SIMILAR PATTERNS OF AMINO ACIDS FOR 3UT5_B_LOCB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)


(Geobacillus
stearothermophilus)
PF00579
(tRNA-synt_1b)
5 LEU A 272
ALA A 220
MET A 193
ILE A 213
ILE A  16
None
1.13A 3ut5B-1d2rA:
undetectable
3ut5B-1d2rA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 LEU A 234
LEU A 115
ASN A  63
ILE A  55
ILE A 117
None
1.11A 3ut5B-1dt2A:
undetectable
3ut5B-1dt2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox)
PF01421
(Reprolysin)
5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
None
1.11A 3ut5B-1htdA:
undetectable
3ut5B-1htdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8a ENDO-1,4-BETA-XYLANA
SE A


(Thermotoga
maritima)
PF06452
(CBM9_1)
5 LEU A  52
LEU A 184
ASN A 183
ILE A 150
ILE A  25
None
1.08A 3ut5B-1i8aA:
undetectable
3ut5B-1i8aA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN


(Pyrococcus
horikoshii)
PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3)
5 LYS A 215
ALA A 156
ILE A 171
LYS A 158
ILE A 138
None
1.15A 3ut5B-1j08A:
undetectable
3ut5B-1j08A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
5 LEU A  99
ALA A 112
THR A  51
ALA A  53
ILE A  29
None
1.02A 3ut5B-1kh2A:
undetectable
3ut5B-1kh2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus)
PF01421
(Reprolysin)
5 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A  53
None
1.16A 3ut5B-1kugA:
undetectable
3ut5B-1kugA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT


(Propionibacterium
freudenreichii)
PF01039
(Carboxyl_trans)
5 CYH A 179
ALA A 183
ASN A 162
ALA A 173
ILE A 193
None
1.17A 3ut5B-1on9A:
2.8
3ut5B-1on9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis)
PF01421
(Reprolysin)
5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
None
1.13A 3ut5B-1wniA:
undetectable
3ut5B-1wniA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5n HARMONIN

(Homo sapiens)
PF00595
(PDZ)
5 CYH A  31
LEU A  29
LEU A  85
ILE A  45
ILE A  65
None
1.13A 3ut5B-1x5nA:
undetectable
3ut5B-1x5nA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE


(Saccharomyces
cerevisiae)
PF06026
(Rib_5-P_isom_A)
5 LEU A  34
ASN A  33
THR A 138
ILE A  44
ILE A  42
None
1.17A 3ut5B-1xtzA:
undetectable
3ut5B-1xtzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
5 LYS A 250
ASN A 251
THR A 352
ALA A 354
ILE A 356
ATP  A 504 (-3.4A)
ATP  A 504 ( 2.7A)
ATP  A 504 (-4.1A)
None
None
1.18A 3ut5B-1y8pA:
undetectable
3ut5B-1y8pA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuj HYPOTHETICAL PROTEIN
LLACC01001955


(Lactococcus
lactis)
no annotation 5 ALA A 147
LYS A 150
LEU A 151
LYS A  67
ILE A  38
None
1.10A 3ut5B-1zujA:
undetectable
3ut5B-1zujA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bu2 PYRUVATE
DEHYDROGENSAE KINASE
ISOENZYME 2


(Homo sapiens)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
5 LYS A 246
ASN A 247
THR A 346
ALA A 348
ILE A 350
ATP  A1386 ( 4.1A)
MG  A1388 ( 2.7A)
ATP  A1386 (-3.9A)
None
None
1.12A 3ut5B-2bu2A:
undetectable
3ut5B-2bu2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV


(Sus scrofa)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
None
1.06A 3ut5B-2bucA:
2.9
3ut5B-2bucA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fur HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum)
PF12900
(Pyridox_ox_2)
5 ALA A  26
LEU A  28
ASN A  31
ALA A 104
ILE A 106
None
1.03A 3ut5B-2furA:
undetectable
3ut5B-2furA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfh GENESIS

(Rattus
norvegicus)
PF00250
(Forkhead)
5 LEU A  55
ASN A  58
ALA A  15
ILE A  33
ILE A  29
None
1.12A 3ut5B-2hfhA:
undetectable
3ut5B-2hfhA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la4 NUCLEAR AND
CYTOPLASMIC
POLYADENYLATED
RNA-BINDING PROTEIN
PUB1


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
5 ALA A 395
THR A 341
ALA A 343
ILE A 345
ILE A 381
None
1.01A 3ut5B-2la4A:
undetectable
3ut5B-2la4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens)
PF00963
(Cohesin)
5 LEU A 134
LEU A  49
ASN A  48
ALA A 125
ILE A 160
None
1.18A 3ut5B-2o4eA:
undetectable
3ut5B-2o4eA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
5 LEU A 288
ALA A 189
LEU A 191
THR A 196
ILE A 232
None
None
None
NAP  A 402 (-3.3A)
NAP  A 402 ( 4.8A)
1.18A 3ut5B-2o7pA:
undetectable
3ut5B-2o7pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okq HYPOTHETICAL PROTEIN
YBAA


(Shigella
flexneri)
PF07237
(DUF1428)
5 ALA A  82
LYS A  85
MET A  92
ALA A  26
ILE A  38
None
0.99A 3ut5B-2okqA:
undetectable
3ut5B-2okqA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aquifex
aeolicus)
PF13561
(adh_short_C2)
5 LEU A 159
THR A  27
ALA A  36
ILE A 237
ILE A  39
None
1.00A 3ut5B-2p91A:
7.2
3ut5B-2p91A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT


(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 ALA M 197
LEU M 218
THR M 451
ALA M 263
ILE M 250
None
1.10A 3ut5B-2w4gM:
undetectable
3ut5B-2w4gM:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus)
PF05025
(RbsD_FucU)
5 LEU A  11
LEU A  19
MET A  22
ILE A  48
ILE A  28
None
1.18A 3ut5B-2wcuA:
undetectable
3ut5B-2wcuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli)
PF01979
(Amidohydro_1)
5 CYH A 285
LEU A 237
LEU A 265
LYS A   6
ILE A 302
None
1.13A 3ut5B-2z2bA:
undetectable
3ut5B-2z2bA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]


(Corynebacterium
glutamicum)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
5 LEU A 252
ALA A 269
LEU A 416
ALA A 414
ILE A 412
None
0.96A 3ut5B-2zciA:
undetectable
3ut5B-2zciA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN


(Campylobacter
jejuni)
PF02516
(STT3)
5 LEU A 491
ALA A 682
LEU A 562
LYS A 695
ILE A 560
None
MLY  A 493 ( 3.6A)
None
MLY  A 694 ( 3.3A)
None
1.12A 3ut5B-3aagA:
undetectable
3ut5B-3aagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Novosphingobium
aromaticivorans)
PF00903
(Glyoxalase)
5 ALA A 188
LEU A 147
ASN A 197
ILE A   9
ILE A  68
None
1.01A 3ut5B-3b59A:
undetectable
3ut5B-3b59A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ALA A1174
LYS A1177
LEU A1178
ASN A1181
ILE A1141
None
1.00A 3ut5B-3cmvA:
undetectable
3ut5B-3cmvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LEU A 178
ALA A 131
THR A  89
ALA A  91
ILE A  93
None
1.14A 3ut5B-3cmvA:
undetectable
3ut5B-3cmvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 LYS A1177
LEU A1178
ASN A1181
ILE A1128
ILE A1141
None
1.06A 3ut5B-3cmvA:
undetectable
3ut5B-3cmvA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
5 ALA A   5
LEU A 254
MET A 250
ILE A 157
ILE A 188
None
1.11A 3ut5B-3ewmA:
6.1
3ut5B-3ewmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Moraxella sp.)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ALA A 131
LEU A 103
THR A 119
ALA A 117
ILE A  93
None
1.15A 3ut5B-3fn4A:
undetectable
3ut5B-3fn4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus)
PF00724
(Oxidored_FMN)
5 ALA A  97
LYS A  17
LEU A  16
ASN A  18
ILE A  57
None
1.18A 3ut5B-3gr8A:
undetectable
3ut5B-3gr8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG


(Helicobacter
pylori)
PF00072
(Response_reg)
5 LEU A  64
LYS A  40
LEU A  41
ASN A  44
ILE A  77
None
1.02A 3ut5B-3h1gA:
5.5
3ut5B-3h1gA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilr HEPARIN LYASE I

(Bacteroides
thetaiotaomicron)
PF14099
(Polysacc_lyase)
5 LEU A 317
THR A 277
ALA A 279
ILE A 334
ILE A 240
None
1.12A 3ut5B-3ilrA:
undetectable
3ut5B-3ilrA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN


(Paenarthrobacter
aurescens)
PF05960
(DUF885)
5 ALA A 111
LEU A 104
ASN A 105
ILE A 169
ILE A 165
None
1.03A 3ut5B-3iukA:
undetectable
3ut5B-3iukA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA


(Homo sapiens)
PF00194
(Carb_anhydrase)
5 LEU A 217
ASN A 108
ALA A 123
LYS A 122
ILE A 155
None
1.12A 3ut5B-3jxfA:
undetectable
3ut5B-3jxfA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knw PUTATIVE
TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)


(Acinetobacter
sp. ADP1)
PF00440
(TetR_N)
PF16925
(TetR_C_13)
5 ALA A  84
LYS A  87
LEU A  88
ALA A 163
ILE A 166
None
1.17A 3ut5B-3knwA:
undetectable
3ut5B-3knwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxr IPGB2

(Shigella
flexneri)
PF03278
(IpaB_EvcA)
5 LYS F 172
LEU F 173
ASN F 176
MET F 177
ILE F 108
None
0.97A 3ut5B-3lxrF:
undetectable
3ut5B-3lxrF:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE


(Methylobacillus
flagellatus)
PF00117
(GATase)
5 ALA A 229
LEU A 128
ALA A 163
ILE A 171
ILE A 153
None
1.13A 3ut5B-3m3pA:
undetectable
3ut5B-3m3pA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Toxoplasma
gondii)
PF01048
(PNP_UDP_1)
5 CYH A 243
LEU A 246
LEU A 143
ALA A  94
ILE A  25
None
1.10A 3ut5B-3mb8A:
undetectable
3ut5B-3mb8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Allochromatium
vinosum)
PF00374
(NiFeSe_Hases)
5 LEU B1536
ALA B1021
ILE B1019
LYS B1003
ILE B1028
None
1.18A 3ut5B-3myrB:
undetectable
3ut5B-3myrB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY


(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
None
1.14A 3ut5B-3oc4A:
undetectable
3ut5B-3oc4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis)
PF01177
(Asp_Glu_race)
5 LEU A 216
ASN A 219
ALA A  69
ILE A  71
ILE A   7
None
1.01A 3ut5B-3outA:
undetectable
3ut5B-3outA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis)
PF13354
(Beta-lactamase2)
5 ALA A 118
ALA A 103
ILE A  88
LYS A 104
ILE A  93
None
1.03A 3ut5B-3p09A:
undetectable
3ut5B-3p09A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE


(Escherichia
coli)
PF00501
(AMP-binding)
5 LYS A 119
LEU A 120
ALA A  78
ILE A  80
ILE A 132
None
0.91A 3ut5B-3pbkA:
2.1
3ut5B-3pbkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN


(Salmonella
enterica)
PF00291
(PALP)
5 LEU B 271
ALA B 284
THR B 199
ALA B 191
ILE B 238
None
1.09A 3ut5B-3pr2B:
undetectable
3ut5B-3pr2B:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica)
PF13561
(adh_short_C2)
5 ALA A  68
THR A 184
ALA A 133
ILE A 131
ILE A 182
None
NAD  A 300 ( 4.4A)
None
None
None
1.18A 3ut5B-3r3sA:
6.8
3ut5B-3r3sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
5 LEU A 300
LYS A 383
LEU A 349
ASN A 348
ILE A 277
None
1.16A 3ut5B-3rr5A:
undetectable
3ut5B-3rr5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE


(Vibrio cholerae)
PF00579
(tRNA-synt_1b)
5 ALA A 226
ASN A 208
MET A 199
ILE A 219
ILE A  18
None
1.05A 3ut5B-3sz3A:
undetectable
3ut5B-3sz3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Listeria
monocytogenes)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
5 ALA A  99
LEU A 101
ALA A 105
ILE A  93
LYS A 106
None
1.17A 3ut5B-3tx1A:
undetectable
3ut5B-3tx1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 LEU A  22
MET A   0
ALA A 237
ILE A 136
ILE A  84
None
1.06A 3ut5B-3v2hA:
7.3
3ut5B-3v2hA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L


(Escherichia
coli)
PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM)
5 LEU A  43
LEU A  20
THR A   8
ALA A   6
ILE A  57
None
1.15A 3ut5B-3v8vA:
3.7
3ut5B-3v8vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aliivibrio
fischeri)
PF00275
(EPSP_synthase)
5 ALA A 174
LEU A 183
MET A 159
ALA A 166
ILE A 168
None
None
None
UD1  A 501 ( 4.7A)
None
1.11A 3ut5B-3vcyA:
undetectable
3ut5B-3vcyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF00106
(adh_short)
5 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
None
1.00A 3ut5B-3wtcA:
6.8
3ut5B-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens)
PF03372
(Exo_endo_phos)
5 ALA A  47
LYS A  50
LEU A  51
ASN A  54
ILE A   8
None
1.14A 3ut5B-4awnA:
undetectable
3ut5B-4awnA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwr PROTEIN
CORRESPONDING TO
LOCUS C5321 FROM
CFT073 E.COLI STRAIN


(Escherichia
coli)
PF08238
(Sel1)
5 LEU A  84
ALA A  82
LEU A  94
ASN A  93
ILE A  77
None
1.17A 3ut5B-4bwrA:
undetectable
3ut5B-4bwrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4erd TELOMERASE
ASSOCIATED PROTEIN
P65


(Tetrahymena
thermophila)
PF08777
(RRM_3)
5 LYS A 486
LEU A 487
THR A 501
ILE A 383
ILE A 381
None
1.18A 3ut5B-4erdA:
undetectable
3ut5B-4erdA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE


(Bacteroides
thetaiotaomicron)
PF14488
(DUF4434)
PF17134
(DUF5109)
5 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
None
1.15A 3ut5B-4h41A:
3.6
3ut5B-4h41A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans)
PF11701
(UNC45-central)
5 LEU A 753
LEU A 799
THR A 812
ILE A 770
ILE A 776
None
1.09A 3ut5B-4i2wA:
undetectable
3ut5B-4i2wA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE


(Protobothrops
mucrosquamatus)
PF01421
(Reprolysin)
5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
None
1.16A 3ut5B-4j4mA:
undetectable
3ut5B-4j4mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Flavobacterium
johnsoniae)
PF01884
(PcrB)
5 ALA A  96
LEU A  98
ILE A  13
LYS A 175
ILE A 206
None
1.13A 3ut5B-4jejA:
undetectable
3ut5B-4jejA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI


(Escherichia
coli)
PF13561
(adh_short_C2)
5 LEU A 144
THR A  12
ALA A  21
ILE A 222
ILE A  24
NAD  A 302 (-3.9A)
None
None
None
None
0.95A 3ut5B-4jx8A:
6.7
3ut5B-4jx8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1n SUPERANTIGEN-LIKE
PROTEIN


(Staphylococcus
aureus)
PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB)
5 LEU A 142
ASN A 195
MET A 166
ILE A 133
ILE A 189
None
1.12A 3ut5B-4o1nA:
undetectable
3ut5B-4o1nA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1e TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Escherichia
fergusonii)
PF03480
(DctP)
5 LEU A 248
LEU A  30
ASN A  31
ILE A 242
ILE A 241
None
1.13A 3ut5B-4p1eA:
undetectable
3ut5B-4p1eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus)
PF00493
(MCM)
5 LEU A 325
ALA A 801
LEU A 761
MET A 764
ILE A 772
None
1.13A 3ut5B-4r7zA:
undetectable
3ut5B-4r7zA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]


(Staphylococcus
aureus)
PF01380
(SIS)
5 LYS A 435
THR A 404
ALA A 408
ILE A 412
ILE A 267
None
1.09A 3ut5B-4s1wA:
5.5
3ut5B-4s1wA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 LEU A  84
LEU A  56
ASN A  55
ILE A  68
ILE A  41
None
1.14A 3ut5B-4u08A:
undetectable
3ut5B-4u08A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2


(Neisseria
gonorrhoeae)
PF00905
(Transpeptidase)
5 LEU A 431
THR A 534
ALA A 532
ILE A 530
ILE A 519
None
0.87A 3ut5B-4u3tA:
undetectable
3ut5B-4u3tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)


(Candidatus
Korarchaeum
cryptofilum)
PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig)
5 ALA A 451
LEU A 447
MET A 444
THR A 378
ALA A 376
None
1.10A 3ut5B-4xz3A:
undetectable
3ut5B-4xz3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zng PROLIDASE

(Lactococcus
lactis)
no annotation 5 LEU C 133
ASN C 312
ALA C 270
ILE C 316
ILE C 308
None
1.15A 3ut5B-4zngC:
undetectable
3ut5B-4zngC:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
5 CYH A 205
LEU A 204
ALA A 202
MET A 254
ILE A 250
None
1.18A 3ut5B-5ao0A:
undetectable
3ut5B-5ao0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 LEU A 266
LEU A 146
ASN A  94
ILE A  86
ILE A 148
None
1.06A 3ut5B-5c2zA:
undetectable
3ut5B-5c2zA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2


(Human
immunodeficiency
virus 2)
PF00516
(GP120)
6 ALA G 282
LYS G 303
LEU G 301
ASN G 302
ILE G 298
ILE G 466
None
None
None
NAG  G 610 (-3.3A)
None
None
1.44A 3ut5B-5cayG:
undetectable
3ut5B-5cayG:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus)
PF05505
(Ebola_NP)
5 CYH A 136
LEU A 133
LEU A  56
ILE A 182
ILE A  42
None
0.93A 3ut5B-5f5oA:
undetectable
3ut5B-5f5oA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG


(Caenorhabditis
elegans)
PF03159
(XRN_N)
5 LEU A 196
ALA A 101
ASN A  56
ILE A  85
ILE A  81
None
None
SO4  A1788 (-4.7A)
None
None
1.17A 3ut5B-5firA:
undetectable
3ut5B-5firA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE


(Magnaporthe
oryzae)
PF00305
(Lipoxygenase)
5 LEU A 594
LEU A 538
MET A 541
ALA A 462
ILE A 402
None
1.14A 3ut5B-5fnoA:
undetectable
3ut5B-5fnoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL


(Homo sapiens)
PF00180
(Iso_dh)
5 LEU A  93
LYS A  65
ASN A  64
ILE A  53
ILE A  10
None
1.17A 3ut5B-5griA:
undetectable
3ut5B-5griA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385)
5 ALA A1990
LEU A1995
ASN A1997
MET A1998
ILE A1943
None
1.12A 3ut5B-5h64A:
undetectable
3ut5B-5h64A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 CYH A 529
LEU A 530
LEU A 179
ASN A 180
ILE A 210
None
1.16A 3ut5B-5i2gA:
2.0
3ut5B-5i2gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE GAMMA
CHAIN


(Caldalkalibacillus
thermarum)
PF00231
(ATP-synt)
5 LEU G 189
MET G  67
ALA G 222
ILE G 226
ILE G 157
None
1.12A 3ut5B-5ik2G:
undetectable
3ut5B-5ik2G:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Homo sapiens)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU A1216
LEU A1166
MET A1296
ILE A1259
ILE A1235
None
1.13A 3ut5B-5iy9A:
undetectable
3ut5B-5iy9A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA


(Escherichia
coli)
PF01335
(DED)
PF13416
(SBP_bac_8)
5 LEU A 151
LEU A 134
THR A 257
ILE A 144
LYS A 139
None
1.11A 3ut5B-5jqeA:
undetectable
3ut5B-5jqeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron)
PF13402
(Peptidase_M60)
PF17291
(M60-like_N)
5 LYS A 844
LEU A 845
ALA A 794
ILE A 792
ILE A 803
None
1.08A 3ut5B-5kd5A:
undetectable
3ut5B-5kd5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK


(Gluconacetobacter
diazotrophicus)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
5 LEU B 457
LYS B 488
LEU B 485
ILE B 364
ILE B 378
None
1.15A 3ut5B-5kohB:
undetectable
3ut5B-5kohB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Vibrio
vulnificus)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 LEU A 318
LYS A 247
LEU A 183
ALA A 235
ILE A 233
None
1.11A 3ut5B-5ks1A:
3.9
3ut5B-5ks1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN


(Francisella
tularensis)
PF00291
(PALP)
5 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
None
1.16A 3ut5B-5kzmB:
undetectable
3ut5B-5kzmB:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe)
no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
None
1.09A 3ut5B-5mjsA:
53.6
3ut5B-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 6 ALA B 250
LYS B 254
ASN B 258
MET B 259
THR B 314
ILE B 378
None
0.84A 3ut5B-5n5nB:
54.4
3ut5B-5n5nB:
96.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
None
0.92A 3ut5B-5n5nB:
54.4
3ut5B-5n5nB:
96.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
None
1.02A 3ut5B-5n5nB:
54.4
3ut5B-5n5nB:
96.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0v IRON SULFUR CLUSTER
ASSEMBLY PROTEIN 1,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01491
(Frataxin_Cyay)
5 ALA a 150
LEU a  75
MET a  73
ALA a 143
ILE a 121
None
1.08A 3ut5B-5t0va:
undetectable
3ut5B-5t0va:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2)
PF03863
(Phage_mat-A)
5 CYH M 101
ALA M  98
LEU M  96
ALA M 349
ILE M 333
None
1.13A 3ut5B-5tc1M:
undetectable
3ut5B-5tc1M:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuq ECF RNA POLYMERASE
SIGMA FACTOR SIGW


(Bacillus
subtilis)
PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
5 ALA A 179
LYS A 182
LEU A 184
ILE A 134
ILE A 130
None
1.13A 3ut5B-5wuqA:
undetectable
3ut5B-5wuqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus)
PF05505
(Ebola_NP)
5 CYH A 120
LEU A 117
LEU A  40
ILE A 166
ILE A  26
None
0.93A 3ut5B-5xsqA:
undetectable
3ut5B-5xsqA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN


(Trichomonas
vaginalis)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
5 ALA C 198
LEU C 202
MET C 205
ALA C 118
ILE C 116
U  2   4 ( 4.3A)
None
None
None
None
1.13A 3ut5B-5xyiC:
undetectable
3ut5B-5xyiC:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1


(Escherichia
coli;
Homo sapiens)
no annotation 5 LEU A 139
LEU A 122
ASN A 124
ILE A 132
LYS A 127
None
1.12A 3ut5B-6apxA:
undetectable
3ut5B-6apxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT


(Homo sapiens)
no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
None
0.93A 3ut5B-6c9mA:
undetectable
3ut5B-6c9mA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
ASSOCIATED PROTEIN
P65


(Tetrahymena
thermophila)
no annotation 5 LYS H 486
LEU H 487
THR H 501
ILE H 383
ILE H 381
None
1.18A 3ut5B-6d6vH:
undetectable
3ut5B-6d6vH:
12.39