SIMILAR PATTERNS OF AMINO ACIDS FOR 3V5V_C_ACTC510

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ARG A 324
THR A 361
ASP A 362
GLU A 200
 None
None
None
ZN  A 501 ( 1.9A)
 1.09A 3v5vC-1cg2A:
0.8
3v5vD-1cg2A:
0.7		 3v5vC-1cg2A:
23.95
3v5vD-1cg2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		4 THR A 119
ASP A 118
LYS A 126
GLU A 162
 None
 1.33A 3v5vC-1j08A:
0.0
3v5vD-1j08A:
0.0		 3v5vC-1j08A:
20.76
3v5vD-1j08A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 ARG A  51
THR A  10
ASP A  12
LYS A  42
 None
 0.97A 3v5vC-1qjcA:
0.0
3v5vD-1qjcA:
0.0		 3v5vC-1qjcA:
18.40
3v5vD-1qjcA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 237
THR A 238
ASP A 205
GLU A 250
 None
 1.13A 3v5vC-1rrhA:
0.0
3v5vD-1rrhA:
0.0		 3v5vC-1rrhA:
19.33
3v5vD-1rrhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 THR A  81
ASP A  82
LYS A 292
GLU A 289
 None
 1.31A 3v5vC-1txgA:
0.0
3v5vD-1txgA:
0.0		 3v5vC-1txgA:
23.50
3v5vD-1txgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u69 HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		4 ARG A 121
THR A  82
ASP A  83
GLU A  87
 None
 0.93A 3v5vC-1u69A:
0.0
3v5vD-1u69A:
0.4		 3v5vC-1u69A:
18.18
3v5vD-1u69A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 232
THR A 233
ASP A 201
GLU A 245
 None
 1.30A 3v5vC-2iujA:
0.0
3v5vD-2iujA:
0.0		 3v5vC-2iujA:
20.07
3v5vD-2iujA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 243
THR A 244
ASP A 213
GLU A 256
 None
 1.17A 3v5vC-2iukA:
0.0
3v5vD-2iukA:
0.0		 3v5vC-2iukA:
20.44
3v5vD-2iukA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 ARG A 316
THR A 321
ASP A 319
GLU A 292
 None
 1.20A 3v5vC-2r14A:
0.0
3v5vD-2r14A:
0.3		 3v5vC-2r14A:
24.62
3v5vD-2r14A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 THR A 473
ASP A 475
LYS A 310
GLU A 313
 None
 1.38A 3v5vC-2ze0A:
undetectable
3v5vD-2ze0A:
0.2		 3v5vC-2ze0A:
21.35
3v5vD-2ze0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 ARG A 271
THR A 246
ASP A 272
GLU A 209
 None
 1.40A 3v5vC-3ef1A:
undetectable
3v5vD-3ef1A:
undetectable		 3v5vC-3ef1A:
22.11
3v5vD-3ef1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 ARG A 280
THR A 233
ASP A 284
GLU A 235
 None
 1.13A 3v5vC-3griA:
undetectable
3v5vD-3griA:
0.7		 3v5vC-3griA:
23.95
3v5vD-3griA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR

(Streptococcus
pneumoniae) 		PF01047
(MarR) 		4 ARG A 102
THR A  98
ASP A  99
GLU A  82
 None
 1.18A 3v5vC-3tgnA:
undetectable
3v5vD-3tgnA:
undetectable		 3v5vC-3tgnA:
14.87
3v5vD-3tgnA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a11 DNA EXCISION REPAIR
PROTEIN ERCC-8

(Homo sapiens) 		PF00400
(WD40) 		4 ARG B 354
ASP B 338
LYS B 293
GLU B 103
 None
 1.37A 3v5vC-4a11B:
undetectable
3v5vD-4a11B:
undetectable		 3v5vC-4a11B:
20.39
3v5vD-4a11B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6f UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14730
(DUF4468) 		4 ARG A 175
THR A 155
ASP A 156
GLU A  43
 None
 1.42A 3v5vC-4e6fA:
undetectable
3v5vD-4e6fA:
undetectable		 3v5vC-4e6fA:
18.57
3v5vD-4e6fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 THR A 256
ASP A 263
LYS A  75
GLU A  36
 None
 1.08A 3v5vC-4gk8A:
undetectable
3v5vD-4gk8A:
1.1		 3v5vC-4gk8A:
20.58
3v5vD-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 THR A 256
ASP A 263
LYS A  77
GLU A  36
 None
 1.13A 3v5vC-4gk8A:
undetectable
3v5vD-4gk8A:
1.1		 3v5vC-4gk8A:
20.58
3v5vD-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		4 ARG A 349
THR A 351
ASP A 338
GLU A 353
 None
 1.45A 3v5vC-5ivaA:
undetectable
3v5vD-5ivaA:
undetectable		 3v5vC-5ivaA:
20.74
3v5vD-5ivaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 ARG A 219
THR A 220
ASP A 187
GLU A 232
 None
 1.17A 3v5vC-5tr0A:
undetectable
3v5vD-5tr0A:
undetectable		 3v5vC-5tr0A:
19.86
3v5vD-5tr0A:
19.86