SIMILAR PATTERNS OF AMINO ACIDS FOR 3UVV_A_T3A501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00355
(Rieske)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ARG A 822
MET B  93
ARG A 722
 None
 1.45A 3uvvA-1g8kA:
0.0		 3uvvA-1g8kA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		3 ARG D 463
MET G 140
ARG G 143
 None
 0.79A 3uvvA-1mtyD:
0.0		 3uvvA-1mtyD:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ARG A 228
MET A 259
ARG A 262
 IH5  A 600 (-4.2A)
IH5  A 600 (-4.7A)
None
 0.49A 3uvvA-1navA:
36.4		 3uvvA-1navA:
90.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 ARG A 284
MET A 260
ARG A 259
 None
 1.35A 3uvvA-1q51A:
0.0		 3uvvA-1q51A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ARG A 477
MET A 382
ARG A 389
 None
 1.20A 3uvvA-1qo8A:
0.0		 3uvvA-1qo8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		3 ARG A 111
MET A 117
ARG A 113
 None
 1.29A 3uvvA-1yfyA:
0.0		 3uvvA-1yfyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A  12
MET A  29
ARG A  28
 None
 1.33A 3uvvA-2fknA:
0.0		 3uvvA-2fknA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ARG A 241
MET A 324
ARG A 273
 None
 1.33A 3uvvA-2ip2A:
undetectable		 3uvvA-2ip2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		3 ARG A 201
MET A 205
ARG A 204
 None
 1.43A 3uvvA-2iv0A:
undetectable		 3uvvA-2iv0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A  16
MET A  33
ARG A  32
 None
 1.34A 3uvvA-2v7gA:
undetectable		 3uvvA-2v7gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		3 ARG A  81
MET A  85
ARG A  84
 None
 1.49A 3uvvA-2xubA:
undetectable		 3uvvA-2xubA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		3 ARG A 126
MET A 138
ARG A 140
 None
 1.21A 3uvvA-3beoA:
undetectable		 3uvvA-3beoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		3 ARG A  75
MET A 107
ARG A 108
 None
 1.42A 3uvvA-3ga7A:
undetectable		 3uvvA-3ga7A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		3 ARG A  66
MET A  70
ARG A  69
 None
 1.38A 3uvvA-3kh1A:
undetectable		 3uvvA-3kh1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lri PROTEIN
(INSULIN-LIKE GROWTH
FACTOR I)

(Homo sapiens) 		PF00049
(Insulin) 		3 ARG A  68
MET A  72
ARG A  69
 None
 1.42A 3uvvA-3lriA:
undetectable		 3uvvA-3lriA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 336
MET A   1
ARG A 349
 None
 1.36A 3uvvA-3moiA:
undetectable		 3uvvA-3moiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ARG A 314
MET A 318
ARG A 317
 None
 1.48A 3uvvA-3se7A:
undetectable		 3uvvA-3se7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 270
MET A 274
ARG A 273
 None
 1.28A 3uvvA-3u4fA:
undetectable		 3uvvA-3u4fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 873
MET A 876
ARG A 877
 None
 1.25A 3uvvA-3va7A:
undetectable		 3uvvA-3va7A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w34 URIDINE KINASE

(Thermus
thermophilus) 		PF00485
(PRK) 		3 ARG A 204
MET A 208
ARG A 207
 None
 1.30A 3uvvA-3w34A:
undetectable		 3uvvA-3w34A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		3 ARG A 251
MET A 294
ARG A 293
 None
FAD  A 601 (-4.9A)
None
 1.23A 3uvvA-3x0vA:
undetectable		 3uvvA-3x0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 ARG A 304
MET A 131
ARG A 135
 None
 1.40A 3uvvA-4bokA:
undetectable		 3uvvA-4bokA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fw1 INTEGRASE

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		3 ARG A 201
MET A 155
ARG A 158
 None
 1.23A 3uvvA-4fw1A:
undetectable		 3uvvA-4fw1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		3 ARG A  75
MET A 107
ARG A 108
 None
 1.38A 3uvvA-4kryA:
undetectable		 3uvvA-4kryA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn0 BEROVIN

(Beroe
abyssicola) 		PF10591
(SPARC_Ca_bdg) 		3 ARG A  66
MET A  79
ARG A  80
 None
 1.39A 3uvvA-4mn0A:
undetectable		 3uvvA-4mn0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)

(Paraburkholderia
xenovorans) 		PF02441
(Flavoprotein) 		3 ARG A  69
MET A  88
ARG A  17
 None
 1.30A 3uvvA-4mwgA:
undetectable		 3uvvA-4mwgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc7 FORMIN-LIKE PROTEIN
2

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ARG B 115
MET B 226
ARG B 229
 None
 1.50A 3uvvA-4yc7B:
undetectable		 3uvvA-4yc7B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		3 ARG B  30
MET B  98
ARG B  97
 None
 1.49A 3uvvA-5ey5B:
undetectable		 3uvvA-5ey5B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsz NUCLEOID OCCLUSION
FACTOR SLMA

(Klebsiella
pneumoniae) 		PF00440
(TetR_N) 		3 ARG A 137
MET A 140
ARG A 141
 None
 1.24A 3uvvA-5hszA:
undetectable		 3uvvA-5hszA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 873
MET A 876
ARG A 877
 None
 1.25A 3uvvA-5i8iA:
undetectable		 3uvvA-5i8iA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		3 ARG A 345
MET A  96
ARG A  97
 HEM  A 402 (-3.9A)
HEM  A 402 ( 4.8A)
HEM  A 402 (-3.8A)
 0.95A 3uvvA-5l1tA:
undetectable		 3uvvA-5l1tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		3 ARG A 304
MET A 131
ARG A 135
 None
None
EDO  A 601 (-4.0A)
 1.44A 3uvvA-5m77A:
undetectable		 3uvvA-5m77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 3 ARG B 251
MET B 285
ARG B 288
 None
 1.34A 3uvvA-6bcqB:
undetectable		 3uvvA-6bcqB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 3 ARG A 111
MET A 117
ARG A 113
 None
 1.39A 3uvvA-6bvpA:
undetectable		 3uvvA-6bvpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 3 ARG A 447
MET A 200
ARG A 198
 None
 1.43A 3uvvA-6c01A:
undetectable		 3uvvA-6c01A:
15.27