SIMILAR PATTERNS OF AMINO ACIDS FOR 3V5V_A_ACTA511

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		4 ASN A  89
PHE A  90
SER A  88
GLN A  93
 None
 1.23A 3v5vA-1byrA:
0.0		 3v5vA-1byrA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb1 CALBINDIN D9K

(Sus scrofa) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 ASN A  21
PHE A  63
SER A  62
GLN A  67
 None
 1.06A 3v5vA-1cb1A:
undetectable		 3v5vA-1cb1A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 ASN A 259
PHE A 260
SER A 262
GLN A 320
 None
 1.40A 3v5vA-1kfwA:
0.3		 3v5vA-1kfwA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ASN A1033
PHE A1179
SER A1180
GLN A1063
 None
None
SO4  A1502 (-2.6A)
None
 1.36A 3v5vA-1s16A:
0.3		 3v5vA-1s16A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ASN A1269
PHE A1107
SER A1108
GLN A1106
 None
 1.13A 3v5vA-1s16A:
0.3		 3v5vA-1s16A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 ASN A 257
PHE A 254
SER A 256
GLN A 253
 None
 1.22A 3v5vA-2pbiA:
0.0		 3v5vA-2pbiA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we3 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Human
gammaherpesvirus
4) 		PF00692
(dUTPase) 		4 ASN A 197
PHE A 198
SER A 199
GLN A  88
 None
 1.02A 3v5vA-2we3A:
0.0		 3v5vA-2we3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 ASN A 209
PHE A 210
SER A 211
GLN A 182
 None
 1.08A 3v5vA-2yfsA:
0.0		 3v5vA-2yfsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 ASN A 471
PHE A 334
SER A 333
GLN A 337
 None
XCC  A 800 (-4.2A)
None
None
 1.37A 3v5vA-3i04A:
0.0		 3v5vA-3i04A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3son HYPOTHETICAL NUDIX
HYDROLASE

(Listeria
monocytogenes) 		PF00293
(NUDIX) 		4 ASN A  76
PHE A  79
SER A  80
GLN A   6
 None
 1.48A 3v5vA-3sonA:
0.0		 3v5vA-3sonA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayz HEME-BINDING PROTEIN
2

(Homo sapiens) 		PF04832
(SOUL) 		4 ASN A 189
PHE A 142
SER A 141
GLN A 154
 None
 1.38A 3v5vA-4ayzA:
0.0		 3v5vA-4ayzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 ASN A 284
PHE A 281
SER A 280
GLN A 372
 None
 1.35A 3v5vA-4m8jA:
undetectable		 3v5vA-4m8jA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 ASN A  72
PHE A  69
SER A  68
GLN A 293
 None
 1.48A 3v5vA-4o5jA:
undetectable		 3v5vA-4o5jA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r03 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12930
(DUF3836) 		4 ASN A 116
PHE A 117
SER A 118
GLN A  91
 None
 1.37A 3v5vA-4r03A:
undetectable		 3v5vA-4r03A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cff STAUFEN

(Drosophila
melanogaster) 		PF16482
(Staufen_C) 		4 ASN E 967
PHE E 968
SER E 969
GLN E1004
 None
 1.09A 3v5vA-5cffE:
undetectable		 3v5vA-5cffE:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqw PUTATIVE MAJOR COAT
PROTEIN

(Acidianus
tailed spindle
virus) 		no annotation 4 ASN A  25
PHE A  82
SER A  84
GLN A 101
 None
 1.50A 3v5vA-5eqwA:
undetectable		 3v5vA-5eqwA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 ASN N 681
PHE N 682
SER N 684
GLN N 703
 None
 1.37A 3v5vA-5mpdN:
undetectable		 3v5vA-5mpdN:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		4 ASN A 258
PHE A 259
SER A 260
GLN A 151
 None
 1.14A 3v5vA-5muaA:
undetectable		 3v5vA-5muaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 4 ASN A 543
PHE A 541
SER A 542
GLN A 538
 None
 1.14A 3v5vA-5n2gA:
1.5		 3v5vA-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 4 ASN A 532
PHE A 876
SER A 851
GLN A 877
 None
 1.37A 3v5vA-5u30A:
0.5		 3v5vA-5u30A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ASN A 126
PHE A 155
SER A 157
GLN A 182
 DMS  A 508 ( 4.8A)
None
DMS  A 508 (-3.2A)
None
 1.29A 3v5vA-5vcsA:
undetectable		 3v5vA-5vcsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 ASN A 277
PHE A 215
SER A 214
GLN A 219
 None
 1.39A 3v5vA-6fhwA:
undetectable		 3v5vA-6fhwA:
undetectable