SIMILAR PATTERNS OF AMINO ACIDS FOR 3UZZ_A_TESA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  24
TYR A  55
HIS A 117
TRP A 227
 None
NDP  A1003 (-4.9A)
NDP  A1003 (-4.3A)
None
 1.33A 3uzzA-1q5mA:
50.5		 3uzzA-1q5mA:
56.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TYR A  26
TYR A  58
TYR A 132
TRP A 230
MET A 313
TRP A 314
 CI2  A 328 ( 4.0A)
CI2  A 328 ( 4.5A)
None
CI2  A 328 (-4.2A)
CI2  A 328 (-4.0A)
None
 0.57A 3uzzA-3cavA:
54.5		 3uzzA-3cavA:
93.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibx PUTATIVE THIAMINASE
II

(Helicobacter
pylori) 		PF03070
(TENA_THI-4) 		4 TYR A 165
HIS A  86
TYR A  47
TRP A 211
 None
 1.47A 3uzzA-3ibxA:
0.0		 3uzzA-3ibxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1

(Saccharomyces
cerevisiae) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 TYR A 256
TYR A 328
TRP A 173
TRP A 228
 None
 1.25A 3uzzA-3opwA:
0.0		 3uzzA-3opwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		4 TYR A 145
TYR A 195
MET A 202
TRP A 198
 NDP  A2001 ( 4.7A)
None
None
None
 1.37A 3uzzA-3p19A:
1.9		 3uzzA-3p19A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 TYR A 427
TYR A 292
TYR A 381
MET A 444
 None
 1.19A 3uzzA-4c02A:
0.0		 3uzzA-4c02A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
1AY  A 405 (-4.3A)
1AY  A 405 (-3.4A)
None
 1.22A 3uzzA-4hxxA:
0.0		 3uzzA-4hxxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 TYR A 117
TYR A 195
HIS A 310
MET A 148
 None
FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.4A)
None
 1.24A 3uzzA-4iu6A:
undetectable		 3uzzA-4iu6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 4 TYR A  87
HIS A 172
TYR A 188
TRP A 197
 None
 1.48A 3uzzA-4lypA:
10.1		 3uzzA-4lypA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		4 TYR B 289
TYR B 339
HIS B  71
TYR B 501
 CU  B 701 (-4.7A)
EDO  B 715 (-4.6A)
None
CU  B 701 (-4.4A)
 1.32A 3uzzA-5lxzB:
undetectable		 3uzzA-5lxzB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 HIS A 248
TYR A 133
TRP A  90
TRP A 340
 FE2  A 601 ( 3.4A)
83D  A 602 (-4.4A)
None
None
 1.27A 3uzzA-5u8zA:
undetectable		 3uzzA-5u8zA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 TYR A 413
HIS A 568
TYR A 379
TRP A 383
 None
 1.42A 3uzzA-5x7hA:
9.5		 3uzzA-5x7hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 TYR A  93
HIS A 388
TRP A 247
MET A 338
 FMN  A 501 (-3.9A)
FMN  A 501 (-3.2A)
None
None
 1.30A 3uzzA-5xdeA:
undetectable		 3uzzA-5xdeA:
22.62