SIMILAR PATTERNS OF AMINO ACIDS FOR 3V3N_C_MIYC2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 PHE A 215
GLY A 214
GLY A 254
ASN A 249
 None
 0.93A 3v3nC-1bu8A:
undetectable		 3v3nC-1bu8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A 268
HIS A  42
GLY A 269
GLY A 174
 None
 0.95A 3v3nC-1bxzA:
undetectable		 3v3nC-1bxzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 PHE A 137
GLY A 138
GLY A 302
MET A  74
 None
K  A 853 (-4.1A)
None
None
 1.01A 3v3nC-1c1dA:
4.0		 3v3nC-1c1dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 GLN A 366
GLY A 260
GLY A 600
MET A  42
 None
None
None
R03  A 800 ( 4.9A)
 0.90A 3v3nC-1h39A:
undetectable		 3v3nC-1h39A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		4 PHE A 267
GLY A 266
GLY A 389
ASN A 218
 None
 0.90A 3v3nC-1jneA:
undetectable		 3v3nC-1jneA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		4 ARG A  79
HIS A  70
GLY A 229
ASN A  88
 None
 0.98A 3v3nC-1m72A:
3.5		 3v3nC-1m72A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 None
TEI  A3006 (-3.6A)
None
None
 0.82A 3v3nC-1n5xA:
undetectable		 3v3nC-1n5xA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		4 PHE A  27
GLY A  61
GLY A 169
ASN A  45
 None
 0.95A 3v3nC-1p3cA:
undetectable		 3v3nC-1p3cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4i ANTIBODY VARIABLE
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLN L   6
PHE L 139
GLY L 140
GLY L  57
 None
 0.91A 3v3nC-1p4iL:
undetectable		 3v3nC-1p4iL:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 166
GLY A 196
ASN A 420
MET A 387
 None
 0.97A 3v3nC-1rblA:
undetectable		 3v3nC-1rblA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 159
GLY A 189
ASN A 413
MET A 380
 None
 0.88A 3v3nC-1svdA:
undetectable		 3v3nC-1svdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		4 HIS A 110
GLY A 227
GLY A  41
ASN A 304
 FE  A 401 (-3.5A)
None
None
None
 0.97A 3v3nC-1wraA:
undetectable		 3v3nC-1wraA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		4 PHE A 329
HIS A 322
GLY A 325
GLY A 342
 None
 0.91A 3v3nC-1x1nA:
undetectable		 3v3nC-1x1nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 HIS A  29
GLY A 182
GLY A 162
ASN A 363
 None
None
None
FE  A 429 ( 4.3A)
 0.91A 3v3nC-1xzwA:
undetectable		 3v3nC-1xzwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		4 ARG A 207
HIS A 210
GLY A 502
ASN A 413
 None
 0.95A 3v3nC-1yifA:
undetectable		 3v3nC-1yifA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvf 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Saccharomyces
cerevisiae) 		PF06052
(3-HAO) 		4 ARG A 114
GLY A  32
GLY A 144
ASN A  26
 None
 1.00A 3v3nC-1zvfA:
undetectable		 3v3nC-1zvfA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 PHE A 168
GLY A 169
GLY A 296
MET A  62
 ODT  A1001 (-3.7A)
None
None
ODT  A1001 ( 3.9A)
 0.87A 3v3nC-2bacA:
16.0		 3v3nC-2bacA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		4 HIS A  85
GLY A 202
GLY A  16
ASN A 279
 ZN  A1550 (-3.3A)
None
None
None
 0.95A 3v3nC-2bibA:
undetectable		 3v3nC-2bibA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 HIS A 215
GLY A 181
GLY A 234
MET A 124
 None
 0.90A 3v3nC-2dwsA:
undetectable		 3v3nC-2dwsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 PHE A 178
HIS A 180
GLY A 177
GLY A 291
 None
 0.97A 3v3nC-2hj9A:
2.8		 3v3nC-2hj9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		4 PHE A 178
HIS A 180
GLY A 177
GLY A 292
 None
 1.01A 3v3nC-2hj9A:
2.8		 3v3nC-2hj9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PHE A 163
GLY A 162
GLY A  33
ASN A  39
 None
 0.93A 3v3nC-2hlpA:
2.3		 3v3nC-2hlpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4

(Azotobacter
vinelandii) 		PF12708
(Pectate_lyase_3) 		4 PHE A 198
GLY A 197
GLY A 241
ASN A 187
 None
 0.98A 3v3nC-2pyhA:
undetectable		 3v3nC-2pyhA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 PHE A1005
HIS A1116
GLY A1006
GLY A1151
 None
 0.99A 3v3nC-2rhpA:
undetectable		 3v3nC-2rhpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 PHE A 231
HIS A 235
GLY A 263
GLY A  17
 None
 0.79A 3v3nC-2x7iA:
undetectable		 3v3nC-2x7iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A  47
GLY A  48
GLY A 321
MET A 279
 None
 0.71A 3v3nC-2y24A:
undetectable		 3v3nC-2y24A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A 182
GLY A 179
GLY A 229
ASN A 164
 None
None
None
XYP  A1001 (-3.1A)
 0.99A 3v3nC-2y24A:
undetectable		 3v3nC-2y24A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ARG A 227
GLY A 234
GLY A 531
MET A 505
 None
 0.77A 3v3nC-2yheA:
undetectable		 3v3nC-2yheA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 PHE A  76
GLY A 314
GLY A 195
MET A 280
 None
 0.87A 3v3nC-2yp1A:
undetectable		 3v3nC-2yp1A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 194
GLY A 244
 None
A5A  A 801 (-2.7A)
None
A5A  A 801 (-4.0A)
 0.65A 3v3nC-2ztgA:
undetectable		 3v3nC-2ztgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 195
GLY A 250
 None
A5A  A 999 (-3.0A)
None
A5A  A 999 (-3.5A)
 0.49A 3v3nC-2zzgA:
undetectable		 3v3nC-2zzgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfk CATALYTIC ANTIBODY
FAB 34E4 LIGHT
CHAIN,UNCHARACTERIZE
D PROTEIN

(Homo sapiens;
Mus musculus) 		no annotation 4 GLN L   6
PHE L  98
GLY L  99
GLY L  46
 None
 1.00A 3v3nC-3cfkL:
undetectable		 3v3nC-3cfkL:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpg UNCHARACTERIZED
PROTEIN

(Bifidobacterium
adolescentis) 		PF01168
(Ala_racemase_N) 		4 ARG A 262
GLY A 200
GLY A 205
ASN A 168
 None
 0.98A 3v3nC-3cpgA:
undetectable		 3v3nC-3cpgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 PHE A 494
GLY A 495
GLY A 422
MET A 398
 None
None
PCD  A 921 (-3.4A)
None
 0.95A 3v3nC-3fahA:
undetectable		 3v3nC-3fahA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 GLN A 261
GLY A 282
GLY A 202
ASN A 207
 None
 0.86A 3v3nC-3h5lA:
2.2		 3v3nC-3h5lA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 807
HIS A 773
GLY A 608
MET A 587
 MN  A2002 ( 4.0A)
MN  A2002 (-3.4A)
None
None
 1.01A 3v3nC-3ho8A:
3.4		 3v3nC-3ho8A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 PHE A 527
GLY A 526
GLY A 463
ASN A 453
 None
 0.92A 3v3nC-3i04A:
3.3		 3v3nC-3i04A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im0 VAL-1

(Paramecium
bursaria
Chlorella virus
CVK2) 		no annotation 4 PHE A 221
GLY A  91
GLY A  55
ASN A 230
 None
 1.00A 3v3nC-3im0A:
undetectable		 3v3nC-3im0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		4 PHE A 114
HIS A 257
GLY A 117
ASN A 200
 None
 0.97A 3v3nC-3jyoA:
4.0		 3v3nC-3jyoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		4 PHE A  19
GLY A  20
GLY A 300
MET A 257
 None
 0.76A 3v3nC-3kl0A:
undetectable		 3v3nC-3kl0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ARG A 140
GLY A 489
GLY A 502
ASN A 508
 None
 0.67A 3v3nC-3lfuA:
undetectable		 3v3nC-3lfuA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 GLN A 100
HIS A 259
GLY A 104
ASN A 433
 None
 0.98A 3v3nC-3om5A:
undetectable		 3v3nC-3om5A:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		4 ARG A 213
HIS A 234
GLY A 236
GLY A 321
 SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
 0.41A 3v3nC-3p9uA:
58.4		 3v3nC-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		4 ARG A 213
HIS A 234
GLY A 236
MET A 375
 SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
 0.46A 3v3nC-3p9uA:
58.4		 3v3nC-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		4 ARG A 213
HIS A 234
GLY A 321
ASN A 371
 SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
 0.96A 3v3nC-3p9uA:
58.4		 3v3nC-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		4 GLN A 192
ARG A 213
HIS A 234
GLY A 321
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
 0.88A 3v3nC-3p9uA:
58.4		 3v3nC-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		4 GLN A 192
ARG A 213
HIS A 234
MET A 375
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
 0.86A 3v3nC-3p9uA:
58.4		 3v3nC-3p9uA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		4 PHE A 147
HIS A 188
GLY A 148
GLY A  49
 None
MIR  A 120 ( 3.7A)
MIR  A 120 ( 4.2A)
None
 0.97A 3v3nC-3qpcA:
undetectable		 3v3nC-3qpcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpd CUTINASE 1

(Aspergillus
oryzae) 		PF01083
(Cutinase) 		4 PHE A 153
HIS A 194
GLY A 154
GLY A  55
 None
SEP  A 126 ( 4.1A)
SEP  A 126 ( 4.5A)
None
 1.00A 3v3nC-3qpdA:
2.9		 3v3nC-3qpdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN K   6
PHE K 100
GLY K 101
GLY K  51
 None
 0.89A 3v3nC-3ri5K:
undetectable		 3v3nC-3ri5K:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN C 918
PHE C 914
GLY C 915
GLY C 800
 None
RMO  C1317 (-3.6A)
None
None
 0.79A 3v3nC-3sr6C:
undetectable		 3v3nC-3sr6C:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 PHE A 741
GLY A 742
GLY A 672
MET A 652
 None
 0.93A 3v3nC-3ut2A:
undetectable		 3v3nC-3ut2A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vab DIAMINOPIMELATE
DECARBOXYLASE 1

(Brucella
melitensis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLN A 204
GLY A 242
GLY A 286
ASN A  63
 None
 0.93A 3v3nC-3vabA:
undetectable		 3v3nC-3vabA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		4 PHE A 294
HIS A 262
GLY A 292
ASN A 330
 None
None
None
SO4  A 404 (-3.9A)
 0.99A 3v3nC-3vupA:
undetectable		 3v3nC-3vupA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 GLN A 105
ARG A 128
GLY A 194
GLY A 244
 None
A5A  A1001 (-3.4A)
None
A5A  A1001 (-3.7A)
 0.52A 3v3nC-3wqyA:
undetectable		 3v3nC-3wqyA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 PHE A 137
GLY A 149
GLY A  69
ASN A 120
 None
 0.92A 3v3nC-3zq4A:
undetectable		 3v3nC-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 923
PHE A 919
GLY A 920
GLY A 805
 None
 0.59A 3v3nC-3zyvA:
undetectable		 3v3nC-3zyvA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 ARG A 676
GLY A 804
GLY A 580
MET A 690
 None
 0.92A 3v3nC-4ammA:
undetectable		 3v3nC-4ammA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 GLN A  76
HIS A 166
GLY A  70
GLY A 149
 None
 0.76A 3v3nC-4at0A:
9.4		 3v3nC-4at0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwr PROTEIN
CORRESPONDING TO
LOCUS C5321 FROM
CFT073 E.COLI STRAIN

(Escherichia
coli) 		PF08238
(Sel1) 		4 GLN A  92
ARG A 116
GLY A 126
GLY A 139
 None
None
None
EDO  A1487 ( 4.8A)
 0.89A 3v3nC-4bwrA:
undetectable		 3v3nC-4bwrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		4 GLN A 123
PHE A 120
GLY A 121
GLY A  96
 None
 1.00A 3v3nC-4evzA:
undetectable		 3v3nC-4evzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A  19
GLY A  20
GLY A 297
MET A 254
 None
 0.70A 3v3nC-4fmvA:
undetectable		 3v3nC-4fmvA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		4 GLN A 179
ARG A 370
GLY A 198
GLY A  30
 None
 0.92A 3v3nC-4iheA:
undetectable		 3v3nC-4iheA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 ARG A 621
PHE A 614
GLY A 254
GLY A 304
 None
 0.89A 3v3nC-4jc8A:
undetectable		 3v3nC-4jc8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 166
GLY A 196
ASN A 420
MET A 387
 None
 0.93A 3v3nC-4mkvA:
undetectable		 3v3nC-4mkvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 PHE A 184
GLY A 181
GLY A 246
MET A 278
 None
 0.95A 3v3nC-4mnrA:
undetectable		 3v3nC-4mnrA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 GLN A 521
GLY A 241
GLY A  32
ASN A 231
 None
None
None
BMA  A 607 ( 2.7A)
 0.94A 3v3nC-4pfwA:
undetectable		 3v3nC-4pfwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 GLN A1136
GLY A1137
GLY A1300
ASN A1268
 None
ANP  A1501 ( 3.8A)
None
None
 0.76A 3v3nC-4pj3A:
undetectable		 3v3nC-4pj3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 PHE A  18
GLY A  19
GLY A 299
MET A 256
 None
 0.73A 3v3nC-4qawA:
undetectable		 3v3nC-4qawA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ARG A 217
GLY A 350
GLY A 101
MET A 229
 FMT  A 500 (-2.9A)
None
None
None
 0.67A 3v3nC-4qbuA:
undetectable		 3v3nC-4qbuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 4 PHE A  79
GLY A  78
GLY A 101
MET A 151
 None
 0.94A 3v3nC-4r7kA:
2.3		 3v3nC-4r7kA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 PHE A 684
GLY A 681
GLY A 746
MET A 778
 None
NXU  A1001 ( 4.0A)
None
None
 0.94A 3v3nC-4ra7A:
undetectable		 3v3nC-4ra7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 PHE A 242
GLY A 241
GLY A 167
ASN A 127
 None
 1.01A 3v3nC-4rxmA:
undetectable		 3v3nC-4rxmA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
no annotation 		4 GLN D 349
GLY D 192
GLY A 362
ASN A 354
 None
 0.83A 3v3nC-4x28D:
undetectable		 3v3nC-4x28D:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 GLN A 230
PHE A 222
GLY A 226
GLY A 290
 None
None
None
GOL  A 504 (-3.2A)
 0.97A 3v3nC-4x8dA:
undetectable		 3v3nC-4x8dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 918
PHE A 914
GLY A 915
GLY A 800
 BCT  A3006 (-3.0A)
URC  A3007 ( 3.4A)
BCT  A3006 (-3.9A)
None
 0.74A 3v3nC-4yswA:
undetectable		 3v3nC-4yswA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2k IG LAMBDA-1 CHAIN V
REGION S43

(Mus musculus) 		PF07686
(V-set) 		4 GLN H1007
PHE H1098
GLY H1099
GLY H1049
 None
None
None
EDO  H3005 ( 4.7A)
 0.87A 3v3nC-5a2kH:
undetectable		 3v3nC-5a2kH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajh CUTINASE

(Fusarium
oxysporum) 		PF01083
(Cutinase) 		4 PHE A 148
HIS A 189
GLY A 149
GLY A  50
 None
MPD  A1221 (-4.0A)
None
None
 0.88A 3v3nC-5ajhA:
2.8		 3v3nC-5ajhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 GLN A  77
PHE A  67
HIS A 201
GLY A  39
 None
 0.97A 3v3nC-5bnzA:
undetectable		 3v3nC-5bnzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 PHE A  68
HIS A  60
GLY A  28
GLY A 352
 None
HEM  A 502 (-3.1A)
None
None
 1.00A 3v3nC-5djqA:
undetectable		 3v3nC-5djqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 GLN A 560
PHE A 113
GLY A 163
ASN A 174
 None
 0.96A 3v3nC-5ecoA:
undetectable		 3v3nC-5ecoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 GLN A 556
HIS A 533
GLY A 535
GLY A 292
 None
 0.88A 3v3nC-5ehkA:
undetectable		 3v3nC-5ehkA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLN A 927
PHE A 923
GLY A 924
GLY A 809
 None
MOS  A3005 (-4.2A)
None
None
 0.61A 3v3nC-5epgA:
undetectable		 3v3nC-5epgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 GLN H   6
PHE H 100
GLY H 101
GLY H  51
 None
 0.86A 3v3nC-5fcsH:
undetectable		 3v3nC-5fcsH:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 PHE A 144
HIS A 101
GLY A 146
GLY A 136
 None
None
None
REA  A 602 (-3.4A)
 0.74A 3v3nC-5fhzA:
1.4		 3v3nC-5fhzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 ARG I 361
PHE I 503
GLY I 502
MET I 469
 None
 0.93A 3v3nC-5furI:
undetectable		 3v3nC-5furI:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		4 PHE A 252
HIS A 173
GLY A 253
GLY A 120
 None
 0.96A 3v3nC-5heeA:
undetectable		 3v3nC-5heeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 PHE A 704
HIS A 711
GLY A 713
GLY A  32
 None
 0.69A 3v3nC-5ijlA:
undetectable		 3v3nC-5ijlA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE

(Auricularia
auricula-judae) 		PF04261
(Dyp_perox) 		4 GLN A 424
GLY A 403
GLY A 393
ASN A 380
 None
 0.87A 3v3nC-5ikgA:
undetectable		 3v3nC-5ikgA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 168
GLY A 198
ASN A 421
MET A 388
 None
 1.00A 3v3nC-5nv3A:
undetectable		 3v3nC-5nv3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE L  98
GLY L  99
GLY H  60
MET H 100
 None
 0.74A 3v3nC-5u3pL:
undetectable		 3v3nC-5u3pL:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		4 GLN A  39
GLY A  42
GLY A 244
ASN A 156
 None
FAD  A 401 (-3.3A)
NAP  A 407 (-3.2A)
None
 0.91A 3v3nC-5u63A:
9.2		 3v3nC-5u63A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 HIS J 326
GLY J 322
GLY J 388
ASN J 384
 A  M  14 ( 3.9A)
None
None
None
 0.93A 3v3nC-5vzjJ:
undetectable		 3v3nC-5vzjJ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgv PYRE3

(Streptomyces
rugosporus) 		no annotation 4 GLN A  56
ARG A 322
GLY A 440
GLY A 289
 None
 0.74A 3v3nC-5xgvA:
27.1		 3v3nC-5xgvA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 ARG A 207
HIS A 210
GLY A 502
ASN A 413
 None
 0.93A 3v3nC-5zqjA:
undetectable		 3v3nC-5zqjA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9r HYDROXYETHYLPHOSPHON
ATE DIOXYGENASE

(Streptomyces
albus) 		no annotation 4 PHE A 187
HIS A 190
GLY A 148
GLY A 209
 None
FE  A 501 ( 3.3A)
None
None
 0.73A 3v3nC-6b9rA:
undetectable		 3v3nC-6b9rA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9s METHYLPHOSPHONATE
SYNTHASE

(Nitrosopumilus
maritimus) 		no annotation 4 PHE A 187
HIS A 190
GLY A 147
GLY A 210
 None
FE  A 501 (-3.6A)
None
None
 0.81A 3v3nC-6b9sA:
undetectable		 3v3nC-6b9sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 PHE A 389
GLY A 386
GLY A 264
ASN A 220
 None
 0.86A 3v3nC-6bdzA:
undetectable		 3v3nC-6bdzA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 4 GLN B 281
HIS B 279
GLY B 290
GLY B 259
 None
 0.80A 3v3nC-6btmB:
undetectable		 3v3nC-6btmB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4a EXORIBONUCLEASE II,
MITOCHONDRIAL

([Candida]
glabrata) 		no annotation 4 PHE A 503
HIS A 781
GLY A 501
GLY A 771
 None
 0.74A 3v3nC-6f4aA:
undetectable		 3v3nC-6f4aA:
12.70