SIMILAR PATTERNS OF AMINO ACIDS FOR 3V4T_E_ACTE502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3r FV ANTIBODY FRAGMENT

(Rattus
norvegicus) 		PF07686
(V-set) 		3 LYS B 177
ARG B 199
LEU B 185
 None
 1.31A 3v4tE-1f3rB:
undetectable		 3v4tE-1f3rB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5x RHO-GEF VAV

(Mus musculus) 		PF00621
(RhoGEF) 		3 LYS A  27
ARG A 165
LEU A 172
 None
 1.35A 3v4tE-1f5xA:
undetectable		 3v4tE-1f5xA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 LYS A 260
ARG A 160
LEU A 108
 None
FAD  A 699 (-3.1A)
None
 1.29A 3v4tE-1fcdA:
1.5		 3v4tE-1fcdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 LYS A  22
ARG A 139
LEU A 111
 None
 1.38A 3v4tE-1h54A:
0.0		 3v4tE-1h54A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin) 		3 LYS A 229
ARG A 289
LEU A 237
 None
 1.17A 3v4tE-1ldkA:
undetectable		 3v4tE-1ldkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE
METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		3 LYS B  75
ARG G  44
LEU G  54
 None
 1.36A 3v4tE-1mtyB:
0.0		 3v4tE-1mtyB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 LYS A 251
ARG A 368
LEU A 258
 None
 1.05A 3v4tE-1nfgA:
0.0		 3v4tE-1nfgA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 LYS A  31
ARG A  42
LEU A 122
 HEM  A 992 (-2.7A)
HEM  A 992 ( 2.7A)
HEM  A 991 (-4.3A)
 1.22A 3v4tE-1pbyA:
undetectable		 3v4tE-1pbyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		3 LYS A 359
ARG A 199
LEU A 195
 None
 1.33A 3v4tE-1qcxA:
undetectable		 3v4tE-1qcxA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		3 LYS A 258
ARG A  69
LEU A 102
 RIS  A 901 (-2.7A)
IPE  A 900 (-3.2A)
None
 1.41A 3v4tE-1rqjA:
undetectable		 3v4tE-1rqjA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 LYS A 199
ARG A 222
LEU A 238
 CIT  A2001 ( 2.7A)
CIT  A2001 ( 2.9A)
DKA  A1003 (-4.3A)
 1.08A 3v4tE-1tf0A:
undetectable		 3v4tE-1tf0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe0 NUCLEOPHOSMIN

(Xenopus laevis) 		PF03066
(Nucleoplasmin) 		3 LYS A  13
ARG A  47
LEU A 118
 None
 1.22A 3v4tE-1xe0A:
undetectable		 3v4tE-1xe0A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 LYS A 302
ARG A 393
LEU A 497
 None
CIT  A1103 ( 3.7A)
None
 1.13A 3v4tE-1xf1A:
undetectable		 3v4tE-1xf1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 LYS A 375
ARG A 663
LEU A 585
 None
 1.07A 3v4tE-1z68A:
undetectable		 3v4tE-1z68A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 LYS A1035
ARG A 998
LEU A1318
 None
 1.32A 3v4tE-2b39A:
undetectable		 3v4tE-2b39A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		3 LYS A 482
ARG A 452
LEU A 479
 GOL  A2012 (-3.3A)
GOL  A2012 (-3.0A)
None
 1.36A 3v4tE-2hb6A:
undetectable		 3v4tE-2hb6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		3 LYS A 105
ARG A  79
LEU A 126
 None
 0.98A 3v4tE-2iqtA:
undetectable		 3v4tE-2iqtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		3 LYS A  89
ARG A 105
LEU A 222
 None
 1.24A 3v4tE-2jfwA:
undetectable		 3v4tE-2jfwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd3 SCLEROSTIN

(Mus musculus) 		PF05463
(Sclerostin) 		3 LYS A  48
ARG A 115
LEU A  78
 None
 1.32A 3v4tE-2kd3A:
undetectable		 3v4tE-2kd3A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2
SEPTIN-6

(Homo sapiens;
Homo sapiens) 		PF00735
(Septin)
PF00735
(Septin) 		3 LYS B 185
ARG A 194
LEU A 187
 GTP  B 428 (-2.8A)
GTP  B 428 (-3.6A)
None
 1.18A 3v4tE-2qagB:
undetectable		 3v4tE-2qagB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		3 LYS A 162
ARG A 250
LEU A 310
 None
None
ADP  A1789 (-4.3A)
 1.02A 3v4tE-2v26A:
undetectable		 3v4tE-2v26A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		3 LYS A  45
ARG A 244
LEU A 241
 FAD  A1385 (-2.6A)
FAD  A1385 ( 4.6A)
None
 1.31A 3v4tE-2v3bA:
undetectable		 3v4tE-2v3bA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		3 LYS A 118
ARG A 356
LEU A 131
 None
 1.11A 3v4tE-2vhlA:
undetectable		 3v4tE-2vhlA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 LYS D 687
ARG D 740
LEU D 733
 None
 1.26A 3v4tE-2vnuD:
undetectable		 3v4tE-2vnuD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LYS A 432
ARG A 950
LEU A 887
 None
 1.39A 3v4tE-2xvgA:
undetectable		 3v4tE-2xvgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw4 4-HYDROXY-2-OXOGLUTA
RATE
ALDOLASE/2-DEYDRO-3-
DEOXYPHOSPHOGLUCONAT
E ALDOLASE

(Thermus
thermophilus) 		PF01081
(Aldolase) 		3 LYS A 129
ARG A  47
LEU A  18
 None
 1.39A 3v4tE-2yw4A:
undetectable		 3v4tE-2yw4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z9v ASPARTATE
AMINOTRANSFERASE

(Mesorhizobium
loti) 		PF00266
(Aminotran_5) 		3 LYS A  51
ARG A  31
LEU A  44
 None
 1.43A 3v4tE-2z9vA:
undetectable		 3v4tE-2z9vA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		3 LYS A 309
ARG A 321
LEU A 251
 None
 1.23A 3v4tE-3eq2A:
undetectable		 3v4tE-3eq2A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 LYS A 441
ARG A 229
LEU A 362
 None
 1.35A 3v4tE-3fdhA:
undetectable		 3v4tE-3fdhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		3 LYS A 370
ARG A 410
LEU A 403
 None
 1.33A 3v4tE-3focA:
undetectable		 3v4tE-3focA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 3 LYS A 222
ARG A 115
LEU A  89
 None
 1.23A 3v4tE-3fokA:
undetectable		 3v4tE-3fokA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LYS A 417
ARG A 270
LEU A 227
 PO4  A 556 ( 2.5A)
PO4  A 556 ( 4.8A)
PO4  A 556 ( 4.5A)
 1.41A 3v4tE-3gdeA:
undetectable		 3v4tE-3gdeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		3 LYS A 321
ARG A 183
LEU A 377
 None
 1.40A 3v4tE-3gg0A:
undetectable		 3v4tE-3gg0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 LYS A 454
ARG A 244
LEU A 366
 None
 1.36A 3v4tE-3gzsA:
undetectable		 3v4tE-3gzsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkf PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		3 LYS A 106
ARG A  34
LEU A 116
 P6G  A 206 (-2.7A)
P6G  A 206 ( 4.6A)
P6G  A 206 (-4.0A)
 1.11A 3v4tE-3kkfA:
undetectable		 3v4tE-3kkfA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		3 LYS A   2
ARG A 111
LEU A  84
 None
 1.25A 3v4tE-3kxiA:
undetectable		 3v4tE-3kxiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mh9 LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		no annotation 3 LYS C  34
ARG C 167
LEU C  38
 None
 1.32A 3v4tE-3mh9C:
undetectable		 3v4tE-3mh9C:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		3 LYS A 367
ARG A 447
LEU A 159
 None
 1.36A 3v4tE-3n6xA:
undetectable		 3v4tE-3n6xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 LYS A 756
ARG A 234
LEU A 272
 SO4  A 996 (-3.0A)
SO4  A 996 (-3.5A)
None
 0.89A 3v4tE-3opyA:
undetectable		 3v4tE-3opyA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 LYS B 730
ARG B 205
LEU B 244
 SO4  B 944 (-2.8A)
SO4  B 944 (-2.7A)
None
 0.70A 3v4tE-3opyB:
undetectable		 3v4tE-3opyB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LYS A 431
ARG A 281
LEU A 237
 None
 1.38A 3v4tE-3rr5A:
undetectable		 3v4tE-3rr5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stb SINGLE DOMAIN
ANTIBODY VHH
MP18 RNA EDITING
COMPLEX PROTEIN

(Lama glama;
Trypanosoma
brucei) 		PF07686
(V-set)
PF00436
(SSB) 		3 LYS A   4
ARG A 101
LEU D 105
 None
 1.41A 3v4tE-3stbA:
undetectable		 3v4tE-3stbA:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 120
LEU A 370
 EPZ  A 501 (-2.7A)
EPZ  A 501 (-4.1A)
EPZ  A 501 ( 4.6A)
 0.78A 3v4tE-3swdA:
68.5		 3v4tE-3swdA:
93.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 331
LEU A 370
 EPZ  A 501 (-2.7A)
EPZ  A 501 ( 4.2A)
EPZ  A 501 ( 4.6A)
 0.97A 3v4tE-3swdA:
68.5		 3v4tE-3swdA:
93.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 122
LEU A 372
 EPZ  A 508 (-2.5A)
EPZ  A 508 (-3.9A)
EPZ  A 508 (-4.2A)
 0.63A 3v4tE-3sweA:
67.1		 3v4tE-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 333
LEU A 372
 EPZ  A 508 (-2.5A)
EPZ  A 508 (-3.7A)
EPZ  A 508 (-4.2A)
 0.97A 3v4tE-3sweA:
67.1		 3v4tE-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		3 LYS A  31
ARG A 129
LEU A 376
 EPZ  A 518 (-2.6A)
EPZ  A 518 (-4.0A)
EPZ  A 518 (-4.4A)
 0.61A 3v4tE-3swgA:
61.1		 3v4tE-3swgA:
44.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		3 LYS A  31
ARG A 337
LEU A 376
 EPZ  A 518 (-2.6A)
EPZ  A 518 ( 4.1A)
EPZ  A 518 (-4.4A)
 1.06A 3v4tE-3swgA:
61.1		 3v4tE-3swgA:
44.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		3 LYS A  71
ARG A 459
LEU A  27
 None
 1.36A 3v4tE-3up4A:
undetectable		 3v4tE-3up4A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		3 LYS A 111
ARG A 191
LEU A  53
 None
None
GOL  A 404 (-3.4A)
 1.43A 3v4tE-3v4yA:
undetectable		 3v4tE-3v4yA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 LYS A 125
ARG A 385
LEU A  48
 None
 0.41A 3v4tE-3va8A:
undetectable		 3v4tE-3va8A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		3 LYS A 351
ARG A 553
LEU A 560
 None
 1.36A 3v4tE-3wonA:
undetectable		 3v4tE-3wonA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		3 LYS A 162
ARG A 250
LEU A 310
 None
None
ADP  A2230 ( 4.3A)
 1.05A 3v4tE-4anjA:
undetectable		 3v4tE-4anjA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 LYS A 188
ARG A 205
LEU A 109
 None
 1.27A 3v4tE-4c30A:
undetectable		 3v4tE-4c30A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckm SAS-6

(Leishmania
major) 		PF16531
(SAS-6_N) 		3 LYS A 242
ARG A 153
LEU A 236
 None
 0.79A 3v4tE-4ckmA:
undetectable		 3v4tE-4ckmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 LYS A  12
ARG A 397
LEU A  41
 None
 1.27A 3v4tE-4cnsA:
undetectable		 3v4tE-4cnsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 122
ARG A 381
LEU A  45
 None
 0.99A 3v4tE-4dhgA:
undetectable		 3v4tE-4dhgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY

(Bacillus
subtilis) 		PF00171
(Aldedh) 		3 LYS A 288
ARG A 162
LEU A 409
 None
 1.17A 3v4tE-4dngA:
undetectable		 3v4tE-4dngA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		3 LYS A 264
ARG A  51
LEU A  95
 0MW  A 404 ( 3.0A)
IPE  A 405 (-2.5A)
None
 1.40A 3v4tE-4e1eA:
undetectable		 3v4tE-4e1eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ely DNA GYRASE SUBUNIT A

(Shigella
flexneri) 		PF00521
(DNA_topoisoIV) 		3 LYS A 465
ARG A 376
LEU A 383
 None
 1.20A 3v4tE-4elyA:
undetectable		 3v4tE-4elyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6q PROLINE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF01619
(Pro_dh) 		3 LYS A  98
ARG A 292
LEU A  62
 TFB  A2002 (-2.8A)
TFB  A2002 ( 2.6A)
None
 0.94A 3v4tE-4h6qA:
1.8		 3v4tE-4h6qA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 LYS A 171
ARG A 145
LEU A 164
 NCN  A 301 (-3.3A)
None
None
 1.34A 3v4tE-4i9aA:
undetectable		 3v4tE-4i9aA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		3 LYS A 264
ARG A  51
LEU A  95
 476  A 402 (-2.9A)
IPE  A 401 (-2.8A)
None
 1.42A 3v4tE-4jzxA:
undetectable		 3v4tE-4jzxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		3 LYS A  51
ARG A 181
LEU A 254
 None
 1.43A 3v4tE-4l22A:
undetectable		 3v4tE-4l22A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 LYS A 456
ARG A 421
LEU A 464
 None
 1.41A 3v4tE-4mx2A:
undetectable		 3v4tE-4mx2A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		3 LYS A 234
ARG A 342
LEU A 338
 None
 1.41A 3v4tE-4nesA:
undetectable		 3v4tE-4nesA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqq HUMAN ANTI-HIV-1
ANTIBODY PGDM1400
LIGHT CHAIN

(Homo sapiens) 		no annotation 3 LYS L  39
ARG L  61
LEU L  47
 None
 1.40A 3v4tE-4rqqL:
undetectable		 3v4tE-4rqqL:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		3 LYS A 567
ARG A  48
LEU A  86
 PO4  A 804 ( 3.9A)
PO4  A 804 (-3.2A)
None
 1.11A 3v4tE-4u1rA:
undetectable		 3v4tE-4u1rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy4 SPINDLIN-4

(Homo sapiens) 		PF02513
(Spin-Ssty) 		3 LYS A 223
ARG A  94
LEU A  87
 None
 0.97A 3v4tE-4uy4A:
undetectable		 3v4tE-4uy4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		3 LYS A 731
ARG A 743
LEU A 511
 None
 1.24A 3v4tE-4v1uA:
undetectable		 3v4tE-4v1uA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		3 LYS A 440
ARG A  84
LEU A 418
 None
 1.38A 3v4tE-4wjsA:
undetectable		 3v4tE-4wjsA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 3 LYS A 407
ARG A  34
LEU A 397
 None
 1.22A 3v4tE-4yubA:
undetectable		 3v4tE-4yubA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 LYS A 951
ARG A 551
LEU A 964
 None
 1.36A 3v4tE-4zmhA:
undetectable		 3v4tE-4zmhA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		3 LYS E  62
ARG E 263
LEU E 326
 None
 1.11A 3v4tE-5b04E:
undetectable		 3v4tE-5b04E:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		3 LYS A  30
ARG A 173
LEU A 122
 SO4  A 401 (-2.7A)
None
None
 1.24A 3v4tE-5b3fA:
undetectable		 3v4tE-5b3fA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 122
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 (-3.9A)
EPU  A 501 (-4.5A)
 0.60A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 334
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 ( 4.2A)
EPU  A 501 (-4.5A)
 1.08A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cj5 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycolicibacterium
thermoresistibile) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		3 LYS A 431
ARG A 489
LEU A 438
 None
 1.10A 3v4tE-5cj5A:
undetectable		 3v4tE-5cj5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza C
virus;
Influenza C
virus) 		PF00602
(Flu_PB1)
PF00604
(Flu_PB2) 		3 LYS B 747
ARG C 739
LEU B 719
 None
 1.29A 3v4tE-5d9aB:
undetectable		 3v4tE-5d9aB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ekp UNCHARACTERIZED
GLYCOSYLTRANSFERASE
SLL0501

(Synechocystis
sp. PCC 6803) 		no annotation 3 LYS C 296
ARG C 177
LEU C 300
 None
 1.41A 3v4tE-5ekpC:
undetectable		 3v4tE-5ekpC:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 LYS A1237
ARG A 429
LEU A 438
 None
FAD  A3004 (-4.1A)
FAD  A3004 (-4.8A)
 1.39A 3v4tE-5epgA:
undetectable		 3v4tE-5epgA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Candida
albicans) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		3 LYS A 276
ARG A 356
LEU A 218
 None
 1.34A 3v4tE-5jpeA:
undetectable		 3v4tE-5jpeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		3 LYS A  22
ARG A  96
LEU A  67
 None
 1.27A 3v4tE-5lb8A:
1.4		 3v4tE-5lb8A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		3 LYS A  17
ARG A 302
LEU A 336
 None
 1.05A 3v4tE-5lzlA:
undetectable		 3v4tE-5lzlA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 LYS A1917
ARG A1679
LEU A2324
 None
 1.06A 3v4tE-5nugA:
undetectable		 3v4tE-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3
CONDENSIN COMPLEX
SUBUNIT 2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		no annotation
no annotation 		3 LYS C 536
ARG A 315
LEU A 404
 None
 1.04A 3v4tE-5oqrC:
undetectable		 3v4tE-5oqrC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		3 LYS A 505
ARG A 601
LEU A 619
 None
 1.42A 3v4tE-5svcA:
undetectable		 3v4tE-5svcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 LYS A  62
ARG A 183
LEU A2262
 None
MK6  A2402 (-4.0A)
None
 1.19A 3v4tE-5tzyA:
undetectable		 3v4tE-5tzyA:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 LYS A  22
ARG A 332
LEU A 371
 FMT  A 507 ( 2.7A)
FMT  A 507 (-3.5A)
FMT  A 507 ( 4.9A)
 1.42A 3v4tE-5u4hA:
64.0		 3v4tE-5u4hA:
58.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 LYS A 255
ARG A 246
LEU A 403
 None
 1.42A 3v4tE-5wu7A:
undetectable		 3v4tE-5wu7A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		3 LYS A  22
ARG A  31
LEU A  77
 None
 1.24A 3v4tE-5wx1A:
undetectable		 3v4tE-5wx1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5

(Komagataella
phaffii;
Komagataella
phaffii) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2) 		3 LYS C 224
ARG K  47
LEU K  52
 None
 1.27A 3v4tE-5xogC:
undetectable		 3v4tE-5xogC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 3 LYS A1348
ARG A1319
LEU A1375
 None
 1.30A 3v4tE-5xyaA:
undetectable		 3v4tE-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3, PUTATIVE

(Trichomonas
vaginalis) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 LYS D 201
ARG D  94
LEU D 191
 None
 1.29A 3v4tE-5xyiD:
undetectable		 3v4tE-5xyiD:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C 124
ARG C  70
LEU C 130
 None
 1.39A 3v4tE-5y3rC:
undetectable		 3v4tE-5y3rC:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5w SPINDLIN-1

(Homo sapiens) 		no annotation 3 LYS A 246
ARG A 107
LEU A 100
 None
 0.87A 3v4tE-5y5wA:
undetectable		 3v4tE-5y5wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 3 LYS A  48
ARG A 116
LEU A 102
 None
 1.06A 3v4tE-5yudA:
2.1		 3v4tE-5yudA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 3 LYS A  22
ARG A 122
LEU A 373
 EPU  A 501 (-4.1A)
EPU  A 501 (-3.9A)
EPU  A 501 (-4.6A)
 1.07A 3v4tE-6cn1A:
63.6		 3v4tE-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgb IS607 FAMILY
TRANSPOSASE IS1535

(Mycobacterium
tuberculosis) 		no annotation 3 LYS A  98
ARG A 168
LEU A  96
 None
 1.39A 3v4tE-6dgbA:
undetectable		 3v4tE-6dgbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus;
Influenza B
virus) 		no annotation
no annotation 		3 LYS B 530
ARG C 211
LEU C 149
 None
 1.35A 3v4tE-6f5oB:
undetectable		 3v4tE-6f5oB:
undetectable