SIMILAR PATTERNS OF AMINO ACIDS FOR 3V1N_A_BEZA288

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY C  91
GLY C 451
GLY C  87
LEU C  70
VAL C  66
 None
 1.36A 3v1nA-1a5lC:
undetectable		 3v1nA-1a5lC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 GLY B  45
GLY B  42
SER B  40
ILE B 100
VAL B  37
 None
 1.33A 3v1nA-1a6dB:
undetectable		 3v1nA-1a6dB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		5 GLY B 192
GLY B 191
GLY B 128
LEU B  56
VAL B 131
 None
FE  B 501 ( 4.8A)
None
None
None
 1.33A 3v1nA-1bouB:
undetectable		 3v1nA-1bouB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLY A 485
GLY A 484
ILE A 232
LEU A 251
VAL A 234
 AMO  A 831 (-4.0A)
AMO  A 831 (-3.2A)
None
None
None
 1.18A 3v1nA-1c0aA:
undetectable		 3v1nA-1c0aA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 GLY A 229
GLY A 197
SER A 230
GLY A 194
LEU A 556
 None
 1.36A 3v1nA-1cjyA:
undetectable		 3v1nA-1cjyA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbu CYSTEINYL-TRNA(PRO)
DEACYLASE

(Haemophilus
influenzae) 		PF04073
(tRNA_edit) 		5 GLY A 131
GLY A 130
SER A 104
ILE A 139
LEU A   8
 None
 1.38A 3v1nA-1dbuA:
undetectable		 3v1nA-1dbuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgn ICEBERG (PROTEASE
INHIBITOR)

(Homo sapiens) 		PF00619
(CARD) 		5 GLY A  65
GLY A  63
SER A  68
ILE A  35
LEU A  57
 None
 1.21A 3v1nA-1dgnA:
undetectable		 3v1nA-1dgnA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		5 GLY A 192
GLY A 195
GLY A  93
ILE A 181
LEU A  35
 None
 0.99A 3v1nA-1dofA:
undetectable		 3v1nA-1dofA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		5 GLY A 301
GLY A 381
ILE D  47
LEU A 330
VAL A 383
 None
SF4  A   3 ( 3.9A)
None
None
None
 1.17A 3v1nA-1e08A:
undetectable		 3v1nA-1e08A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 GLY B 163
GLY B 174
ILE B  54
LEU B  58
VAL B 140
 None
 1.40A 3v1nA-1e6vB:
undetectable		 3v1nA-1e6vB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 GLY A 138
MET A 131
GLY A 135
ILE A  90
VAL A  75
 None
 1.32A 3v1nA-1e6zA:
undetectable		 3v1nA-1e6zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 183
GLY A 184
GLY A 192
LEU A 227
VAL A 202
 None
 1.22A 3v1nA-1ebdA:
undetectable		 3v1nA-1ebdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		5 GLY A 196
GLY A 197
GLY A 190
LEU A 160
VAL A 216
 None
 1.30A 3v1nA-1eltA:
undetectable		 3v1nA-1eltA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN
PORCINE E-TRYPSIN

(Sus scrofa;
Sus scrofa) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		5 GLY C 197
GLY C 196
ILE B 103
LEU B 105
VAL C 231
 None
 1.09A 3v1nA-1eptC:
undetectable		 3v1nA-1eptC:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 148
GLY A 150
GLY A 142
ILE A 113
VAL A 219
 None
 1.17A 3v1nA-1escA:
3.2		 3v1nA-1escA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 208
MET A 212
GLY A 215
ILE A 359
LEU A 219
 None
 1.25A 3v1nA-1evjA:
undetectable		 3v1nA-1evjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A  15
GLY A  84
SER A  82
GLY A 106
VAL A 232
 OCP  A 382 (-3.5A)
None
OCP  A 382 (-1.5A)
None
None
 1.38A 3v1nA-1ex9A:
13.9		 3v1nA-1ex9A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezr NUCLEOSIDE HYDROLASE

(Leishmania
major) 		PF01156
(IU_nuc_hydro) 		5 GLY A 190
GLY A 154
MET A 152
LEU A 129
VAL A 186
 None
 1.36A 3v1nA-1ezrA:
3.6		 3v1nA-1ezrA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi8 ECOTIN
ECOTIN

(Escherichia
coli;
Escherichia
coli) 		PF03974
(Ecotin)
PF03974
(Ecotin) 		5 GLY C  57
GLY C  56
GLY C  43
LEU C  46
VAL D 123
 None
 1.18A 3v1nA-1fi8C:
undetectable		 3v1nA-1fi8C:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 GLY A1130
GLY A1129
SER A1127
GLY A1105
LEU A1049
 None
 1.40A 3v1nA-1foeA:
undetectable		 3v1nA-1foeA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 GLY A1061
GLY A1060
GLY A1018
ILE A 907
LEU A 913
 DTT  A1124 ( 3.7A)
None
DTT  A1124 ( 4.4A)
None
None
 1.15A 3v1nA-1fx2A:
undetectable		 3v1nA-1fx2A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 GLY A1049
GLY A1048
GLY A1006
ILE A 895
LEU A 901
 None
 1.15A 3v1nA-1fx4A:
undetectable		 3v1nA-1fx4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 117
GLY A 118
SER A 200
GLY A 227
VAL A 400
 SAF  A1998 (-3.1A)
SAF  A1998 ( 3.5A)
EMM  A1999 ( 1.4A)
None
None
 1.42A 3v1nA-1gqrA:
12.5		 3v1nA-1gqrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 GLY A 139
GLY A 209
ILE A 189
LEU A 207
VAL A 213
 None
PGH  A 287 ( 3.1A)
None
None
None
 1.35A 3v1nA-1gvfA:
undetectable		 3v1nA-1gvfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		5 GLY A  45
GLY A  42
SER A  44
GLY A  18
VAL A 206
 None
 1.35A 3v1nA-1h2sA:
undetectable		 3v1nA-1h2sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 260
MET A 264
GLY A 267
ILE A 411
LEU A 271
 None
 1.23A 3v1nA-1h6dA:
undetectable		 3v1nA-1h6dA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 222
GLY A 255
MET A 226
GLY A  19
ILE A 266
 None
 0.99A 3v1nA-1h74A:
undetectable		 3v1nA-1h74A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
PF02256
(Fe_hyd_SSU) 		5 GLY L 301
GLY L 300
GLY L 381
ILE S  47
VAL L 383
 None
None
SF4  L 424 ( 4.4A)
None
None
 1.31A 3v1nA-1hfeL:
undetectable		 3v1nA-1hfeL:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i81 PUTATIVE SNRNP
SM-LIKE PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF01423
(LSM) 		5 GLY A  19
SER A  21
ILE A  79
LEU A  49
VAL A  26
 None
 1.38A 3v1nA-1i81A:
undetectable		 3v1nA-1i81A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ifg ECOTIN

(Escherichia
coli) 		PF03974
(Ecotin) 		5 GLY A  57
GLY A  56
GLY A  43
LEU A  46
VAL A 123
 None
 1.11A 3v1nA-1ifgA:
undetectable		 3v1nA-1ifgA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 GLY A 156
GLY A 155
ILE A 257
LEU A 290
VAL A 253
 None
 1.13A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 GLY A 156
GLY A 155
ILE A 257
LEU A 293
VAL A 253
 None
 1.02A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 GLY A 157
GLY A 155
ILE A 257
LEU A 290
VAL A 253
 None
 1.16A 3v1nA-1jcfA:
undetectable		 3v1nA-1jcfA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 GLY A 717
GLY A 718
SER A 542
GLY A 538
LEU A 536
 None
None
ADP  A 752 (-3.4A)
None
None
 1.41A 3v1nA-1jj7A:
undetectable		 3v1nA-1jj7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 356
GLY A 355
GLY A 222
ILE A 500
VAL A 496
 None
NA  A 542 (-4.4A)
None
None
None
 1.26A 3v1nA-1knrA:
undetectable		 3v1nA-1knrA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 GLY A 168
GLY A 270
GLY A 276
ILE A 310
LEU A 258
 None
 0.78A 3v1nA-1kq3A:
2.5		 3v1nA-1kq3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 495
GLY A 412
GLY A 418
ILE A 464
LEU A 460
 None
 1.41A 3v1nA-1l5jA:
undetectable		 3v1nA-1l5jA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 189
GLY A 187
GLY A 196
ILE A 273
LEU A 183
 None
 1.31A 3v1nA-1lpfA:
undetectable		 3v1nA-1lpfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 GLY A 639
GLY A 638
ILE A 541
LEU A 543
VAL A 673
 None
 1.11A 3v1nA-1md7A:
undetectable		 3v1nA-1md7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		5 GLY A 151
GLY A 150
SER A 250
GLY A 249
ILE A 263
 None
 1.25A 3v1nA-1mpoA:
undetectable		 3v1nA-1mpoA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 GLY A 464
GLY A 466
ILE A 440
LEU A 411
VAL A 387
 None
 1.37A 3v1nA-1mqqA:
undetectable		 3v1nA-1mqqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 169
MET A  63
GLY A  64
LEU A  99
VAL A 146
 None
 1.30A 3v1nA-1mzjA:
undetectable		 3v1nA-1mzjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 MET C 274
GLY C 272
ILE C 214
LEU C 216
VAL C 247
 None
 1.19A 3v1nA-1n61C:
undetectable		 3v1nA-1n61C:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 GLY A  41
GLY A  71
GLY A  45
ILE A  77
LEU A 103
 None
 1.02A 3v1nA-1nnwA:
undetectable		 3v1nA-1nnwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A1319
GLY A1320
SER A1316
GLY A1315
VAL A1289
 None
 1.39A 3v1nA-1p0cA:
3.6		 3v1nA-1p0cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 GLY A 194
GLY A 317
ILE A 348
LEU A 338
VAL A 314
 None
ADP  A 396 ( 3.9A)
None
None
None
 1.29A 3v1nA-1phpA:
undetectable		 3v1nA-1phpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLY A 367
GLY A 368
GLY A 360
ILE A 495
LEU A 376
 None
 0.85A 3v1nA-1q8iA:
undetectable		 3v1nA-1q8iA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 GLY A  43
MET A  44
ILE A  62
LEU A  50
VAL A  70
 None
 1.42A 3v1nA-1q8kA:
undetectable		 3v1nA-1q8kA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)
PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae;
Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		5 GLY D  16
GLY D  89
SER D  87
GLY D 111
VAL E 266
 None
 1.42A 3v1nA-1qgeD:
8.7		 3v1nA-1qgeD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Rattus
norvegicus) 		PF00025
(Arf) 		5 GLY A  70
GLY A  69
GLY A  29
ILE A  22
VAL A  91
 GNP  A1201 (-3.9A)
GNP  A1201 (-3.6A)
GNP  A1201 (-3.1A)
None
None
 0.94A 3v1nA-1r4aA:
4.4		 3v1nA-1r4aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME

(Arabidopsis
thaliana) 		PF01946
(Thi4) 		5 GLY A  77
GLY A  76
GLY A  51
ILE A  68
LEU A 129
 AHZ  A 600 (-3.2A)
None
None
None
None
 1.27A 3v1nA-1rp0A:
undetectable		 3v1nA-1rp0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4z ADAPTIVE-RESPONSE
SENSORY-KINASE SASA

(Synechococcus
elongatus) 		PF07689
(KaiB) 		5 GLY A  76
GLY A  74
ILE A  45
LEU A  94
VAL A  43
 None
 1.28A 3v1nA-1t4zA:
undetectable		 3v1nA-1t4zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 GLY B  16
GLY B  89
SER B  87
GLY B 111
VAL B 266
 None
 1.42A 3v1nA-1tahB:
12.6		 3v1nA-1tahB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		5 GLY A 245
GLY A 246
SER A 136
ILE A 112
VAL A  92
 None
 0.96A 3v1nA-1to6A:
undetectable		 3v1nA-1to6A:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 GLY A  39
SER A 110
MET A 111
ILE A 151
VAL A 238
 CL  A1002 ( 3.7A)
None
None
None
None
 0.50A 3v1nA-1u2eA:
45.2		 3v1nA-1u2eA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 GLY A 614
GLY A 615
MET A 616
GLY A 620
VAL A 635
 None
 1.20A 3v1nA-1u2lA:
undetectable		 3v1nA-1u2lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3b AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING,
FAMILY A, MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A 138
GLY A 139
MET A 136
ILE A 114
VAL A 146
 None
 1.12A 3v1nA-1u3bA:
undetectable		 3v1nA-1u3bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		5 GLY A   4
SER A   7
MET A   8
ILE A  86
LEU A 377
 None
 1.36A 3v1nA-1uhgA:
undetectable		 3v1nA-1uhgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY B  69
GLY A 155
MET B  70
GLY B  74
LEU A 163
 None
 1.06A 3v1nA-1umbB:
4.4		 3v1nA-1umbB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ust HISTONE H1

(Saccharomyces
cerevisiae) 		PF00538
(Linker_histone) 		5 GLY A 108
GLY A 111
ILE A  94
LEU A  55
VAL A  98
 None
 1.29A 3v1nA-1ustA:
undetectable		 3v1nA-1ustA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		5 GLY A  66
GLY A  67
GLY A  26
ILE A 107
LEU A 103
 None
HEM  A 144 ( 4.2A)
None
None
HEM  A 144 (-4.4A)
 1.42A 3v1nA-1v4uA:
undetectable		 3v1nA-1v4uA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v59 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 190
GLY A 191
GLY A 199
LEU A 234
VAL A 209
 NAD  A 482 (-3.0A)
NAD  A 482 ( 4.6A)
None
None
None
 1.27A 3v1nA-1v59A:
undetectable		 3v1nA-1v59A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 GLY A 186
GLY A 191
ILE A 267
LEU A 269
VAL A 176
 None
 1.18A 3v1nA-1w1kA:
undetectable		 3v1nA-1w1kA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 386
GLY A 385
MET A 293
GLY A 296
VAL A 286
 None
CSO  A  92 ( 4.1A)
COA  A1001 (-4.5A)
None
None
 1.11A 3v1nA-1wl4A:
undetectable		 3v1nA-1wl4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 386
MET A 293
GLY A 296
ILE A 390
VAL A 286
 None
COA  A1001 (-4.5A)
None
None
None
 1.25A 3v1nA-1wl4A:
undetectable		 3v1nA-1wl4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 GLY B 135
GLY B 283
ILE B 142
LEU B 292
VAL B 259
 None
 1.26A 3v1nA-1wytB:
undetectable		 3v1nA-1wytB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		5 GLY A  57
GLY A  54
ILE A 259
LEU A 289
VAL A 266
 None
 1.28A 3v1nA-1x3wA:
undetectable		 3v1nA-1x3wA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A  33
GLY A 167
SER A  34
GLY A 171
VAL A  19
 None
 1.21A 3v1nA-1y8tA:
undetectable		 3v1nA-1y8tA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 GLY A 236
GLY A 235
GLY A 232
LEU A  42
VAL A  12
 None
 1.12A 3v1nA-1ydoA:
undetectable		 3v1nA-1ydoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 GLY A 236
GLY A 235
SER A 233
GLY A 232
VAL A  12
 None
 1.30A 3v1nA-1ydoA:
undetectable		 3v1nA-1ydoA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		5 GLY X  16
GLY X  89
SER X  87
GLY X 111
VAL X 267
 2HS  X 600 (-3.4A)
None
2HS  X 600 (-1.6A)
None
None
 1.36A 3v1nA-1ys2X:
13.0		 3v1nA-1ys2X:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		5 GLY X  89
GLY X  90
SER X  87
GLY X 111
VAL X 267
 None
None
2HS  X 600 (-1.6A)
None
None
 1.41A 3v1nA-1ys2X:
13.0		 3v1nA-1ys2X:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 GLY A 207
SER A 210
MET A 208
ILE A  67
LEU A 188
 None
 1.22A 3v1nA-1ytmA:
undetectable		 3v1nA-1ytmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		5 GLY A 105
GLY A 108
SER A 103
ILE A 151
LEU A 149
 None
 1.11A 3v1nA-1za4A:
undetectable		 3v1nA-1za4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag8 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Neisseria
meningitidis) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 GLY A 120
GLY A 146
SER A 122
GLY A 123
VAL A 109
 None
 1.21A 3v1nA-2ag8A:
undetectable		 3v1nA-2ag8A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 527
GLY A 517
GLY A 495
ILE A 546
VAL A 514
 None
 1.20A 3v1nA-2akjA:
undetectable		 3v1nA-2akjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 GLY A  12
SER A  14
GLY A 220
ILE A   8
VAL A 204
 FAD  A 301 (-3.1A)
FAD  A 301 (-2.7A)
None
None
None
 1.30A 3v1nA-2culA:
undetectable		 3v1nA-2culA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 373
GLY A 372
MET A 376
GLY A 385
ILE A 182
 None
 1.27A 3v1nA-2cxeA:
undetectable		 3v1nA-2cxeA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 GLY A 158
SER A 155
GLY A 218
ILE A 171
LEU A 268
 None
 1.27A 3v1nA-2d5lA:
16.6		 3v1nA-2d5lA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 133
GLY A  65
ILE A 389
LEU A 369
VAL A  39
 None
 1.42A 3v1nA-2dphA:
undetectable		 3v1nA-2dphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		5 GLY A  30
GLY A 179
SER A 199
ILE A 193
LEU A 155
 None
None
None
None
GLU  A1055 (-4.1A)
 1.17A 3v1nA-2dvzA:
undetectable		 3v1nA-2dvzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A  11
GLY A   8
GLY A 357
ILE A 121
LEU A 354
 None
FAD  A1002 (-3.5A)
None
None
FAD  A1002 (-3.7A)
 1.33A 3v1nA-2e5vA:
undetectable		 3v1nA-2e5vA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 GLY A  57
SER A  60
GLY A 285
ILE A 326
VAL A  64
 None
 1.24A 3v1nA-2eo5A:
undetectable		 3v1nA-2eo5A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina) 		no annotation 5 GLY A  90
GLY A 131
MET A 134
GLY A 136
VAL A 141
 None
 1.34A 3v1nA-2fx5A:
15.0		 3v1nA-2fx5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4r MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN

(Mycobacterium
tuberculosis) 		PF00994
(MoCF_biosynth) 		5 GLY A  70
GLY A 130
SER A  69
ILE A  27
LEU A 139
 CL  A 201 (-3.3A)
CL  A 201 (-3.9A)
None
None
None
 1.31A 3v1nA-2g4rA:
3.4		 3v1nA-2g4rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		5 GLY A 351
GLY A 352
ILE A 344
LEU A 232
VAL A 336
 None
 1.42A 3v1nA-2gp4A:
undetectable		 3v1nA-2gp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv8 MONOOXYGENASE

(Schizosaccharomyces
pombe) 		PF00743
(FMO-like)
PF13450
(NAD_binding_8) 		5 GLY A  45
GLY A  44
GLY A  18
ILE A 132
LEU A 128
 FAD  A 500 (-3.3A)
None
None
None
None
 1.01A 3v1nA-2gv8A:
undetectable		 3v1nA-2gv8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 121
GLY A 120
SER A 123
ILE A  23
LEU A  32
 None
 1.30A 3v1nA-2h6eA:
undetectable		 3v1nA-2h6eA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 GLY A 135
GLY A 287
ILE A 122
LEU A 271
VAL A 131
 None
 1.37A 3v1nA-2i14A:
undetectable		 3v1nA-2i14A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		5 GLY A 208
GLY A 209
GLY A 227
ILE A 242
VAL A   7
 None
 1.20A 3v1nA-2i9eA:
undetectable		 3v1nA-2i9eA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 212
GLY A 395
GLY A 217
ILE A 285
LEU A 304
 None
 1.26A 3v1nA-2ix4A:
undetectable		 3v1nA-2ix4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00089
(Trypsin)
PF00089
(Trypsin) 		5 GLY C 197
GLY C 196
ILE B 103
LEU B 105
VAL C 231
 None
 1.01A 3v1nA-2jetC:
undetectable		 3v1nA-2jetC:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 GLY A 190
GLY A 154
MET A 152
LEU A 129
VAL A 186
 None
None
PIR  A 400 (-3.5A)
None
None
 1.27A 3v1nA-2masA:
4.0		 3v1nA-2masA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 5 GLY A  48
GLY A  47
ILE A  83
LEU A  93
VAL A 138
 CA  A 203 (-4.2A)
CA  A 203 (-4.6A)
None
None
None
 1.03A 3v1nA-2ml2A:
undetectable		 3v1nA-2ml2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 GLY A  60
GLY A  62
GLY A 265
ILE A 241
VAL A  92
 None
 1.18A 3v1nA-2o0rA:
2.4		 3v1nA-2o0rA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  91
GLY A  92
SER A 169
GLY A 203
ILE A 230
 4PA  A 369 ( 3.8A)
4PA  A 369 (-3.5A)
4PA  A 369 (-1.8A)
4PA  A 369 ( 3.7A)
4PA  A 369 ( 4.7A)
 1.08A 3v1nA-2o7rA:
16.4		 3v1nA-2o7rA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 GLY A 660
GLY A 661
SER A 659
GLY A 657
LEU A 600
 None
 1.37A 3v1nA-2odpA:
undetectable		 3v1nA-2odpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)

(Homo sapiens) 		PF01583
(APS_kinase) 		5 GLY A 184
SER A 190
GLY A 187
ILE A 132
LEU A  60
 ADX  A 400 (-4.8A)
None
None
ADX  A 400 (-3.9A)
None
 1.34A 3v1nA-2peyA:
2.5		 3v1nA-2peyA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY A 357
SER A 353
ILE A 395
LEU A 366
VAL A 391
 None
 1.36A 3v1nA-2pkgA:
undetectable		 3v1nA-2pkgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		5 GLY A 151
GLY A 156
ILE A 127
LEU A 281
VAL A  97
 None
 0.95A 3v1nA-2pl5A:
22.6		 3v1nA-2pl5A:
23.94