SIMILAR PATTERNS OF AMINO ACIDS FOR 3UT5_D_LOCD502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 244
ALA A 188
ALA A 255
ALA A  92
ILE A 257
 None
 1.20A 3ut5D-1e5mA:
undetectable		 3ut5D-1e5mA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 GLN A 409
LEU A 370
ASN A 420
ALA A 400
ILE A 401
 None
 0.73A 3ut5D-1i41A:
undetectable		 3ut5D-1i41A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.17A 3ut5D-1kugA:
undetectable		 3ut5D-1kugA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE

(Homo sapiens) 		PF02574
(S-methyl_trans) 		5 GLN A  72
ASN A 216
ALA A 182
ALA A 119
ILE A 212
 CBH  A 601 ( 4.1A)
None
None
None
None
 1.07A 3ut5D-1lt8A:
3.2		 3ut5D-1lt8A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		5 GLN A 123
LEU A 108
MET A  60
ALA A  82
ALA A 124
 None
None
NDP  A1501 (-4.8A)
NDP  A1501 (-3.5A)
NDP  A1501 (-3.0A)
 1.14A 3ut5D-1rpnA:
6.5		 3ut5D-1rpnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 MET A  81
ALA A 326
LYS A   7
ALA A   9
ILE A  93
 None
 1.13A 3ut5D-1vfwA:
undetectable		 3ut5D-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 CYH A 360
LEU A  96
ALA A  98
ALA A 260
ILE A  10
 None
 1.00A 3ut5D-1wl4A:
undetectable		 3ut5D-1wl4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		5 GLN A 356
ALA A 310
LEU A 314
ALA A 360
ILE A 363
 None
 1.08A 3ut5D-1xrsA:
undetectable		 3ut5D-1xrsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 5 ALA A 158
LEU A 156
ASN A  67
MET A  69
ALA A 166
 None
 1.16A 3ut5D-1yc6A:
undetectable		 3ut5D-1yc6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.09A 3ut5D-1yp1A:
undetectable		 3ut5D-1yp1A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 5 GLN A 111
ALA A 138
ASN A 169
ALA A 105
ALA A 110
 None
 1.13A 3ut5D-1yrgA:
undetectable		 3ut5D-1yrgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LYS A 156
LEU A 158
ASN A 157
ALA A  44
ILE A 211
 None
 1.18A 3ut5D-1yx2A:
undetectable		 3ut5D-1yx2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 ALA A 148
ALA A 228
LYS A 226
ALA A 140
ILE A  86
 None
 1.13A 3ut5D-1z34A:
undetectable		 3ut5D-1z34A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		5 ALA A  88
LEU A  90
ALA A  74
ALA A 148
ILE A 121
 None
 1.13A 3ut5D-1z69A:
undetectable		 3ut5D-1z69A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.11A 3ut5D-1z9dA:
undetectable		 3ut5D-1z9dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuj HYPOTHETICAL PROTEIN
LLACC01001955

(Lactococcus
lactis) 		no annotation 5 ALA A 147
LYS A 150
LEU A 151
LYS A  67
ILE A  38
 None
 1.11A 3ut5D-1zujA:
undetectable		 3ut5D-1zujA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 1.04A 3ut5D-2bucA:
3.1		 3ut5D-2bucA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE
FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF02803
(Thiolase_C) 		5 LEU C 142
LEU A 223
ASN A 264
ALA A 233
ILE A 259
 None
 1.10A 3ut5D-2d3tC:
undetectable		 3ut5D-2d3tC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A 185
LEU A 292
MET A 295
ALA A 282
ILE A 278
 None
 0.96A 3ut5D-2fj0A:
2.9		 3ut5D-2fj0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fur HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF12900
(Pyridox_ox_2) 		5 ALA A  26
LEU A  28
ASN A  31
ALA A 104
ILE A 106
 None
 1.02A 3ut5D-2furA:
undetectable		 3ut5D-2furA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 LEU A   9
ALA A 162
LYS A 181
ALA A 186
ILE A 167
 None
 1.20A 3ut5D-2i6bA:
5.8		 3ut5D-2i6bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		5 LEU A 147
ALA A 297
ASN A  81
ALA A  87
ILE A  96
 None
 1.12A 3ut5D-2iksA:
3.5		 3ut5D-2iksA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		5 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.05A 3ut5D-2irwA:
7.0		 3ut5D-2irwA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00963
(Cohesin) 		5 LEU A 134
LEU A  49
ASN A  48
ALA A 125
ILE A 160
 None
 1.18A 3ut5D-2o4eA:
undetectable		 3ut5D-2o4eA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pft EXOCYTOSIS PROTEIN

(Mus musculus) 		PF03081
(Exo70) 		5 LYS A 469
LEU A 471
ASN A 473
ALA A 424
ILE A 425
 None
 1.17A 3ut5D-2pftA:
undetectable		 3ut5D-2pftA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		5 ALA A  41
LEU A  43
ASN A  47
ALA A  33
ILE A  52
 None
 0.88A 3ut5D-2qsjA:
2.7		 3ut5D-2qsjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.15A 3ut5D-2wyxA:
undetectable		 3ut5D-2wyxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLN A 203
LEU A 279
ALA A 242
ALA A 229
ILE A 263
 None
 1.19A 3ut5D-2y0kA:
undetectable		 3ut5D-2y0kA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli;
[Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 220
LEU A 222
ALA A 341
ALA A 366
ILE A 316
 None
 0.99A 3ut5D-2yfhA:
undetectable		 3ut5D-2yfhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		5 ALA A 283
LEU A 260
MET A 254
ALA A 233
ILE A  77
 None
 1.17A 3ut5D-2yjpA:
undetectable		 3ut5D-2yjpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 LEU A 286
ASN A 291
MET A 306
ALA A 397
ILE A 336
 None
 1.14A 3ut5D-2zufA:
undetectable		 3ut5D-2zufA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN

(Campylobacter
jejuni) 		PF02516
(STT3) 		5 LEU A 491
ALA A 682
LEU A 562
LYS A 695
ILE A 560
 None
MLY  A 493 ( 3.6A)
None
MLY  A 694 ( 3.3A)
None
 1.13A 3ut5D-3aagA:
undetectable		 3ut5D-3aagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgw DNAB-LIKE
REPLICATIVE HELICASE

(Bacillus phage
SPP1) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ALA A 344
LYS A 341
LEU A 340
ALA A 353
ILE A 314
 None
 1.19A 3ut5D-3bgwA:
2.8		 3ut5D-3bgwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 CYH A 596
LEU A 600
ALA A 572
LEU A 569
ALA A 546
 None
 1.18A 3ut5D-3bjcA:
undetectable		 3ut5D-3bjcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 0.92A 3ut5D-3bz5A:
undetectable		 3ut5D-3bz5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A1174
LYS A1177
LEU A1178
ASN A1181
ILE A1141
 None
 0.97A 3ut5D-3cmvA:
undetectable		 3ut5D-3cmvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A 309
GLN A 304
ASN A 258
ALA A 300
ILE A 281
 None
 1.04A 3ut5D-3dadA:
undetectable		 3ut5D-3dadA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLN A 134
ALA A 138
LEU A 136
ALA A 128
ALA A 132
 None
 1.13A 3ut5D-3ddmA:
undetectable		 3ut5D-3ddmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 151
ASN A 150
MET A 119
ALA A  54
ILE A 201
 None
 1.12A 3ut5D-3dslA:
undetectable		 3ut5D-3dslA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwf 11-BETA-HYDROXYSTERO
ID DEHYDROGENASE 1

(Cavia porcellus) 		PF00106
(adh_short) 		5 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.13A 3ut5D-3dwfA:
7.3		 3ut5D-3dwfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 CYH A 251
LEU A 255
LEU A 225
MET A 224
ALA A 375
 None
 1.21A 3ut5D-3f8tA:
undetectable		 3ut5D-3f8tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 5 ALA A 667
LYS A 662
LEU A 661
ALA A 718
ILE A 746
 None
 1.21A 3ut5D-3g40A:
2.0		 3ut5D-3g40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER

(Methanosarcina
acetivorans) 		no annotation 5 LEU A 757
ALA A 695
LEU A 691
ALA A 658
ILE A 635
 None
 1.14A 3ut5D-3g40A:
2.0		 3ut5D-3g40A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 LEU A 146
ASN A 145
MET A 114
ALA A  49
ILE A 196
 None
 1.06A 3ut5D-3gboA:
undetectable		 3ut5D-3gboA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		5 LEU A  64
LYS A  40
LEU A  41
ASN A  44
ILE A  77
 None
 0.97A 3ut5D-3h1gA:
5.5		 3ut5D-3h1gA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		PF13419
(HAD_2) 		5 ALA A 108
LEU A 106
ALA A 116
ALA A  53
ILE A 135
 None
 0.88A 3ut5D-3ib6A:
4.1		 3ut5D-3ib6A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LYS A 162
ASN A 163
ALA A 170
ALA A 196
ILE A 171
 None
 1.17A 3ut5D-3juxA:
2.2		 3ut5D-3juxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 LEU A 217
ASN A 108
ALA A 123
LYS A 122
ILE A 155
 None
 1.12A 3ut5D-3jxfA:
undetectable		 3ut5D-3jxfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.85A 3ut5D-3k1jA:
undetectable		 3ut5D-3k1jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.13A 3ut5D-3klbA:
4.4		 3ut5D-3klbA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		5 LEU A  10
LEU A 219
ASN A 221
ALA A  57
ILE A 209
 None
 1.21A 3ut5D-3kmhA:
undetectable		 3ut5D-3kmhA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF00440
(TetR_N)
PF16925
(TetR_C_13) 		5 ALA A  84
LYS A  87
LEU A  88
ALA A 163
ILE A 166
 None
 1.19A 3ut5D-3knwA:
undetectable		 3ut5D-3knwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l49 ABC SUGAR (RIBOSE)
TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
SUBUNIT

(Rhodobacter
sphaeroides) 		PF13407
(Peripla_BP_4) 		5 LEU A  47
GLN A  94
ALA A  49
ALA A  66
ALA A  38
 None
 1.08A 3ut5D-3l49A:
3.9		 3ut5D-3l49A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 269
ALA A 264
LEU A 260
ALA A 273
ILE A 247
 None
 1.08A 3ut5D-3m6cA:
undetectable		 3ut5D-3m6cA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.14A 3ut5D-3oc4A:
undetectable		 3ut5D-3oc4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		5 LEU A 330
ALA A 224
LEU A 227
ALA A 195
ALA A 199
 None
 1.21A 3ut5D-3ox4A:
3.4		 3ut5D-3ox4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 257
ASN A 254
LYS A 251
ALA A 246
ILE A 218
 None
 1.19A 3ut5D-3pfrA:
undetectable		 3ut5D-3pfrA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ALA X  89
ASN X  45
ALA X 103
ALA X 140
ILE X  48
 None
 1.13A 3ut5D-3rwkX:
undetectable		 3ut5D-3rwkX:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		5 ALA A 293
LEU A 244
ALA A 260
LYS A 263
ILE A 257
 None
 1.06A 3ut5D-3si9A:
2.8		 3ut5D-3si9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		6 LEU A 195
LEU A 122
ASN A 153
MET A 149
ALA A 131
ILE A 145
 None
 1.38A 3ut5D-3uswA:
undetectable		 3ut5D-3uswA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		5 LYS A  89
LEU A  88
ALA A  64
ALA A 306
ILE A   9
 None
 1.20A 3ut5D-3vglA:
undetectable		 3ut5D-3vglA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 LEU A 377
ALA A 189
LEU A 404
MET A 270
ILE A 267
 None
 1.22A 3ut5D-3vs8A:
undetectable		 3ut5D-3vs8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		5 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.08A 3ut5D-4akmA:
undetectable		 3ut5D-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LYS A 418
LEU A 416
ALA A 395
ALA A 399
ILE A 392
 None
 1.22A 3ut5D-4bejA:
3.2		 3ut5D-4bejA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ALA A 221
LEU A 223
ALA A 342
ALA A 367
ILE A 317
 None
 0.94A 3ut5D-4bhtA:
undetectable		 3ut5D-4bhtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 CYH A 413
LEU A 414
ALA A 416
ALA A 437
ILE A 438
 None
 1.06A 3ut5D-4bjuA:
undetectable		 3ut5D-4bjuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		5 ALA A 151
MET A 122
ALA A 135
ALA A 208
ILE A 106
 None
 1.00A 3ut5D-4fblA:
3.5		 3ut5D-4fblA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq0 FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF14841
(FliG_M) 		6 LEU C 195
LEU C 122
ASN C 153
MET C 149
ALA C 131
ILE C 145
 None
 1.43A 3ut5D-4fq0C:
undetectable		 3ut5D-4fq0C:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		5 LEU A 206
LEU A 204
MET A 242
ALA A 282
ILE A 261
 None
 1.17A 3ut5D-4g1gA:
undetectable		 3ut5D-4g1gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		5 LYS A  87
LEU A  86
ALA A  61
ALA A 282
ILE A   8
 None
 1.12A 3ut5D-4htlA:
undetectable		 3ut5D-4htlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
 None
 1.15A 3ut5D-4j4mA:
undetectable		 3ut5D-4j4mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k26 CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Mus musculus) 		PF00106
(adh_short) 		5 CYH A  78
LEU A  79
ALA A  83
MET A 110
ALA A  51
 None
 1.18A 3ut5D-4k26A:
2.4		 3ut5D-4k26A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF13646
(HEAT_2) 		5 LEU A 102
ALA A  98
LEU A  57
ALA A  42
ALA A  83
 None
 1.17A 3ut5D-4l7mA:
2.5		 3ut5D-4l7mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		5 LEU A 727
ALA A 717
LYS A 718
ALA A 720
ILE A 643
 None
 1.18A 3ut5D-4mi5A:
undetectable		 3ut5D-4mi5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 CYH A 356
LEU A  92
ALA A  94
ALA A 256
ILE A   6
 None
 1.05A 3ut5D-4o99A:
undetectable		 3ut5D-4o99A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 ALA A 255
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.01A 3ut5D-4pfmA:
undetectable		 3ut5D-4pfmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 325
ALA A 801
LEU A 761
MET A 764
ILE A 772
 None
 1.11A 3ut5D-4r7zA:
undetectable		 3ut5D-4r7zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toi 30S RIBOSOMAL
PROTEIN S2,RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00318
(Ribosomal_S2)
PF00575
(S1) 		5 ALA A 185
ALA A 176
LYS A 174
ALA A 172
ILE A 181
 None
 1.04A 3ut5D-4toiA:
3.0		 3ut5D-4toiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.18A 3ut5D-4wyiA:
3.9		 3ut5D-4wyiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 LEU C 292
LEU C 322
ALA C  56
ALA C 289
ILE C  60
 None
 1.17A 3ut5D-4xgcC:
undetectable		 3ut5D-4xgcC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		5 ALA A  99
LEU A  58
ASN A  56
ALA A  50
ILE A 354
 None
 1.13A 3ut5D-4yhgA:
undetectable		 3ut5D-4yhgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ALA A 342
LYS A 339
LEU A 338
ALA A 351
ILE A 312
 None
 1.19A 3ut5D-4zc0A:
2.6		 3ut5D-4zc0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		5 GLN A 400
LEU A  39
LYS A 405
ALA A 403
ILE A  57
 None
 1.20A 3ut5D-4zm4A:
undetectable		 3ut5D-4zm4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
 None
 0.90A 3ut5D-4zpxA:
undetectable		 3ut5D-4zpxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 LEU A 360
LEU A 431
ASN A 434
MET A 435
ALA A 366
 None
EDO  A1579 ( 4.3A)
None
None
None
 1.15A 3ut5D-5a29A:
undetectable		 3ut5D-5a29A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN

(Bacillus
thuringiensis) 		PF13424
(TPR_12) 		5 LEU A 299
LEU A 273
ASN A 275
MET A 276
ALA A 259
 None
 1.13A 3ut5D-5dbkA:
undetectable		 3ut5D-5dbkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyq YD REPEAT-CONTAINING
PROTEIN

(Verrucosispora
maris) 		no annotation 5 LEU A  45
ALA A 135
MET A 139
ALA A 108
ILE A  87
 None
 1.18A 3ut5D-5dyqA:
undetectable		 3ut5D-5dyqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx INTERLEUKIN-4

(Homo sapiens) 		PF00727
(IL4) 		5 LEU A  52
LEU A 116
MET A 120
ALA A  94
ILE A  10
 None
 1.10A 3ut5D-5fhxA:
undetectable		 3ut5D-5fhxA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 LEU A 594
LEU A 538
MET A 541
ALA A 462
ILE A 402
 None
 1.14A 3ut5D-5fnoA:
undetectable		 3ut5D-5fnoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 LEU A 223
LEU A 289
ALA A 297
ALA A 377
ILE A 294
 None
 1.09A 3ut5D-5ft6A:
undetectable		 3ut5D-5ft6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU B 117
LEU B 112
ASN B 111
ALA B 160
ILE B 125
 None
None
NAG  B 702 (-1.8A)
None
None
 1.20A 3ut5D-5gqrB:
undetectable		 3ut5D-5gqrB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.11A 3ut5D-5lm7A:
undetectable		 3ut5D-5lm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 5 LEU A  84
ALA A  80
LEU A  41
ALA A  58
ILE A  23
 None
 0.99A 3ut5D-5n3uA:
undetectable		 3ut5D-5n3uA:
10.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B 250
LYS B 254
ASN B 258
MET B 259
ILE B 378
 None
 0.80A 3ut5D-5n5nB:
53.8		 3ut5D-5n5nB:
96.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN SA

(Trypanosoma
cruzi) 		no annotation 5 LEU f 126
ALA f 149
ALA f 140
ALA f 136
ILE f 145
 None
 1.15A 3ut5D-5optf:
3.7		 3ut5D-5optf:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdy HEAT SHOCK PROTEIN
HTRA

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 310
ASN A 297
LYS A 283
ALA A 275
ILE A 243
 None
 1.20A 3ut5D-5xdyA:
undetectable		 3ut5D-5xdyA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.19A 3ut5D-6bu3A:
undetectable		 3ut5D-6bu3A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 377
LEU A 269
MET A 273
ALA A 422
ILE A 126
 None
 1.21A 3ut5D-6c4nA:
3.0		 3ut5D-6c4nA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 0.94A 3ut5D-6c9mA:
undetectable		 3ut5D-6c9mA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 5 ALA A 149
LEU A 131
ALA A 175
ALA A 179
ILE A 172
 None
 1.19A 3ut5D-6cn1A:
undetectable		 3ut5D-6cn1A:
13.39