SIMILAR PATTERNS OF AMINO ACIDS FOR 3V35_A_NTIA317_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		4 VAL A 287
TRP A 291
PRO A 179
TRP A 175
 None
 1.47A 3v35A-1aq0A:
10.1		 3v35A-1aq0A:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		5 TRP A  20
TRP A  79
HIS A 110
PHE A 122
PRO A 218
 NAP  A 350 (-4.4A)
None
NAP  A 350 (-4.0A)
None
None
 0.53A 3v35A-1c9wA:
50.4		 3v35A-1c9wA:
69.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 TRP A 297
HIS A  81
TRP A  49
TRP A 301
 None
 0.95A 3v35A-1fobA:
6.3		 3v35A-1fobA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		4 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 None
 0.98A 3v35A-1hjqA:
7.4		 3v35A-1hjqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		4 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 TRS  A 704 (-3.8A)
None
None
None
 0.94A 3v35A-1hjuA:
7.3		 3v35A-1hjuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0d ENDODEOXYRIBONUCLEAS
E I

(Escherichia
virus T7) 		PF05367
(Phage_endo_I) 		4 TRP A  70
HIS A  78
PHE A  94
TRP A 129
 None
 1.30A 3v35A-1m0dA:
undetectable		 3v35A-1m0dA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 VAL A 218
HIS A 369
PHE A 220
PRO A 327
 None
 1.20A 3v35A-1ry2A:
undetectable		 3v35A-1ry2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 TRP A 320
HIS A 110
TRP A  70
TRP A 324
 None
 1.12A 3v35A-1ur4A:
7.2		 3v35A-1ur4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		4 HIS A 164
PHE A  20
PRO A  42
TRP A  50
 None
 1.26A 3v35A-1uxoA:
undetectable		 3v35A-1uxoA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 TRP A  23
TRP A  79
HIS A 110
TRP A 111
 CIT  A4001 ( 3.8A)
None
CIT  A4001 ( 3.7A)
CIT  A4001 (-4.4A)
 0.27A 3v35A-1vbjA:
39.4		 3v35A-1vbjA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdm PURINE
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		PF00156
(Pribosyltran) 		4 VAL A   4
TRP A 139
PRO A 123
TRP A 124
 None
 1.32A 3v35A-1vdmA:
undetectable		 3v35A-1vdmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG

(Thermotoga
maritima) 		PF01725
(Ham1p_like) 		4 HIS A  62
PHE A 119
PRO A  24
TRP A  26
 None
 1.21A 3v35A-1vp2A:
undetectable		 3v35A-1vp2A:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		4 TRP A  24
TRP A  83
HIS A 114
PHE A 132
 NAD  A1350 (-4.7A)
None
NAD  A1350 (-4.4A)
None
 0.66A 3v35A-1z9aA:
43.3		 3v35A-1z9aA:
40.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		4 TRP A  89
HIS A 120
TRP A 121
PHE A 132
 None
NAP  A 755 (-4.2A)
NAP  A 755 ( 4.3A)
None
 0.94A 3v35A-1zgdA:
41.0		 3v35A-1zgdA:
34.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare) 		PF00248
(Aldo_ket_red) 		4 TRP A  32
TRP A  90
HIS A 121
TRP A 122
 BCT  A1322 ( 3.3A)
None
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
 0.29A 3v35A-2bgsA:
42.7		 3v35A-2bgsA:
39.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 315
VAL A 303
TRP A 215
PHE A 208
 None
 1.16A 3v35A-2bucA:
undetectable		 3v35A-2bucA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 VAL A 171
HIS A 251
PRO A 653
TRP A 654
 None
 1.23A 3v35A-2c11A:
undetectable		 3v35A-2c11A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A2(A5) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		4 TRP B  32
HIS B  62
PHE B 107
PRO B 100
 None
HEM  B 200 ( 4.1A)
HEM  B 200 (-3.7A)
None
 1.32A 3v35A-2d2nB:
undetectable		 3v35A-2d2nB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA

(Escherichia
coli) 		PF00282
(Pyridoxal_deC) 		4 VAL A 206
TRP A 166
HIS A 241
PHE A 169
 None
 1.43A 3v35A-2dgkA:
undetectable		 3v35A-2dgkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE

(Comamonas
testosteroni) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 VAL A 330
HIS A 390
PHE A 345
PRO A 179
 None
 1.04A 3v35A-2dkhA:
undetectable		 3v35A-2dkhA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		4 VAL A 177
HIS A 111
PRO A 131
TRP A 133
 None
 1.42A 3v35A-2dppA:
undetectable		 3v35A-2dppA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 315
VAL A 303
TRP A 215
PHE A 208
 None
 1.34A 3v35A-2g5tA:
undetectable		 3v35A-2g5tA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		4 VAL A 194
HIS A 158
PHE A 203
PRO A  63
 None
 1.34A 3v35A-2gb4A:
undetectable		 3v35A-2gb4A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gxa REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 TRP A 564
PHE A 568
PRO A 517
TRP A 419
 None
 1.17A 3v35A-2gxaA:
undetectable		 3v35A-2gxaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 HIS A  38
TRP A  37
PRO A 112
TRP A 113
 None
 1.18A 3v35A-2h8xA:
10.3		 3v35A-2h8xA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		8 TRP A  20
VAL A  47
TRP A  79
HIS A 110
TRP A 111
PHE A 122
PRO A 218
TRP A 219
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
None
 0.34A 3v35A-2is7A:
54.0		 3v35A-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TRP A  79
HIS A 110
TRP A 111
PHE A 115
 None
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
None
 1.38A 3v35A-2is7A:
54.0		 3v35A-2is7A:
99.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpi HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09981
(DUF2218) 		4 VAL A  73
HIS A  77
TRP A  24
PHE A  41
 None
 1.32A 3v35A-2jpiA:
undetectable		 3v35A-2jpiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 TRP A 375
TRP A 427
PHE A 382
PRO A 212
 None
 1.24A 3v35A-2ny0A:
undetectable		 3v35A-2ny0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 313
VAL A 301
TRP A 213
PHE A 206
 None
 1.33A 3v35A-2oaeA:
undetectable		 3v35A-2oaeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 VAL A 276
HIS A 204
PRO A 251
TRP A 243
 None
 1.05A 3v35A-2ph5A:
undetectable		 3v35A-2ph5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 TRP B 148
VAL B 149
PHE A  20
TRP B 313
 None
 1.13A 3v35A-2v4jB:
undetectable		 3v35A-2v4jB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 TRP A 564
PHE A 568
PRO A 517
TRP A 419
 None
 1.10A 3v35A-2v9pA:
undetectable		 3v35A-2v9pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 VAL A  37
HIS A 130
PHE A  24
PRO A 119
 None
 1.29A 3v35A-2vatA:
undetectable		 3v35A-2vatA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		4 VAL A 479
TRP A 163
HIS A 485
PHE A 160
 ETE  A1524 (-4.2A)
ETE  A1524 (-3.9A)
None
ETE  A1524 (-4.0A)
 1.49A 3v35A-2vroA:
undetectable		 3v35A-2vroA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		4 TRP J 180
HIS J 184
PHE J 148
PRO J  68
 None
 1.42A 3v35A-2wp8J:
undetectable		 3v35A-2wp8J:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT
SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 TRP B 148
VAL B 149
PHE A  20
TRP B 318
 None
 1.14A 3v35A-2xsjB:
undetectable		 3v35A-2xsjB:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 TRP A 200
VAL A 201
TRP A 203
PRO A 167
 None
 1.43A 3v35A-3a0fA:
undetectable		 3v35A-3a0fA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 HIS B 469
TRP B 468
PHE B 479
PRO B   4
 CLA  B1019 (-3.8A)
CLA  B1019 ( 3.4A)
None
None
 1.29A 3v35A-3a0hB:
undetectable		 3v35A-3a0hB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Plasmodium
falciparum) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 VAL A 334
HIS A 392
PHE A 399
PRO A 294
 None
 1.14A 3v35A-3au9A:
undetectable		 3v35A-3au9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		4 VAL A 146
HIS A 144
PRO A 284
TRP A 225
 None
MN  A 602 (-3.5A)
None
None
 1.25A 3v35A-3b59A:
undetectable		 3v35A-3b59A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq BETA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		4 VAL B 114
TRP B 131
TRP B  15
PRO B  25
 None
 1.33A 3v35A-3bcqB:
undetectable		 3v35A-3bcqB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxd PROTEIN ICMQ
PROTEIN ICMR

(Legionella
pneumophila) 		PF09475
(Dot_icm_IcmQ)
no annotation 		4 VAL B  56
PHE A  31
PRO A  25
TRP A  26
 None
 1.32A 3v35A-3fxdB:
undetectable		 3v35A-3fxdB:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 TRP A  24
TRP A  83
HIS A 114
TRP A 115
TRP A 216
 ACT  A 501 ( 3.2A)
None
ACT  A 501 ( 3.8A)
NAP  A 401 ( 3.9A)
None
 1.11A 3v35A-3h7uA:
44.8		 3v35A-3h7uA:
47.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 TRP A  12
TRP A  73
HIS A 104
PHE A 118
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.1A)
None
 1.28A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		5 TRP A  12
VAL A  39
TRP A  73
HIS A 104
TRP A 105
 UNX  A 402 (-4.3A)
None
None
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
 0.32A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		5 VAL A  39
TRP A  73
HIS A 104
TRP A 105
PHE A 109
 None
None
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
None
 1.23A 3v35A-3krbA:
41.5		 3v35A-3krbA:
40.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A 302
TRP A 298
PHE A 294
PRO A 170
 None
 1.49A 3v35A-3ld8A:
undetectable		 3v35A-3ld8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 TRP A 265
TRP A 257
PHE A 239
PRO A 210
 None
 1.46A 3v35A-3lscA:
4.2		 3v35A-3lscA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 VAL A  97
TRP A 106
PRO A  14
TRP A 188
 None
 1.41A 3v35A-3m1tA:
undetectable		 3v35A-3m1tA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		4 TRP A  41
TRP A  96
HIS A 127
TRP A 128
 GOL  A 300 (-4.5A)
None
GOL  A 300 (-4.1A)
GOL  A 300 ( 4.8A)
 0.70A 3v35A-3o0kA:
35.6		 3v35A-3o0kA:
36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 TRP A  21
VAL A  48
TRP A  80
HIS A 111
PRO A 219
 None
None
None
NAP  A 317 (-4.3A)
None
 0.58A 3v35A-3o3rA:
50.3		 3v35A-3o3rA:
65.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TRP A1026
HIS A1022
PHE A1041
PRO A1032
 None
None
NX3  A2001 (-4.1A)
NX3  A2001 (-4.0A)
 1.40A 3v35A-3qciA:
undetectable		 3v35A-3qciA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 VAL A 326
TRP A 325
HIS A 322
PRO A 375
 None
 1.35A 3v35A-3rhdA:
undetectable		 3v35A-3rhdA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 VAL A 149
HIS A 209
PHE A 183
TRP A 176
 None
FE2  A 301 (-3.4A)
None
None
 1.15A 3v35A-3vb0A:
undetectable		 3v35A-3vb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vus POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1) 		4 VAL A 140
TRP A 143
HIS A 189
PHE A 164
 None
None
ZN  A 401 ( 3.4A)
None
 1.03A 3v35A-3vusA:
3.2		 3v35A-3vusA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 TRP A 117
VAL A 114
TRP A 108
PHE A  70
 None
 1.24A 3v35A-3w08A:
undetectable		 3v35A-3w08A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 VAL A 355
HIS A 446
PHE A 407
PRO A 364
 None
None
None
NAG  A2401 (-3.9A)
 1.46A 3v35A-4acqA:
undetectable		 3v35A-4acqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 GOL  A1343 ( 3.5A)
GOL  A1343 ( 4.6A)
None
None
 1.01A 3v35A-4bf7A:
12.5		 3v35A-4bf7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 TRP A 479
VAL A 487
PHE A 545
PRO A 437
 None
 1.44A 3v35A-4bh6A:
undetectable		 3v35A-4bh6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 VAL A 308
TRP A  99
HIS A 347
PHE A  96
 None
 1.38A 3v35A-4cgnA:
undetectable		 3v35A-4cgnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 TRP A  54
TRP A 305
HIS A 246
PRO A  61
 None
 1.04A 3v35A-4dpkA:
undetectable		 3v35A-4dpkA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 VAL A 178
HIS A 252
PHE A 266
PRO A 240
 None
 1.45A 3v35A-4dvjA:
undetectable		 3v35A-4dvjA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A 165
HIS A 108
PHE A 366
PRO A 331
 None
 1.30A 3v35A-4ewtA:
undetectable		 3v35A-4ewtA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		4 TRP A  25
TRP A  81
HIS A 112
PHE A 284
 EDO  A 308 (-4.0A)
None
EDO  A 308 (-4.1A)
None
 1.16A 3v35A-4f40A:
38.8		 3v35A-4f40A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE

(Leishmania
major) 		PF00248
(Aldo_ket_red) 		4 TRP A  25
TRP A  81
HIS A 112
TRP A 113
 EDO  A 308 (-4.0A)
None
EDO  A 308 (-4.1A)
EDO  A 308 ( 4.3A)
 0.80A 3v35A-4f40A:
38.8		 3v35A-4f40A:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 VAL A 140
TRP A 143
HIS A 189
PHE A 164
 None
None
NI  A 701 ( 3.4A)
None
 1.06A 3v35A-4f9dA:
7.0		 3v35A-4f9dA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fzi PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
cruzi) 		PF00248
(Aldo_ket_red) 		4 TRP A  24
TRP A  80
HIS A 111
TRP A 112
 GLU  A 301 (-3.5A)
None
GLU  A 301 (-3.8A)
GLU  A 301 (-4.1A)
 0.50A 3v35A-4fziA:
37.8		 3v35A-4fziA:
39.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 TRP A 407
PHE A 473
PRO A 365
TRP A 366
 None
 1.22A 3v35A-4ggaA:
undetectable		 3v35A-4ggaA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 VAL A  47
TRP A  79
HIS A 110
TRP A 111
PHE A 122
 None
 0.63A 3v35A-4hbkA:
45.8		 3v35A-4hbkA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		4 TRP A 102
HIS A 131
TRP A 132
PHE A 136
 None
NDP  A 401 (-3.9A)
NDP  A 401 ( 4.1A)
None
 1.46A 3v35A-4ijrA:
40.3		 3v35A-4ijrA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF08020
(DUF1706) 		4 TRP A  54
HIS A  -3
PRO A  74
TRP A  80
 None
 1.43A 3v35A-4n6cA:
undetectable		 3v35A-4n6cA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 HIS A 247
TRP A 251
PHE A 149
PRO A 280
 None
 1.22A 3v35A-4qb9A:
undetectable		 3v35A-4qb9A:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdd 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE

(Rhodococcus
rhodochrous) 		PF00355
(Rieske) 		4 TRP A 135
HIS A  33
PHE A 343
PRO A 144
 None
 1.49A 3v35A-4qddA:
undetectable		 3v35A-4qddA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 VAL A 280
HIS A 282
PRO A 193
TRP A 191
 None
 1.30A 3v35A-4rihA:
undetectable		 3v35A-4rihA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		no annotation 4 VAL B  50
TRP B  84
HIS B 117
PHE B  19
 None
 1.44A 3v35A-4w78B:
undetectable		 3v35A-4w78B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whn APXC

(Actinobacillus
pleuropneumoniae) 		PF02794
(HlyC) 		4 HIS A  24
TRP A  18
PHE A  57
TRP A  83
 None
 1.34A 3v35A-4whnA:
undetectable		 3v35A-4whnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 VAL A 454
HIS A 408
PRO A 427
TRP A 404
 None
 1.47A 3v35A-4xwhA:
4.1		 3v35A-4xwhA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 VAL A 139
TRP A 142
HIS A 189
PHE A 164
 None
None
NI  A 401 ( 3.3A)
None
 1.19A 3v35A-5bu6A:
4.8		 3v35A-5bu6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 4 VAL C 209
TRP C 169
HIS C 244
PHE C 172
 None
 1.46A 3v35A-5gp4C:
undetectable		 3v35A-5gp4C:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 4 VAL A 274
HIS A 317
PRO A 157
TRP A 531
 None
MN  A 602 (-3.2A)
None
None
 1.37A 3v35A-5hrmA:
undetectable		 3v35A-5hrmA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 TRP A  31
TRP A  89
HIS A 120
TRP A 121
 EDO  A 402 ( 3.2A)
None
6KB  A 401 ( 4.0A)
6KB  A 401 ( 4.4A)
 0.33A 3v35A-5jgyA:
42.0		 3v35A-5jgyA:
39.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrl DIPEPTIDYL
AMINOPEPTIDASES/ACYL
AMINOACYL-PEPTIDASES
-LIKE PROTEIN

(Sphingopyxis
alaskensis) 		PF00326
(Peptidase_S9) 		4 TRP A 264
VAL A 244
TRP A 239
TRP A 170
 None
 1.49A 3v35A-5jrlA:
undetectable		 3v35A-5jrlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 TRP Q 407
PHE Q 473
PRO Q 365
TRP Q 366
 None
 1.20A 3v35A-5lcwQ:
undetectable		 3v35A-5lcwQ:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 TRP R 407
PHE R 473
PRO R 365
TRP R 366
 None
 1.20A 3v35A-5lcwR:
undetectable		 3v35A-5lcwR:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TRP X  21
VAL X  48
TRP X  80
HIS X 111
PRO X 219
TRP X 220
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
None
DQP  X 402 ( 4.1A)
DQP  X 402 (-4.5A)
None
 0.69A 3v35A-5liyX:
50.8		 3v35A-5liyX:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 4 HIS A  39
TRP A  38
PRO A 113
TRP A 114
 None
 1.33A 3v35A-5nuxA:
11.2		 3v35A-5nuxA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opf CHITIN-BINDING
DOMAIN 3 PROTEIN

(Micromonospora
aurantiaca) 		no annotation 4 TRP A 212
HIS A 144
PHE A 138
TRP A  84
 None
CU  A 301 (-3.2A)
None
None
 1.49A 3v35A-5opfA:
undetectable		 3v35A-5opfA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 VAL A 107
HIS A 116
PHE A 166
PRO A 223
 None
 1.44A 3v35A-5tlcA:
4.8		 3v35A-5tlcA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 HIS A 313
PHE A 337
PRO A  77
TRP A  90
 FE2  A 601 ( 3.4A)
83D  A 602 (-4.6A)
None
None
 1.39A 3v35A-5u8zA:
undetectable		 3v35A-5u8zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		4 VAL A 281
TRP A 143
HIS A 141
PHE A  48
 None
None
ZN  A 401 (-3.3A)
None
 1.26A 3v35A-5uygA:
undetectable		 3v35A-5uygA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 VAL A  49
HIS A  43
PRO A   6
TRP A   8
 None
 1.37A 3v35A-5vaeA:
3.0		 3v35A-5vaeA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 4 VAL A  53
TRP A  54
PHE A 416
PRO A 393
 None
EPE  A 702 (-3.8A)
None
None
 1.47A 3v35A-5verA:
undetectable		 3v35A-5verA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w15 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Burkholderia
ambifaria) 		PF12697
(Abhydrolase_6) 		4 TRP A 179
VAL A 155
HIS A 151
PHE A 132
 None
 1.23A 3v35A-5w15A:
undetectable		 3v35A-5w15A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 VAL A 167
TRP A 163
PHE A 115
PRO A 125
 None
 0.95A 3v35A-5wy0A:
undetectable		 3v35A-5wy0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 4 TRP A 136
HIS A  67
PHE A  78
TRP A  59
 None
 1.41A 3v35A-6anrA:
undetectable		 3v35A-6anrA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 TRP B 660
PHE B 637
PRO B 591
TRP B 590
 None
 1.40A 3v35A-6bywB:
undetectable		 3v35A-6bywB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 TRP A 210
PHE A 115
PRO A 406
TRP A 412
 None
 1.30A 3v35A-6etzA:
7.8		 3v35A-6etzA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 4 VAL B 809
HIS C  60
PHE B 740
PRO B 754
 None
 0.88A 3v35A-6exvB:
undetectable		 3v35A-6exvB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3

(Rattus rattus) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 152
TRP A 146
PHE A 183
PRO A  15
 None
 1.30A 3v35A-6gswA:
undetectable		 3v35A-6gswA:
21.49