SIMILAR PATTERNS OF AMINO ACIDS FOR 3UR0_C_SVRC516

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF01012
(ETF) 		5 PRO B   6
GLY B 120
ALA B 119
ALA B 130
LEU B 135
 AMP  A 400 (-4.3A)
AMP  A 400 (-3.5A)
AMP  A 400 (-3.3A)
AMP  A 400 (-4.4A)
None
 1.34A 3ur0C-1efpB:
0.0		 3ur0C-1efpB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		5 PRO A 333
GLY A 330
ALA A 326
ALA A 343
ASP A 341
 None
None
None
CL  A 413 (-3.0A)
None
 1.48A 3ur0C-1eu8A:
0.0		 3ur0C-1eu8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLY A  84
ALA A  86
ALA A  91
ARG A  90
LEU A 295
 None
 1.09A 3ur0C-1httA:
0.0		 3ur0C-1httA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5z C4-DICARBOXYLATE
TRANSPORT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DCTD

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		5 GLY A  50
ALA A  49
ALA A  46
ASP A  47
ARG A 130
 None
 1.21A 3ur0C-1l5zA:
0.0		 3ur0C-1l5zA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 GLY A 139
ALA A 138
ASP A 401
ARG A 402
LEU A 405
 None
 1.16A 3ur0C-1mb9A:
0.0		 3ur0C-1mb9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLY A 207
ALA A 250
ALA A 236
ARG A 253
LEU A 223
 None
 1.27A 3ur0C-1mhsA:
1.8		 3ur0C-1mhsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qez PROTEIN (INORGANIC
PYROPHOSPHATASE)

(Sulfolobus
acidocaldarius) 		PF00719
(Pyrophosphatase) 		5 PRO A1086
GLY A1088
ALA A1158
ALA A1100
ARG A1161
 None
 1.49A 3ur0C-1qezA:
undetectable		 3ur0C-1qezA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 PRO A 221
GLY A  44
ALA A 222
ASP A  47
ARG A 227
 None
None
None
None
FFO  A2887 (-3.6A)
 1.35A 3ur0C-1wopA:
0.0		 3ur0C-1wopA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 ALA A 126
ALA A  69
ASP A  71
ARG A 129
LEU A  72
 None
 1.38A 3ur0C-1wzzA:
0.0		 3ur0C-1wzzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 PRO A 100
GLY A  98
ALA A  97
ALA A  19
LEU A 247
 None
 1.38A 3ur0C-2gp6A:
undetectable		 3ur0C-2gp6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 241
ALA A 240
ALA A 235
ARG A 239
LEU A 181
 None
 1.21A 3ur0C-2h88A:
0.8		 3ur0C-2h88A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mna SINGLE-STRANDED DNA
BINDING PROTEIN
(SSB)

(Sulfolobus
solfataricus) 		PF01336
(tRNA_anti-codon) 		5 GLY A  88
ALA A  87
TRP A  56
ALA A  60
LEU A  53
 None
 1.17A 3ur0C-2mnaA:
undetectable		 3ur0C-2mnaA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 GLY A 412
ALA A 413
ALA A 511
ASP A 513
LEU A 471
 None
 1.14A 3ur0C-2qveA:
undetectable		 3ur0C-2qveA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmn TUMOR PROTEIN 63

(Homo sapiens) 		PF00870
(P53) 		5 PRO A 181
GLY A 183
ALA A 184
ARG A 187
LEU A 288
 None
 1.23A 3ur0C-2rmnA:
undetectable		 3ur0C-2rmnA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLY A 369
LYS A 305
ASP A 363
ARG A 312
LEU A 362
 None
 1.42A 3ur0C-2z1qA:
0.5		 3ur0C-2z1qA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		5 PRO A  62
GLY A  64
ALA A  65
ALA A  68
LEU A  73
 None
 1.35A 3ur0C-2z5lA:
undetectable		 3ur0C-2z5lA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 PRO A 534
GLY A 531
ALA A 532
ALA A 525
LEU A 580
 None
 1.48A 3ur0C-2z6hA:
1.5		 3ur0C-2z6hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		5 PRO A  70
GLY A 185
ALA A 184
ALA A 179
ASP A 180
 None
 1.39A 3ur0C-3bywA:
undetectable		 3ur0C-3bywA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 GLY A  31
ALA A  32
ALA A  36
ASP A  91
LEU A   3
 None
 1.38A 3ur0C-3hzuA:
undetectable		 3ur0C-3hzuA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY A 260
ALA A 259
ALA A  94
ASP A  92
LEU A  91
 None
 1.46A 3ur0C-3lxdA:
undetectable		 3ur0C-3lxdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myd FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Helicobacter
pylori) 		PF00771
(FHIPEP) 		5 PRO A 566
GLY A 568
ALA A 569
ASP A 604
LEU A 608
 None
 1.16A 3ur0C-3mydA:
undetectable		 3ur0C-3mydA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 GLY A 254
ALA A 256
ALA A 142
ASP A 117
LEU A 215
 None
 1.41A 3ur0C-3nk7A:
undetectable		 3ur0C-3nk7A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 PRO A 526
GLY A 497
ALA A 527
ALA A 413
ASP A 672
 None
 1.46A 3ur0C-3o8lA:
undetectable		 3ur0C-3o8lA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 PRO A 201
GLY A 221
ALA A 219
ALA A 405
LEU A 435
 None
 1.13A 3ur0C-3w3aA:
undetectable		 3ur0C-3w3aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 PRO A 201
GLY A 222
ALA A 219
ALA A 405
LEU A 435
 None
 1.11A 3ur0C-3w3aA:
undetectable		 3ur0C-3w3aA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 PRO A 233
GLY A 235
ALA A 236
ARG A 208
LEU A 204
 None
 1.47A 3ur0C-3whpA:
undetectable		 3ur0C-3whpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad8 DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 GLY A 479
ALA A 482
ALA A 475
ASP A 474
ARG A 452
 None
 1.13A 3ur0C-4ad8A:
undetectable		 3ur0C-4ad8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		5 GLY A 864
ALA A 863
ALA A 817
ASP A 818
LEU A 558
 None
 1.25A 3ur0C-4ammA:
undetectable		 3ur0C-4ammA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 PRO A 162
GLY A  38
ALA A  39
ALA A 276
LEU A  56
 None
 1.12A 3ur0C-4c1oA:
1.2		 3ur0C-4c1oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		5 PRO A 327
GLY A 329
ALA A 326
ALA A  73
LEU A  98
 None
None
FE  A1387 ( 3.9A)
None
None
 1.48A 3ur0C-4ci0A:
undetectable		 3ur0C-4ci0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ALA A 117
LYS A 119
ALA A 156
ASP A 155
ARG A 118
 None
 1.36A 3ur0C-4cxhA:
undetectable		 3ur0C-4cxhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacteroides
abscessus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 304
ALA A 305
ALA A  49
ASP A  50
ARG A  17
 None
 1.19A 3ur0C-4emdA:
undetectable		 3ur0C-4emdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963

(Streptomyces
coelicolor) 		no annotation 5 PRO B 234
ALA B  96
ALA B 203
ASP B 202
ARG B  97
 GOL  B 505 ( 4.8A)
None
None
None
None
 1.45A 3ur0C-4gt2B:
undetectable		 3ur0C-4gt2B:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 ALA A 441
ALA A 196
ASP A 197
ARG A 198
LEU A 200
 None
 1.41A 3ur0C-4impA:
undetectable		 3ur0C-4impA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		7 GLY A  40
ALA A  41
TRP A  42
ALA A 409
ASP A 412
ARG A 413
LEU A 416
 None
 0.52A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 PRO A  38
GLY A  40
ALA A  41
TRP A  42
ALA A 409
 None
 0.73A 3ur0C-4nruA:
57.1		 3ur0C-4nruA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		5 PRO A  65
GLY A 150
ALA A 149
ALA A 116
LEU A  69
 None
 1.38A 3ur0C-4p58A:
undetectable		 3ur0C-4p58A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psn SSDNA BINDING
PROTEIN

(Aeropyrum
pernix) 		PF10015
(DUF2258) 		5 GLY A  13
ALA A  12
ALA A  61
ASP A  65
LEU A  64
 None
 1.40A 3ur0C-4psnA:
undetectable		 3ur0C-4psnA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		5 GLY A  78
TRP A 458
ALA A 459
ASP A 460
ARG A 462
 None
 1.28A 3ur0C-4pucA:
0.5		 3ur0C-4pucA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		5 PRO A 194
ALA A 195
TRP A 169
ALA A 111
ASP A 110
 None
NAD  A 601 (-3.9A)
NAD  A 601 (-3.8A)
None
NA  A 609 (-3.6A)
 1.28A 3ur0C-4pxlA:
undetectable		 3ur0C-4pxlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz2 ZMALDH

(Zea mays) 		PF00171
(Aldedh) 		5 GLY A 227
ALA A 226
ALA A 104
ASP A 108
LEU A 109
 None
 1.19A 3ur0C-4pz2A:
undetectable		 3ur0C-4pz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 PRO A 536
GLY A 507
ALA A 537
ALA A 423
ASP A 682
 None
 1.48A 3ur0C-4u1rA:
undetectable		 3ur0C-4u1rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 PRO A 529
GLY A 232
ALA A 530
TRP A 234
LEU A 497
 None
 1.44A 3ur0C-4u33A:
undetectable		 3ur0C-4u33A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 PRO L 478
GLY L 480
ALA L 477
ALA L  91
LEU L 116
 NWN  L 601 (-3.7A)
None
NWN  L 601 (-3.4A)
None
None
 1.38A 3ur0C-4u9iL:
undetectable		 3ur0C-4u9iL:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgx FAD:PROTEIN FMN
TRANSFERASE

(Escherichia
coli) 		PF02424
(ApbE) 		5 PRO A 274
GLY A 232
ALA A 273
ALA A 281
LEU A 303
 NO3  A 406 (-3.3A)
None
NO3  A 406 (-4.4A)
None
None
 1.45A 3ur0C-4xgxA:
undetectable		 3ur0C-4xgxA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 PRO A 488
GLY A 491
ALA A 490
TRP A 494
ALA A 539
 None
 1.48A 3ur0C-4xwhA:
undetectable		 3ur0C-4xwhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 PRO A 488
GLY A 491
ALA A 490
TRP A 494
LEU A 550
 None
 1.46A 3ur0C-4xwhA:
undetectable		 3ur0C-4xwhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 PRO A 233
GLY A 235
ALA A 236
ARG A 208
LEU A 204
 None
 1.38A 3ur0C-5c8aA:
2.0		 3ur0C-5c8aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 PRO A 167
GLY A 206
ALA A 205
ARG A 229
LEU A 230
 None
AMP  A 303 (-4.3A)
None
None
None
 1.48A 3ur0C-5djiA:
undetectable		 3ur0C-5djiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLY A  86
ALA A  88
ALA A  93
ARG A  92
LEU A 297
 None
 1.15A 3ur0C-5e3iA:
undetectable		 3ur0C-5e3iA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 PRO A 160
GLY A 162
ALA A 163
ASP A 177
LEU A 166
 None
 1.45A 3ur0C-5f2oA:
undetectable		 3ur0C-5f2oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 GLY A  47
ALA A  46
ALA A  82
ASP A  44
LEU A  43
 None
 1.47A 3ur0C-5ffnA:
undetectable		 3ur0C-5ffnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		5 PRO A 234
ALA A  96
ALA A 203
ASP A 202
ARG A  97
 None
 1.48A 3ur0C-5mapA:
undetectable		 3ur0C-5mapA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		5 GLY A 273
TRP A 264
ALA A 254
ASP A 134
LEU A 133
 None
None
CL  A 402 ( 4.5A)
None
None
 1.38A 3ur0C-5swnA:
undetectable		 3ur0C-5swnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 PRO A  17
GLY A  11
ALA A  12
ARG A  40
LEU A  39
 None
FAD  A 402 (-3.2A)
FAD  A 402 (-4.9A)
FAD  A 402 (-3.0A)
None
 1.30A 3ur0C-5tukA:
undetectable		 3ur0C-5tukA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 GLY A 183
ALA A 185
ALA A 228
ASP A 222
LEU A 221
 SO4  A 401 (-3.5A)
None
None
None
None
 1.46A 3ur0C-5um2A:
undetectable		 3ur0C-5um2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 GLY A 184
ALA A 185
ALA A 228
ASP A 222
LEU A 221
 SO4  A 401 (-3.3A)
None
None
None
None
 1.39A 3ur0C-5um2A:
undetectable		 3ur0C-5um2A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 5 PRO A  16
GLY C 300
ALA C 299
ALA A 149
LEU A  33
 None
 1.33A 3ur0C-5wasA:
undetectable		 3ur0C-5wasA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 GLY A  95
ALA A  94
ALA A  68
ASP A  72
LEU A  73
 None
 1.15A 3ur0C-6byiA:
undetectable		 3ur0C-6byiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 5 PRO J 711
GLY J 713
ALA J 714
ARG J 684
LEU J 683
 None
 1.20A 3ur0C-6fhsJ:
undetectable		 3ur0C-6fhsJ:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 PRO A  14
GLY A  10
ALA A  13
ALA A   4
ASP A   3
 None
 1.42A 3ur0C-6fsaA:
undetectable		 3ur0C-6fsaA:
undetectable