SIMILAR PATTERNS OF AMINO ACIDS FOR 3UZZ_B_ASDB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 TYR A  53
HIS A 278
LEU A 124
MET A 122
 None
 1.24A 3uzzB-1bwdA:
undetectable		 3uzzB-1bwdA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 TYR A  16
HIS A   8
LEU A  39
MET A  57
 None
 1.32A 3uzzB-1j0hA:
5.1		 3uzzB-1j0hA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 HIS A 269
TYR A 138
LEU A 248
MET A 188
 ZN  A 401 ( 3.3A)
None
None
None
 1.39A 3uzzB-1kq3A:
undetectable		 3uzzB-1kq3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 TYR A 656
TRP A 779
LEU A 819
MET A 822
 None
 1.18A 3uzzB-1nl3A:
undetectable		 3uzzB-1nl3A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otw COENZYME PQQ
SYNTHESIS PROTEIN C

(Klebsiella
pneumoniae) 		PF03070
(TENA_THI-4) 		4 TYR A 175
HIS A 154
LEU A 218
MET A 221
 PQQ  A 500 (-4.3A)
PQQ  A 500 ( 4.2A)
None
None
 1.36A 3uzzB-1otwA:
undetectable		 3uzzB-1otwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		4 TYR A 244
TYR A 255
HIS A 179
LEU A 241
 None
 1.30A 3uzzB-1poiA:
undetectable		 3uzzB-1poiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 TYR A 171
HIS A 128
TYR A 478
LEU A 153
 None
 1.39A 3uzzB-1q15A:
undetectable		 3uzzB-1q15A:
20.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  24
TYR A  55
HIS A 117
TRP A 227
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
 1.32A 3uzzB-1q5mA:
50.8		 3uzzB-1q5mA:
56.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 TYR A  16
HIS A   8
LEU A  39
MET A  57
 None
 1.38A 3uzzB-1smaA:
9.2		 3uzzB-1smaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 TYR B 183
HIS B 341
TYR B 176
LEU B 282
 None
 1.22A 3uzzB-1tnuB:
undetectable		 3uzzB-1tnuB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 TYR A 175
TYR A 121
LEU A 129
TRP A  82
 None
 1.43A 3uzzB-1wcgA:
8.0		 3uzzB-1wcgA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkb LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 535
TYR A 539
TYR A  57
LEU A  45
 None
 1.44A 3uzzB-1wkbA:
undetectable		 3uzzB-1wkbA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 TYR A  98
TYR A 197
LEU A 223
TRP A 242
 None
 0.88A 3uzzB-1wzaA:
8.4		 3uzzB-1wzaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 HIS A   7
TYR A 180
LEU A 162
MET A 170
 None
 1.38A 3uzzB-1zswA:
undetectable		 3uzzB-1zswA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 TYR A 362
HIS A 245
LEU A 388
TRP A 392
 None
 1.36A 3uzzB-1zzgA:
undetectable		 3uzzB-1zzgA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 TYR A  28
TYR A  24
LEU A  87
TRP A  93
 None
 1.10A 3uzzB-2b3bA:
undetectable		 3uzzB-2b3bA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 TYR A1012
TRP A1073
LEU A1125
TRP A  38
 None
 1.29A 3uzzB-2boaA:
undetectable		 3uzzB-2boaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 TYR A  40
TYR A 221
LEU A 190
TRP A 225
 None
PCA  A   0 ( 4.7A)
HEM  A 396 ( 4.3A)
None
 1.39A 3uzzB-2ciyA:
undetectable		 3uzzB-2ciyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		4 TYR A 179
TYR A 122
LEU A 130
TRP A  82
 None
 1.39A 3uzzB-2e3zA:
10.5		 3uzzB-2e3zA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 TYR A 373
TYR A 236
TYR A 228
LEU A  95
 None
 1.33A 3uzzB-2fv0A:
undetectable		 3uzzB-2fv0A:
19.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 TYR A  24
TYR A  55
HIS A 117
LEU A 129
 None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
 1.24A 3uzzB-2fvlA:
51.0		 3uzzB-2fvlA:
53.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 TYR X 174
TYR X 119
LEU X 127
TRP X  80
 None
 1.38A 3uzzB-2jfeX:
9.5		 3uzzB-2jfeX:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		4 TYR A 212
TYR A 231
LEU A 182
MET A 239
 None
 1.40A 3uzzB-2pbeA:
undetectable		 3uzzB-2pbeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A  74
HIS A 322
TYR A 260
TRP A 242
 None
 1.43A 3uzzB-2wc7A:
8.8		 3uzzB-2wc7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 TYR A 531
HIS A 360
LEU A 410
TRP A 288
 None
 1.17A 3uzzB-2xydA:
undetectable		 3uzzB-2xydA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2c CYTOCHROME C2

(Rhodospirillum
rubrum) 		PF00034
(Cytochrom_C) 		4 TYR A  52
TYR A  48
HIS A  42
LEU A  67
 HEM  A 113 (-4.2A)
HEM  A 113 (-4.2A)
HEM  A 113 (-3.3A)
None
 1.26A 3uzzB-3c2cA:
undetectable		 3uzzB-3c2cA:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		7 TYR A  26
TYR A  58
TYR A 132
TRP A 230
LEU A 311
MET A 313
TRP A 314
 CI2  A 328 ( 4.0A)
CI2  A 328 ( 4.5A)
None
CI2  A 328 (-4.2A)
None
CI2  A 328 (-4.0A)
None
 0.46A 3uzzB-3cavA:
55.4		 3uzzB-3cavA:
93.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 TYR A 164
TYR A 172
LEU A  80
TRP A 175
 None
 1.35A 3uzzB-3cc1A:
3.3		 3uzzB-3cc1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR X  13
TYR X 212
LEU X  89
TRP X 177
 None
 1.44A 3uzzB-3e3bX:
undetectable		 3uzzB-3e3bX:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 263
HIS A 109
TYR A 208
LEU A  93
 None
None
GOL  A1005 ( 4.2A)
None
 1.26A 3uzzB-3etcA:
undetectable		 3uzzB-3etcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 TYR A  76
TYR A  70
HIS A 200
LEU A 171
 None
 1.44A 3uzzB-3fdbA:
undetectable		 3uzzB-3fdbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg2 SUGAR DEHYDROGENASE,
UDP-GLUCOSE/GDP-MANN
OSE DEHYDROGENASE
FAMILY

(Porphyromonas
gingivalis) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 456
TRP A 479
LEU A 465
MET A 486
 None
 1.16A 3uzzB-3gg2A:
undetectable		 3uzzB-3gg2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		4 TYR A 450
HIS A 306
TRP A 495
LEU A 444
 ME8  A 801 (-4.7A)
None
None
None
 1.38A 3uzzB-3kflA:
undetectable		 3uzzB-3kflA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 TYR A 669
TYR A 783
LEU A 728
TRP A 782
 None
 1.17A 3uzzB-3lh5A:
undetectable		 3uzzB-3lh5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF04777
(Evr1_Alr) 		4 HIS A 412
LEU A 436
MET A 464
TRP A 476
 FAD  A 550 (-3.1A)
None
None
None
 1.42A 3uzzB-3llkA:
undetectable		 3uzzB-3llkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 HIS A 422
TYR A  59
LEU A 358
MET A 213
 EDO  A 516 ( 4.3A)
EDO  A 516 (-4.8A)
None
None
 1.38A 3uzzB-3myvA:
undetectable		 3uzzB-3myvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1

(Saccharomyces
cerevisiae) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 256
TYR A 328
TRP A 173
TRP A 228
 None
 1.28A 3uzzB-3opwA:
undetectable		 3uzzB-3opwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		4 TYR A 145
TYR A 195
MET A 202
TRP A 198
 NDP  A2001 ( 4.7A)
None
None
None
 1.34A 3uzzB-3p19A:
undetectable		 3uzzB-3p19A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TYR A 290
TRP A 237
LEU A 201
MET A 228
 None
 1.41A 3uzzB-3r44A:
undetectable		 3uzzB-3r44A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL

(Homo sapiens) 		PF00271
(Helicase_C)
PF12513
(SUV3_C) 		4 TYR A 572
HIS A 511
LEU A 185
TRP A 191
 None
 1.30A 3uzzB-3rc3A:
undetectable		 3uzzB-3rc3A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		4 TYR A 267
HIS A 180
LEU A 187
MET A 191
 None
 1.40A 3uzzB-3ripA:
undetectable		 3uzzB-3ripA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 TYR A 669
TYR A 783
LEU A 728
TRP A 782
 None
 1.20A 3uzzB-3shwA:
undetectable		 3uzzB-3shwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjr SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 TYR A 165
LEU A 103
MET A 106
TRP A 111
 None
 0.95A 3uzzB-3tjrA:
undetectable		 3uzzB-3tjrA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 TYR A 669
TYR A 783
LEU A 728
TRP A 782
 None
 1.25A 3uzzB-3tswA:
undetectable		 3uzzB-3tswA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		4 TYR A 326
TYR A 453
MET A 174
TRP A 178
 None
GDU  A 802 (-4.8A)
None
None
 1.22A 3uzzB-3ukfA:
undetectable		 3uzzB-3ukfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c47 INNER MEMBRANE
LIPOPROTEIN

(Salmonella
enterica) 		PF11622
(DUF3251) 		4 TYR A  92
TYR A 200
LEU A 160
TRP A 163
 None
 1.23A 3uzzB-4c47A:
undetectable		 3uzzB-4c47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 TYR A 499
HIS A 492
TRP A 544
LEU A 533
 None
 1.11A 3uzzB-4cj0A:
undetectable		 3uzzB-4cj0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		4 TYR A  41
TYR A  37
TYR A 250
LEU A 341
 None
 1.42A 3uzzB-4e3eA:
undetectable		 3uzzB-4e3eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 TYR A 131
LEU A 341
MET A 343
TRP A 136
 None
 1.43A 3uzzB-4fl3A:
undetectable		 3uzzB-4fl3A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 TYR A 148
TYR A 152
LEU A 100
TRP A 167
 None
 1.13A 3uzzB-4gboA:
undetectable		 3uzzB-4gboA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 TYR A1005
TYR A 803
LEU A 696
TRP A 817
 None
 1.44A 3uzzB-4gfhA:
undetectable		 3uzzB-4gfhA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 181
TYR A 176
HIS A 397
LEU A 234
 None
 1.39A 3uzzB-4gisA:
3.4		 3uzzB-4gisA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
1AY  A 405 (-4.3A)
1AY  A 405 (-3.4A)
None
 1.30A 3uzzB-4hxxA:
undetectable		 3uzzB-4hxxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilt INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Streptomyces
sp. SirexAA-E) 		PF00775
(Dioxygenase_C) 		4 TYR A 167
TYR A 138
HIS A 175
LEU A 203
 None
FE  A 301 (-3.9A)
FE  A 301 (-3.2A)
None
 1.02A 3uzzB-4iltA:
undetectable		 3uzzB-4iltA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.4A)
None
 1.32A 3uzzB-4iu6A:
undetectable		 3uzzB-4iu6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 TYR A  12
TYR A 250
LEU A  89
TRP A 215
 None
 1.39A 3uzzB-4jr7A:
undetectable		 3uzzB-4jr7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		4 TYR A 216
HIS A 170
TYR A 133
LEU A 142
 None
 1.11A 3uzzB-4l7aA:
undetectable		 3uzzB-4l7aA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 TYR A 131
HIS A 271
LEU A 250
MET A 190
 None
ZN  A1000 ( 3.3A)
None
None
 1.39A 3uzzB-4mcaA:
undetectable		 3uzzB-4mcaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TYR A 138
TYR A 143
HIS A  32
LEU A 130
 None
 1.02A 3uzzB-4oflA:
undetectable		 3uzzB-4oflA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TYR A 138
TYR A 143
LEU A 130
MET A  98
 None
 1.32A 3uzzB-4oflA:
undetectable		 3uzzB-4oflA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		4 TYR C 288
TRP C 341
LEU C 248
MET C 252
 None
 0.98A 3uzzB-4oogC:
undetectable		 3uzzB-4oogC:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 TYR A 188
TYR A 132
LEU A 140
TRP A  94
 None
 1.43A 3uzzB-4re2A:
7.9		 3uzzB-4re2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		4 TYR A 197
TYR A 227
LEU A 162
MET A 166
 None
 1.44A 3uzzB-4rk9A:
undetectable		 3uzzB-4rk9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 TYR A  88
HIS A 266
TYR A 227
LEU A 262
 None
 1.37A 3uzzB-4tx8A:
5.0		 3uzzB-4tx8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		4 TYR A 194
HIS A 347
LEU A 381
MET A 377
 None
 1.42A 3uzzB-4u0zA:
undetectable		 3uzzB-4u0zA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 TYR C 442
HIS C 611
TYR C 394
LEU C 385
 None
 1.39A 3uzzB-4u1cC:
undetectable		 3uzzB-4u1cC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		4 HIS A 592
TYR A 568
TRP A 586
LEU A 527
 None
 1.39A 3uzzB-4u1fA:
undetectable		 3uzzB-4u1fA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		4 TYR c 442
HIS c 611
TYR c 394
LEU c 385
 None
 1.38A 3uzzB-4uerc:
undetectable		 3uzzB-4uerc:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 TYR A 591
HIS A 196
TYR A 576
LEU A 350
 PO4  A 810 (-4.4A)
PO4  A 810 (-4.0A)
None
None
 1.29A 3uzzB-4wgkA:
undetectable		 3uzzB-4wgkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN

(Thermus
thermophilus) 		PF00877
(NLPC_P60)
PF01476
(LysM) 		4 TYR A 234
HIS A 216
TYR A 220
LEU A 151
 None
 1.32A 3uzzB-4xcmA:
undetectable		 3uzzB-4xcmA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 TYR A  65
TYR A 100
TYR A  31
LEU A  40
 None
 1.35A 3uzzB-4xpdA:
undetectable		 3uzzB-4xpdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 TYR A 100
TYR A 104
LEU A 204
TRP A 203
 None
 1.17A 3uzzB-4y21A:
undetectable		 3uzzB-4y21A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y49 N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX CATALYTIC
SUBUNIT ARD1

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		4 TYR B  28
HIS B  36
TYR B  95
MET B 134
 None
 1.17A 3uzzB-4y49B:
undetectable		 3uzzB-4y49B:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		4 TYR A  16
HIS A  26
LEU A 175
TRP A 173
 None
 1.11A 3uzzB-4znjA:
undetectable		 3uzzB-4znjA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 144
HIS A 227
MET A 380
TRP A 382
 None
 1.36A 3uzzB-4zzqA:
undetectable		 3uzzB-4zzqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 144
LEU A 383
MET A 380
TRP A 382
 None
 1.01A 3uzzB-4zzqA:
undetectable		 3uzzB-4zzqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 TYR C 556
TYR C 503
HIS C 572
LEU C 594
 None
 0.98A 3uzzB-5a5tC:
undetectable		 3uzzB-5a5tC:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 TYR A 184
TYR A 235
HIS A 190
LEU A 270
 GLC  A 703 ( 4.4A)
GLC  A 703 ( 4.7A)
GLC  A 703 ( 4.0A)
None
 1.37A 3uzzB-5axhA:
7.9		 3uzzB-5axhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnd ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
epidermidis) 		no annotation 4 HIS A 396
LEU A 471
MET A 465
TRP A 500
 None
 1.08A 3uzzB-5bndA:
undetectable		 3uzzB-5bndA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 642
TYR A 241
TRP A 616
LEU A 234
 None
 1.18A 3uzzB-5ck0A:
undetectable		 3uzzB-5ck0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 TYR A 235
HIS A 254
LEU A 152
MET A 156
 None
 1.44A 3uzzB-5edjA:
undetectable		 3uzzB-5edjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		4 TYR A  94
TYR A 152
LEU A 177
TRP A 188
 None
 1.10A 3uzzB-5h05A:
9.2		 3uzzB-5h05A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		4 TYR A 201
HIS A  29
TYR A  16
LEU A 212
 None
 1.33A 3uzzB-5h3bA:
undetectable		 3uzzB-5h3bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 TYR A 181
TYR A 124
LEU A 132
TRP A  84
 None
 1.42A 3uzzB-5jboA:
10.9		 3uzzB-5jboA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		4 TYR A  59
HIS A 120
LEU A 299
MET A 131
 6KB  A 401 ( 4.6A)
6KB  A 401 ( 4.0A)
EDO  A 404 (-4.3A)
None
 1.05A 3uzzB-5jgyA:
40.5		 3uzzB-5jgyA:
37.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 TYR A 106
TYR A  33
LEU A  74
TRP A  71
 None
 1.41A 3uzzB-5josA:
undetectable		 3uzzB-5josA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 TYR B 289
TYR B 339
HIS B  71
TYR B 501
 CU  B 701 (-4.7A)
EDO  B 715 (-4.6A)
None
CU  B 701 (-4.4A)
 1.31A 3uzzB-5lxzB:
undetectable		 3uzzB-5lxzB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 TYR A 481
HIS A 337
TRP A 527
LEU A 475
 MET  A 807 ( 4.9A)
None
None
None
 1.39A 3uzzB-5nfhA:
undetectable		 3uzzB-5nfhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 TYR A 145
LEU A 377
MET A 374
TRP A 376
 BTB  A 604 (-3.8A)
None
None
BTB  A 604 (-4.9A)
 1.04A 3uzzB-5o5dA:
undetectable		 3uzzB-5o5dA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 TYR A  10
TYR A  11
LEU A 290
MET A 301
 None
 1.43A 3uzzB-5tvtA:
undetectable		 3uzzB-5tvtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 701
TYR A 642
LEU A 655
TRP A 603
 None
 1.31A 3uzzB-5vanA:
3.9		 3uzzB-5vanA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 4 TYR A 170
TYR A 116
LEU A 124
TRP A  78
 None
 1.41A 3uzzB-5wkaA:
10.4		 3uzzB-5wkaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 TYR A 413
HIS A 568
TYR A 379
TRP A 383
 None
 1.43A 3uzzB-5x7hA:
9.3		 3uzzB-5x7hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 TYR A 373
TYR A1267
HIS A1181
LEU A1165
 MES  A1707 (-3.6A)
MES  A1707 (-4.4A)
None
None
 0.91A 3uzzB-5x7sA:
undetectable		 3uzzB-5x7sA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 TYR A  93
HIS A 388
TRP A 247
MET A 338
 FMN  A 501 (-3.9A)
FMN  A 501 (-3.2A)
None
None
 1.25A 3uzzB-5xdeA:
undetectable		 3uzzB-5xdeA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 4 TYR A 228
TYR A 321
LEU A 355
TRP A 377
 None
 0.87A 3uzzB-5z0uA:
10.0		 3uzzB-5z0uA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAL

(Cyanidioschyzon
merolae) 		no annotation 4 TYR L  37
LEU L 117
MET L  93
TRP L 114
 None
None
BCR  L 205 (-3.4A)
None
 1.16A 3uzzB-5zgbL:
undetectable		 3uzzB-5zgbL:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 4 TYR A  35
HIS A  67
TYR A  84
LEU A 103
 None
TAR  A 401 ( 3.3A)
None
None
 1.39A 3uzzB-5zmyA:
10.0		 3uzzB-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 4 TYR A 352
TRP A 240
LEU A 255
TRP A 493
 None
FAD  A 601 (-4.2A)
None
None
 1.39A 3uzzB-6f74A:
undetectable		 3uzzB-6f74A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 TYR A 321
TYR A  90
MET A  49
TRP A  59
 None
 1.42A 3uzzB-6fcxA:
9.0		 3uzzB-6fcxA:
13.08