SIMILAR PATTERNS OF AMINO ACIDS FOR 3V3N_A_MIYA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 HIS A 100
GLY A 157
SER A 176
GLY A  73
ASN A  92
 None
None
None
None
PTT  A 800 (-3.5A)
 1.48A 3v3nA-1b25A:
undetectable		 3v3nA-1b25A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opg OPG2 FAB (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN H 117
MET H  34
GLY H 116
GLY H  26
ASN H  77
 None
 1.36A 3v3nA-1opgH:
undetectable		 3v3nA-1opgH:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN A 112
MET A  34
GLY A 111
GLY A  26
ASN A  77
 None
 1.29A 3v3nA-1qgcA:
undetectable		 3v3nA-1qgcA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjx IMMUNOGLOBULIN VH
DOMAIN

(Lama glama) 		PF07686
(V-set) 		5 GLN A 911
MET A 834
GLY A 910
GLY A 826
ASN A 876
 None
MPD  A8001 ( 3.5A)
None
None
None
 1.39A 3v3nA-1sjxA:
undetectable		 3v3nA-1sjxA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		5 ARG A 334
PHE A 384
GLY A 252
PRO A 151
ASN A  94
 None
NAD  A1490 (-3.7A)
NAD  A1490 (-3.4A)
NAD  A1490 (-4.6A)
None
 1.48A 3v3nA-1t90A:
2.7		 3v3nA-1t90A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ty4 APOPTOSIS REGULATOR
CED-9

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4) 		5 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.38A 3v3nA-1ty4A:
undetectable		 3v3nA-1ty4A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1via SHIKIMATE KINASE

(Campylobacter
jejuni) 		PF01202
(SKI) 		5 PHE A  84
GLY A  81
SER A  35
PHE A  70
GLY A  94
 None
 1.02A 3v3nA-1viaA:
undetectable		 3v3nA-1viaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5y APOPTOSIS REGULATOR
CED-9

(Caenorhabditis
elegans) 		PF00452
(Bcl-2)
PF02180
(BH4) 		5 PHE A 123
GLY A 120
SER A 176
PHE A 131
ASN A 130
 None
 1.17A 3v3nA-2a5yA:
undetectable		 3v3nA-2a5yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhx SPM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 PHE B  61
HIS B 263
PRO B  86
GLY B 123
ASN B  89
 None
CSO  B 221 (-3.5A)
None
None
None
 1.44A 3v3nA-2fhxB:
undetectable		 3v3nA-2fhxB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF13247
(Fer4_11) 		5 PHE B  97
HIS B 112
PRO B 124
PHE B  95
GLY B 121
 None
 1.21A 3v3nA-2ivfB:
undetectable		 3v3nA-2ivfB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 HIS A 758
GLY A 445
SER A 442
PHE A 449
ASN A 450
 None
 1.41A 3v3nA-2pggA:
undetectable		 3v3nA-2pggA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		5 ARG A 218
GLY A 156
SER A 247
GLY A 211
ASN A  22
 None
 1.28A 3v3nA-2wknA:
undetectable		 3v3nA-2wknA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nA-2wzfA:
undetectable		 3v3nA-2wzfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nA-2wzgA:
undetectable		 3v3nA-2wzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLN A 753
GLY A 747
PRO A 726
PHE A 731
GLY A 684
 None
 1.29A 3v3nA-2zxqA:
undetectable		 3v3nA-2zxqA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 GLN A1064
PHE A1068
GLY A1067
GLY A1059
ASN A1083
 None
 1.31A 3v3nA-3asiA:
undetectable		 3v3nA-3asiA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		5 MET A 156
PHE A 152
GLY A 138
SER A 140
PHE A  95
 None
 1.44A 3v3nA-3bt6A:
undetectable		 3v3nA-3bt6A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 459
SER A 457
PHE A 405
GLY A 427
ASN A 404
 None
 1.11A 3v3nA-3cdiA:
undetectable		 3v3nA-3cdiA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 436
SER A 434
PHE A 382
GLY A 404
ASN A 381
 None
 1.17A 3v3nA-3gmeA:
undetectable		 3v3nA-3gmeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 PHE A 309
GLY A 308
SER A 297
GLY A 350
ASN A 294
 None
 1.45A 3v3nA-3gq9A:
undetectable		 3v3nA-3gq9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrr AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF14765
(PS-DH) 		5 GLN A1547
HIS A1345
PHE A1526
GLY A1529
ASN A1582
 None
HC8  A4000 (-3.5A)
None
None
None
 1.46A 3v3nA-3hrrA:
undetectable		 3v3nA-3hrrA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		5 PHE A 302
GLY A 303
SER A 640
PRO A 616
ASN A 621
 None
 1.22A 3v3nA-3i6sA:
undetectable		 3v3nA-3i6sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		5 MET D 407
GLY D 401
PRO D 448
PHE D 449
GLY D 453
 None
 1.26A 3v3nA-3k70D:
undetectable		 3v3nA-3k70D:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 PHE B 954
GLY B 980
PRO B 946
PHE B 945
GLY B 948
 None
 1.46A 3v3nA-3k70B:
undetectable		 3v3nA-3k70B:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 MET A 161
HIS A  68
GLY A 156
GLY A 193
ASN A 196
 None
TDP  A 701 (-4.0A)
TDP  A 701 ( 3.7A)
None
None
 1.04A 3v3nA-3m49A:
1.1		 3v3nA-3m49A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		5 GLN A 279
GLY A 234
PRO A 203
PHE A 209
GLY A 196
 None
PO4  A 307 (-3.7A)
None
None
None
 1.31A 3v3nA-3m4uA:
undetectable		 3v3nA-3m4uA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		8 ARG A 213
HIS A 234
GLY A 236
SER A 238
PRO A 318
PHE A 319
GLY A 321
ASN A 371
 SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
None
FAD  A 401 (-4.4A)
None
None
None
 0.84A 3v3nA-3p9uA:
58.0		 3v3nA-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		8 ARG A 213
MET A 215
HIS A 234
GLY A 236
SER A 238
PRO A 318
PHE A 319
ASN A 371
 SO4  A   1 (-4.5A)
None
SO4  A   1 ( 4.6A)
None
None
FAD  A 401 (-4.4A)
None
None
 0.90A 3v3nA-3p9uA:
58.0		 3v3nA-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		8 GLN A 192
ARG A 213
HIS A 234
SER A 238
PRO A 318
PHE A 319
GLY A 321
ASN A 371
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
SO4  A   1 ( 4.6A)
None
FAD  A 401 (-4.4A)
None
None
None
 0.99A 3v3nA-3p9uA:
58.0		 3v3nA-3p9uA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		8 GLN A 192
ARG A 213
MET A 215
HIS A 234
SER A 238
PRO A 318
PHE A 319
ASN A 371
 FAD  A 401 (-3.4A)
SO4  A   1 (-4.5A)
None
SO4  A   1 ( 4.6A)
None
FAD  A 401 (-4.4A)
None
None
 1.04A 3v3nA-3p9uA:
58.0		 3v3nA-3p9uA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		5 GLN A 320
HIS A  99
GLY A 107
PHE A  49
GLY A  65
 None
None
None
None
CA  A 900 ( 4.9A)
 1.49A 3v3nA-3powA:
undetectable		 3v3nA-3powA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		5 GLY A 105
SER A 134
PHE A 243
GLY A 246
ASN A 240
 None
 1.24A 3v3nA-3qmwA:
1.8		 3v3nA-3qmwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 PHE A 309
GLY A 308
SER A 297
GLY A 350
ASN A 294
 None
 1.44A 3v3nA-3sucA:
undetectable		 3v3nA-3sucA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3x OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ARG A 272
HIS A 298
GLY A 292
PRO A 266
GLY A 269
 None
 1.39A 3v3nA-3u3xA:
4.2		 3v3nA-3u3xA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 HIS A 168
GLY A  71
PRO A 172
PHE A 403
GLY A 319
 None
 1.47A 3v3nA-3v8uA:
undetectable		 3v3nA-3v8uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 PHE A 137
HIS A 161
GLY A 149
GLY A  69
ASN A 120
 None
 1.27A 3v3nA-3zq4A:
undetectable		 3v3nA-3zq4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 438
SER A 436
PHE A 384
GLY A 406
ASN A 383
 PO4  A1622 (-3.9A)
PO4  A1622 (-3.1A)
None
None
None
 1.20A 3v3nA-4am3A:
undetectable		 3v3nA-4am3A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		5 MET A 474
GLY A 427
SER A 477
GLY A 501
ASN A 499
 EDO  A1601 (-4.6A)
None
None
None
None
 1.48A 3v3nA-4amfA:
undetectable		 3v3nA-4amfA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
 None
 1.45A 3v3nA-4ci8A:
undetectable		 3v3nA-4ci8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		5 ARG A 161
HIS A 154
GLY A 157
GLY A 183
ASN A  76
 None
 1.49A 3v3nA-4e7wA:
undetectable		 3v3nA-4e7wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		5 PHE A 459
HIS A 457
PHE A 101
GLY A 288
ASN A  56
 None
 1.29A 3v3nA-4e8dA:
undetectable		 3v3nA-4e8dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		5 GLN C 284
SER C 276
PRO C  13
GLY C  10
ASN C  37
 None
FAD  C 500 ( 4.1A)
FAD  C 500 (-3.5A)
FAD  C 500 (-3.2A)
FAD  C 500 (-4.6A)
 1.29A 3v3nA-4fk1C:
13.3		 3v3nA-4fk1C:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 MET A 314
PHE A 280
GLY A 279
PRO A 292
GLY A 288
 None
 1.44A 3v3nA-4iaoA:
3.4		 3v3nA-4iaoA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifa EXTRACELLULAR
PROTEIN CONTAINING A
SCP DOMAIN

(Bacillus
anthracis) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		5 MET A  59
PHE A  99
GLY A 100
PRO A  74
GLY A  72
 None
 1.47A 3v3nA-4ifaA:
undetectable		 3v3nA-4ifaA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		5 HIS A 247
SER A 243
PHE A 278
GLY A  84
ASN A 279
 None
 1.48A 3v3nA-4ly4A:
undetectable		 3v3nA-4ly4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 GLY A 439
SER A 437
PHE A 385
GLY A 407
ASN A 384
 SO4  A 701 (-4.2A)
SO4  A 701 (-2.9A)
None
None
None
 1.15A 3v3nA-4nbqA:
undetectable		 3v3nA-4nbqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 MET A 116
PHE A  88
HIS A  86
GLY A  89
GLY A 306
 None
 1.42A 3v3nA-4rihA:
2.9		 3v3nA-4rihA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC

(Pisum sativum) 		PF00223
(PsaA_PsaB)
PF01241
(PSI_PSAK) 		5 GLN G  94
ARG G 107
GLY G  98
GLY B 298
ASN B 176
 None
None
None
CLA  B1218 (-3.8A)
None
 1.49A 3v3nA-4rkuG:
undetectable		 3v3nA-4rkuG:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLN A 729
GLY A 723
PRO A 702
PHE A 707
GLY A 660
 None
 1.32A 3v3nA-5a55A:
undetectable		 3v3nA-5a55A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 5 PHE B 583
HIS B 573
GLY B 582
SER B 531
GLY B 713
 None
 1.39A 3v3nA-5efnB:
1.3		 3v3nA-5efnB:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnb SPIKE GLYCOPROTEIN

(Human
coronavirus
HKU1) 		PF09408
(Spike_rec_bind) 		5 GLN A 535
PHE A 574
GLY A 550
PRO A 475
GLY A 557
 None
 1.15A 3v3nA-5gnbA:
undetectable		 3v3nA-5gnbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 PHE A 213
HIS A 211
GLY A 212
PHE A 250
GLY A 248
 None
 1.28A 3v3nA-5jayA:
undetectable		 3v3nA-5jayA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		5 MET A 278
PHE A 280
GLY A 232
PHE A  81
GLY A  48
 None
 1.33A 3v3nA-5jftA:
3.8		 3v3nA-5jftA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 ARG B 222
HIS B 413
PRO B 356
GLY B 354
ASN B 327
 None
 1.47A 3v3nA-5lb3B:
undetectable		 3v3nA-5lb3B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		5 PHE A 352
GLY A 354
SER A 356
PRO A 222
PHE A 173
 None
 1.49A 3v3nA-5lxgA:
undetectable		 3v3nA-5lxgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 GLY A 438
SER A 436
PHE A 384
GLY A 406
ASN A 383
 None
 1.22A 3v3nA-6d6kA:
undetectable		 3v3nA-6d6kA:
10.05