SIMILAR PATTERNS OF AMINO ACIDS FOR 3V4T_C_ACTC502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		3 PRO A  16
ASP A  21
GLU A  19
 None
 0.88A 3v4tC-1c9eA:
0.0		 3v4tC-1c9eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jba PROTEIN (GUANYLATE
CYCLASE ACTIVATING
PROTEIN 2)

(Bos taurus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 PRO A  52
ASP A  53
GLU A  55
 None
 0.78A 3v4tC-1jbaA:
undetectable		 3v4tC-1jbaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 PRO A 219
ASP A 212
GLU A 210
 None
 0.75A 3v4tC-1l5jA:
0.0		 3v4tC-1l5jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 PRO A  17
ASP A 222
GLU A  22
 None
 0.81A 3v4tC-1li7A:
0.0		 3v4tC-1li7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		3 PRO A 223
ASP A 293
GLU A 225
 None
 0.88A 3v4tC-1miqA:
0.0		 3v4tC-1miqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		3 PRO A 640
ASP A 642
GLU A 653
 None
 0.86A 3v4tC-1p15A:
0.0		 3v4tC-1p15A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PRO A 427
ASP A 456
GLU A  60
 None
 0.87A 3v4tC-1poxA:
0.0		 3v4tC-1poxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00355
(Rieske) 		3 PRO C 203
ASP C 196
GLU C 194
 None
 0.72A 3v4tC-1q90C:
undetectable		 3v4tC-1q90C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		3 PRO A 180
ASP A 179
GLU A  19
 None
 0.78A 3v4tC-1rptA:
undetectable		 3v4tC-1rptA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13531
(SBP_bac_11) 		3 PRO A 213
ASP A 111
GLU A 215
 None
 0.80A 3v4tC-1sbpA:
0.0		 3v4tC-1sbpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0l PROBABLE GTPASE ENGC

(Thermotoga
maritima) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		3 PRO A  53
ASP A  54
GLU A  62
 None
 0.88A 3v4tC-1u0lA:
undetectable		 3v4tC-1u0lA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7k GAG POLYPROTEIN

(Murine leukemia
virus) 		PF02093
(Gag_p30) 		3 PRO A  98
ASP A  94
GLU A 100
 None
 0.75A 3v4tC-1u7kA:
undetectable		 3v4tC-1u7kA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M

(Homo sapiens) 		PF00179
(UQ_con) 		3 PRO A 144
ASP A 143
GLU A 142
 None
 0.84A 3v4tC-1y8xA:
undetectable		 3v4tC-1y8xA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		3 PRO A  84
ASP A  85
GLU A 117
 None
 0.79A 3v4tC-1yewA:
undetectable		 3v4tC-1yewA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yua TOPOISOMERASE I

(Escherichia
coli) 		PF08272
(Topo_Zn_Ribbon) 		3 PRO A  12
ASP A  11
GLU A  10
 None
 0.86A 3v4tC-1yuaA:
undetectable		 3v4tC-1yuaA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1d STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		3 PRO D 202
ASP D 198
GLU D 199
 None
 0.82A 3v4tC-2a1dD:
undetectable		 3v4tC-2a1dD:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjt UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		3 PRO A  93
ASP A 124
GLU A  95
 EDO  A1132 (-3.9A)
EDO  A1132 ( 3.4A)
EDO  A1133 ( 4.5A)
 0.67A 3v4tC-2cjtA:
undetectable		 3v4tC-2cjtA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		3 PRO A 102
ASP A  35
GLU A  33
 NAD  A2001 (-4.2A)
None
None
 0.88A 3v4tC-2d4vA:
undetectable		 3v4tC-2d4vA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 PRO A 426
ASP A 554
GLU A 428
 None
 0.88A 3v4tC-2d7dA:
1.7		 3v4tC-2d7dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daz INAD-LIKE PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 PRO A  63
ASP A  34
GLU A  32
 None
 0.89A 3v4tC-2dazA:
undetectable		 3v4tC-2dazA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcw ALPHA-2-MACROGLOBULI
N
RECEPTOR-ASSOCIATED
PROTEIN
LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens;
Homo sapiens) 		PF06401
(Alpha-2-MRAP_C)
PF00057
(Ldl_recept_a) 		3 PRO B 150
ASP B 149
GLU A 299
 None
 0.81A 3v4tC-2fcwB:
undetectable		 3v4tC-2fcwB:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr5 CYTIDINE DEAMINASE

(Mus musculus) 		PF00383
(dCMP_cyt_deam_1) 		3 PRO A 120
ASP A 121
GLU A  93
 None
 0.79A 3v4tC-2fr5A:
undetectable		 3v4tC-2fr5A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 PRO I 209
ASP I 207
GLU I 462
 None
NGT  A  21 (-3.8A)
NGT  A  21 (-3.0A)
 0.77A 3v4tC-2gk1I:
undetectable		 3v4tC-2gk1I:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gze COLICIN-E9 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		3 PRO A  56
ASP A  60
GLU A  58
 None
 0.87A 3v4tC-2gzeA:
undetectable		 3v4tC-2gzeA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2q COFILIN

(Schizosaccharomyces
pombe) 		PF00241
(Cofilin_ADF) 		3 PRO A  88
ASP A 121
GLU A  59
 None
LDA  A 900 (-3.6A)
None
 0.79A 3v4tC-2i2qA:
undetectable		 3v4tC-2i2qA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kaa HIRSUTELLIN A

(Hirsutella
thompsonii) 		no annotation 3 PRO A  41
ASP A  40
GLU A  66
 None
 0.85A 3v4tC-2kaaA:
undetectable		 3v4tC-2kaaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m7u METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Thermosynechococcus
elongatus) 		PF01590
(GAF) 		3 PRO A 493
ASP A 492
GLU A 491
 VRB  A 600 (-3.6A)
VRB  A 600 (-2.8A)
None
 0.83A 3v4tC-2m7uA:
undetectable		 3v4tC-2m7uA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n4d UNCHARACTERIZED
PROTEIN ATU1203

(Agrobacterium
fabrum) 		PF00403
(HMA) 		3 PRO A  63
ASP A   9
GLU A   8
 None
 0.85A 3v4tC-2n4dA:
undetectable		 3v4tC-2n4dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		3 PRO B1041
ASP B1042
GLU B1045
 None
 0.88A 3v4tC-2nvuB:
undetectable		 3v4tC-2nvuB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 PRO A 185
ASP A 180
GLU A 187
 None
 0.83A 3v4tC-2oejA:
0.5		 3v4tC-2oejA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		3 PRO A 112
ASP A 120
GLU A 114
 None
 0.86A 3v4tC-2ogaA:
undetectable		 3v4tC-2ogaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pm9 PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 PRO A  21
ASP A  18
GLU A 311
 None
 0.75A 3v4tC-2pm9A:
undetectable		 3v4tC-2pm9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 PRO A 394
ASP A 362
GLU A 356
 None
 0.79A 3v4tC-2vsqA:
undetectable		 3v4tC-2vsqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wim NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		3 PRO A 209
ASP A 290
GLU A 289
 None
 0.83A 3v4tC-2wimA:
undetectable		 3v4tC-2wimA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		3 PRO A1135
ASP A1133
GLU A1231
 None
CA  A2414 (-3.2A)
None
 0.88A 3v4tC-2wqsA:
undetectable		 3v4tC-2wqsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		3 PRO A  94
ASP A  95
GLU A  17
 None
 0.79A 3v4tC-2y4fA:
undetectable		 3v4tC-2y4fA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		3 PRO A 796
ASP A 795
GLU A 793
 None
 0.60A 3v4tC-2y6eA:
0.1		 3v4tC-2y6eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		3 PRO A 188
ASP A 177
GLU A 175
 None
 0.86A 3v4tC-2zg6A:
undetectable		 3v4tC-2zg6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 PRO A  40
ASP A  43
GLU A  44
 None
 0.83A 3v4tC-2zzgA:
undetectable		 3v4tC-2zzgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		3 PRO A  81
ASP A  85
GLU A  83
 None
 0.73A 3v4tC-3a4tA:
0.0		 3v4tC-3a4tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bordetella
parapertussis) 		PF00440
(TetR_N) 		3 PRO A 179
ASP A 180
GLU A  97
 None
 0.79A 3v4tC-3ccyA:
undetectable		 3v4tC-3ccyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		3 PRO A 104
ASP A  37
GLU A  35
 None
 0.87A 3v4tC-3dmsA:
undetectable		 3v4tC-3dmsA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0m PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA/MSRB 1

(Streptococcus
pneumoniae) 		PF01625
(PMSR)
PF01641
(SelR) 		3 PRO A 104
ASP A 102
GLU A 100
 None
 0.83A 3v4tC-3e0mA:
undetectable		 3v4tC-3e0mA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejn SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		3 PRO A 126
ASP A 144
GLU A 142
 None
PG4  A   3 (-3.4A)
PG4  A   3 (-3.8A)
 0.78A 3v4tC-3ejnA:
undetectable		 3v4tC-3ejnA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		3 PRO A 277
ASP A 495
GLU A 143
 None
 0.87A 3v4tC-3fotA:
undetectable		 3v4tC-3fotA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj4 MINOR
EDITOSOME-ASSOCIATED
TUTASE

(Trypanosoma
brucei) 		no annotation 3 PRO A 205
ASP A 216
GLU A 211
 None
 0.89A 3v4tC-3hj4A:
undetectable		 3v4tC-3hj4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		3 PRO A 247
ASP A 171
GLU A 176
 None
 0.82A 3v4tC-3iehA:
undetectable		 3v4tC-3iehA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL

(Bos taurus) 		PF14955
(MRP-S24) 		3 PRO c  74
ASP c  89
GLU c  91
 None
 0.87A 3v4tC-3jd5c:
undetectable		 3v4tC-3jd5c:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		3 PRO A  58
ASP A  56
GLU A  39
 None
 0.78A 3v4tC-3k53A:
undetectable		 3v4tC-3k53A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l06 N-ACETYLORNITHINE
CARBAMOYLTRANSFERASE

(Xanthomonas
campestris) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PRO A 268
ASP A 271
GLU A 266
 None
 0.84A 3v4tC-3l06A:
undetectable		 3v4tC-3l06A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3led 3-OXOACYL-ACYL
CARRIER PROTEIN
SYNTHASE III

(Rhodopseudomonas
palustris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 PRO A 315
ASP A 314
GLU A 304
 None
 0.87A 3v4tC-3ledA:
undetectable		 3v4tC-3ledA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 PRO B 475
ASP B 476
GLU B 477
 None
 0.72A 3v4tC-3pcoB:
undetectable		 3v4tC-3pcoB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		3 PRO A 208
ASP A 211
GLU A   6
 None
 0.85A 3v4tC-3qh4A:
undetectable		 3v4tC-3qh4A:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 PRO A 256
ASP A 257
GLU A 277
 None
 0.48A 3v4tC-3swdA:
68.6		 3v4tC-3swdA:
93.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE

(Pyrobaculum
neutrophilum) 		PF01950
(FBPase_3) 		3 PRO A 235
ASP A 233
GLU A 135
 None
 0.80A 3v4tC-3t2cA:
undetectable		 3v4tC-3t2cA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 PRO A 426
ASP A 427
GLU A 660
 None
 0.88A 3v4tC-3txoA:
undetectable		 3v4tC-3txoA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PIX

(Bovine
mastadenovirus
B) 		PF03955
(Adeno_PIX) 		3 PRO N  71
ASP N  25
GLU N  77
 None
 0.74A 3v4tC-3zifN:
undetectable		 3v4tC-3zifN:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1r LIP

(Serratia
marcescens) 		PF12790
(T6SS-SciN) 		3 PRO A  34
ASP A 156
GLU A 157
 None
 0.86A 3v4tC-4a1rA:
undetectable		 3v4tC-4a1rA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		3 PRO A  21
ASP A  18
GLU A 311
 None
 0.76A 3v4tC-4bzkA:
undetectable		 3v4tC-4bzkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 PRO A 177
ASP A 176
GLU A 174
 None
 0.71A 3v4tC-4e4gA:
0.9		 3v4tC-4e4gA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 PRO A 235
ASP A 234
GLU A 231
 None
 0.84A 3v4tC-4e5tA:
undetectable		 3v4tC-4e5tA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		3 PRO A 451
ASP A 452
GLU A 487
 None
 0.84A 3v4tC-4ebaA:
undetectable		 3v4tC-4ebaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		3 PRO A 243
ASP A 244
GLU A 205
 None
 0.80A 3v4tC-4efhA:
undetectable		 3v4tC-4efhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 3 PRO A 502
ASP A 349
GLU A 504
 None
 0.88A 3v4tC-4iegA:
undetectable		 3v4tC-4iegA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4o PHYCOCYANOBILIN
LYASE CPCT

(Nostoc sp. PCC
7120) 		PF06206
(CpeT) 		3 PRO A  64
ASP A  63
GLU A  90
 None
 0.85A 3v4tC-4o4oA:
undetectable		 3v4tC-4o4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oje EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		3 PRO H 174
ASP H 181
GLU H 179
 None
 0.89A 3v4tC-4ojeH:
undetectable		 3v4tC-4ojeH:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		3 PRO A 254
ASP A 204
GLU A 202
 None
 0.88A 3v4tC-4ovjA:
undetectable		 3v4tC-4ovjA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		3 PRO A 243
ASP A 244
GLU A 205
 None
 0.67A 3v4tC-4pl7A:
undetectable		 3v4tC-4pl7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmg STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase) 		3 PRO A  74
ASP A  75
GLU A  76
 None
 0.84A 3v4tC-4qmgA:
undetectable		 3v4tC-4qmgA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro1 DIS3-LIKE
EXONUCLEASE 2

(Schizosaccharomyces
pombe) 		no annotation 3 PRO B 635
ASP B 630
GLU B 829
 None
 0.89A 3v4tC-4ro1B:
undetectable		 3v4tC-4ro1B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf5 NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN

(Homo sapiens) 		no annotation 3 PRO B  46
ASP B  45
GLU B  44
 None
 0.76A 3v4tC-4uf5B:
undetectable		 3v4tC-4uf5B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		3 PRO A 454
ASP A 455
GLU A 348
 None
 0.80A 3v4tC-4uygA:
undetectable		 3v4tC-4uygA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		3 PRO A 566
ASP A 567
GLU A 649
 None
 0.87A 3v4tC-4x6kA:
undetectable		 3v4tC-4x6kA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		3 PRO A 296
ASP A 375
GLU A 299
 None
 0.71A 3v4tC-4xz3A:
1.5		 3v4tC-4xz3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		3 PRO A 178
ASP A 177
GLU A 175
 None
None
NAD  A 501 (-2.8A)
 0.79A 3v4tC-4zz7A:
undetectable		 3v4tC-4zz7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dje ZUOTIN

(Saccharomyces
cerevisiae) 		no annotation 3 PRO A  78
ASP A  79
GLU A  91
 None
 0.83A 3v4tC-5djeA:
undetectable		 3v4tC-5djeA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		3 PRO A 325
ASP A  78
GLU A  79
 None
 0.86A 3v4tC-5ekuA:
undetectable		 3v4tC-5ekuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		3 PRO A 105
ASP A 103
GLU A  75
 PRO  A 105 ( 1.1A)
ASP  A 103 ( 0.6A)
GLU  A  75 ( 0.6A)
 0.83A 3v4tC-5ep8A:
undetectable		 3v4tC-5ep8A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frh ANTI-SIGMA FACTOR
RSRA

(Streptomyces
coelicolor) 		PF13490
(zf-HC2) 		3 PRO A  97
ASP A  92
GLU A  90
 None
 0.82A 3v4tC-5frhA:
undetectable		 3v4tC-5frhA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		3 PRO A 373
ASP A 371
GLU A 397
 None
CA  A 704 (-2.5A)
None
 0.86A 3v4tC-5hp5A:
undetectable		 3v4tC-5hp5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij8 POLYCOMB PROTEIN
SUZ12

(Homo sapiens) 		PF09733
(VEFS-Box) 		3 PRO S 589
ASP S 588
GLU S 586
 None
 0.84A 3v4tC-5ij8S:
undetectable		 3v4tC-5ij8S:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 PRO A  35
ASP A  34
GLU A 800
 None
 0.86A 3v4tC-5ijlA:
undetectable		 3v4tC-5ijlA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyq INSULIN 1
INSULIN 1B

(Conus
geographus;
Conus
geographus) 		PF00049
(Insulin)
no annotation 		3 PRO B   3
ASP B   1
GLU A  15
 None
 0.82A 3v4tC-5jyqB:
undetectable		 3v4tC-5jyqB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kiq PLATELET-BINDING
GLYCOPROTEIN

(Streptococcus
sanguinis) 		no annotation 3 PRO A 429
ASP A 430
GLU A 271
 None
 0.87A 3v4tC-5kiqA:
undetectable		 3v4tC-5kiqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 PRO A2086
ASP A2084
GLU A2082
 None
 0.82A 3v4tC-5m59A:
undetectable		 3v4tC-5m59A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 PRO A 323
ASP A 328
GLU A 329
 None
 0.81A 3v4tC-5mt2A:
undetectable		 3v4tC-5mt2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		3 PRO A 561
ASP A 562
GLU A 565
 None
 0.89A 3v4tC-5mzoA:
undetectable		 3v4tC-5mzoA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4m PROTOCADHERIN-15

(Homo sapiens) 		PF00028
(Cadherin) 		3 PRO A 314
ASP A 312
GLU A 311
 None
 0.66A 3v4tC-5t4mA:
undetectable		 3v4tC-5t4mA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
AAC) 		PF00171
(Aldedh) 		3 PRO A 178
ASP A 177
GLU A 175
 None
None
ADP  A 501 (-3.4A)
 0.74A 3v4tC-5tjrA:
undetectable		 3v4tC-5tjrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum) 		PF03421
(Acetyltransf_14) 		3 PRO A 311
ASP A 279
GLU A 284
 None
 0.66A 3v4tC-5w40A:
undetectable		 3v4tC-5w40A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 3 PRO A2589
ASP A2588
GLU A2586
 None
 0.88A 3v4tC-5wg6A:
undetectable		 3v4tC-5wg6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 3 PRO A 346
ASP A 347
GLU A 361
 None
 0.86A 3v4tC-5xnrA:
undetectable		 3v4tC-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PRO A  48
ASP A  42
GLU A  50
 None
 0.84A 3v4tC-5xogA:
undetectable		 3v4tC-5xogA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 3 PRO A 150
ASP A 149
GLU A 260
 None
CA  A 801 (-3.3A)
None
 0.66A 3v4tC-5yl7A:
undetectable		 3v4tC-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 3 PRO A 245
ASP A 246
GLU A  91
 None
 0.70A 3v4tC-5yp3A:
undetectable		 3v4tC-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 3 PRO A 413
ASP A 414
GLU A 286
 None
 0.86A 3v4tC-6bqlA:
undetectable		 3v4tC-6bqlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN DEPDC5

(Homo sapiens) 		no annotation 3 PRO D1086
ASP D1084
GLU D1196
 None
 0.88A 3v4tC-6cetD:
1.1		 3v4tC-6cetD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 3 PRO A 413
ASP A 414
GLU A 286
 None
 0.88A 3v4tC-6cmjA:
undetectable		 3v4tC-6cmjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 3 PRO A 964
ASP A 963
GLU A 962
 None
 0.70A 3v4tC-6d6yA:
1.9		 3v4tC-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC1

(Saccharomyces
cerevisiae) 		no annotation 3 PRO C 110
ASP C 111
GLU C 312
 None
 0.63A 3v4tC-6f42C:
undetectable		 3v4tC-6f42C:
undetectable