SIMILAR PATTERNS OF AMINO ACIDS FOR 3V4T_H_ACTH504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aur CARBOXYLESTERASE

(Pseudomonas
fluorescens) 		PF02230
(Abhydrolase_2) 		3 LYS A 184
GLU A 181
TRP A 192
 None
 1.24A 3v4tH-1aurA:
0.7		 3v4tH-1aurA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ear UREASE ACCESSORY
PROTEIN UREE

(Sporosarcina
pasteurii) 		PF02814
(UreE_N)
PF05194
(UreE_C) 		3 LYS A  74
GLU A  76
TRP A  27
 None
 1.08A 3v4tH-1earA:
0.0		 3v4tH-1earA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 LYS A 332
GLU A 206
TRP A 204
 None
 0.91A 3v4tH-1hcyA:
0.0		 3v4tH-1hcyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		3 LYS A 306
GLU A 309
TRP A  51
 None
 1.49A 3v4tH-1lf9A:
0.0		 3v4tH-1lf9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		3 LYS A  43
GLU A  45
TRP A 277
 None
 0.74A 3v4tH-1m2xA:
0.0		 3v4tH-1m2xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 LYS A 127
GLU A 148
TRP A 131
 None
 1.32A 3v4tH-1t0bA:
0.0		 3v4tH-1t0bA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc6 CILIARY NEUROTROPHIC
FACTOR RECEPTOR
ALPHA

(Homo sapiens) 		PF00041
(fn3) 		3 LYS A  45
GLU A  62
TRP A  94
 None
 1.37A 3v4tH-1uc6A:
0.0		 3v4tH-1uc6A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		3 LYS A 378
GLU A 380
TRP A 227
 None
 1.38A 3v4tH-1ue0A:
0.0		 3v4tH-1ue0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 LYS A  33
GLU A  62
TRP A  63
 None
 1.36A 3v4tH-1vljA:
0.0		 3v4tH-1vljA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		3 LYS A  16
GLU A 233
TRP A 125
 None
 1.37A 3v4tH-1vlpA:
undetectable		 3v4tH-1vlpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 LYS A 299
GLU A 296
TRP A 291
 None
 1.37A 3v4tH-1xfdA:
undetectable		 3v4tH-1xfdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 LYS A 129
GLU A  60
TRP A 124
 None
 1.16A 3v4tH-1xmbA:
1.7		 3v4tH-1xmbA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 LYS A 111
GLU A 156
TRP A  33
 None
 1.34A 3v4tH-1zy9A:
0.7		 3v4tH-1zy9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH

(Desulfovibrio
vulgaris) 		PF01814
(Hemerythrin) 		3 LYS A 121
GLU A 122
TRP A 114
 None
 1.32A 3v4tH-2awcA:
undetectable		 3v4tH-2awcA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		3 LYS A 204
GLU A 230
TRP A 261
 None
 0.83A 3v4tH-2bexA:
1.3		 3v4tH-2bexA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjm IGE SPE7 HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		3 LYS H  38
GLU H  46
TRP H  47
 None
 1.31A 3v4tH-2bjmH:
undetectable		 3v4tH-2bjmH:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 LYS A 348
GLU A 350
TRP A 314
 None
 1.23A 3v4tH-2bvgA:
undetectable		 3v4tH-2bvgA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 LYS A 638
GLU A 641
TRP A 677
 CA  A1738 (-2.7A)
CA  A1738 ( 3.9A)
None
 1.43A 3v4tH-2c11A:
undetectable		 3v4tH-2c11A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		3 LYS A 400
GLU A 325
TRP A 396
 None
 1.31A 3v4tH-2e9qA:
undetectable		 3v4tH-2e9qA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlc DNA REPAIR PROTEIN
RADC HOMOLOG

(Chlorobaculum
tepidum) 		PF04002
(RadC) 		3 LYS A  16
GLU A  13
TRP A 117
 None
 0.73A 3v4tH-2qlcA:
undetectable		 3v4tH-2qlcA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v19 DODECIN

(Thermus
thermophilus) 		PF07311
(Dodecin) 		3 LYS A  42
GLU A  61
TRP A  38
 None
None
FMN  A 101 (-3.5A)
 1.20A 3v4tH-2v19A:
undetectable		 3v4tH-2v19A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpt LIPOLYTIC ENZYME

(Ruminiclostridium
thermocellum) 		PF13472
(Lipase_GDSL_2) 		3 LYS A 166
GLU A 163
TRP A 161
 None
 1.28A 3v4tH-2vptA:
0.8		 3v4tH-2vptA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wim NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		3 LYS A 260
GLU A 265
TRP A 244
 None
 1.39A 3v4tH-2wimA:
undetectable		 3v4tH-2wimA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 3 LYS A 136
GLU A  68
TRP A 118
 None
 1.03A 3v4tH-2y0oA:
undetectable		 3v4tH-2y0oA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 LYS A 143
GLU A 144
TRP A 141
 None
 1.21A 3v4tH-2y6cA:
undetectable		 3v4tH-2y6cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF01842
(ACT)
PF13840
(ACT_7) 		3 LYS B  26
GLU B  29
TRP B  86
 None
 1.13A 3v4tH-3ab4B:
undetectable		 3v4tH-3ab4B:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS L   1
GLU L  26
TRP L  91
 None
 1.45A 3v4tH-3cvhL:
undetectable		 3v4tH-3cvhL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID

(Escherichia
coli) 		PF01510
(Amidase_2) 		3 LYS A 144
GLU A 146
TRP A  90
 None
 1.25A 3v4tH-3d2zA:
undetectable		 3v4tH-3d2zA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LYS A 384
GLU A 388
TRP A 248
 None
 1.27A 3v4tH-3gdeA:
undetectable		 3v4tH-3gdeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl3 PUTATIVE
THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		3 LYS A  82
GLU A 160
TRP A  75
 None
 1.49A 3v4tH-3gl3A:
undetectable		 3v4tH-3gl3A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		3 LYS A 308
GLU A 312
TRP A 346
 None
 1.44A 3v4tH-3hnoA:
1.3		 3v4tH-3hnoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		3 LYS D 334
GLU D 330
TRP D 302
 None
 0.60A 3v4tH-3k8pD:
undetectable		 3v4tH-3k8pD:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koj UNCHARACTERIZED
PROTEIN YCF41

(Synechococcus
elongatus) 		PF00436
(SSB) 		3 LYS A  46
GLU A  28
TRP A  50
 None
 1.42A 3v4tH-3kojA:
undetectable		 3v4tH-3kojA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 LYS A 207
GLU A 230
TRP A 181
 None
 1.14A 3v4tH-3kt4A:
0.4		 3v4tH-3kt4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on6 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF06824
(Glyco_hydro_125) 		3 LYS A  64
GLU A  77
TRP A  74
 None
 1.48A 3v4tH-3on6A:
undetectable		 3v4tH-3on6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		3 LYS A 185
GLU A 189
TRP A 137
 None
 1.36A 3v4tH-3opxA:
undetectable		 3v4tH-3opxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 LYS A 195
GLU A 192
TRP A 110
 None
 1.23A 3v4tH-3ps5A:
undetectable		 3v4tH-3ps5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psq HYPOTHETICAL
EXPORTED PROTEIN

(Streptococcus
pyogenes) 		PF04203
(Sortase) 		3 LYS A 161
GLU A 155
TRP A  70
 ZN  A 320 ( 4.3A)
ZN  A 320 ( 2.5A)
None
 1.16A 3v4tH-3psqA:
undetectable		 3v4tH-3psqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00348
(polyprenyl_synt) 		3 LYS A 258
GLU A 268
TRP A 251
 None
 1.49A 3v4tH-3rmgA:
undetectable		 3v4tH-3rmgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 LYS A 127
GLU A  90
TRP A 120
 None
 1.09A 3v4tH-3se5A:
undetectable		 3v4tH-3se5A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		3 LYS A 107
GLU A  92
TRP A  91
 None
 1.38A 3v4tH-3wj9A:
undetectable		 3v4tH-3wj9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 LYS A 337
GLU A 347
TRP A 334
 None
 1.43A 3v4tH-3wxoA:
undetectable		 3v4tH-3wxoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LYS A 374
GLU A 349
TRP A 372
 None
 0.95A 3v4tH-3zl8A:
1.6		 3v4tH-3zl8A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 280
GLU A 216
TRP A 273
 None
 0.88A 3v4tH-4a3rA:
undetectable		 3v4tH-4a3rA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		3 LYS A 250
GLU A 251
TRP A 293
 None
 1.04A 3v4tH-4au2A:
undetectable		 3v4tH-4au2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		3 LYS A 320
GLU A 317
TRP A 316
 None
 1.31A 3v4tH-4c60A:
undetectable		 3v4tH-4c60A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkd INTERLEUKIN-34

(Homo sapiens) 		PF15036
(IL34) 		3 LYS A  32
GLU A  34
TRP A 188
 None
 1.41A 3v4tH-4dkdA:
undetectable		 3v4tH-4dkdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		3 LYS A 295
GLU A 293
TRP A 172
 None
 0.93A 3v4tH-4dpyA:
undetectable		 3v4tH-4dpyA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkh PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF05638
(T6SS_HCP) 		3 LYS A 105
GLU A  86
TRP A   8
 None
SO4  A 203 (-4.0A)
SO4  A 203 (-3.9A)
 1.47A 3v4tH-4hkhA:
undetectable		 3v4tH-4hkhA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1

(Homo sapiens) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		3 LYS A 222
GLU A 322
TRP A 215
 None
 1.26A 3v4tH-4ig8A:
undetectable		 3v4tH-4ig8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jeg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		3 LYS A 198
GLU A 195
TRP A 112
 None
 1.32A 3v4tH-4jegA:
undetectable		 3v4tH-4jegA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		3 LYS A 267
GLU A 269
TRP A 439
 None
 1.09A 3v4tH-4jqtA:
undetectable		 3v4tH-4jqtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 LYS A 165
GLU A 168
TRP A 161
 None
 1.47A 3v4tH-4jsoA:
2.0		 3v4tH-4jsoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3x HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS A  56
GLU A  83
TRP A  84
 None
 1.04A 3v4tH-4k3xA:
undetectable		 3v4tH-4k3xA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 LYS A 127
GLU A 128
TRP A 189
 None
 1.36A 3v4tH-4k3yA:
undetectable		 3v4tH-4k3yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 LYS A 172
GLU A 174
TRP A 189
 None
 1.46A 3v4tH-4k3yA:
undetectable		 3v4tH-4k3yA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 LYS A 229
GLU A 138
TRP A 195
 None
NAG  A1002 (-3.7A)
NAG  A1002 (-4.0A)
 0.96A 3v4tH-4kxbA:
undetectable		 3v4tH-4kxbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus) 		PF03328
(HpcH_HpaI) 		3 LYS A 123
GLU A 125
TRP A 128
 None
 0.85A 3v4tH-4l7zA:
undetectable		 3v4tH-4l7zA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 LYS A 307
GLU A 310
TRP A 311
 None
 1.30A 3v4tH-4m0mA:
undetectable		 3v4tH-4m0mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 LYS A  51
GLU A  79
TRP A  80
 None
 1.20A 3v4tH-4mc5A:
undetectable		 3v4tH-4mc5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oig NON-STRUCTURAL
PROTEIN 1, NS1

(Dengue virus) 		PF00948
(Flavi_NS1) 		3 LYS A 339
GLU A 340
TRP A 311
 SO4  A 406 (-2.9A)
SO4  A 406 (-4.0A)
None
 1.17A 3v4tH-4oigA:
undetectable		 3v4tH-4oigA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		3 LYS A 259
GLU A 263
TRP A 243
 None
 1.25A 3v4tH-4oueA:
0.1		 3v4tH-4oueA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzi 3-KETOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 3 LYS B  26
GLU B  30
TRP B 213
 None
 0.96A 3v4tH-4rziB:
undetectable		 3v4tH-4rziB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		3 LYS A 168
GLU A 140
TRP A 142
 None
 1.26A 3v4tH-4w78A:
undetectable		 3v4tH-4w78A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yf1 LMO0812 PROTEIN

(Listeria
monocytogenes) 		PF13328
(HD_4) 		3 LYS A  84
GLU A  82
TRP A  88
 None
 1.03A 3v4tH-4yf1A:
undetectable		 3v4tH-4yf1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 LYS B 282
GLU B 295
TRP B 299
 None
 0.94A 3v4tH-5a8rB:
undetectable		 3v4tH-5a8rB:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LYS B 388
GLU B 413
TRP B 414
 None
 1.28A 3v4tH-5c24B:
undetectable		 3v4tH-5c24B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LYS A 449
GLU A 445
TRP A 459
 None
 1.01A 3v4tH-5co8A:
undetectable		 3v4tH-5co8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 LYS A 327
GLU A 387
TRP A 150
 None
 1.14A 3v4tH-5cslA:
undetectable		 3v4tH-5cslA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 LYS H 501
GLU H 556
TRP H 754
 None
 1.40A 3v4tH-5dfwH:
undetectable		 3v4tH-5dfwH:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjp O-SUCCINYLBENZOATE
SYNTHASE

(Amycolatopsis
sp.) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 363
GLU A   7
TRP A 365
 None
 1.08A 3v4tH-5fjpA:
undetectable		 3v4tH-5fjpA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		3 LYS A 505
GLU A 508
TRP A 446
 None
 1.00A 3v4tH-5fqeA:
undetectable		 3v4tH-5fqeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		3 LYS A1197
GLU A1201
TRP A1121
 None
 1.31A 3v4tH-5fxvA:
undetectable		 3v4tH-5fxvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 LYS A  62
GLU A 143
TRP A 231
 None
 1.37A 3v4tH-5hqbA:
undetectable		 3v4tH-5hqbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 3 LYS A  71
GLU A  73
TRP A  49
 None
 0.92A 3v4tH-5i4aA:
undetectable		 3v4tH-5i4aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 LYS A 199
GLU A 195
TRP A 112
 None
 1.46A 3v4tH-5i6vA:
undetectable		 3v4tH-5i6vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 LYS B 625
GLU B 623
TRP B 586
 None
 0.88A 3v4tH-5ip9B:
undetectable		 3v4tH-5ip9B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 LYS A 460
GLU A 463
TRP A 324
 None
 1.48A 3v4tH-5kd5A:
undetectable		 3v4tH-5kd5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		3 LYS A 465
GLU A 462
TRP A 488
 None
 1.02A 3v4tH-5lc8A:
undetectable		 3v4tH-5lc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 LYS A 361
GLU A 365
TRP A 349
 None
 1.10A 3v4tH-5lp4A:
undetectable		 3v4tH-5lp4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		3 LYS S  36
GLU S  40
TRP S  54
 None
 1.19A 3v4tH-5mpdS:
undetectable		 3v4tH-5mpdS:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okz EXOSOME COMPLEX
COMPONENT MTR3

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		3 LYS F 163
GLU F 109
TRP F 214
 None
 1.37A 3v4tH-5okzF:
undetectable		 3v4tH-5okzF:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		3 LYS A 111
GLU A 112
TRP A 109
 ZN  A 303 ( 4.5A)
ZN  A 303 (-2.6A)
None
 1.40A 3v4tH-5ub8A:
undetectable		 3v4tH-5ub8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 3 LYS A 294
GLU A 292
TRP A 171
 None
 0.99A 3v4tH-5v2mA:
undetectable		 3v4tH-5v2mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x94 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2) 		3 LYS A 198
GLU A 195
TRP A 112
 None
 1.30A 3v4tH-5x94A:
undetectable		 3v4tH-5x94A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 330
GLU A 351
TRP A 354
 None
 1.34A 3v4tH-5xd7A:
undetectable		 3v4tH-5xd7A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehe OMPT PROTEIN

(Vibrio cholerae) 		no annotation 3 LYS A  55
GLU A  57
TRP A  88
 None
 0.94A 3v4tH-6eheA:
undetectable		 3v4tH-6eheA:
undetectable