SIMILAR PATTERNS OF AMINO ACIDS FOR 3UR0_C_SVRC517_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		6 GLN A  66
GLU A 168
VAL A 170
LYS A 180
ARG A 182
ARG A 245
 None
 0.64A 3ur0C-1sh2A:
50.0		 3ur0C-1sh2A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 GLN A  66
VAL A 170
LYS A 174
LYS A 180
ARG A 245
 None
 1.02A 3ur0C-1sh2A:
50.0		 3ur0C-1sh2A:
57.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 LYS A  66
GLU A 169
LYS A 175
LYS A 180
ARG A 182
 None
 1.37A 3ur0C-2uutA:
39.1		 3ur0C-2uutA:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 GLN A  66
GLU A 168
LYS A 180
ARG A 245
ARG A 392
 None
None
None
None
2NG  A1101 (-3.7A)
 0.86A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		6 TRP A  42
GLN A  66
GLU A 168
VAL A 170
LYS A 180
ARG A 245
 None
 0.32A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		6 TRP A  42
GLN A  66
VAL A 170
LYS A 174
LYS A 180
ARG A 245
 None
 0.85A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00