py5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
ASP A 169
 None
 0.80A 3v5wA-1u5qA:
10.3		 3v5wA-1u5qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A  16
VAL A  18
ALA A  30
VAL A  63
LEU A 132
ASP A 143
 None
 0.80A 3v5wA-1v0bA:
9.2		 3v5wA-1v0bA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
VAL A  68
LEU A 137
SER A 147
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.5A)
 0.79A 3v5wA-1zltA:
8.2		 3v5wA-1zltA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		7 ILE A  18
GLY A  21
GLY A  24
ALA A  39
LYS A  41
LEU A 138
ASP A 154
 CKI  A 300 (-4.1A)
None
None
CKI  A 300 (-3.6A)
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 0.77A 3v5wA-2csnA:
24.3		 3v5wA-2csnA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  20
GLY X  23
VAL X  25
ALA X  37
LYS X  39
ASP X 148
 None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-3.6A)
 0.70A 3v5wA-2dq7X:
8.4		 3v5wA-2dq7X:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  20
GLY X  23
VAL X  25
ALA X  37
LYS X  39
VAL X  67
 None
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
 0.69A 3v5wA-2dq7X:
8.4		 3v5wA-2dq7X:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
ASP A 169
 STU  A 400 (-4.2A)
None
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-3.6A)
 0.64A 3v5wA-2gcdA:
11.1		 3v5wA-2gcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
 STU  A 400 (-4.2A)
None
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
 0.67A 3v5wA-2gcdA:
11.1		 3v5wA-2gcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h34 SERINE/THREONINE-PRO
TEIN KINASE PKNE

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  30
ALA A  43
LYS A  45
VAL A  77
ASP A 157
 None
 0.83A 3v5wA-2h34A:
10.8		 3v5wA-2h34A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
 None
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
 0.69A 3v5wA-2h8hA:
7.2		 3v5wA-2h8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 276
GLY A 279
VAL A 281
ALA A 293
VAL A 323
LEU A 393
ASP A 404
 None
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
None
 1.02A 3v5wA-2hckA:
8.6		 3v5wA-2hckA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 251
GLY A 254
VAL A 256
ALA A 269
LYS A 271
VAL A 299
LEU A 370
 None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
 0.97A 3v5wA-2hz0A:
6.3		 3v5wA-2hz0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
LYS A 454
VAL A 484
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
 0.81A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
GLY A 431
GLY A 434
VAL A 436
ALA A 452
VAL A 484
LEU A 553
 4ST  A1687 (-4.2A)
None
None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
None
4ST  A1687 (-4.4A)
 1.07A 3v5wA-2j0jA:
8.9		 3v5wA-2j0jA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 GLY A 347
GLY A 350
VAL A 352
ALA A 367
LYS A 369
VAL A 399
LEU A 468
SER A 478
ASP A 479
 ANP  A 615 (-3.6A)
None
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 (-4.7A)
MG  A 614 ( 4.1A)
MG  A 614 ( 3.2A)
 0.91A 3v5wA-2ozoA:
8.3		 3v5wA-2ozoA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
VAL B  98
LEU B 171
 None
 1.08A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		6 ILE B  47
GLY B  50
GLY B  53
VAL B  55
ALA B  67
LYS B  69
 None
 0.72A 3v5wA-2qkwB:
22.7		 3v5wA-2qkwB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
ANP  A1480 ( 3.8A)
None
None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
 0.82A 3v5wA-2v55A:
10.9		 3v5wA-2v55A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		7 ILE A 490
GLY A 493
GLY A 496
VAL A 498
ALA A 509
LYS A 511
ASP A 687
 None
None
None
5ID  A1800 ( 4.5A)
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
IOD  A1799 (-4.0A)
 0.60A 3v5wA-2vuwA:
17.1		 3v5wA-2vuwA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  58
GLY C  61
VAL C  63
ALA C  76
LEU C 183
SER C 193
 ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.73A 3v5wA-2wtkC:
10.3		 3v5wA-2wtkC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ILE A 627
GLY A 630
GLY A 633
VAL A 635
ALA A 651
LYS A 653
 None
None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
 0.57A 3v5wA-2xyuA:
21.8		 3v5wA-2xyuA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  30
GLY A  33
VAL A  38
ALA A  51
LEU A 160
SER A 170
ASP A 171
 B49  A1294 (-3.9A)
None
None
B49  A1294 (-3.2A)
B49  A1294 (-4.4A)
B49  A1294 ( 4.9A)
B49  A1294 (-4.2A)
 1.05A 3v5wA-2y7jA:
10.9		 3v5wA-2y7jA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 100
GLY A 103
VAL A 105
ALA A 121
LEU A 125
VAL A 156
 None
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
None
None
 0.75A 3v5wA-3a62A:
11.6		 3v5wA-3a62A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 490
GLY A 493
VAL A 495
ALA A 515
LEU A 633
ASP A 644
 M33  A1996 (-3.0A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
 0.86A 3v5wA-3b2tA:
25.9		 3v5wA-3b2tA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
LYS A 222
VAL A 249
LEU A 321
 None
 1.23A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
GLY A 204
GLY A 207
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.25A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
LYS A 222
VAL A 249
ASP A 332
 None
 1.04A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
GLY A 204
VAL A 209
ALA A 220
VAL A 249
LEU A 321
SER A 331
 None
 1.33A 3v5wA-3d7uA:
8.3		 3v5wA-3d7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ILE A  34
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 155
 DRK  A   1 (-4.2A)
None
None
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
 0.58A 3v5wA-3f3zA:
10.8		 3v5wA-3f3zA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 209
GLY A 212
GLY A 215
VAL A 217
ALA A 228
LEU A 340
SER A 350
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-3.7A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-4.6A)
None
 1.06A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 209
GLY A 212
VAL A 217
ALA A 228
LYS A 230
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-4.6A)
 0.70A 3v5wA-3g2fA:
7.1		 3v5wA-3g2fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 104
GLY A 107
GLY A 110
VAL A 112
ALA A 125
VAL A 160
 GMG  A   1 (-4.3A)
GMG  A   1 (-3.3A)
None
None
GMG  A   1 (-3.4A)
None
 0.78A 3v5wA-3hdnA:
10.9		 3v5wA-3hdnA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  16
GLY A  19
GLY A  22
VAL A  24
ALA A  37
LYS A  39
 ANP  A 329 ( 4.2A)
ANP  A 329 (-3.3A)
None
ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
 0.68A 3v5wA-3hkoA:
9.6		 3v5wA-3hkoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 205
 ANP  A 610 (-2.9A)
ANP  A 610 (-4.5A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
ANP  A 610 (-2.8A)
None
 0.77A 3v5wA-3igoA:
10.7		 3v5wA-3igoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 683
VAL A 689
ALA A 700
LYS A 702
LEU A 804
SER A 827
 ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.4A)
ADP  A2101 ( 4.4A)
 0.82A 3v5wA-3lj0A:
7.8		 3v5wA-3lj0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 GLY A 561
GLY A 564
VAL A 566
ALA A 579
LYS A 581
VAL A 614
LEU A 684
 ANP  A 877 (-3.3A)
ANP  A 877 (-3.9A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.94A 3v5wA-3lltA:
8.0		 3v5wA-3lltA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LEU A 723
LEU A 820
ASP A 831
 None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
None
ITI  A   1 (-4.6A)
ITI  A   1 ( 4.6A)
 1.13A 3v5wA-3lzbA:
7.5		 3v5wA-3lzbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
GLY A 700
VAL A 702
ALA A 719
LYS A 721
LEU A 723
ASP A 831
 None
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
None
ITI  A   1 ( 4.6A)
 1.11A 3v5wA-3lzbA:
7.5		 3v5wA-3lzbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
ASP A 184
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.85A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
VAL A 104
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.79A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  36
GLY A  39
GLY A  42
VAL A  44
ALA A  57
LYS A  59
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-3.0A)
ANP  A 430 (-3.9A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 (-4.4A)
 0.91A 3v5wA-3nieA:
7.4		 3v5wA-3nieA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 GLY A  32
GLY A  35
VAL A  37
ALA A  49
LYS A  51
VAL A  82
LEU A 151
 ADP  A 314 (-3.0A)
None
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 (-4.6A)
 0.90A 3v5wA-3nizA:
27.3		 3v5wA-3nizA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 GLY A 196
GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
ASP A 329
 None
None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.0A)
 1.25A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 GLY A 198
VAL A 200
ALA A 213
LYS A 215
LEU A 217
VAL A 247
LEU A 318
 None
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
 0.89A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		6 GLY A 159
GLY A 162
VAL A 164
ALA A 177
LYS A 179
LEU A 181
 GLY  A 159 ( 0.0A)
GLY  A 162 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
 0.58A 3v5wA-3o96A:
29.3		 3v5wA-3o96A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A1088
GLY A1091
GLY A1094
VAL A1096
ALA A1112
ASP A1226
 ANP  A1358 (-4.3A)
ANP  A1358 (-3.4A)
None
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
MG  A   1 ( 3.2A)
 0.79A 3v5wA-3plsA:
7.2		 3v5wA-3plsA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
GLY A 560
GLY A 563
ALA A 576
LYS A 578
VAL A 609
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.99A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 580
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
 0.71A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ILE A 557
GLY A 560
GLY A 563
VAL A 565
ALA A 576
LYS A 578
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
None
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.94A 3v5wA-3ppzA:
8.2		 3v5wA-3ppzA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  85
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
 None
None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
 0.81A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  82
GLY A  88
VAL A  90
ALA A 103
LYS A 105
LEU A 107
ASP A 218
 None
None
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
EDO  A 417 (-3.7A)
 0.80A 3v5wA-3qfvA:
10.6		 3v5wA-3qfvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A 364
GLY A 367
VAL A 369
ALA A 382
LYS A 384
LEU A 386
 None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.84A 3v5wA-3txoA:
5.6		 3v5wA-3txoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
ASP A 143
 None
None
38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
 0.77A 3v5wA-3zduA:
7.8		 3v5wA-3zduA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  13
GLY A  16
VAL A  18
ALA A  31
LYS A  33
VAL A  64
 D15  A 500 (-4.2A)
D15  A 500 (-3.6A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
 0.82A 3v5wA-4aguA:
11.0		 3v5wA-4aguA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  10
GLY A  16
VAL A  18
ALA A  31
LYS A  33
VAL A  64
LEU A 133
 D15  A 500 (-4.2A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.5A)
 1.09A 3v5wA-4aguA:
11.0		 3v5wA-4aguA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ILE A  83
GLY A  86
GLY A  89
VAL A  91
ALA A 104
LYS A 106
LEU A 108
ASP A 219
 None
None
None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-4.2A)
None
 0.65A 3v5wA-4aw2A:
11.1		 3v5wA-4aw2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  64
GLY A  67
VAL A  69
ALA A  82
LYS A  84
LEU A 189
 None
None
R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.5A)
 0.85A 3v5wA-4b99A:
25.7		 3v5wA-4b99A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 220
VAL A 222
ALA A 233
LYS A 235
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.79A 3v5wA-4c02A:
7.5		 3v5wA-4c02A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 666
GLY A 669
ALA A 684
LYS A 686
LEU A 688
VAL A 721
ASP A 800
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 ( 3.3A)
 0.99A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 GLY A 666
GLY A 669
VAL A 671
ALA A 684
LYS A 686
LEU A 688
VAL A 721
LEU A 789
 AGS  A1985 (-2.9A)
AGS  A1985 (-4.1A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.90A 3v5wA-4crsA:
13.1		 3v5wA-4crsA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ILE A 567
GLY A 573
VAL A 575
ALA A 588
LYS A 590
ASP A 701
 GUI  A 901 (-4.0A)
None
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
GUI  A 901 ( 4.1A)
 0.79A 3v5wA-4e93A:
8.0		 3v5wA-4e93A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
GLY A  67
VAL A  72
ALA A  88
LYS A  90
ASP A 196
 None
ADP  A 601 (-3.7A)
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
MG  A 602 ( 3.1A)
 0.61A 3v5wA-4f99A:
7.4		 3v5wA-4f99A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  64
VAL A  72
ALA A  88
LYS A  90
LEU A  92
ASP A 196
 None
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
MG  A 602 ( 3.1A)
 0.76A 3v5wA-4f99A:
7.4		 3v5wA-4f99A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  34
ALA A  47
LYS A  49
VAL A  79
LEU A 148
SER A 161
 ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
ATP  A 401 (-2.8A)
 0.77A 3v5wA-4fg8A:
9.1		 3v5wA-4fg8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		9 GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
VAL A 379
LEU A 447
SER A 457
ASP A 458
 ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
ANP  A1001 (-4.7A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.86A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		8 ILE A 327
GLY A 330
GLY A 333
VAL A 335
ALA A 348
LYS A 350
SER A 457
ASP A 458
 None
ANP  A1001 (-3.2A)
None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 ( 4.4A)
ANP  A1001 (-2.7A)
 0.85A 3v5wA-4fieA:
10.7		 3v5wA-4fieA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 GLY A 380
GLY A 383
VAL A 385
ALA A 400
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-3.5A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.78A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 383
VAL A 385
ALA A 400
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.82A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
LEU A 404
VAL A 433
LEU A 501
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 1.04A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
VAL A 433
LEU A 501
SER A 511
ASP A 512
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 (-4.5A)
MG  A 702 ( 4.2A)
MG  A 702 ( 3.1A)
 0.93A 3v5wA-4fl3A:
8.9		 3v5wA-4fl3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
LYS A  52
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.70A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  29
GLY A  32
GLY A  35
VAL A  37
ALA A  50
VAL A  84
 STU  A 401 (-4.1A)
None
None
STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
 0.79A 3v5wA-4fr4A:
9.1		 3v5wA-4fr4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 159
GLY A 162
VAL A 164
ALA A 177
LYS A 179
LEU A 181
ASP A 292
 0XZ  A 501 (-4.1A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-4.9A)
0XZ  A 501 ( 3.4A)
 0.71A 3v5wA-4gv1A:
12.4		 3v5wA-4gv1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 831
GLY A 834
VAL A 836
ALA A 853
LYS A 855
VAL A 884
 19S  A1201 ( 4.3A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
 0.77A 3v5wA-4hviA:
7.4		 3v5wA-4hviA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 135
GLY A 138
VAL A 140
ALA A 156
LYS A 158
LEU A 259
 None
None
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.6A)
 0.79A 3v5wA-4id7A:
24.1		 3v5wA-4id7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 276
GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
VAL A 323
ASP A 404
 None
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 (-3.1A)
 0.95A 3v5wA-4k11A:
7.2		 3v5wA-4k11A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 279
VAL A 281
ALA A 293
LYS A 295
LEU A 297
VAL A 323
LEU A 393
ASP A 404
 None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 1.09A 3v5wA-4k11A:
7.2		 3v5wA-4k11A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A 416
GLY A 419
VAL A 421
ALA A 434
VAL A 465
LEU A 533
SER A 543
ASP A 544
 None
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.95A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 416
VAL A 421
ALA A 434
LYS A 436
VAL A 465
LEU A 533
SER A 543
 None
None
B49  A 701 (-3.2A)
None
None
B49  A 701 (-4.5A)
B49  A 701 (-3.0A)
 0.92A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
GLY A 416
GLY A 419
VAL A 421
ALA A 434
SER A 543
ASP A 544
 B49  A 701 (-4.2A)
None
None
None
B49  A 701 (-3.2A)
B49  A 701 (-3.0A)
B49  A 701 (-4.6A)
 0.83A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A 413
GLY A 416
VAL A 421
ALA A 434
LYS A 436
SER A 543
 B49  A 701 (-4.2A)
None
None
B49  A 701 (-3.2A)
None
B49  A 701 (-3.0A)
 0.84A 3v5wA-4ks8A:
11.1		 3v5wA-4ks8A:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		11 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
LEU A 324
SER A 334
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-4.6A)
29X  A 702 (-3.4A)
29X  A 702 ( 4.3A)
 0.47A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		11 ILE A 197
GLY A 200
GLY A 203
VAL A 205
ALA A 218
LYS A 220
LEU A 222
VAL A 255
SER A 334
ASP A 335
ALA A 482
 29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
29X  A 702 ( 4.3A)
 0.61A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		7 ILE A 197
GLY A 203
VAL A 205
ALA A 218
VAL A 255
SER A 334
ASP A 335
 29X  A 702 (-4.7A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-4.8A)
29X  A 702 (-3.4A)
29X  A 702 (-4.4A)
 1.26A 3v5wA-4mk0A:
56.4		 3v5wA-4mk0A:
97.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  81
GLY A  84
VAL A  86
ALA A  99
LYS A 101
VAL A 130
 STU  A 601 (-3.9A)
None
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
 0.83A 3v5wA-4mvfA:
22.6		 3v5wA-4mvfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  33
GLY B  36
VAL B  38
ALA B  51
LYS B  53
LEU B 151
 ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
 0.65A 3v5wA-4o27B:
10.1		 3v5wA-4o27B:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		7 ILE A  19
GLY A  22
GLY A  25
VAL A  27
ALA A  40
LYS A  42
ASP A 159
 None
 0.80A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 ILE A  19
GLY A  25
VAL A  27
ALA A  40
LEU A  44
ASP A 159
 None
 0.84A 3v5wA-4ow8A:
24.2		 3v5wA-4ow8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A 392
VAL A 394
ALA A 407
LYS A 409
LEU A 411
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.83A 3v5wA-4q9zA:
37.4		 3v5wA-4q9zA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ILE A  27
GLY A  30
GLY A  33
VAL A  35
ALA A  49
LYS A  51
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-3.4A)
None
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-4.6A)
 0.92A 3v5wA-4qnyA:
7.9		 3v5wA-4qnyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  48
GLY A  54
VAL A  56
ALA A  69
LYS A  71
LEU A 173
 38Z  A 418 ( 4.4A)
None
None
38Z  A 418 (-3.4A)
38Z  A 418 (-2.9A)
38Z  A 418 (-4.4A)
 0.86A 3v5wA-4qtbA:
8.7		 3v5wA-4qtbA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		3 LEU A 210
MET A 207
ASP A 204
 None
 0.90A 3v5wA-1a5iA:
undetectable		 3v5wA-1a5iA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 LEU A 175
MET A 167
ASP A 199
 None
 0.86A 3v5wA-1e1cA:
undetectable		 3v5wA-1e1cA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU C  84
MET C  56
ASP C  66
 None
 0.73A 3v5wA-1ea9C:
undetectable		 3v5wA-1ea9C:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		3 LEU A 206
MET A 255
ASP A 250
 None
 0.91A 3v5wA-1jkwA:
undetectable		 3v5wA-1jkwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		3 LEU A 104
MET A 106
ASP A 147
 None
 0.89A 3v5wA-1jqkA:
undetectable		 3v5wA-1jqkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LEU A 383
MET A 806
ASP A 882
 None
 0.86A 3v5wA-1p2zA:
undetectable		 3v5wA-1p2zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 LEU A 387
MET A 381
ASP A 325
 None
 0.84A 3v5wA-1rxtA:
undetectable		 3v5wA-1rxtA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 LEU B  52
MET B  63
ASP B 199
 None
None
BR  B 523 ( 4.8A)
 0.83A 3v5wA-1sr4B:
undetectable		 3v5wA-1sr4B:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 LEU B 209
MET B 202
ASP B 168
 None
AGS  B 802 (-4.7A)
None
 0.89A 3v5wA-1sxjB:
undetectable		 3v5wA-1sxjB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v61 RAC/CDC42 GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF) 6

(Mus musculus) 		PF00169
(PH) 		3 LEU A 124
MET A 118
ASP A 113
 None
 0.85A 3v5wA-1v61A:
9.0		 3v5wA-1v61A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		3 LEU C 394
MET C 396
ASP C 407
 None
 0.86A 3v5wA-1w36C:
undetectable		 3v5wA-1w36C:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x75 DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		3 LEU A 417
MET A 423
ASP A 429
 None
 0.92A 3v5wA-1x75A:
undetectable		 3v5wA-1x75A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		3 LEU 1 416
MET 1  10
ASP 1  13
 None
 0.88A 3v5wA-2bpa1:
undetectable		 3v5wA-2bpa1:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		3 LEU A 113
MET A  53
ASP A  48
 None
 0.78A 3v5wA-2lg1A:
9.0		 3v5wA-2lg1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0g SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		3 LEU B 380
MET B 446
ASP B 441
 None
 0.92A 3v5wA-2m0gB:
undetectable		 3v5wA-2m0gB:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npn PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN

(Corynebacterium
diphtheriae) 		PF00590
(TP_methylase) 		3 LEU A 207
MET A 241
ASP A 186
 SAM  A4633 (-3.6A)
SAM  A4633 (-3.9A)
None
 0.73A 3v5wA-2npnA:
undetectable		 3v5wA-2npnA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2x HYPOTHETICAL PROTEIN

(Mesorhizobium
loti) 		PF13242
(Hydrolase_like) 		3 LEU A 174
MET A 166
ASP A  36
 None
 0.72A 3v5wA-2o2xA:
undetectable		 3v5wA-2o2xA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LEU A 353
MET A 771
ASP A 847
 None
2HP  A1620 (-4.4A)
None
 0.85A 3v5wA-2obeA:
undetectable		 3v5wA-2obeA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528

(Vibrio
parahaemolyticus) 		PF07072
(ZapD) 		3 LEU A  62
MET A 102
ASP A  95
 None
 0.85A 3v5wA-2oezA:
3.2		 3v5wA-2oezA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 LEU A 123
MET A 125
ASP A 128
 None
 0.74A 3v5wA-2okcA:
undetectable		 3v5wA-2okcA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9h OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		3 LEU A  44
MET A  46
ASP A  52
 None
 0.89A 3v5wA-2v9hA:
undetectable		 3v5wA-2v9hA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8r GLYCOSYL HYDROLASE

(Aspergillus
fumigatus) 		PF01183
(Glyco_hydro_25) 		3 LEU A  64
MET A  38
ASP A 201
 None
 0.79A 3v5wA-2x8rA:
undetectable		 3v5wA-2x8rA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		3 LEU A 499
MET A 504
ASP A 459
 None
 0.92A 3v5wA-2xgoA:
undetectable		 3v5wA-2xgoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 LEU A 196
MET A 188
ASP A 220
 None
 0.87A 3v5wA-2xijA:
undetectable		 3v5wA-2xijA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LEU A 103
MET A  73
ASP A  88
 None
 0.87A 3v5wA-2y3aA:
undetectable		 3v5wA-2y3aA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zay RESPONSE REGULATOR
RECEIVER PROTEIN

(Desulfuromonas
acetoxidans) 		PF00072
(Response_reg) 		3 LEU A  55
MET A  12
ASP A  15
 None
 0.88A 3v5wA-2zayA:
undetectable		 3v5wA-2zayA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		3 LEU A 385
MET A 320
ASP A 169
 None
ZBA  A 463 (-3.8A)
None
 0.84A 3v5wA-2zbaA:
undetectable		 3v5wA-2zbaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 3 LEU A 365
MET A 383
ASP A 386
 None
None
CA  A 637 (-2.9A)
 0.89A 3v5wA-2zuxA:
undetectable		 3v5wA-2zuxA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		3 LEU A 283
MET A 221
ASP A 324
 None
 0.92A 3v5wA-3beoA:
undetectable		 3v5wA-3beoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh2 ACETOACETATE
DECARBOXYLASE

(Clostridium
acetobutylicum) 		PF06314
(ADC) 		3 LEU A  71
MET A  65
ASP A 230
 None
 0.86A 3v5wA-3bh2A:
undetectable		 3v5wA-3bh2A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A1157
MET A1160
ASP A1164
 CKK  A1500 (-4.7A)
None
CKK  A1500 (-3.7A)
 0.61A 3v5wA-3c1xA:
20.1		 3v5wA-3c1xA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqb PROBABLE PROTEASE
HTPX HOMOLOG

(Vibrio
parahaemolyticus) 		PF01435
(Peptidase_M48) 		3 LEU A  72
MET A  75
ASP A  78
 CL  A 105 ( 4.3A)
None
None
 0.89A 3v5wA-3cqbA:
undetectable		 3v5wA-3cqbA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 LEU B 308
MET B 302
ASP B 299
 None
 0.79A 3v5wA-3exhB:
undetectable		 3v5wA-3exhB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 LEU A 612
MET A 622
ASP A 435
 None
 0.84A 3v5wA-3i5gA:
3.1		 3v5wA-3i5gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 LEU A 577
MET A 583
ASP A 550
 None
 0.87A 3v5wA-3ihyA:
3.7		 3v5wA-3ihyA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 LEU A 441
MET A 435
ASP A 396
 None
 0.89A 3v5wA-3iu1A:
undetectable		 3v5wA-3iu1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 3 LEU A  99
MET A  93
ASP A  57
 None
 0.67A 3v5wA-3ixlA:
undetectable		 3v5wA-3ixlA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 LEU A 728
MET A 647
ASP A 635
 None
 0.88A 3v5wA-3k1dA:
undetectable		 3v5wA-3k1dA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		3 LEU B  52
MET B   6
ASP B   9
 None
 0.85A 3v5wA-3kyjB:
undetectable		 3v5wA-3kyjB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3g EPL1 PROTEIN

(Trichoderma
virens) 		PF07249
(Cerato-platanin) 		3 LEU A  84
MET A 110
ASP A  24
 None
 0.86A 3v5wA-3m3gA:
undetectable		 3v5wA-3m3gA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 LEU A  38
MET A  41
ASP A 134
 None
 0.75A 3v5wA-3ml0A:
undetectable		 3v5wA-3ml0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		3 LEU A 187
MET A 179
ASP A 146
 None
None
GOL  A 229 (-2.8A)
 0.85A 3v5wA-3ndoA:
undetectable		 3v5wA-3ndoA:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 263
MET A 266
ASP A 270
 AMP  A 577 ( 4.7A)
None
AMP  A 577 (-3.6A)
 0.56A 3v5wA-3nyoA:
12.4		 3v5wA-3nyoA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onl T-SNARE VTI1

(Saccharomyces
cerevisiae) 		PF05008
(V-SNARE) 		3 LEU C   4
MET C  55
ASP C  50
 None
 0.63A 3v5wA-3onlC:
undetectable		 3v5wA-3onlC:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdt MYOSIN HEAVY CHAIN
KINASE A

(Dictyostelium
discoideum) 		PF02816
(Alpha_kinase) 		3 LEU A 689
MET A 668
ASP A 663
 None
 0.89A 3v5wA-3pdtA:
4.7		 3v5wA-3pdtA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LEU A 156
MET A 160
ASP A 456
 None
 0.86A 3v5wA-3t6wA:
undetectable		 3v5wA-3t6wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 LEU A 178
MET A 141
ASP A 138
 None
 0.87A 3v5wA-3tqiA:
undetectable		 3v5wA-3tqiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 LEU A  78
MET A 310
ASP A 283
 None
 0.73A 3v5wA-3v39A:
undetectable		 3v5wA-3v39A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		3 LEU A 244
MET A 332
ASP A 327
 None
 0.92A 3v5wA-3v39A:
undetectable		 3v5wA-3v39A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		3 LEU A 897
MET A 843
ASP A 893
 None
 0.81A 3v5wA-3welA:
undetectable		 3v5wA-3welA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A2026
MET A2029
ASP A2033
 VGH  A3000 ( 4.2A)
None
VGH  A3000 (-4.5A)
 0.60A 3v5wA-3zbfA:
7.5		 3v5wA-3zbfA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 3 LEU A  85
MET A 119
ASP A 114
 None
 0.75A 3v5wA-3zheA:
undetectable		 3v5wA-3zheA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		3 LEU A 320
MET A 225
ASP A 220
 None
 0.53A 3v5wA-3zidA:
undetectable		 3v5wA-3zidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A  83
MET A  77
ASP A  71
 None
 0.66A 3v5wA-4aieA:
undetectable		 3v5wA-4aieA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16415
(CNOT1_CAF1_bind) 		3 LEU A 774
MET A 771
ASP A 881
 None
 0.84A 3v5wA-4b8aA:
undetectable		 3v5wA-4b8aA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 137
MET A 140
ASP A 143
 R4L  A1394 (-3.9A)
None
R4L  A1394 ( 4.2A)
 0.57A 3v5wA-4b99A:
25.7		 3v5wA-4b99A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 LEU A 441
MET A 435
ASP A 396
 None
 0.86A 3v5wA-4c2xA:
undetectable		 3v5wA-4c2xA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		3 LEU A 335
MET A 353
ASP A 356
 None
None
CA  A 606 (-2.5A)
 0.78A 3v5wA-4cagA:
undetectable		 3v5wA-4cagA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 LEU A 269
MET A 271
ASP A 240
 None
FDA  A 502 ( 4.9A)
None
 0.80A 3v5wA-4dshA:
undetectable		 3v5wA-4dshA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4s TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
18

(Ochotona
princeps) 		no annotation 3 LEU A  27
MET A  30
ASP A  32
 None
 0.82A 3v5wA-4e4sA:
undetectable		 3v5wA-4e4sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU A 538
MET A 484
ASP A  78
 None
 0.77A 3v5wA-4epaA:
undetectable		 3v5wA-4epaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 3 LEU A 225
MET A 223
ASP A 186
 None
 0.73A 3v5wA-4es9A:
undetectable		 3v5wA-4es9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A1196
MET A1199
ASP A1203
 0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.6A)
 0.40A 3v5wA-4fodA:
8.1		 3v5wA-4fodA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl4 TBC1 DOMAIN FAMILY
MEMBER 20

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 LEU A 266
MET A 207
ASP A 197
 None
 0.90A 3v5wA-4hl4A:
undetectable		 3v5wA-4hl4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN

(Bacteroides
fragilis) 		PF00092
(VWA) 		3 LEU A 144
MET A  93
ASP A 129
 None
 0.80A 3v5wA-4jduA:
undetectable		 3v5wA-4jduA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k29 ENOYL-COA
HYDRATASE/ISOMERASE

(Xanthobacter
autotrophicus) 		PF00378
(ECH_1) 		3 LEU A 119
MET A  93
ASP A  88
 None
 0.83A 3v5wA-4k29A:
undetectable		 3v5wA-4k29A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LEU A 359
MET A 361
ASP A 289
 None
 0.90A 3v5wA-4lutA:
undetectable		 3v5wA-4lutA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 LEU A 271
MET A 274
ASP A 278
 29X  A 702 ( 4.7A)
None
29X  A 702 ( 4.8A)
 0.23A 3v5wA-4mk0A:
56.2		 3v5wA-4mk0A:
97.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 LEU A 156
MET A  84
ASP A 244
 None
None
ZN  A 501 ( 2.5A)
 0.90A 3v5wA-4mrqA:
undetectable		 3v5wA-4mrqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 LEU A 664
MET A 734
ASP A 728
 None
 0.67A 3v5wA-4n3sA:
undetectable		 3v5wA-4n3sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		3 LEU A 162
MET A 153
ASP A 121
 ACT  A 404 (-4.9A)
None
None
 0.88A 3v5wA-4pe3A:
undetectable		 3v5wA-4pe3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		3 LEU A1323
MET A1032
ASP A 250
 None
 0.90A 3v5wA-4pk1A:
2.9		 3v5wA-4pk1A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 263
MET A 266
ASP A 270
 SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.2A)
 0.23A 3v5wA-4tnbA:
13.4		 3v5wA-4tnbA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		3 LEU A1357
MET A1336
ASP A1379
 None
 0.68A 3v5wA-4u48A:
undetectable		 3v5wA-4u48A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 LEU A  45
MET A 378
ASP A 391
 None
 0.80A 3v5wA-4uozA:
undetectable		 3v5wA-4uozA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 LEU A  42
MET A 374
ASP A 387
 None
 0.86A 3v5wA-4uzsA:
undetectable		 3v5wA-4uzsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		3 LEU A 135
MET A 188
ASP A 185
 None
 0.86A 3v5wA-4xkyA:
undetectable		 3v5wA-4xkyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		3 LEU A 128
MET A  73
ASP A  33
 None
 0.90A 3v5wA-4yhgA:
undetectable		 3v5wA-4yhgA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 264
MET A 267
ASP A 271
 AN2  A 601 ( 4.8A)
None
None
 0.34A 3v5wA-4yhjA:
15.6		 3v5wA-4yhjA:
33.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		3 LEU A 348
MET A 342
ASP A 104
 None
 0.92A 3v5wA-4zzeA:
undetectable		 3v5wA-4zzeA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		3 LEU A 106
MET A 102
ASP A  71
 None
 0.75A 3v5wA-5dbkA:
2.2		 3v5wA-5dbkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1t TNF
RECEPTOR-ASSOCIATED
FACTOR 1

(Homo sapiens) 		no annotation 3 LEU A 270
MET A 348
ASP A 351
 None
 0.92A 3v5wA-5e1tA:
undetectable		 3v5wA-5e1tA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		3 LEU A 110
MET A 104
ASP A  98
 None
 0.85A 3v5wA-5h05A:
undetectable		 3v5wA-5h05A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		3 LEU A 767
MET A 787
ASP A 782
 None
 0.75A 3v5wA-5hdhA:
undetectable		 3v5wA-5hdhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		3 LEU A 272
MET A 293
ASP A  88
 None
 0.88A 3v5wA-5hlbA:
undetectable		 3v5wA-5hlbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A1157
MET A1160
ASP A1164
 63K  A1401 (-4.2A)
None
63K  A1401 (-4.0A)
 0.50A 3v5wA-5horA:
7.2		 3v5wA-5horA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc) 		3 LEU A 781
MET A 546
ASP A 911
 None
 0.52A 3v5wA-5jnbA:
undetectable		 3v5wA-5jnbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		3 LEU A 137
MET A 248
ASP A 200
 None
 0.80A 3v5wA-5jnqA:
undetectable		 3v5wA-5jnqA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 598
MET A 590
ASP A 549
 None
 0.81A 3v5wA-5jtaA:
undetectable		 3v5wA-5jtaA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE

(Escherichia
coli) 		PF01977
(UbiD) 		3 LEU A 365
MET A 451
ASP A 454
 None
 0.80A 3v5wA-5m1bA:
undetectable		 3v5wA-5m1bA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 LEU A 603
MET A 631
ASP A  99
 None
 0.63A 3v5wA-5necA:
undetectable		 3v5wA-5necA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 3 LEU A 538
MET A 509
ASP A 531
 None
 0.83A 3v5wA-5nqdA:
undetectable		 3v5wA-5nqdA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 3 LEU A 725
MET A 719
ASP A 712
 None
 0.90A 3v5wA-5ot4A:
2.1		 3v5wA-5ot4A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 671
MET A 674
ASP A 678
 7AE  A1000 (-3.7A)
None
7AE  A1000 ( 4.8A)
 0.63A 3v5wA-5td2A:
10.0		 3v5wA-5td2A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		3 LEU A 130
MET A 132
ASP A 284
 None
 0.64A 3v5wA-5ti8A:
undetectable		 3v5wA-5ti8A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LEU A 271
MET A 274
ASP A 278
 QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
 0.19A 3v5wA-5uuuA:
54.6		 3v5wA-5uuuA:
95.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-) 		no annotation 3 LEU A 119
MET A 199
ASP A  78
 None
 0.55A 3v5wA-5y9pA:
undetectable		 3v5wA-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 3 LEU U 132
MET U 135
ASP U 141
 None
 0.86A 3v5wA-5zvtU:
undetectable		 3v5wA-5zvtU:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 3 LEU A 139
MET A   1
ASP A  27
 None
 0.90A 3v5wA-6dllA:
undetectable		 3v5wA-6dllA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 LEU A2511
MET A2513
ASP A2166
 None
 0.78A 3v5wA-6fb3A:
2.6		 3v5wA-6fb3A:
11.11