SIMILAR PATTERNS OF AMINO ACIDS FOR 3V4T_A_ACTA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6g MYOGLOBIN

(Physeter
catodon)
PF00042
(Globin)
3 THR A  70
VAL A  66
GLU A  18
None
0.71A 3v4tA-1a6gA:
undetectable
3v4tD-1a6gA:
undetectable
3v4tA-1a6gA:
17.94
3v4tD-1a6gA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)


(Homo sapiens)
PF00079
(Serpin)
3 THR A 194
VAL A 197
GLU A 132
None
0.75A 3v4tA-1by7A:
0.0
3v4tD-1by7A:
undetectable
3v4tA-1by7A:
21.85
3v4tD-1by7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli)
PF00155
(Aminotran_1_2)
3 THR A 275
VAL A 271
GLU A  68
None
0.67A 3v4tA-1d2fA:
0.0
3v4tD-1d2fA:
0.3
3v4tA-1d2fA:
22.86
3v4tD-1d2fA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I


(Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
3 THR A 210
VAL A 208
GLU A  41
None
0.77A 3v4tA-1ezvA:
0.0
3v4tD-1ezvA:
0.0
3v4tA-1ezvA:
22.95
3v4tD-1ezvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma)
PF01593
(Amino_oxidase)
3 THR A 431
VAL A 319
GLU A 219
None
0.63A 3v4tA-1f8rA:
0.0
3v4tD-1f8rA:
0.0
3v4tA-1f8rA:
21.89
3v4tD-1f8rA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA


(Desulfovibrio
gigas)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
3 THR A  30
VAL A  28
GLU A  65
None
0.75A 3v4tA-1h0hA:
0.0
3v4tD-1h0hA:
0.0
3v4tA-1h0hA:
18.36
3v4tD-1h0hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT


(Escherichia
coli)
PF01144
(CoA_trans)
3 THR A  31
VAL A  23
GLU A 188
None
0.47A 3v4tA-1k6dA:
0.0
3v4tD-1k6dA:
0.0
3v4tA-1k6dA:
22.51
3v4tD-1k6dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli)
PF02264
(LamB)
3 THR A 216
VAL A 231
GLU A 188
None
0.70A 3v4tA-1mpoA:
0.0
3v4tD-1mpoA:
0.0
3v4tA-1mpoA:
23.11
3v4tD-1mpoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
3 THR A 321
VAL A 316
GLU A 325
None
0.74A 3v4tA-1n5xA:
0.0
3v4tD-1n5xA:
0.0
3v4tA-1n5xA:
16.37
3v4tD-1n5xA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
3 THR A 422
VAL A 413
GLU A 420
None
0.63A 3v4tA-1pz3A:
undetectable
3v4tD-1pz3A:
0.0
3v4tA-1pz3A:
21.63
3v4tD-1pz3A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE


(Marinobacter
hydrocarbonoclasticus)
no annotation 3 THR A 138
VAL A 141
GLU A 173
None
0.52A 3v4tA-1qniA:
undetectable
3v4tD-1qniA:
undetectable
3v4tA-1qniA:
22.17
3v4tD-1qniA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis)
PF00118
(Cpn60_TCP1)
3 THR A 187
VAL A 373
GLU A 185
None
0.72A 3v4tA-1sjpA:
undetectable
3v4tD-1sjpA:
undetectable
3v4tA-1sjpA:
24.24
3v4tD-1sjpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys)
PF01593
(Amino_oxidase)
3 THR A 431
VAL A 319
GLU A 219
None
0.68A 3v4tA-1tdkA:
undetectable
3v4tD-1tdkA:
undetectable
3v4tA-1tdkA:
22.10
3v4tD-1tdkA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE


(Homo sapiens)
PF00061
(Lipocalin)
3 THR A 103
VAL A  92
GLU A 116
None
0.72A 3v4tA-1towA:
undetectable
3v4tD-1towA:
undetectable
3v4tA-1towA:
18.38
3v4tD-1towA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN


(Gallus gallus)
PF00435
(Spectrin)
3 THR A1953
VAL A1949
GLU A1939
None
0.66A 3v4tA-1u4qA:
undetectable
3v4tD-1u4qA:
undetectable
3v4tA-1u4qA:
24.94
3v4tD-1u4qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens)
PF00004
(AAA)
PF09336
(Vps4_C)
3 THR A 256
VAL A 260
GLU A 213
None
0.73A 3v4tA-1xwiA:
1.0
3v4tD-1xwiA:
1.1
3v4tA-1xwiA:
24.33
3v4tD-1xwiA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8i THREONINE ASPARTASE
1


(Homo sapiens)
PF01112
(Asparaginase_2)
3 THR A 286
VAL A 288
GLU A 276
None
0.71A 3v4tA-2a8iA:
undetectable
3v4tD-2a8iA:
undetectable
3v4tA-2a8iA:
24.54
3v4tD-2a8iA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1


(Homo sapiens)
PF16770
(RTT107_BRCT_5)
3 THR A1971
VAL A1969
GLU A1976
None
0.69A 3v4tA-2adoA:
undetectable
3v4tD-2adoA:
undetectable
3v4tA-2adoA:
18.42
3v4tD-2adoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1


(Homo sapiens)
PF00400
(WD40)
3 THR A 716
VAL A 714
GLU A 738
None
0.57A 3v4tA-2ce9A:
undetectable
3v4tD-2ce9A:
undetectable
3v4tA-2ce9A:
21.60
3v4tD-2ce9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clb DPS-LIKE PROTEIN

(Sulfolobus
solfataricus)
PF00210
(Ferritin)
3 THR A 130
VAL A 134
GLU A 156
None
None
ZN  A1175 ( 2.3A)
0.77A 3v4tA-2clbA:
undetectable
3v4tD-2clbA:
undetectable
3v4tA-2clbA:
18.76
3v4tD-2clbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlq GLI-KRUPPEL FAMILY
MEMBER HKR3


(Mus musculus)
PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4)
3 THR A  68
VAL A  66
GLU A  74
None
0.62A 3v4tA-2dlqA:
undetectable
3v4tD-2dlqA:
undetectable
3v4tA-2dlqA:
14.99
3v4tD-2dlqA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN


(Archaeoglobus
fulgidus)
PF01937
(DUF89)
3 THR A 102
VAL A 106
GLU A 174
None
0.76A 3v4tA-2ffjA:
undetectable
3v4tD-2ffjA:
undetectable
3v4tA-2ffjA:
24.59
3v4tD-2ffjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT


(Stenotrophomonas
maltophilia)
PF04268
(SoxG)
3 THR C  79
VAL C  81
GLU C  75
None
0.68A 3v4tA-2gahC:
undetectable
3v4tD-2gahC:
undetectable
3v4tA-2gahC:
20.89
3v4tD-2gahC:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
3 THR A 381
VAL A 398
GLU A 379
None
0.72A 3v4tA-2gaiA:
undetectable
3v4tD-2gaiA:
undetectable
3v4tA-2gaiA:
22.84
3v4tD-2gaiA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB
PROTEIN TONB


(Escherichia
coli;
Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
PF03544
(TonB_C)
3 THR A  11
VAL A   9
GLU B 173
None
0.64A 3v4tA-2gskA:
undetectable
3v4tD-2gskA:
undetectable
3v4tA-2gskA:
21.84
3v4tD-2gskA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpw GREEN FLUORESCENT
PROTEIN


(Clytia gregaria)
PF01353
(GFP)
3 THR A  44
VAL A 223
GLU A  14
None
0.61A 3v4tA-2hpwA:
undetectable
3v4tD-2hpwA:
undetectable
3v4tA-2hpwA:
23.11
3v4tD-2hpwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE


(Myxococcus
xanthus)
PF01593
(Amino_oxidase)
3 THR A  99
VAL A  97
GLU A 336
None
0.71A 3v4tA-2ivdA:
undetectable
3v4tD-2ivdA:
undetectable
3v4tA-2ivdA:
25.29
3v4tD-2ivdA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8o UNCHARACTERIZED
PROTEIN


(Cytophaga
hutchinsonii)
PF08327
(AHSA1)
3 THR A  83
VAL A  70
GLU A  81
None
0.71A 3v4tA-2l8oA:
undetectable
3v4tD-2l8oA:
undetectable
3v4tA-2l8oA:
17.51
3v4tD-2l8oA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf9 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8


(Homo sapiens)
PF00254
(FKBP_C)
3 THR A 146
VAL A 148
GLU A  85
None
0.76A 3v4tA-2mf9A:
undetectable
3v4tD-2mf9A:
undetectable
3v4tA-2mf9A:
17.42
3v4tD-2mf9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica)
PF02264
(LamB)
3 THR A 216
VAL A 231
GLU A 188
None
0.77A 3v4tA-2mprA:
undetectable
3v4tD-2mprA:
undetectable
3v4tA-2mprA:
23.79
3v4tD-2mprA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE


(Salmonella
enterica)
PF01048
(PNP_UDP_1)
3 THR A1233
VAL A1221
GLU A1238
None
0.54A 3v4tA-2oxfA:
undetectable
3v4tD-2oxfA:
undetectable
3v4tA-2oxfA:
21.90
3v4tD-2oxfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron)
PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt)
3 THR A 768
VAL A 676
GLU A 766
None
0.44A 3v4tA-2q1fA:
undetectable
3v4tD-2q1fA:
undetectable
3v4tA-2q1fA:
18.45
3v4tD-2q1fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE


(Neurospora
crassa)
PF00579
(tRNA-synt_1b)
3 THR A 391
VAL A 387
GLU A 410
None
0.42A 3v4tA-2rkjA:
undetectable
3v4tD-2rkjA:
undetectable
3v4tA-2rkjA:
23.40
3v4tD-2rkjA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
3 THR A  73
VAL A  69
GLU A  28
None
0.50A 3v4tA-2v7gA:
undetectable
3v4tD-2v7gA:
undetectable
3v4tA-2v7gA:
24.91
3v4tD-2v7gA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgn INHIBITOR OF
CYSTEINE PEPTIDASE
COMPND 3


(Pseudomonas
aeruginosa)
PF09394
(Inhibitor_I42)
3 THR B  27
VAL B  25
GLU B  71
None
0.69A 3v4tA-2wgnB:
undetectable
3v4tD-2wgnB:
undetectable
3v4tA-2wgnB:
16.35
3v4tD-2wgnB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzk OROTATE
PHOSPHORIBOSYLTRANSF
ERASE


(Aeropyrum
pernix)
PF00156
(Pribosyltran)
3 THR A 117
VAL A 115
GLU A 147
None
0.63A 3v4tA-2yzkA:
undetectable
3v4tD-2yzkA:
undetectable
3v4tA-2yzkA:
20.53
3v4tD-2yzkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD


(Sulfurisphaera
tokodaii)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 THR A  63
VAL A  61
GLU A 137
None
0.68A 3v4tA-2z0mA:
1.6
3v4tD-2z0mA:
1.6
3v4tA-2z0mA:
24.31
3v4tD-2z0mA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186


(Pyrococcus
horikoshii)
PF06745
(ATPase)
3 THR A  36
VAL A 202
GLU A 195
None
0.71A 3v4tA-2ztsA:
undetectable
3v4tD-2ztsA:
undetectable
3v4tA-2ztsA:
22.38
3v4tD-2ztsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47


(Homo sapiens)
PF00270
(DEAD)
3 THR A  99
VAL A  97
GLU A 175
None
0.69A 3v4tA-3berA:
1.2
3v4tD-3berA:
1.3
3v4tA-3berA:
19.44
3v4tD-3berA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE


(Bacteroides
fragilis)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
3 THR A 627
VAL A 658
GLU A 615
None
0.56A 3v4tA-3cmgA:
undetectable
3v4tD-3cmgA:
undetectable
3v4tA-3cmgA:
21.38
3v4tD-3cmgA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhw METHIONINE IMPORT
ATP-BINDING PROTEIN
METN


(Escherichia
coli)
PF00005
(ABC_tran)
PF09383
(NIL)
3 THR C   8
VAL C  10
GLU C  59
None
0.70A 3v4tA-3dhwC:
undetectable
3v4tD-3dhwC:
undetectable
3v4tA-3dhwC:
22.22
3v4tD-3dhwC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28


(Mycobacterium
tuberculosis)
PF00501
(AMP-binding)
3 THR A 444
VAL A 405
GLU A 333
None
0.70A 3v4tA-3e53A:
undetectable
3v4tD-3e53A:
undetectable
3v4tA-3e53A:
23.48
3v4tD-3e53A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG


(Homo sapiens)
PF09445
(Methyltransf_15)
3 THR A 839
VAL A 802
GLU A 825
None
0.78A 3v4tA-3egiA:
undetectable
3v4tD-3egiA:
1.9
3v4tA-3egiA:
20.77
3v4tD-3egiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh1 UNCHARACTERIZED
NTF2-LIKE PROTEIN


(Mesorhizobium
loti)
PF12680
(SnoaL_2)
3 THR A  93
VAL A 109
GLU A  84
None
0.64A 3v4tA-3fh1A:
undetectable
3v4tD-3fh1A:
undetectable
3v4tA-3fh1A:
15.04
3v4tD-3fh1A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
coelicolor)
PF00378
(ECH_1)
3 THR A  22
VAL A  25
GLU A  20
None
0.71A 3v4tA-3g64A:
undetectable
3v4tD-3g64A:
undetectable
3v4tA-3g64A:
24.48
3v4tD-3g64A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gc3 BETA-ARRESTIN-1

(Bos taurus)
PF00339
(Arrestin_N)
PF02752
(Arrestin_C)
3 THR A  56
VAL A  81
GLU A 145
None
0.70A 3v4tA-3gc3A:
undetectable
3v4tD-3gc3A:
undetectable
3v4tA-3gc3A:
24.78
3v4tD-3gc3A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvs THIOL PEROXIDASE

(Escherichia
coli)
PF08534
(Redoxin)
3 THR A  29
VAL A  31
GLU A 113
None
0.78A 3v4tA-3hvsA:
undetectable
3v4tD-3hvsA:
undetectable
3v4tA-3hvsA:
19.09
3v4tD-3hvsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53


(Homo sapiens)
PF00270
(DEAD)
3 THR A 312
VAL A 310
GLU A 386
None
0.68A 3v4tA-3iuyA:
1.2
3v4tD-3iuyA:
1.1
3v4tA-3iuyA:
20.10
3v4tD-3iuyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes)
PF01593
(Amino_oxidase)
3 THR A 431
VAL A 319
GLU A 219
None
0.73A 3v4tA-3kveA:
undetectable
3v4tD-3kveA:
undetectable
3v4tA-3kveA:
22.53
3v4tD-3kveA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B


(Legionella
pneumophila)
PF00501
(AMP-binding)
3 THR A 438
VAL A 402
GLU A 329
None
None
1ZZ  A 589 ( 4.9A)
0.69A 3v4tA-3kxwA:
0.0
3v4tD-3kxwA:
undetectable
3v4tA-3kxwA:
21.30
3v4tD-3kxwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcr NADH DEHYDROGENASE,
SUBUNIT C


(Thermobifida
fusca)
PF00329
(Complex1_30kDa)
3 THR A 109
VAL A 102
GLU A 107
None
0.69A 3v4tA-3mcrA:
undetectable
3v4tD-3mcrA:
undetectable
3v4tA-3mcrA:
20.75
3v4tD-3mcrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwj HEAT RESISTANT RNA
DEPENDENT ATPASE


(Thermus
thermophilus)
PF00270
(DEAD)
3 THR A  79
VAL A  77
GLU A 152
None
0.61A 3v4tA-3mwjA:
0.9
3v4tD-3mwjA:
0.9
3v4tA-3mwjA:
21.09
3v4tD-3mwjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE


(Nostoc sp. PCC
7120)
PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His)
3 THR A 311
VAL A 178
GLU A 309
None
0.76A 3v4tA-3netA:
undetectable
3v4tD-3netA:
undetectable
3v4tA-3netA:
23.63
3v4tD-3netA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I


(Burkholderia
lata)
PF00117
(GATase)
PF00425
(Chorismate_bind)
3 THR A 369
VAL A 371
GLU A 382
BEZ  A 701 (-4.1A)
None
MG  A 700 ( 2.5A)
0.72A 3v4tA-3r75A:
undetectable
3v4tD-3r75A:
undetectable
3v4tA-3r75A:
24.39
3v4tD-3r75A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9l NUCLEOSIDE
DIPHOSPHATE KINASE


(Giardia
intestinalis)
PF00334
(NDK)
3 THR A  93
VAL A 111
GLU A  97
None
0.55A 3v4tA-3r9lA:
undetectable
3v4tD-3r9lA:
undetectable
3v4tA-3r9lA:
17.97
3v4tD-3r9lA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rby UNCHARACTERIZED
PROTEIN YLR301W


(Saccharomyces
cerevisiae)
PF16815
(HRI1)
3 THR A  98
VAL A  70
GLU A 108
None
0.76A 3v4tA-3rbyA:
undetectable
3v4tD-3rbyA:
undetectable
3v4tA-3rbyA:
19.86
3v4tD-3rbyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE


(Bifidobacterium
longum)
PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C)
3 THR A 150
VAL A 116
GLU A 148
None
0.76A 3v4tA-3wfzA:
undetectable
3v4tD-3wfzA:
undetectable
3v4tA-3wfzA:
20.42
3v4tD-3wfzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
halstedii)
PF00501
(AMP-binding)
3 THR A 409
VAL A 376
GLU A 328
None
0.70A 3v4tA-3wv4A:
undetectable
3v4tD-3wv4A:
undetectable
3v4tA-3wv4A:
24.17
3v4tD-3wv4A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvn NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Streptomyces
halstedii)
PF00501
(AMP-binding)
3 THR A 409
VAL A 376
GLU A 328
None
0.71A 3v4tA-3wvnA:
undetectable
3v4tD-3wvnA:
undetectable
3v4tA-3wvnA:
23.67
3v4tD-3wvnA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A


(Bacillus
subtilis;
Bacillus
subtilis)
PF02463
(SMC_N)
PF02616
(SMC_ScpA)
3 THR C  65
VAL C  61
GLU A 183
None
0.50A 3v4tA-3zgxC:
undetectable
3v4tD-3zgxC:
undetectable
3v4tA-3zgxC:
12.41
3v4tD-3zgxC:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
3 THR A 492
VAL A 518
GLU A 521
None
0.67A 3v4tA-3zppA:
undetectable
3v4tD-3zppA:
undetectable
3v4tA-3zppA:
22.36
3v4tD-3zppA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq3 OBP3 PROTEIN

(Rattus
norvegicus)
PF00061
(Lipocalin)
3 THR A 108
VAL A 125
GLU A 106
None
0.72A 3v4tA-3zq3A:
undetectable
3v4tD-3zq3A:
undetectable
3v4tA-3zq3A:
20.15
3v4tD-3zq3A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU


(Streptococcus
pneumoniae)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2)
3 THR A 310
VAL A 308
GLU A 275
None
0.60A 3v4tA-4ac3A:
undetectable
3v4tD-4ac3A:
undetectable
3v4tA-4ac3A:
23.73
3v4tD-4ac3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af2 THIOL PEROXIDASE

(Escherichia
coli)
PF08534
(Redoxin)
3 THR A  29
VAL A  31
GLU A 113
None
0.77A 3v4tA-4af2A:
undetectable
3v4tD-4af2A:
undetectable
3v4tA-4af2A:
21.24
3v4tD-4af2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2


(Homo sapiens)
PF00704
(Glyco_hydro_18)
3 THR A 153
VAL A 157
GLU A 151
None
0.73A 3v4tA-4ay1A:
undetectable
3v4tD-4ay1A:
undetectable
3v4tA-4ay1A:
21.15
3v4tD-4ay1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis)
PF01263
(Aldose_epim)
3 THR A 312
VAL A 162
GLU A 310
None
0.63A 3v4tA-4bzgA:
undetectable
3v4tD-4bzgA:
undetectable
3v4tA-4bzgA:
21.36
3v4tD-4bzgA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis)
PF00141
(peroxidase)
3 THR A 579
VAL A 581
GLU A 577
None
0.63A 3v4tA-4c51A:
undetectable
3v4tD-4c51A:
undetectable
3v4tA-4c51A:
21.60
3v4tD-4c51A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens)
PF01979
(Amidohydro_1)
3 THR A1595
VAL A1599
GLU A1620
None
0.71A 3v4tA-4c6oA:
1.9
3v4tD-4c6oA:
1.4
3v4tA-4c6oA:
23.68
3v4tD-4c6oA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
3 THR A  50
VAL A  46
GLU A  55
None
0.61A 3v4tA-4e3zA:
undetectable
3v4tD-4e3zA:
undetectable
3v4tA-4e3zA:
22.54
3v4tD-4e3zA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans)
PF01036
(Bac_rhodopsin)
3 THR A  76
VAL A  65
GLU A 193
None
0.58A 3v4tA-4fbzA:
undetectable
3v4tD-4fbzA:
undetectable
3v4tA-4fbzA:
18.20
3v4tD-4fbzA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1)
PF11624
(M157)
3 THR A 251
VAL A 218
GLU A 244
None
0.72A 3v4tA-4jo8A:
undetectable
3v4tD-4jo8A:
undetectable
3v4tA-4jo8A:
22.72
3v4tD-4jo8A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kha SPT16M-HISTONE H2B
1.1 CHIMERA


(Xenopus laevis;
Chaetomium
thermophilum)
PF00125
(Histone)
PF08512
(Rtt106)
PF08644
(SPT16)
3 THR A 851
VAL A 849
GLU A 837
None
0.77A 3v4tA-4khaA:
undetectable
3v4tD-4khaA:
undetectable
3v4tA-4khaA:
22.08
3v4tD-4khaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kho UNCHARACTERIZED
PROTEIN SPT16M


(Chaetomium
thermophilum)
PF08512
(Rtt106)
PF08644
(SPT16)
3 THR A 853
VAL A 851
GLU A 839
None
0.75A 3v4tA-4khoA:
undetectable
3v4tD-4khoA:
undetectable
3v4tA-4khoA:
21.13
3v4tD-4khoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1


(Caenorhabditis
elegans)
PF00004
(AAA)
PF09336
(Vps4_C)
3 THR A 437
VAL A 441
GLU A 394
None
0.59A 3v4tA-4l15A:
undetectable
3v4tD-4l15A:
1.1
3v4tA-4l15A:
24.48
3v4tD-4l15A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A


(Streptococcus
pneumoniae)
PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix)
3 THR A 503
VAL A 529
GLU A 532
None
0.57A 3v4tA-4mr0A:
undetectable
3v4tD-4mr0A:
undetectable
3v4tA-4mr0A:
21.17
3v4tD-4mr0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1


(Alicyclobacillus
acidocaldarius)
PF13416
(SBP_bac_8)
3 THR A  49
VAL A  47
GLU A  72
None
0.66A 3v4tA-4ovjA:
undetectable
3v4tD-4ovjA:
undetectable
3v4tA-4ovjA:
22.63
3v4tD-4ovjA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
3 THR A 336
VAL A 338
GLU A 389
None
0.74A 3v4tA-4rdjA:
undetectable
3v4tD-4rdjA:
undetectable
3v4tA-4rdjA:
20.92
3v4tD-4rdjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzk SMALL HEAT SHOCK
PROTEIN HSP20 FAMILY


(Sulfolobus
solfataricus)
PF00011
(HSP20)
3 THR A 124
VAL A 122
GLU A  82
None
0.54A 3v4tA-4rzkA:
undetectable
3v4tD-4rzkA:
undetectable
3v4tA-4rzkA:
13.59
3v4tD-4rzkA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME


(Bacillus cereus)
PF00704
(Glyco_hydro_18)
PF01476
(LysM)
3 THR A 173
VAL A 171
GLU A 219
None
0.69A 3v4tA-4s3jA:
undetectable
3v4tD-4s3jA:
undetectable
3v4tA-4s3jA:
22.27
3v4tD-4s3jA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens)
PF00079
(Serpin)
3 THR A 172
VAL A 175
GLU A 110
None
0.78A 3v4tA-4zk3A:
undetectable
3v4tD-4zk3A:
undetectable
3v4tA-4zk3A:
21.38
3v4tD-4zk3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE


(Rhizomucor
miehei)
PF00291
(PALP)
3 THR A 127
VAL A 131
GLU A 124
None
0.71A 3v4tA-5c3uA:
undetectable
3v4tD-5c3uA:
undetectable
3v4tA-5c3uA:
24.36
3v4tD-5c3uA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18


(Mus musculus)
PF00443
(UCH)
3 THR A 179
VAL A 176
GLU A 181
None
0.73A 3v4tA-5chvA:
undetectable
3v4tD-5chvA:
undetectable
3v4tA-5chvA:
21.23
3v4tD-5chvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 THR A  42
VAL A  40
GLU A 130
None
0.68A 3v4tA-5fr8A:
undetectable
3v4tD-5fr8A:
undetectable
3v4tA-5fr8A:
21.20
3v4tD-5fr8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE


(Aspergillus
flavus)
PF00743
(FMO-like)
3 THR A 128
VAL A 136
GLU A 117
None
0.71A 3v4tA-5j7xA:
undetectable
3v4tD-5j7xA:
undetectable
3v4tA-5j7xA:
23.13
3v4tD-5j7xA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
3 THR A 690
VAL A 687
GLU A 653
None
0.74A 3v4tA-5ja1A:
undetectable
3v4tD-5ja1A:
undetectable
3v4tA-5ja1A:
16.16
3v4tD-5ja1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN


(Homo sapiens)
PF01852
(START)
3 THR B 531
VAL B 533
GLU B 498
None
0.69A 3v4tA-5jjdB:
undetectable
3v4tD-5jjdB:
undetectable
3v4tA-5jjdB:
21.99
3v4tD-5jjdB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII


(Homo sapiens)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
3 THR A 135
VAL A 137
GLU A 124
None
0.63A 3v4tA-5k8dA:
undetectable
3v4tD-5k8dA:
undetectable
3v4tA-5k8dA:
22.03
3v4tD-5k8dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmj RIBOSOME-BINDING
FACTOR PSRP1,
CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 3 THR y 135
VAL y 143
GLU y 111
None
G  a 915 ( 4.6A)
None
0.75A 3v4tA-5mmjy:
undetectable
3v4tD-5mmjy:
undetectable
3v4tA-5mmjy:
22.92
3v4tD-5mmjy:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae)
PF09724
(Dcc1)
3 THR A 375
VAL A 377
GLU A 342
None
0.70A 3v4tA-5msnA:
undetectable
3v4tD-5msnA:
undetectable
3v4tA-5msnA:
21.99
3v4tD-5msnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE


(Staphylococcus
aureus)
no annotation 3 THR A 142
VAL A 144
GLU A 198
None
0.68A 3v4tA-5n9mA:
undetectable
3v4tD-5n9mA:
undetectable
3v4tA-5n9mA:
undetectable
3v4tD-5n9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owj TRIGGER FACTOR

(Escherichia
coli)
no annotation 3 THR A 422
VAL A 130
GLU A 126
None
0.75A 3v4tA-5owjA:
undetectable
3v4tD-5owjA:
undetectable
3v4tA-5owjA:
23.61
3v4tD-5owjA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
3 THR A 600
VAL A 598
GLU A 533
None
0.63A 3v4tA-5t8vA:
undetectable
3v4tD-5t8vA:
undetectable
3v4tA-5t8vA:
16.05
3v4tD-5t8vA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox)
PF01593
(Amino_oxidase)
3 THR A 431
VAL A 319
GLU A 219
None
0.74A 3v4tA-5ts5A:
undetectable
3v4tD-5ts5A:
undetectable
3v4tA-5ts5A:
22.94
3v4tD-5ts5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8d BACILLUS CEREUS
PATB1


(Bacillus cereus)
no annotation 3 THR C 280
VAL C 288
GLU C 317
None
0.68A 3v4tA-5v8dC:
undetectable
3v4tD-5v8dC:
undetectable
3v4tA-5v8dC:
21.95
3v4tD-5v8dC:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 3 THR A 427
VAL A 423
GLU A 469
None
0.40A 3v4tA-5ve8A:
undetectable
3v4tD-5ve8A:
undetectable
3v4tA-5ve8A:
17.81
3v4tD-5ve8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1)
no annotation 3 THR A 396
VAL A 361
GLU A 310
None
0.78A 3v4tA-5wmmA:
1.8
3v4tD-5wmmA:
1.6
3v4tA-5wmmA:
undetectable
3v4tD-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN PLASTID PY

(Spinacia
oleracea)
no annotation 3 THR y 135
VAL y 143
GLU y 111
G  a 915 ( 4.7A)
None
C  a1178 ( 4.7A)
0.66A 3v4tA-5x8ry:
undetectable
3v4tD-5x8ry:
undetectable
3v4tA-5x8ry:
19.15
3v4tD-5x8ry:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN


(Ruminiclostridium
thermocellum)
no annotation 3 THR A 111
VAL A 115
GLU A  96
None
0.63A 3v4tA-5yj6A:
undetectable
3v4tD-5yj6A:
undetectable
3v4tA-5yj6A:
undetectable
3v4tD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D


(Pyrococcus
furiosus)
no annotation 3 THR H  92
VAL H  88
GLU H 123
None
0.67A 3v4tA-6cfwH:
undetectable
3v4tD-6cfwH:
undetectable
3v4tA-6cfwH:
undetectable
3v4tD-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9pcy PLASTOCYANIN

(Phaseolus
vulgaris)
PF00127
(Copper-bind)
3 THR A  73
VAL A  71
GLU A  25
None
0.67A 3v4tA-9pcyA:
undetectable
3v4tD-9pcyA:
undetectable
3v4tA-9pcyA:
13.97
3v4tD-9pcyA:
13.97