SIMILAR PATTERNS OF AMINO ACIDS FOR 3V4T_H_ACTH502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		3 SER A 145
GLY A 146
GLN A 147
 None
 0.53A 3v4tH-1a33A:
0.0		 3v4tH-1a33A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyq INTRON-ENCODED
HOMING ENDONUCLEASE
I-PPOI

(Physarum
polycephalum) 		no annotation 3 SER A 159
GLY A 158
GLN A 156
 None
 0.35A 3v4tH-1cyqA:
0.0		 3v4tH-1cyqA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		3 SER A 156
GLY A 155
GLN A 153
 None
 0.52A 3v4tH-1e2tA:
0.0		 3v4tH-1e2tA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		3 SER A 110
GLY A 109
GLN A 118
 None
 0.58A 3v4tH-1jihA:
0.0		 3v4tH-1jihA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka8 PUTATIVE P4-SPECIFIC
DNA PRIMASE

(Enterobacteria
phage P4) 		PF03288
(Pox_D5) 		3 SER A  19
GLY A  20
GLN A  84
 None
 0.64A 3v4tH-1ka8A:
0.0		 3v4tH-1ka8A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knl ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00652
(Ricin_B_lectin) 		3 SER A  37
GLY A  38
GLN A  42
 None
 0.59A 3v4tH-1knlA:
undetectable		 3v4tH-1knlA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 SER A 292
GLY A 291
GLN A 289
 None
 0.52A 3v4tH-1ko0A:
1.2		 3v4tH-1ko0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 SER A 548
GLY A 547
GLN A 426
 None
 0.61A 3v4tH-1lq2A:
0.0		 3v4tH-1lq2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 3 SER 1  55
GLY 1  56
GLN 1 157
 None
 0.63A 3v4tH-1mec1:
0.0		 3v4tH-1mec1:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 SER A 351
GLY A 352
GLN A 330
 None
 0.64A 3v4tH-1nhcA:
undetectable		 3v4tH-1nhcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc)
PF14671
(DSPn) 		3 SER A 124
GLY A 123
GLN A 129
 None
 0.58A 3v4tH-1oheA:
undetectable		 3v4tH-1oheA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 SER A  99
GLY A  98
GLN A  96
 None
 0.64A 3v4tH-1qh5A:
undetectable		 3v4tH-1qh5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		3 SER A 492
GLY A 493
GLN A 496
 None
 0.60A 3v4tH-1qsaA:
undetectable		 3v4tH-1qsaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spk RIKEN CDNA
1300006M19

(Mus musculus) 		PF14604
(SH3_9) 		3 SER A   6
GLY A   7
GLN A   8
 None
 0.36A 3v4tH-1spkA:
undetectable		 3v4tH-1spkA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		3 SER A 236
GLY A 237
GLN A 241
 None
 0.58A 3v4tH-1vsgA:
undetectable		 3v4tH-1vsgA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		3 SER A  55
GLY A  56
GLN A  60
 None
 0.37A 3v4tH-1wocA:
undetectable		 3v4tH-1wocA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 562
GLY A 561
GLN A 559
 None
None
IOD  A9043 ( 3.6A)
 0.36A 3v4tH-1xc6A:
0.0		 3v4tH-1xc6A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 SER A 141
GLY A 142
GLN A 146
 None
 0.65A 3v4tH-1xvxA:
1.3		 3v4tH-1xvxA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z67 HYPOTHETICAL PROTEIN
S4005

(Shigella
flexneri) 		PF06078
(DUF937) 		3 SER A 105
GLY A 108
GLN A 107
 None
 0.55A 3v4tH-1z67A:
undetectable		 3v4tH-1z67A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE LARGE
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 SER A 365
GLY A 366
GLN A 370
 None
 0.65A 3v4tH-2b24A:
undetectable		 3v4tH-2b24A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccz PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		3 SER A  55
GLY A  56
GLN A  60
 None
 0.64A 3v4tH-2cczA:
undetectable		 3v4tH-2cczA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		3 SER A 124
GLY A 123
GLN A  43
 None
 0.45A 3v4tH-2cdpA:
undetectable		 3v4tH-2cdpA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 SER A  73
GLY A  74
GLN A 112
 None
 0.50A 3v4tH-2hq6A:
undetectable		 3v4tH-2hq6A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdj REDY-LIKE PROTEIN

(Hahella
chejuensis) 		PF11639
(HapK) 		3 SER A 100
GLY A  99
GLN A  97
 None
 0.46A 3v4tH-2jdjA:
undetectable		 3v4tH-2jdjA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2s MICRONEMAL PROTEIN 1

(Toxoplasma
gondii) 		PF11476
(TgMIC1) 		3 SER A  53
GLY A  52
GLN A  50
 None
 0.49A 3v4tH-2k2sA:
undetectable		 3v4tH-2k2sA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lko FERMITIN FAMILY
HOMOLOG 2

(Homo sapiens) 		PF00169
(PH) 		3 SER A 435
GLY A 436
GLN A 437
 None
 0.65A 3v4tH-2lkoA:
undetectable		 3v4tH-2lkoA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf5 CELL SHAPE
DETERMINING PROTEIN
MREC

(Streptococcus
pneumoniae) 		PF04085
(MreC) 		3 SER A 186
GLY A 185
GLN A 183
 None
 0.48A 3v4tH-2qf5A:
undetectable		 3v4tH-2qf5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 SER A 146
GLY A 147
GLN A 148
 None
 0.49A 3v4tH-2wfiA:
undetectable		 3v4tH-2wfiA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 SER A 136
GLY A 135
GLN A 261
 None
 0.63A 3v4tH-2wk2A:
undetectable		 3v4tH-2wk2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		3 SER A 506
GLY A 507
GLN A 362
 None
 0.54A 3v4tH-2x1mA:
undetectable		 3v4tH-2x1mA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		3 SER A 333
GLY A 332
GLN A 330
 None
 0.53A 3v4tH-2yokA:
undetectable		 3v4tH-2yokA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 LYMPHOCYTE ANTIGEN
96

(Homo sapiens) 		PF02221
(E1_DerP2_DerF2) 		3 SER C 141
GLY C 140
GLN C  73
 None
 0.39A 3v4tH-2z65C:
undetectable		 3v4tH-2z65C:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 SER A 739
GLY A 550
GLN A 554
 None
 0.57A 3v4tH-3ahiA:
1.4		 3v4tH-3ahiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01301
(Glyco_hydro_35) 		3 SER A 404
GLY A 403
GLN A 400
 None
 0.56A 3v4tH-3d3aA:
1.2		 3v4tH-3d3aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		3 SER A 306
GLY A 305
GLN A 308
 None
 0.60A 3v4tH-3dc8A:
0.1		 3v4tH-3dc8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		3 SER A  40
GLY A  41
GLN A  43
 None
 0.63A 3v4tH-3ehsA:
1.3		 3v4tH-3ehsA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		3 SER A 232
GLY A 231
GLN A 229
 None
 0.38A 3v4tH-3fhaA:
undetectable		 3v4tH-3fhaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fld PROTEIN TRAI

(Escherichia
coli) 		PF07057
(TraI) 		3 SER A1558
GLY A1559
GLN A1589
 SO4  A1706 (-3.3A)
None
None
 0.63A 3v4tH-3fldA:
undetectable		 3v4tH-3fldA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 SER A  95
GLY A  96
GLN A  35
 None
 0.62A 3v4tH-3fpkA:
undetectable		 3v4tH-3fpkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 3 SER A2080
GLY A2079
GLN A2086
 None
 0.60A 3v4tH-3fyqA:
undetectable		 3v4tH-3fyqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvz UNCHARACTERIZED
PROTEIN CV2077

(Chromobacterium
violaceum) 		PF03417
(AAT) 		3 SER A 168
GLY A 169
GLN A 166
 None
 0.61A 3v4tH-3gvzA:
undetectable		 3v4tH-3gvzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL

(Bos taurus) 		PF00380
(Ribosomal_S9) 		3 SER I 333
GLY I 334
GLN I 340
 None
 0.61A 3v4tH-3jd5I:
undetectable		 3v4tH-3jd5I:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 SER A  63
GLY A  64
GLN A  65
 None
 0.37A 3v4tH-3juuA:
undetectable		 3v4tH-3juuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 SER A  69
GLY A  72
GLN A 124
 None
 0.64A 3v4tH-3kg5A:
undetectable		 3v4tH-3kg5A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		3 SER A 380
GLY A 381
GLN A 382
 None
 0.48A 3v4tH-3odnA:
undetectable		 3v4tH-3odnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		3 SER A  71
GLY A  70
GLN A  39
 DCK  A 401 (-4.4A)
None
DCK  A 401 (-3.0A)
 0.55A 3v4tH-3ppoA:
undetectable		 3v4tH-3ppoA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 SER A 236
GLY A 235
GLN A 233
 None
 0.42A 3v4tH-3r5tA:
undetectable		 3v4tH-3r5tA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 SER A 206
GLY A 207
GLN A 208
 None
 0.20A 3v4tH-3swdA:
68.9		 3v4tH-3swdA:
93.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 SER A 663
GLY A 662
GLN A 607
 None
 0.43A 3v4tH-3syjA:
undetectable		 3v4tH-3syjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		3 SER A 134
GLY A 135
GLN A 138
 None
 0.59A 3v4tH-3te7A:
undetectable		 3v4tH-3te7A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 SER A 554
GLY A 553
GLN A 428
 None
 0.55A 3v4tH-3uszA:
undetectable		 3v4tH-3uszA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 SER A  54
GLY A  53
GLN A  51
 None
 0.60A 3v4tH-4bmbA:
undetectable		 3v4tH-4bmbA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		3 SER A 380
GLY A 381
GLN A 385
 None
 0.49A 3v4tH-4dykA:
undetectable		 3v4tH-4dykA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbo PSEUDOMONAS
FLUORESCENS
AGGLUTININ

(Pseudomonas
fluorescens) 		no annotation 3 SER A  13
GLY A  12
GLN A   9
 None
 0.36A 3v4tH-4fboA:
undetectable		 3v4tH-4fboA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 3 SER A  13
GLY A  12
GLN A   9
 None
 0.52A 3v4tH-4fbvA:
undetectable		 3v4tH-4fbvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbv MYXOBACTERIAL
HEMAGGLUTININ

(Myxococcus
xanthus) 		no annotation 3 SER A 147
GLY A 146
GLN A 143
 None
MAN  A 303 (-3.4A)
None
 0.48A 3v4tH-4fbvA:
undetectable		 3v4tH-4fbvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqk ANTIBODY CR8059
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER E 100
GLY E 100
GLN E  97
 None
 0.61A 3v4tH-4fqkE:
undetectable		 3v4tH-4fqkE:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 3 SER A  21
GLY A  20
GLN A  17
 None
MAN  A 319 (-3.5A)
None
 0.64A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 3 SER A  88
GLY A  87
GLN A  84
 None
MAN  A 309 (-3.4A)
None
 0.36A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 3 SER A 155
GLY A 154
GLN A 151
 None
MAN  A 304 (-3.5A)
None
 0.27A 3v4tH-4gk9A:
undetectable		 3v4tH-4gk9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		3 SER A  77
GLY A 132
GLN A 133
 None
 0.49A 3v4tH-4h4cA:
undetectable		 3v4tH-4h4cA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 SER A 501
GLY A 500
GLN A 498
 None
 0.35A 3v4tH-4i3gA:
undetectable		 3v4tH-4i3gA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		3 SER A  41
GLY A 223
GLN A 263
 None
 0.59A 3v4tH-4iw7A:
undetectable		 3v4tH-4iw7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 3 SER D 516
GLY D 515
GLN D 513
 None
 0.65A 3v4tH-4jf7D:
undetectable		 3v4tH-4jf7D:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		3 SER A 144
GLY A 145
GLN A 146
 None
 0.34A 3v4tH-4kc8A:
undetectable		 3v4tH-4kc8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 3 SER B 506
GLY B 507
GLN B 488
 None
 0.58A 3v4tH-4o9dB:
undetectable		 3v4tH-4o9dB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		3 SER A 510
GLY A 511
GLN A 528
 None
 0.54A 3v4tH-4pw5A:
undetectable		 3v4tH-4pw5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwt PEPTIDOGLYCAN-ASSOCI
ATED LIPOPROTEIN

(Yersinia pestis) 		PF00691
(OmpA) 		3 SER A  45
GLY A  44
GLN A  52
 None
 0.55A 3v4tH-4pwtA:
undetectable		 3v4tH-4pwtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A 784
GLY A 783
GLN A 781
 None
 0.37A 3v4tH-4qpmA:
undetectable		 3v4tH-4qpmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		3 SER A  73
GLY A  74
GLN A 112
 GOL  A 403 (-2.7A)
None
GOL  A 402 (-3.5A)
 0.48A 3v4tH-4r3eA:
undetectable		 3v4tH-4r3eA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		3 SER A 310
GLY A 309
GLN A 312
 None
 0.61A 3v4tH-4tqtA:
undetectable		 3v4tH-4tqtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 SER A  38
GLY A  39
GLN A  77
 FAD  A 402 (-3.4A)
FES  A 401 (-3.5A)
FAD  A 402 ( 4.7A)
 0.65A 3v4tH-4wqmA:
undetectable		 3v4tH-4wqmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqx JES6-1 VL DOMAIN

(Rattus
norvegicus) 		PF07686
(V-set) 		3 SER L  35
GLY L  36
GLN L  38
 None
 0.64A 3v4tH-4yqxL:
undetectable		 3v4tH-4yqxL:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		3 SER D 228
GLY D 229
GLN D 288
 None
 0.50A 3v4tH-5d9qD:
undetectable		 3v4tH-5d9qD:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 3 SER A 283
GLY A 284
GLN A 287
 None
 0.52A 3v4tH-5f9aA:
undetectable		 3v4tH-5f9aA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		3 SER G  97
GLY G  98
GLN G 212
 None
 0.58A 3v4tH-5fq8G:
undetectable		 3v4tH-5fq8G:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hir HIRUDIN VARIANT-1

(Hirudo
medicinalis) 		PF00713
(Hirudin) 		3 SER A   9
GLY A  10
GLN A  11
 None
 0.64A 3v4tH-5hirA:
undetectable		 3v4tH-5hirA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 240
GLY A 241
GLN A 288
 None
 0.65A 3v4tH-5ihrA:
undetectable		 3v4tH-5ihrA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		3 SER A 126
GLY A 125
GLN A 121
 None
 0.58A 3v4tH-5jjpA:
undetectable		 3v4tH-5jjpA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		3 SER B2129
GLY B2126
GLN B2096
 None
 0.63A 3v4tH-5m59B:
undetectable		 3v4tH-5m59B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 3 SER A 564
GLY A 563
GLN A 444
 None
 0.55A 3v4tH-5m6gA:
undetectable		 3v4tH-5m6gA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 SER A 268
GLY A 269
GLN A 271
 None
 0.62A 3v4tH-5mewA:
undetectable		 3v4tH-5mewA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxf PHOTORHABDUS
ASYMBIOTICA LECTIN
PHL

(Photorhabdus
asymbiotica) 		PF03984
(DUF346) 		3 SER A 304
GLY A 305
GLN A 299
 None
 0.45A 3v4tH-5mxfA:
undetectable		 3v4tH-5mxfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ney FUCOSE-BINDING
LECTIN II (PA-IIL)

(Pseudomonas
aeruginosa) 		PF07472
(PA-IIL) 		3 SER A  23
GLY A  24
GLN A  43
 ZDC  A 201 (-2.7A)
None
None
 0.63A 3v4tH-5neyA:
undetectable		 3v4tH-5neyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 SER A 559
GLY A 560
GLN A 583
 None
 0.64A 3v4tH-5um6A:
undetectable		 3v4tH-5um6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5waq OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMD

(Neisseria
gonorrhoeae) 		no annotation 3 SER A 207
GLY A 206
GLN A 209
 None
 0.65A 3v4tH-5waqA:
undetectable		 3v4tH-5waqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 SER E  28
GLY E  29
GLN E  88
 MAN  G 626 (-4.0A)
NAG  G 633 ( 4.5A)
None
 0.00A 3v4tH-5wduE:
undetectable		 3v4tH-5wduE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		3 SER B  30
GLY B  30
GLN B  30
 None
 0.37A 3v4tH-5xcuB:
undetectable		 3v4tH-5xcuB:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xje LOW AFFINITY
IMMUNOGLOBULIN GAMMA
FC REGION RECEPTOR
III-A

(Homo sapiens) 		no annotation 3 SER C 149
GLY C 150
GLN C 125
 None
 0.54A 3v4tH-5xjeC:
undetectable		 3v4tH-5xjeC:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US9

(Toxoplasma
gondii) 		PF00380
(Ribosomal_S9) 		3 SER Q  75
GLY Q  76
GLN Q  82
 A  21479 ( 4.8A)
A  21479 ( 3.8A)
C  21478 ( 3.4A)
 0.63A 3v4tH-5xxuQ:
undetectable		 3v4tH-5xxuQ:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 3 SER A 814
GLY A 815
GLN A 727
 None
 0.36A 3v4tH-5yimA:
undetectable		 3v4tH-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z1w POLYCYSTIC KIDNEY
DISEASE 2-LIKE 1
PROTEIN

(Mus musculus) 		no annotation 3 SER A 256
GLY A 255
GLN A 250
 None
 0.60A 3v4tH-5z1wA:
undetectable		 3v4tH-5z1wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 3 SER A 442
GLY A 441
GLN A 280
 None
 0.57A 3v4tH-5zb3A:
undetectable		 3v4tH-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6

(Mus musculus) 		no annotation 3 SER A 114
GLY A 113
GLN A 111
 None
EPE  A 206 ( 3.7A)
None
 0.34A 3v4tH-5zryA:
undetectable		 3v4tH-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zry ANKYRIN REPEAT AND
SAM
DOMAIN-CONTAINING
PROTEIN 1A,EPHRIN
TYPE-A RECEPTOR 6

(Mus musculus) 		no annotation 3 SER A 115
GLY A 116
GLN A 111
 None
EPE  A 206 (-3.8A)
None
 0.51A 3v4tH-5zryA:
undetectable		 3v4tH-5zryA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0i KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		no annotation 3 SER K 478
GLY K 479
GLN K 480
 None
 0.58A 3v4tH-6b0iK:
undetectable		 3v4tH-6b0iK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 3 SER A 130
GLY A 129
GLN A 127
 None
 0.49A 3v4tH-6brmA:
undetectable		 3v4tH-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 SER A 404
GLY A 403
GLN A 400
 None
 0.55A 3v4tH-6eonA:
undetectable		 3v4tH-6eonA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 3 SER B 336
GLY B 337
GLN B 349
 None
 0.51A 3v4tH-6epiB:
2.3		 3v4tH-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h25


(;
) 		no annotation
no annotation 		3 SER A 237
GLY A 238
GLN B 105
 None
 0.54A 3v4tH-6h25A:
undetectable		 3v4tH-6h25A:
undetectable