SIMILAR PATTERNS OF AMINO ACIDS FOR 3V3O_A_T1CA404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE


(Escherichia
coli)
PF00343
(Phosphorylase)
5 THR A 452
PHE A 778
GLY A 776
GLY A 642
ASN A 661
None
None
None
PLP  A 999 (-3.4A)
None
1.22A 3v3oA-1e4oA:
undetectable
3v3oA-1e4oA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum)
PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N)
5 THR A 220
ASN A 216
GLY A  82
ALA A 154
GLY A 233
None
1.27A 3v3oA-1lf9A:
undetectable
3v3oA-1lf9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1


(Elephantulus
edwardii)
PF00171
(Aldedh)
5 GLN A 292
PHE A 295
ASN A 297
GLY A 293
GLN A 382
None
1.06A 3v3oA-1o9jA:
undetectable
3v3oA-1o9jA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT


(Mus musculus)
PF00514
(Arm)
PF16186
(Arm_3)
5 ASN B 375
HIS B 376
ALA B 364
GLY B 365
ASN B 403
None
1.18A 3v3oA-1pjmB:
undetectable
3v3oA-1pjmB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 111
GLY A 126
ALA A  60
GLY A  59
MET A 295
None
HEM  A 501 (-3.8A)
None
None
None
0.99A 3v3oA-1si8A:
undetectable
3v3oA-1si8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 THR A  94
PHE A 111
GLY A 126
MET A 295
GLN A 219
None
None
HEM  A 501 (-3.8A)
None
None
1.24A 3v3oA-1si8A:
undetectable
3v3oA-1si8A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
5 PHE A 149
GLY A 164
ALA A  98
GLY A  97
MET A 337
None
HDD  A1880 ( 3.9A)
None
None
None
0.95A 3v3oA-1sy7A:
undetectable
3v3oA-1sy7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis)
PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C)
5 THR A 675
GLN A 336
ALA A 664
GLY A 666
MET A 616
None
1.19A 3v3oA-1ulvA:
undetectable
3v3oA-1ulvA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens)
PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N)
5 GLN A 135
ARG A 177
ASN A 178
GLY A 140
GLY A 167
None
1.18A 3v3oA-1w6jA:
undetectable
3v3oA-1w6jA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1


(Methylobacterium
extorquens)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 ASN A 394
HIS A 393
GLY A 410
ALA A  57
GLY A  56
PQQ  A1596 (-3.6A)
None
None
None
None
1.16A 3v3oA-1w6sA:
undetectable
3v3oA-1w6sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2


(Homo sapiens)
PF10373
(EST1_DNA_bind)
PF10374
(EST1)
5 THR A 298
GLY A 340
ALA A 358
ASN A 357
GLN A 456
None
1.16A 3v3oA-1ya0A:
undetectable
3v3oA-1ya0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011


(Haemophilus
influenzae)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 THR A 217
GLY A   2
ALA A 224
GLY A 221
ASN A  21
None
1.11A 3v3oA-1yzyA:
undetectable
3v3oA-1yzyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE


(Agrobacterium
fabrum)
PF03009
(GDPD)
5 PHE A  84
GLY A  78
ALA A  10
GLY A   9
GLN A  27
None
1.02A 3v3oA-1zccA:
undetectable
3v3oA-1zccA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)


(Black beetle
virus)
PF01829
(Peptidase_A6)
5 THR A 189
ASN A 230
ALA A 360
GLY A 238
ASN A 363
None
1.22A 3v3oA-2bbvA:
undetectable
3v3oA-2bbvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Synechococcus
elongatus)
PF00202
(Aminotran_3)
5 THR A 248
GLN A 237
PHE A 229
GLY A 235
ALA A  82
None
1.22A 3v3oA-2cfbA:
undetectable
3v3oA-2cfbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT


(Hyphomicrobium
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 ASN A 108
GLY A 539
ALA A 176
GLY A 175
ASN A 261
None
PQQ  A 601 (-3.4A)
PQQ  A 601 (-3.3A)
PQQ  A 601 (-3.2A)
CA  A 775 (-2.8A)
1.20A 3v3oA-2d0vA:
undetectable
3v3oA-2d0vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT


(Hyphomicrobium
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 ASN A 394
HIS A 393
GLY A 410
ALA A  57
GLY A  56
PQQ  A 601 (-3.5A)
None
None
None
None
1.18A 3v3oA-2d0vA:
undetectable
3v3oA-2d0vA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE


(Geobacillus
kaustophilus)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 THR A 122
ASN A 108
GLY A 152
GLY A 264
ASN A 261
None
1.12A 3v3oA-2eggA:
undetectable
3v3oA-2eggA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE


(Escherichia
coli)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
5 THR A 159
ARG A 228
GLY A 165
ALA A 129
GLY A 130
None
1.00A 3v3oA-2fmtA:
4.7
3v3oA-2fmtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda)
PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C)
5 ASN A 138
GLY A 135
ALA A 148
GLY A 145
ASN A 149
None
1.25A 3v3oA-2i1jA:
undetectable
3v3oA-2i1jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibj CYTOCHROME B5

(Musca domestica)
PF00173
(Cyt-b5)
5 THR A   8
GLY A  77
ALA A  50
GLY A  51
ASN A  21
None
1.21A 3v3oA-2ibjA:
undetectable
3v3oA-2ibjA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 113
GLY A 128
ALA A  62
GLY A  61
MET A 297
None
HEM  A 501 (-3.7A)
None
None
None
0.98A 3v3oA-2j2mA:
undetectable
3v3oA-2j2mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri6 2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE


(Paraburkholderia
xenovorans)
PF12697
(Abhydrolase_6)
5 THR A 219
ASN A 251
ALA A 112
GLY A 138
ASN A 111
None
None
MLI  A   2 (-3.2A)
None
None
0.91A 3v3oA-2ri6A:
undetectable
3v3oA-2ri6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5


(Escherichia
coli;
Homo sapiens)
PF04619
(Adhesin_Dr)
PF07686
(V-set)
5 THR A  95
GLY A   8
ALA N  55
GLY N  47
GLN N  53
MTN  N1111 ( 4.7A)
None
None
None
None
1.25A 3v3oA-2verA:
undetectable
3v3oA-2verA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 PHE A  47
GLY A 366
ALA A 360
GLY A 361
ASN A 357
None
1.10A 3v3oA-2vqrA:
undetectable
3v3oA-2vqrA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 121
GLY A 136
ALA A  70
GLY A  69
MET A 309
None
HDD  A 690 (-3.9A)
None
None
None
1.01A 3v3oA-2xf2A:
4.2
3v3oA-2xf2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE


(Pseudoalteromonas
haloplanktis)
PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
5 GLN A 436
ASN A 416
ALA A 428
GLY A 429
ASN A 375
None
1.23A 3v3oA-2zooA:
undetectable
3v3oA-2zooA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7m CELLULASE

(Rhodothermus
marinus)
PF01670
(Glyco_hydro_12)
5 ASN A 120
GLY A 123
ALA A 204
GLY A 205
GLN A  32
None
1.19A 3v3oA-3b7mA:
undetectable
3v3oA-3b7mA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE


(Homo sapiens)
PF16113
(ECH_2)
5 GLN A 313
PHE A 183
GLY A 181
ALA A 166
GLY A 199
None
1.19A 3v3oA-3bptA:
undetectable
3v3oA-3bptA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE


(Streptomyces
ansochromogenes)
PF03060
(NMO)
5 ARG A 281
PHE A 282
GLY A 287
ALA A  93
GLY A  91
None
1.22A 3v3oA-3bw2A:
undetectable
3v3oA-3bw2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD


(Chromobacterium
violaceum)
no annotation 5 HIS A 102
GLY A  99
ALA A  11
GLY A  12
GLN A 290
None
None
FAD  A 401 (-3.4A)
None
None
0.88A 3v3oA-3c4aA:
26.7
3v3oA-3c4aA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
5 THR A 487
PHE A 811
GLY A 809
GLY A 677
ASN A 696
None
None
None
PLP  A 832 (-3.8A)
None
1.27A 3v3oA-3cemA:
2.1
3v3oA-3cemA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE


(Homo sapiens)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ASN A 140
GLY A 445
GLY A 134
ASN A 455
GLN A 454
ZN  A2002 ( 4.7A)
None
None
None
None
1.25A 3v3oA-3dljA:
undetectable
3v3oA-3dljA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE


(Salmonella
enterica)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 GLN A 161
GLY A  96
ALA A 196
GLY A 167
GLN A 189
None
1.21A 3v3oA-3dqqA:
undetectable
3v3oA-3dqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3s GCN5-RELATED
N-ACETYLTRANSFERASE


(Streptococcus
suis)
PF12746
(GNAT_acetyltran)
5 THR A 135
ASN A 131
ALA A 174
GLY A 173
GLN A 206
None
1.02A 3v3oA-3g3sA:
undetectable
3v3oA-3g3sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC


(Escherichia
coli)
PF01095
(Pectinesterase)
5 ARG A  14
PHE A 340
GLY A 311
ALA A 335
GLY A 388
None
1.27A 3v3oA-3grhA:
undetectable
3v3oA-3grhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus)
no annotation 5 THR A  77
GLN A 140
GLY A 141
GLY A  53
ASN A 119
None
1.26A 3v3oA-3icvA:
undetectable
3v3oA-3icvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus)
PF00901
(Orbi_VP5)
5 THR D 163
ASN D 159
ALA D 251
GLY D 249
ASN D 108
None
1.18A 3v3oA-3j9eD:
undetectable
3v3oA-3j9eD:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE


(Marinobacter
hydrocarbonoclasticus)
PF00365
(PFK)
5 THR A  71
GLN A  27
ASN A  19
GLY A  24
ALA A 308
None
1.27A 3v3oA-3k2qA:
undetectable
3v3oA-3k2qA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE


(Methanothermobacter
thermautotrophicus)
PF03059
(NAS)
5 THR A 182
PHE A 205
ASN A 207
ALA A 195
GLY A 130
None
None
None
3O3  A   1 (-3.5A)
None
1.18A 3v3oA-3o31A:
4.4
3v3oA-3o31A:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron)
PF01494
(FAD_binding_3)
9 THR A  59
GLN A 192
ARG A 213
ASN A 226
HIS A 234
GLY A 236
ALA A 320
GLY A 321
ASN A 371
SO4  A   1 (-3.7A)
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
None
None
0.81A 3v3oA-3p9uA:
57.5
3v3oA-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron)
PF01494
(FAD_binding_3)
9 THR A  59
GLN A 192
ARG A 213
ASN A 226
HIS A 234
GLY A 236
ALA A 320
GLY A 321
MET A 375
SO4  A   1 (-3.7A)
FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
None
None
0.75A 3v3oA-3p9uA:
57.5
3v3oA-3p9uA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdf 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Mycobacterium
marinum)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
5 PHE A 116
ASN A 257
GLY A 118
ALA A 195
GLY A 194
None
1.05A 3v3oA-3qdfA:
undetectable
3v3oA-3qdfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 GLN A  59
HIS A  13
GLY A  60
ALA A 352
ASN A 367
None
ZN  A 512 (-3.5A)
None
None
None
1.26A 3v3oA-3qfkA:
undetectable
3v3oA-3qfkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15


(Mycobacterium
marinum)
PF00378
(ECH_1)
5 THR A 141
PHE A 239
GLY A 241
ALA A 117
GLY A 116
None
None
None
UNL  A 291 ( 3.3A)
None
1.27A 3v3oA-3qk8A:
undetectable
3v3oA-3qk8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r67 PUTATIVE GLYCOSIDASE

(Bacteroides
thetaiotaomicron)
PF04041
(Glyco_hydro_130)
5 ARG A 258
GLY A 294
ALA A 305
GLY A 306
ASN A 285
None
EDO  A 389 ( 3.7A)
None
None
None
1.22A 3v3oA-3r67A:
undetectable
3v3oA-3r67A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 PHE A 141
HIS A 143
GLY A 144
ALA A 110
GLY A 109
None
FAD  A 501 (-4.8A)
None
None
None
1.22A 3v3oA-3rj8A:
undetectable
3v3oA-3rj8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00141
(peroxidase)
5 THR A 240
PHE A 149
GLY A 150
ALA A 105
GLY A 106
None
None
GOL  A 273 ( 4.2A)
None
None
1.15A 3v3oA-3rrwA:
undetectable
3v3oA-3rrwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
5 GLY A  94
ALA A 218
GLY A 222
ASN A 214
GLN A 229
None
1.20A 3v3oA-3swxA:
undetectable
3v3oA-3swxA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tav METHIONINE
AMINOPEPTIDASE


(Mycobacteroides
abscessus)
PF00557
(Peptidase_M24)
5 HIS A 184
GLY A 185
ALA A 146
GLY A 143
ASN A 151
MG  A 266 (-3.4A)
None
None
None
None
1.21A 3v3oA-3tavA:
undetectable
3v3oA-3tavA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE


(Arabidopsis
thaliana;
Vitis vinifera)
PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C)
5 THR A 851
PHE A 785
GLY A 671
ALA A 800
GLY A 798
None
1.27A 3v3oA-3tsyA:
undetectable
3v3oA-3tsyA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
5 THR A 562
GLY A 244
ALA A 596
GLY A 595
ASN A 569
None
1.19A 3v3oA-3welA:
undetectable
3v3oA-3welA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE


(Aspergillus
niger)
PF00150
(Cellulase)
5 THR A 336
GLN A 291
GLY A 288
ALA A 345
GLY A 343
None
1.16A 3v3oA-3wh9A:
undetectable
3v3oA-3wh9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
5 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
None
1.17A 3v3oA-3zq4A:
undetectable
3v3oA-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE


(Methylophilus
methylotrophus)
PF13360
(PQQ_2)
5 ASN A 387
HIS A 386
GLY A 403
ALA A  57
GLY A  56
PQQ  A 701 (-3.5A)
None
None
None
None
1.15A 3v3oA-4aahA:
undetectable
3v3oA-4aahA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 159
GLY A 174
ALA A 108
GLY A 107
MET A 347
None
HEM  A1715 (-3.8A)
None
None
None
0.99A 3v3oA-4aj9A:
4.5
3v3oA-4aj9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9


(Homo sapiens)
PF11979
(DUF3480)
5 THR A1312
ARG A1310
GLY A 969
ALA A1008
GLY A1009
None
1.24A 3v3oA-4bkwA:
undetectable
3v3oA-4bkwA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
6 THR A 126
PHE A 143
GLY A 158
ALA A  87
GLY A  86
MET A 327
None
None
HEM  A 537 (-4.0A)
None
None
None
1.41A 3v3oA-4cabA:
undetectable
3v3oA-4cabA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cx9 CYTOCHROME C, CLASS
II


(Shewanella
frigidimarina)
PF01322
(Cytochrom_C_2)
5 PHE A  23
ASN A  47
GLY A  24
ALA A 110
ASN A 113
HEC  A1129 ( 4.0A)
None
None
None
None
1.22A 3v3oA-4cx9A:
undetectable
3v3oA-4cx9A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d70 SORTASE FAMILY
PROTEIN


(Clostridium
perfringens)
PF04203
(Sortase)
5 THR A 167
ASN A 103
GLY A  99
ALA A  77
GLY A  90
None
0.95A 3v3oA-4d70A:
undetectable
3v3oA-4d70A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
5 THR A 235
GLY A 160
ALA A  55
GLY A  54
GLN A  89
None
1.19A 3v3oA-4ff5A:
undetectable
3v3oA-4ff5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE


(Paenarthrobacter
ureafaciens)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 THR A 420
ARG A 421
GLY A 497
GLY A 437
GLN A 488
None
1.13A 3v3oA-4fffA:
undetectable
3v3oA-4fffA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2a HYPOTHETICAL PROTEIN

(Legionella
pneumophila)
PF13308
(YARHG)
PF14415
(DUF4424)
5 GLY A  35
ALA A 108
GLY A 109
ASN A  61
GLN A  66
None
SO4  A 411 (-3.5A)
SO4  A 411 (-3.5A)
None
None
1.19A 3v3oA-4g2aA:
undetectable
3v3oA-4g2aA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Vibrio cholerae)
PF00496
(SBP_bac_5)
5 THR A 245
ASN A 293
ALA A 413
GLY A 412
ASN A  46
None
1.17A 3v3oA-4gf8A:
undetectable
3v3oA-4gf8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 THR A  53
GLY A 112
ALA A 350
GLY A 351
MET A 362
None
None
None
GOL  A 501 (-3.5A)
None
1.24A 3v3oA-4ip4A:
undetectable
3v3oA-4ip4A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Ruegeria
pomeroyi)
PF00378
(ECH_1)
5 THR A 135
GLY A 119
ALA A  63
GLY A  64
ASN A  27
None
1.13A 3v3oA-4izdA:
undetectable
3v3oA-4izdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE


([Bacillus]
clarkii)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 PHE A 338
GLY A 335
GLY A 344
MET A 296
GLN A 301
None
1.19A 3v3oA-4jcmA:
undetectable
3v3oA-4jcmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN


(Ketogulonicigenium
vulgare)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 PHE A 202
ASN A 231
GLY A 108
GLY A 227
MET A 169
None
1.17A 3v3oA-4lswA:
3.4
3v3oA-4lswA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans)
PF01301
(Glyco_hydro_35)
5 GLN A 542
ARG A  28
ALA A 285
GLY A 284
ASN A 286
None
None
None
None
PG0  A 900 ( 4.7A)
1.20A 3v3oA-4madA:
undetectable
3v3oA-4madA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
5 THR A 237
ASN A 211
GLY A 266
GLY A 216
ASN A 283
None
1.05A 3v3oA-4oe5A:
3.1
3v3oA-4oe5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE


(Saccharophagus
degradans)
PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III)
5 PHE A 416
ASN A 420
GLY A 414
GLY A 577
GLN A 472
None
1.17A 3v3oA-4ojzA:
undetectable
3v3oA-4ojzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onz PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
ovatus)
PF04041
(Glyco_hydro_130)
5 ARG A 259
GLY A 294
ALA A 305
GLY A 306
ASN A 286
None
1.20A 3v3oA-4onzA:
undetectable
3v3oA-4onzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE


(Bacteroides
fragilis)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
5 ASN A 269
GLY A 240
ALA A 201
GLY A 200
GLN A 209
None
1.20A 3v3oA-4pysA:
undetectable
3v3oA-4pysA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qor CATALASE

(Bacillus
pumilus)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 114
GLY A 129
ALA A  63
GLY A  62
MET A 298
None
HEM  A 501 ( 3.8A)
None
None
None
1.01A 3v3oA-4qorA:
undetectable
3v3oA-4qorA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvr UNCHARACTERIZED
HYPOTHETICAL PROTEIN
FTT_1539C


(Francisella
tularensis)
no annotation 5 GLN A 311
ARG A 295
GLY A 310
ALA A 121
GLN A 126
None
1.10A 3v3oA-4qvrA:
undetectable
3v3oA-4qvrA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT


(Methylococcus
capsulatus)
no annotation 5 ASN B 136
GLY B 560
ALA B 204
GLY B 203
ASN B 289
None
PQQ  B 702 (-3.6A)
PQQ  B 702 (-3.0A)
PQQ  B 702 (-3.1A)
CA  B 701 ( 2.8A)
1.21A 3v3oA-4tqoB:
undetectable
3v3oA-4tqoB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urs DIGUANYLATE CYCLASE

(Thermotoga
maritima)
PF00990
(GGDEF)
5 GLY A 167
ALA A 128
GLY A 129
ASN A 210
MET A 234
GLY  A 167 ( 0.0A)
ALA  A 128 ( 0.0A)
GLY  A 129 ( 0.0A)
ASN  A 210 ( 0.6A)
MET  A 234 ( 0.0A)
1.23A 3v3oA-4ursA:
undetectable
3v3oA-4ursA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620)
no annotation 5 ARG A 505
GLY A 529
ALA A 474
GLY A 473
ASN A 476
None
1.13A 3v3oA-4xn3A:
undetectable
3v3oA-4xn3A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120)
no annotation 5 PHE B 362
GLY B 175
ALA B 312
GLY B 311
MET B 298
None
1.24A 3v3oA-4xsrB:
3.7
3v3oA-4xsrB:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus)
no annotation 5 THR A  43
GLN A 106
GLY A 107
GLY A  19
ASN A  85
None
1.27A 3v3oA-4zv7A:
undetectable
3v3oA-4zv7A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE


(Saccharophagus
degradans)
PF00150
(Cellulase)
5 THR A 328
GLN A 351
PHE A 332
ASN A  72
GLY A  98
None
1.25A 3v3oA-5a8qA:
undetectable
3v3oA-5a8qA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE


(Saccharophagus
degradans)
PF00150
(Cellulase)
5 THR A 328
PHE A 332
ASN A  72
ALA A  94
ASN A  95
None
1.19A 3v3oA-5a8qA:
undetectable
3v3oA-5a8qA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE


(Saccharophagus
degradans)
PF00150
(Cellulase)
5 THR A 328
PHE A 332
ASN A  72
GLY A  98
ASN A  96
None
1.20A 3v3oA-5a8qA:
undetectable
3v3oA-5a8qA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT


(Sulfurisphaera
tokodaii)
PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C)
5 PHE B 101
HIS B 103
GLY B  99
ALA B 154
ASN B 151
None
1.04A 3v3oA-5b47B:
undetectable
3v3oA-5b47B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
5 PHE A 334
ASN A 333
GLY A 336
ALA A 386
GLY A 384
None
1.18A 3v3oA-5cerA:
undetectable
3v3oA-5cerA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN


(Photobacterium
profundum)
PF00759
(Glyco_hydro_9)
5 PHE A  99
HIS A 104
ALA A 562
GLY A 561
ASN A 168
None
1.25A 3v3oA-5dgqA:
undetectable
3v3oA-5dgqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31


(Trueperella
pyogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 THR A 274
PHE A 280
ASN A 278
ALA A 550
GLY A 551
None
1.02A 3v3oA-5f7sA:
undetectable
3v3oA-5f7sA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gka CAPSID PROTEIN VP0

(Aichivirus A)
PF00073
(Rhv)
5 GLN B 334
ARG B 288
ASN B 290
GLY B 190
ALA B 283
None
1.23A 3v3oA-5gkaB:
undetectable
3v3oA-5gkaB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00202
(Aminotran_3)
5 THR A 271
GLN A 260
PHE A 252
GLY A 258
ALA A 105
None
1.26A 3v3oA-5hdmA:
undetectable
3v3oA-5hdmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp4 PROTOPLAST SECRETED
PROTEIN 2


(Saccharomyces
cerevisiae)
PF03358
(FMN_red)
5 THR A 166
GLN A 187
ALA A 122
GLY A 119
ASN A 126
None
1.00A 3v3oA-5mp4A:
3.6
3v3oA-5mp4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
5 ASN A 788
GLY A 739
ALA A 782
GLY A 783
GLN A 806
None
None
None
CA  A9009 ( 3.7A)
None
0.86A 3v3oA-5n8pA:
undetectable
3v3oA-5n8pA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
5 ASN A 788
GLY A 739
ALA A 782
GLY A 783
GLN A 806
None
None
None
CA  A9009 ( 3.7A)
None
0.87A 3v3oA-5n97A:
undetectable
3v3oA-5n97A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2


(Homo sapiens)
PF01652
(IF4E)
5 GLN A  84
ASN A  59
GLY A  86
ALA A 169
GLY A 168
None
1.17A 3v3oA-5nvmA:
2.3
3v3oA-5nvmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1


(Cocos nucifera)
no annotation 5 THR A  58
GLN A 204
ARG A  60
GLY A 252
ASN A 170
None
1.25A 3v3oA-5wpwA:
undetectable
3v3oA-5wpwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus)
no annotation 5 GLN A  56
ARG A 322
ASN A 297
GLY A 440
GLY A 289
None
1.26A 3v3oA-5xgvA:
27.0
3v3oA-5xgvA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE


(Methylophaga
aminisulfidivorans)
no annotation 5 ASN A 264
GLY A 233
ALA A 207
GLY A 210
ASN A 292
None
None
PQQ  A 701 (-3.0A)
None
MG  A 702 ( 3.0A)
1.16A 3v3oA-5xm3A:
undetectable
3v3oA-5xm3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S8E


(Leishmania
donovani)
no annotation 5 THR K  95
ASN K  35
GLY K 193
ALA K  40
GLY K  39
None
None
G  1 375 ( 3.8A)
None
None
1.06A 3v3oA-6az1K:
undetectable
3v3oA-6az1K:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE


(Elizabethkingia
anophelis)
no annotation 5 THR A 466
GLN A 426
PHE A 387
HIS A 392
GLN A 349
GOL  A 605 ( 4.6A)
None
None
None
None
1.24A 3v3oA-6bzcA:
undetectable
3v3oA-6bzcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3i -

(-)
no annotation 5 THR A 115
ASN A 218
HIS A 111
GLY A 107
GLY A 195
None
None
CO  A 301 ( 3.2A)
AKG  A 302 (-3.1A)
None
1.25A 3v3oA-6d3iA:
undetectable
3v3oA-6d3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN


(Azotobacter
vinelandii)
no annotation 5 ASN A 184
HIS A 180
GLY A  53
GLY A 237
ASN A  93
None
D6N  A 502 (-4.6A)
None
None
None
1.27A 3v3oA-6feaA:
undetectable
3v3oA-6feaA:
17.87