SIMILAR PATTERNS OF AMINO ACIDS FOR 3UVV_A_T3A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 ILE A 186
LEU A 211
LEU A 207
ILE A 127
PHE A 151
 None
 1.06A 3uvvA-1bsgA:
0.0		 3uvvA-1bsgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 ALA A 201
LEU A 181
LEU A 238
LEU A 240
ILE A 210
 None
 1.10A 3uvvA-1d6sA:
0.0		 3uvvA-1d6sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		5 ILE A  89
ALA A  92
LEU A  52
LEU A   8
ILE A  27
 None
 0.99A 3uvvA-1hmlA:
0.0		 3uvvA-1hmlA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 221
ILE A 222
ALA A 225
MET A 256
ALA A 263
LEU A 276
LEU A 287
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-3.6A)
IH5  A 600 ( 3.8A)
IH5  A 600 (-4.0A)
None
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.51A 3uvvA-1navA:
36.4		 3uvvA-1navA:
90.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Rattus
norvegicus) 		PF01239
(PPTA) 		5 ILE A 283
LEU A 284
LEU A 295
LEU A 299
ILE A 318
 None
 1.09A 3uvvA-1nl4A:
1.3		 3uvvA-1nl4A:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 275
ILE A 276
ALA A 279
MET A 310
ALA A 317
LEU A 330
LEU A 341
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.1A)
G24  A 462 ( 3.9A)
None
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.42A 3uvvA-1q4xA:
36.8		 3uvvA-1q4xA:
83.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE

(Cryptococcus
neoformans) 		PF00475
(IGPD) 		5 ALA A 151
LEU A  81
LEU A  50
LEU A 177
ILE A 181
 None
 0.90A 3uvvA-1rhyA:
0.0		 3uvvA-1rhyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		5 ILE A 306
ILE A 278
LEU A 304
LEU A 321
ILE A 296
 None
 0.84A 3uvvA-1s8eA:
0.0		 3uvvA-1s8eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3h DEPHOSPHO-COA KINASE

(Escherichia
coli) 		PF01121
(CoaE) 		5 ILE A  92
ALA A  46
LEU A  88
LEU A  84
ILE A  50
 None
 1.08A 3uvvA-1t3hA:
1.2		 3uvvA-1t3hA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		5 ILE A 254
ALA A 261
LEU A 170
LEU A 172
ILE A 166
 None
 1.00A 3uvvA-1vmkA:
undetectable		 3uvvA-1vmkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 358
ILE A 359
LEU A 409
ILE A 142
PHE A 402
 None
 0.97A 3uvvA-1x55A:
undetectable		 3uvvA-1x55A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z94 CONSERVED
HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF08327
(AHSA1) 		5 ALA A  27
LEU A 137
LEU A 110
LEU A 101
ILE A  99
 None
 0.93A 3uvvA-1z94A:
undetectable		 3uvvA-1z94A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 MET A  26
ALA A  20
LEU A  17
LEU A 108
LEU A 112
 None
 1.13A 3uvvA-1zh4A:
undetectable		 3uvvA-1zh4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 ILE A  13
ALA A  11
ALA A  66
LEU A  76
ILE A 114
 None
 0.86A 3uvvA-2dulA:
undetectable		 3uvvA-2dulA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyu FORMAMIDASE

(Helicobacter
pylori) 		PF00795
(CN_hydrolase) 		5 ILE A 189
ILE A 165
ALA A 118
ALA A 162
LEU A 174
 None
 0.95A 3uvvA-2dyuA:
undetectable		 3uvvA-2dyuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 ILE A 334
ILE A 333
LEU A 325
LEU A 242
ILE A 183
 None
 1.06A 3uvvA-2eg5A:
undetectable		 3uvvA-2eg5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		5 ILE A 110
ALA A 113
ALA A  84
LEU A  81
LEU A  10
 None
 1.01A 3uvvA-2gasA:
undetectable		 3uvvA-2gasA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		5 ILE A 207
ILE A 212
ALA A 205
LEU A  45
ILE A   4
 None
 1.13A 3uvvA-2it1A:
undetectable		 3uvvA-2it1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 ILE A 133
LEU A 104
LEU A  95
LEU A  91
ILE A  58
 None
 1.07A 3uvvA-2iy8A:
undetectable		 3uvvA-2iy8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00069
(Pkinase)
PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		5 ILE B 254
ALA A  48
LEU A  37
ILE A  35
HIS A  71
 None
 1.10A 3uvvA-2jgzB:
undetectable		 3uvvA-2jgzB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf3 EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		5 ILE A 347
ALA A 350
ALA A 320
LEU A 329
LEU A 379
 None
 1.13A 3uvvA-2lf3A:
undetectable		 3uvvA-2lf3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwm PUTATIVE TRP
REPRESSOR BINDING
PROTEIN

(Lactobacillus
acidophilus) 		PF12682
(Flavodoxin_4) 		5 ILE A  24
ALA A 110
LEU A  81
LEU A  79
ILE A 137
 None
 1.05A 3uvvA-2mwmA:
undetectable		 3uvvA-2mwmA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3e MAJOR AMPULLATE
SPIDROIN 1

(Latrodectus
hesperus) 		PF16763
(Spidroin_N) 		5 ILE A 119
ILE A 115
ALA A  26
ILE A  23
PHE A 111
 None
 1.08A 3uvvA-2n3eA:
undetectable		 3uvvA-2n3eA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 ILE A 276
ALA A 282
LEU A 277
LEU A 291
HIS A 286
 None
None
None
None
SO4  A 503 (-4.0A)
 1.09A 3uvvA-2o0xA:
undetectable		 3uvvA-2o0xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		5 ILE A 134
ALA A 128
LEU A 148
LEU A 230
ILE A 185
 None
None
ACT  A 239 (-4.5A)
None
None
 1.05A 3uvvA-2odhA:
undetectable		 3uvvA-2odhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 481
ALA A 477
LEU A 535
LEU A 541
ILE A 288
 SCN  A 601 (-3.5A)
SCN  A 601 ( 4.3A)
None
None
None
 0.97A 3uvvA-2pa5A:
undetectable		 3uvvA-2pa5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A 481
ALA A 575
LEU A 535
LEU A 541
ILE A 288
 SCN  A 601 (-3.5A)
None
None
None
None
 0.83A 3uvvA-2pa5A:
undetectable		 3uvvA-2pa5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ALA A1024
LEU A1007
LEU A 480
LEU A1016
ILE A1034
 None
 1.07A 3uvvA-2qf7A:
undetectable		 3uvvA-2qf7A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A 208
ALA A 212
ALA A 256
LEU A 264
ILE A 224
 CYC  A1521 (-4.0A)
CYC  A1521 ( 3.8A)
CYC  A1521 (-3.9A)
None
None
 0.70A 3uvvA-2veaA:
undetectable		 3uvvA-2veaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		5 ALA A  53
LEU A   3
LEU A 139
LEU A  31
ILE A 116
 None
None
None
None
DUQ  A 400 ( 4.9A)
 1.08A 3uvvA-2y8cA:
undetectable		 3uvvA-2y8cA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		5 ILE A  31
ILE A   4
ALA A  29
ALA A  21
LEU A 178
 None
 1.07A 3uvvA-2ywrA:
undetectable		 3uvvA-2ywrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ILE A 127
ILE A 144
ALA A 353
ILE A 412
HIS A 394
 None
 0.93A 3uvvA-2zzgA:
undetectable		 3uvvA-2zzgA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 5 ILE A 484
ILE A 485
ALA A 486
MET A 424
LEU A 432
 None
 1.04A 3uvvA-3afbA:
undetectable		 3uvvA-3afbA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE

(Gluconobacter
frateurii) 		PF13561
(adh_short_C2) 		5 ILE A  19
ILE A  23
ALA A  22
LEU A 233
PHE A  27
 NDP  A 270 (-3.7A)
None
None
None
None
 1.09A 3uvvA-3ai2A:
undetectable		 3uvvA-3ai2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		5 ALA C 515
ALA C 555
LEU C 551
LEU C 503
LEU C 588
 None
 1.05A 3uvvA-3al0C:
undetectable		 3uvvA-3al0C:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 ALA A 224
LEU A 228
LEU A 283
LEU A 301
MET A 345
 None
 1.00A 3uvvA-3beoA:
undetectable		 3uvvA-3beoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 ALA A 224
LEU A 283
LEU A 301
ILE A 328
MET A 345
 None
 1.07A 3uvvA-3beoA:
undetectable		 3uvvA-3beoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A  84
ALA A 113
ALA A 190
LEU A 207
ILE A 209
 None
 1.02A 3uvvA-3ek1A:
undetectable		 3uvvA-3ek1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		5 MET A 187
LEU A  41
LEU A 227
LEU A 229
ILE A 213
 None
 1.10A 3uvvA-3eqxA:
undetectable		 3uvvA-3eqxA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 399
ALA A 360
LEU A 311
LEU A 376
ILE A 358
 None
 0.89A 3uvvA-3iuyA:
undetectable		 3uvvA-3iuyA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaz VIRAL STRUCTURAL
PROTEIN 5

(Cypovirus 1) 		no annotation 5 ILE D  72
ALA D  75
ALA D 140
LEU D 137
LEU D 285
 None
 1.07A 3uvvA-3jazD:
undetectable		 3uvvA-3jazD:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  15
ILE A  16
LEU A  90
LEU A 101
ILE A  99
 None
 1.06A 3uvvA-3k4xA:
undetectable		 3uvvA-3k4xA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A 282
ILE A 283
LEU A 357
LEU A 368
ILE A 366
 None
 1.08A 3uvvA-3k4xA:
undetectable		 3uvvA-3k4xA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A  15
ILE A  16
LEU A  90
LEU A 101
ILE A  99
 None
 1.12A 3uvvA-3l10A:
undetectable		 3uvvA-3l10A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		5 ILE A 109
ALA A 134
LEU A 138
LEU A 176
ILE A 178
 None
 0.82A 3uvvA-3lzdA:
undetectable		 3uvvA-3lzdA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		5 ALA A 135
LEU A  88
LEU A  31
LEU A  35
ILE A  51
 None
 1.13A 3uvvA-3ntxA:
undetectable		 3uvvA-3ntxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE B 118
ILE B 122
ALA B 121
LEU B  21
PHE B 130
 None
 1.11A 3uvvA-3o2rB:
undetectable		 3uvvA-3o2rB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ILE A  13
ALA A 120
LEU A  23
ILE A 123
PHE A 102
 None
None
GOL  A 318 ( 4.5A)
None
None
 1.07A 3uvvA-3op1A:
undetectable		 3uvvA-3op1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r07 PUTATIVE
LIPOATE-PROTEIN
LIGASE A SUBUNIT 2

(Thermoplasma
acidophilum) 		PF10437
(Lip_prot_lig_C) 		5 ILE C  16
LEU C  85
LEU C  51
LEU C  47
PHE C  36
 None
 0.95A 3uvvA-3r07C:
undetectable		 3uvvA-3r07C:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 ILE A 546
ALA A 539
LEU A 527
LEU A 503
ILE A 511
 None
 0.84A 3uvvA-3t6qA:
undetectable		 3uvvA-3t6qA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv1 DER F 7 ALLERGEN

(Dermatophagoides
farinae) 		PF16984
(Grp7_allergen) 		5 ILE A 135
ALA A  19
LEU A 193
LEU A 125
LEU A  86
 None
 0.93A 3uvvA-3uv1A:
undetectable		 3uvvA-3uv1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		5 ILE A 495
ALA A 559
LEU A 644
LEU A 629
ILE A 631
 None
 0.92A 3uvvA-4aeeA:
undetectable		 3uvvA-4aeeA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		5 ALA A 744
LEU A 753
LEU A 822
LEU A 771
ILE A 824
 None
 0.94A 3uvvA-4cvuA:
undetectable		 3uvvA-4cvuA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		5 ALA A 222
LEU A 281
LEU A 299
ILE A 326
MET A 343
 None
 1.13A 3uvvA-4fkzA:
undetectable		 3uvvA-4fkzA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp9 MTERF
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF02536
(mTERF) 		5 ILE B 127
LEU B 151
LEU B 180
LEU B 176
ILE B 186
 None
 1.05A 3uvvA-4fp9B:
undetectable		 3uvvA-4fp9B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g79 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 ILE A  95
ILE A  38
LEU A  98
LEU A 120
ILE A 105
 None
 1.00A 3uvvA-4g79A:
undetectable		 3uvvA-4g79A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 328
ILE A 295
LEU A 302
ILE A 200
PHE A 251
 None
None
GOL  A 502 (-4.6A)
None
None
 0.94A 3uvvA-4ijaA:
undetectable		 3uvvA-4ijaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 ILE A 218
LEU A 158
LEU A  58
LEU A  62
ILE A  45
 None
 1.02A 3uvvA-4jjaA:
undetectable		 3uvvA-4jjaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 ALA A1024
LEU A1007
LEU A 480
LEU A1016
ILE A1034
 None
 1.11A 3uvvA-4jx6A:
undetectable		 3uvvA-4jx6A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		5 ILE A 421
ALA A 420
LEU A  80
LEU A  58
PHE A 425
 None
 0.85A 3uvvA-4kbmA:
undetectable		 3uvvA-4kbmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 ILE A 340
ILE A 318
ALA A 338
LEU A 333
LEU A 310
 None
 0.98A 3uvvA-4kngA:
undetectable		 3uvvA-4kngA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 MET A  26
ALA A  20
LEU A  17
LEU A 108
LEU A 112
 None
 1.09A 3uvvA-4knyA:
undetectable		 3uvvA-4knyA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 ILE A  34
ALA A 289
LEU A  27
LEU A  47
ILE A  76
 None
 1.02A 3uvvA-4mlcA:
undetectable		 3uvvA-4mlcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4non FERROUS IRON UPTAKE
TRANSPORTER PROTEIN
B

(Streptococcus
thermophilus) 		PF02421
(FeoB_N) 		5 ILE A 251
LEU A  91
LEU A 130
LEU A 134
ILE A 110
 ILE  A 251 ( 0.6A)
LEU  A  91 ( 0.6A)
LEU  A 130 ( 0.6A)
LEU  A 134 ( 0.6A)
ILE  A 110 ( 0.7A)
 0.80A 3uvvA-4nonA:
undetectable		 3uvvA-4nonA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 ILE A 351
LEU A  31
LEU A 307
LEU A 311
ILE A 328
 None
 1.10A 3uvvA-4o6zA:
undetectable		 3uvvA-4o6zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		5 ILE A 879
ILE A 886
ALA A 850
LEU A 859
LEU A 842
 None
 0.99A 3uvvA-4ogcA:
undetectable		 3uvvA-4ogcA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		5 ILE A  59
ILE A  54
ALA A 119
ALA A 135
LEU A  70
 None
 0.97A 3uvvA-4p3gA:
undetectable		 3uvvA-4p3gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 192
ALA A 221
LEU A 218
LEU A 444
ILE A 440
 None
 0.69A 3uvvA-4pd3A:
undetectable		 3uvvA-4pd3A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ILE A 423
ILE A 424
ALA A 427
LEU A 333
ILE A 295
 None
 1.01A 3uvvA-4q6rA:
undetectable		 3uvvA-4q6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tq2 PUTATIVE
PHYCOERYTHRIN LYASE

(Guillardia
theta) 		PF09367
(CpeS) 		5 ILE A 151
ILE A 152
ALA A  24
LEU A 161
HIS A 156
 None
 0.83A 3uvvA-4tq2A:
undetectable		 3uvvA-4tq2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhh ESTERASE

(Thermogutta
terrifontis) 		PF00561
(Abhydrolase_1) 		5 ILE A 224
LEU A 251
LEU A  37
ILE A 182
MET A 197
 CAD  A1275 (-4.3A)
None
None
None
CAD  A1275 ( 4.2A)
 0.78A 3uvvA-4uhhA:
undetectable		 3uvvA-4uhhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		5 ILE A  87
LEU A  81
LEU A 109
ILE A 106
PHE A 152
 None
 1.11A 3uvvA-4v39A:
undetectable		 3uvvA-4v39A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Escherichia
coli) 		PF00814
(Peptidase_M22) 		5 ILE C  77
LEU C  81
LEU C  53
LEU C  46
ILE C  56
 None
 1.11A 3uvvA-4wq5C:
undetectable		 3uvvA-4wq5C:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 5 ILE B 156
ILE B 209
ALA B 152
ALA B 111
ILE B  42
 None
 0.79A 3uvvA-4x0rB:
undetectable		 3uvvA-4x0rB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 186
ILE A 210
ALA A 219
LEU A 203
LEU A 229
 None
 1.01A 3uvvA-4z0cA:
undetectable		 3uvvA-4z0cA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 ILE A 222
ALA A 239
LEU A 248
ILE A 149
PHE A 226
 None
 0.86A 3uvvA-4zw2A:
undetectable		 3uvvA-4zw2A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 ILE A 239
ILE A 382
ALA A 253
LEU A 250
ILE A 270
 None
 0.89A 3uvvA-5d6aA:
undetectable		 3uvvA-5d6aA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		5 ILE A  44
ALA A  40
LEU A  12
LEU A 106
LEU A 112
 None
 0.95A 3uvvA-5ee5A:
undetectable		 3uvvA-5ee5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.79A 3uvvA-5egeA:
undetectable		 3uvvA-5egeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 484
LEU A 603
LEU A 502
LEU A 466
ILE A 464
 None
 0.98A 3uvvA-5erbA:
undetectable		 3uvvA-5erbA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f42 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Francisella
tularensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A 166
ALA A 164
LEU A 148
LEU A 136
ILE A 124
 None
 0.89A 3uvvA-5f42A:
undetectable		 3uvvA-5f42A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ILE B  49
ALA B  19
LEU B 212
LEU B  56
LEU B  54
 None
None
FAD  B 321 (-4.6A)
None
None
 0.97A 3uvvA-5g5gB:
undetectable		 3uvvA-5g5gB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		5 ILE A  56
ALA A  53
ALA A  46
LEU A  35
LEU A   9
 None
 1.11A 3uvvA-5gmbA:
undetectable		 3uvvA-5gmbA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw4 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I

(Escherichia
coli) 		PF00590
(TP_methylase) 		5 ILE A  41
ALA A  88
ALA A  31
LEU A  52
ILE A  27
 None
 1.05A 3uvvA-5hw4A:
undetectable		 3uvvA-5hw4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		5 ILE A 236
ILE A 309
LEU A 279
ILE A 252
PHE A 304
 None
 1.12A 3uvvA-5i1tA:
undetectable		 3uvvA-5i1tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 ILE A 525
ILE A 526
ALA A 529
ALA A 562
ILE A 587
 None
 0.74A 3uvvA-5i35A:
undetectable		 3uvvA-5i35A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV
LYSOZYME C

(Bacillus
subtilis;
Gallus gallus) 		PF00062
(Lys)
PF11738
(DUF3298)
PF13739
(DUF4163) 		5 ILE B  58
ALA A 167
ALA B  31
LEU B  56
LEU B  17
 None
 1.00A 3uvvA-5jenB:
undetectable		 3uvvA-5jenB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ILE A 747
ILE A 717
LEU A 671
ILE A 664
PHE A 654
 None
 1.08A 3uvvA-5kcaA:
undetectable		 3uvvA-5kcaA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0w SEC71
SEC72

(Chaetomium
thermophilum) 		PF09802
(Sec66)
no annotation 		5 ILE B  55
ALA B 111
LEU B  47
LEU A  64
ILE A 137
 None
 0.97A 3uvvA-5l0wB:
undetectable		 3uvvA-5l0wB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		5 ILE D 524
ILE D 553
ALA D 520
ALA D 482
PHE D 554
 None
 1.02A 3uvvA-5mg3D:
undetectable		 3uvvA-5mg3D:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nc8 POTASSIUM EFFLUX
SYSTEM PROTEIN

(Shewanella
denitrificans) 		PF02254
(TrkA_N) 		5 ILE A 500
ALA A 502
ALA A 412
LEU A 474
LEU A 463
 None
 1.04A 3uvvA-5nc8A:
undetectable		 3uvvA-5nc8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1

(Plasmodium
falciparum) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ILE A  76
ILE A  75
ALA A 108
LEU A 183
ILE A 212
 LPA  A 401 ( 4.2A)
None
None
None
None
 0.95A 3uvvA-5t8uA:
undetectable		 3uvvA-5t8uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 ILE C 418
ALA C 417
LEU C  77
LEU C  55
PHE C 422
 None
 1.01A 3uvvA-5tw1C:
undetectable		 3uvvA-5tw1C:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 5 555
ALA 5 523
LEU 5 413
LEU 5 547
ILE 5 540
 None
 1.08A 3uvvA-5udb5:
undetectable		 3uvvA-5udb5:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 ILE A1424
LEU A1423
LEU A1448
LEU A1444
ILE A1877
 None
 0.90A 3uvvA-5v6tA:
undetectable		 3uvvA-5v6tA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 5 ILE A 650
ILE A 654
LEU A 792
LEU A 706
ILE A 680
 None
 1.05A 3uvvA-5wtkA:
undetectable		 3uvvA-5wtkA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 5 ILE A 741
ALA A 752
LEU A 819
LEU A 823
ILE A 802
 None
 1.09A 3uvvA-6eoqA:
undetectable		 3uvvA-6eoqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 ALA A 247
ALA A 262
LEU A 258
LEU A 103
ILE A 105
 None
 0.82A 3uvvA-6f5dA:
undetectable		 3uvvA-6f5dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 ALA A 262
LEU A 258
LEU A 103
ILE A 105
HIS A 121
 None
 0.92A 3uvvA-6f5dA:
undetectable		 3uvvA-6f5dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 ILE A 181
ALA A 180
LEU A 173
LEU A 171
LEU A 162
 None
 0.87A 3uvvA-6fhsA:
undetectable		 3uvvA-6fhsA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00355
(Rieske)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ARG A 822
MET B  93
ARG A 722
 None
 1.45A 3uvvA-1g8kA:
0.0		 3uvvA-1g8kA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		3 ARG D 463
MET G 140
ARG G 143
 None
 0.79A 3uvvA-1mtyD:
0.0		 3uvvA-1mtyD:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ARG A 228
MET A 259
ARG A 262
 IH5  A 600 (-4.2A)
IH5  A 600 (-4.7A)
None
 0.49A 3uvvA-1navA:
36.4		 3uvvA-1navA:
90.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 ARG A 284
MET A 260
ARG A 259
 None
 1.35A 3uvvA-1q51A:
0.0		 3uvvA-1q51A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 ARG A 477
MET A 382
ARG A 389
 None
 1.20A 3uvvA-1qo8A:
0.0		 3uvvA-1qo8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		3 ARG A 111
MET A 117
ARG A 113
 None
 1.29A 3uvvA-1yfyA:
0.0		 3uvvA-1yfyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A  12
MET A  29
ARG A  28
 None
 1.33A 3uvvA-2fknA:
0.0		 3uvvA-2fknA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ARG A 241
MET A 324
ARG A 273
 None
 1.33A 3uvvA-2ip2A:
undetectable		 3uvvA-2ip2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv0 ISOCITRATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00180
(Iso_dh) 		3 ARG A 201
MET A 205
ARG A 204
 None
 1.43A 3uvvA-2iv0A:
undetectable		 3uvvA-2iv0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 ARG A  16
MET A  33
ARG A  32
 None
 1.34A 3uvvA-2v7gA:
undetectable		 3uvvA-2v7gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		3 ARG A  81
MET A  85
ARG A  84
 None
 1.49A 3uvvA-2xubA:
undetectable		 3uvvA-2xubA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		3 ARG A 126
MET A 138
ARG A 140
 None
 1.21A 3uvvA-3beoA:
undetectable		 3uvvA-3beoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		3 ARG A  75
MET A 107
ARG A 108
 None
 1.42A 3uvvA-3ga7A:
undetectable		 3uvvA-3ga7A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		3 ARG A  66
MET A  70
ARG A  69
 None
 1.38A 3uvvA-3kh1A:
undetectable		 3uvvA-3kh1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lri PROTEIN
(INSULIN-LIKE GROWTH
FACTOR I)

(Homo sapiens) 		PF00049
(Insulin) 		3 ARG A  68
MET A  72
ARG A  69
 None
 1.42A 3uvvA-3lriA:
undetectable		 3uvvA-3lriA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 336
MET A   1
ARG A 349
 None
 1.36A 3uvvA-3moiA:
undetectable		 3uvvA-3moiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 ARG A 314
MET A 318
ARG A 317
 None
 1.48A 3uvvA-3se7A:
undetectable		 3uvvA-3se7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 270
MET A 274
ARG A 273
 None
 1.28A 3uvvA-3u4fA:
undetectable		 3uvvA-3u4fA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 873
MET A 876
ARG A 877
 None
 1.25A 3uvvA-3va7A:
undetectable		 3uvvA-3va7A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w34 URIDINE KINASE

(Thermus
thermophilus) 		PF00485
(PRK) 		3 ARG A 204
MET A 208
ARG A 207
 None
 1.30A 3uvvA-3w34A:
undetectable		 3uvvA-3w34A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		3 ARG A 251
MET A 294
ARG A 293
 None
FAD  A 601 (-4.9A)
None
 1.23A 3uvvA-3x0vA:
undetectable		 3uvvA-3x0vA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bok ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03663
(Glyco_hydro_76) 		3 ARG A 304
MET A 131
ARG A 135
 None
 1.40A 3uvvA-4bokA:
undetectable		 3uvvA-4bokA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fw1 INTEGRASE

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve) 		3 ARG A 201
MET A 155
ARG A 158
 None
 1.23A 3uvvA-4fw1A:
undetectable		 3uvvA-4fw1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		3 ARG A  75
MET A 107
ARG A 108
 None
 1.38A 3uvvA-4kryA:
undetectable		 3uvvA-4kryA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn0 BEROVIN

(Beroe
abyssicola) 		PF10591
(SPARC_Ca_bdg) 		3 ARG A  66
MET A  79
ARG A  80
 None
 1.39A 3uvvA-4mn0A:
undetectable		 3uvvA-4mn0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)

(Paraburkholderia
xenovorans) 		PF02441
(Flavoprotein) 		3 ARG A  69
MET A  88
ARG A  17
 None
 1.30A 3uvvA-4mwgA:
undetectable		 3uvvA-4mwgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc7 FORMIN-LIKE PROTEIN
2

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ARG B 115
MET B 226
ARG B 229
 None
 1.50A 3uvvA-4yc7B:
undetectable		 3uvvA-4yc7B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCA-B

(synthetic
construct) 		PF00291
(PALP) 		3 ARG B  30
MET B  98
ARG B  97
 None
 1.49A 3uvvA-5ey5B:
undetectable		 3uvvA-5ey5B:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsz NUCLEOID OCCLUSION
FACTOR SLMA

(Klebsiella
pneumoniae) 		PF00440
(TetR_N) 		3 ARG A 137
MET A 140
ARG A 141
 None
 1.24A 3uvvA-5hszA:
undetectable		 3uvvA-5hszA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ARG A 873
MET A 876
ARG A 877
 None
 1.25A 3uvvA-5i8iA:
undetectable		 3uvvA-5i8iA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		3 ARG A 345
MET A  96
ARG A  97
 HEM  A 402 (-3.9A)
HEM  A 402 ( 4.8A)
HEM  A 402 (-3.8A)
 0.95A 3uvvA-5l1tA:
undetectable		 3uvvA-5l1tA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		3 ARG A 304
MET A 131
ARG A 135
 None
None
EDO  A 601 (-4.0A)
 1.44A 3uvvA-5m77A:
undetectable		 3uvvA-5m77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 3 ARG B 251
MET B 285
ARG B 288
 None
 1.34A 3uvvA-6bcqB:
undetectable		 3uvvA-6bcqB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvp 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		no annotation 3 ARG A 111
MET A 117
ARG A 113
 None
 1.39A 3uvvA-6bvpA:
undetectable		 3uvvA-6bvpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 3 ARG A 447
MET A 200
ARG A 198
 None
 1.43A 3uvvA-6c01A:
undetectable		 3uvvA-6c01A:
15.27