SIMILAR PATTERNS OF AMINO ACIDS FOR 3UQ6_B_ADNB401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus)
PF00285
(Citrate_synt)
4 LEU A  77
GLY A  76
MET A 164
ASN A 160
None
1.18A 3uq6B-1aj8A:
undetectable
3uq6B-1aj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE


(Trypanosoma
cruzi)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A  18
GLY A  14
PHE A 123
ASN A  55
None
FAD  A 492 (-3.3A)
None
None
1.06A 3uq6B-1aogA:
5.1
3uq6B-1aogA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
4 LEU S 934
GLY S 931
MET S 824
ASN S 869
None
1.11A 3uq6B-1bkdS:
undetectable
3uq6B-1bkdS:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN


(Homo sapiens)
PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C)
4 LEU A 154
GLY A 152
MET A 100
PHE A  41
None
1.12A 3uq6B-1bp1A:
undetectable
3uq6B-1bp1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
4 LEU A 307
GLY A 309
PHE A 290
ASN A 364
None
1.32A 3uq6B-1br2A:
undetectable
3uq6B-1br2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs0 ATP SYNTHASE GAMMA
SUBUNIT


(Escherichia
coli)
PF00231
(ATP-synt)
4 LEU G 115
GLY G 131
PHE G  96
ASN G 127
None
1.24A 3uq6B-1fs0G:
undetectable
3uq6B-1fs0G:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9m DD-TRANSPEPTIDASE

(Streptomyces
sp. K15)
PF00768
(Peptidase_S11)
4 LEU A  92
GLY A  91
PHE A 170
ASN A 198
None
1.11A 3uq6B-1j9mA:
undetectable
3uq6B-1j9mA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q18 GLUCOKINASE

(Escherichia
coli)
PF02685
(Glucokinase)
4 LEU A 298
GLY A 262
MET A 241
PHE A 268
None
1.23A 3uq6B-1q18A:
undetectable
3uq6B-1q18A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))


(Sulfolobus
solfataricus)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
4 LEU A 281
GLY A 313
PHE A 228
ASN A 233
None
1.27A 3uq6B-1qdlA:
undetectable
3uq6B-1qdlA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
4 LEU A 510
GLY A 489
PHE A 235
ASN A 163
None
None
None
NAG  A 991 ( 4.6A)
1.26A 3uq6B-1qonA:
undetectable
3uq6B-1qonA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE


(Homo sapiens)
PF03414
(Glyco_transf_6)
4 LEU A 118
GLY A 117
MET A 142
PHE A 269
None
1.17A 3uq6B-1r82A:
undetectable
3uq6B-1r82A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl2 PROTEIN
(TACHYLECTIN-2)


(Tachypleus
tridentatus)
PF14517
(Tachylectin)
4 LEU A 109
GLY A 130
PHE A 137
ASN A 168
None
NDG  A 239 (-3.0A)
None
NDG  A 239 (-3.5A)
1.27A 3uq6B-1tl2A:
undetectable
3uq6B-1tl2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE


(Crithidia
fasciculata)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A  17
GLY A  13
PHE A 122
ASN A  54
SPD  A 496 (-4.6A)
FAD  A 493 (-3.2A)
None
None
1.08A 3uq6B-1typA:
5.2
3uq6B-1typA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli)
PF02541
(Ppx-GppA)
4 LEU A 441
GLY A 442
PHE A 471
ASN A 447
None
None
None
SO4  A 705 ( 3.9A)
1.32A 3uq6B-1u6zA:
undetectable
3uq6B-1u6zA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN


(Sulfurisphaera
tokodaii)
PF01950
(FBPase_3)
4 LEU A 248
GLY A 249
PHE A 311
ASN A 152
None
1.22A 3uq6B-1umgA:
undetectable
3uq6B-1umgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus)
PF00063
(Myosin_head)
4 LEU A 279
GLY A 280
PHE A 262
ASN A 337
None
1.17A 3uq6B-1w8jA:
undetectable
3uq6B-1w8jA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1


(Homo sapiens)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF)
4 LEU A 934
GLY A 931
MET A 824
ASN A 869
None
1.11A 3uq6B-1xdvA:
undetectable
3uq6B-1xdvA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF00497
(SBP_bac_3)
4 GLY A  44
MET A 107
PHE A 244
ASN A  89
None
0.90A 3uq6B-1xt8A:
undetectable
3uq6B-1xt8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE


(Corynebacterium
glutamicum)
PF03971
(IDH)
4 LEU A 567
GLY A 570
PHE A 574
ASN A 617
None
1.10A 3uq6B-2b0tA:
undetectable
3uq6B-2b0tA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjs ISOPENICILLIN N
SYNTHETASE


(Aspergillus
nidulans)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
4 LEU A 157
GLY A 159
MET A 257
PHE A 170
None
1.33A 3uq6B-2bjsA:
undetectable
3uq6B-2bjsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE


(Phanerochaete
chrysosporium)
no annotation 4 LEU A  52
GLY A  11
PHE A  18
ASN A   8
None
1.14A 3uq6B-2cl2A:
undetectable
3uq6B-2cl2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7


(Homo sapiens)
PF04857
(CAF1)
4 LEU A 259
GLY A 159
MET A  39
PHE A 189
None
1.22A 3uq6B-2d5rA:
undetectable
3uq6B-2d5rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae)
PF01843
(DIL)
4 LEU X 299
GLY X 302
PHE X 232
ASN X 258
None
1.06A 3uq6B-2f6hX:
undetectable
3uq6B-2f6hX:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE


(Streptomyces
exfoliatus)
PF13561
(adh_short_C2)
4 LEU A 165
GLY A 161
MET A 119
ASN A 136
None
1.27A 3uq6B-2hsdA:
6.1
3uq6B-2hsdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli)
PF00781
(DAGK_cat)
4 LEU A 223
GLY A 251
PHE A 226
ASN A 213
None
1.02A 3uq6B-2jgrA:
undetectable
3uq6B-2jgrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1


(Homo sapiens)
PF04683
(Proteasom_Rpn13)
PF16550
(RPN13_C)
4 LEU A 288
GLY A 341
MET A 297
PHE A 377
None
1.25A 3uq6B-2kr0A:
undetectable
3uq6B-2kr0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwh ANTI-HIV LECTIN OAA

(Planktothrix
agardhii)
no annotation 4 LEU A 114
GLY A 130
MET A 118
ASN A   8
None
0.89A 3uq6B-2mwhA:
undetectable
3uq6B-2mwhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzj TWO-COMPONENT
RESPONSE REGULATOR


(Clostridioides
difficile)
PF00072
(Response_reg)
4 LEU A  58
GLY A  12
MET A  81
ASN A  16
None
1.33A 3uq6B-2qzjA:
undetectable
3uq6B-2qzjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re3 UNCHARACTERIZED
PROTEIN


(Ruegeria
pomeroyi)
PF06938
(DUF1285)
4 LEU A 175
GLY A 166
MET A 185
PHE A 159
None
1.09A 3uq6B-2re3A:
undetectable
3uq6B-2re3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica)
PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3)
4 LEU A 333
GLY A 356
PHE A 347
ASN A 359
None
1.05A 3uq6B-2uvfA:
undetectable
3uq6B-2uvfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae)
PF00756
(Esterase)
4 GLY A 159
MET A 121
PHE A 168
ASN A  76
None
1.20A 3uq6B-2uz0A:
undetectable
3uq6B-2uz0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp9 SUCCINATE
DEHYDROGENASE
IRON-SULFUR SUBUNIT


(Escherichia
coli)
PF13085
(Fer2_3)
PF13534
(Fer4_17)
4 LEU B  97
GLY B  96
PHE B 110
ASN B  71
None
1.22A 3uq6B-2wp9B:
undetectable
3uq6B-2wp9B:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase)
4 LEU A 567
GLY A 591
MET A 516
PHE A 587
None
1.09A 3uq6B-2yn9A:
undetectable
3uq6B-2yn9A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN


(Thermus
thermophilus)
PF03480
(DctP)
4 GLY A  48
MET A 252
PHE A 217
ASN A  96
None
None
LAC  A 401 ( 4.6A)
None
1.30A 3uq6B-2zzwA:
undetectable
3uq6B-2zzwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON


(Staphylococcus
saprophyticus)
PF13377
(Peripla_BP_3)
4 LEU A  64
GLY A  95
PHE A  74
ASN A 125
None
None
GOL  A   1 ( 4.5A)
None
1.33A 3uq6B-3e61A:
undetectable
3uq6B-3e61A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewm UNCHARACTERIZED
SUGAR KINASE PH1459


(Pyrococcus
horikoshii)
PF00294
(PfkB)
4 LEU A  11
GLY A  34
PHE A 110
ASN A 162
None
1.23A 3uq6B-3ewmA:
30.3
3uq6B-3ewmA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1


(Thermus
thermophilus)
PF02074
(Peptidase_M32)
4 LEU A 275
GLY A 273
PHE A 223
ASN A 268
None
1.25A 3uq6B-3hoaA:
undetectable
3uq6B-3hoaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX


(Aspergillus
fumigatus)
PF02374
(ArsA_ATPase)
4 LEU A 259
GLY A 263
PHE A  30
ASN A 227
None
1.25A 3uq6B-3ibgA:
undetectable
3uq6B-3ibgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus)
PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
4 LEU A 307
GLY A 309
PHE A 290
ASN A 364
None
1.29A 3uq6B-3j04A:
undetectable
3uq6B-3j04A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1


(Danio rerio)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
4 LEU A 200
GLY A  65
PHE A 230
ASN A  77
None
1.11A 3uq6B-3jafA:
undetectable
3uq6B-3jafA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4


(Mus musculus)
no annotation 4 LEU K 293
GLY K 291
MET K 274
ASN K 268
None
1.33A 3uq6B-3jblK:
undetectable
3uq6B-3jblK:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
4 LEU A2201
GLY A2203
MET A2327
PHE A2358
None
1.24A 3uq6B-3jbzA:
undetectable
3uq6B-3jbzA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6i UNCHARACTERIZED
LIPOPROTEIN YCEB


(Escherichia
coli)
PF07273
(DUF1439)
4 LEU A  88
GLY A  69
MET A 108
PHE A  34
None
1.21A 3uq6B-3l6iA:
undetectable
3uq6B-3l6iA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE


(Anopheles
gambiae)
PF00294
(PfkB)
4 LEU A  16
GLY A  63
PHE A 168
ASN A 296
B4P  A 349 (-4.7A)
B4P  A 349 ( 3.8A)
B4P  A 349 (-3.4A)
B4P  A 349 (-3.6A)
0.59A 3uq6B-3looA:
46.6
3uq6B-3looA:
38.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE


(Desulfovibrio
vulgaris)
PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7)
4 LEU A 327
GLY A 325
PHE A 178
ASN A 409
None
GOL  A   1 ( 3.8A)
MES  A  14 (-4.1A)
None
1.26A 3uq6B-3m1uA:
undetectable
3uq6B-3m1uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE


(Desulfovibrio
vulgaris)
PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7)
4 LEU A 327
GLY A 326
PHE A 178
ASN A 409
None
None
MES  A  14 (-4.1A)
None
0.74A 3uq6B-3m1uA:
undetectable
3uq6B-3m1uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mix FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA


(Bacillus
subtilis)
PF00771
(FHIPEP)
4 LEU A 364
GLY A 362
PHE A 348
ASN A 359
None
1.22A 3uq6B-3mixA:
undetectable
3uq6B-3mixA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1


(Homo sapiens)
PF03493
(BK_channel_a)
4 LEU A 503
GLY A 502
PHE A 493
ASN A 509
None
1.32A 3uq6B-3nafA:
3.3
3uq6B-3nafA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix DIHYDROOROTATE
OXIDASE
PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE


(Streptococcus
mutans)
PF01180
(DHO_dh)
4 LEU A 101
GLY A  47
MET A 115
ASN A  79
None
MLY  A  45 ( 3.8A)
None
None
1.31A 3uq6B-3oixA:
undetectable
3uq6B-3oixA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani)
PF01083
(Cutinase)
4 LEU A  51
GLY A  52
PHE A 170
ASN A  58
None
1.14A 3uq6B-3qpcA:
4.2
3uq6B-3qpcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 161
GLY A 217
MET A 242
PHE A 249
None
1.31A 3uq6B-3qtpA:
undetectable
3uq6B-3qtpA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 324
GLY A 321
PHE A 299
ASN A 342
None
1.30A 3uq6B-3qtpA:
undetectable
3uq6B-3qtpA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
5 LEU A  16
GLY A  63
MET A 134
PHE A 169
ASN A 298
ADN  A 401 (-4.7A)
ADN  A 401 ( 3.8A)
ADN  A 401 ( 4.0A)
ADN  A 401 (-3.7A)
ADN  A 401 (-3.7A)
0.25A 3uq6B-3vasA:
58.8
3uq6B-3vasA:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vas PUTATIVE ADENOSINE
KINASE


(Schistosoma
mansoni)
PF00294
(PfkB)
4 LEU A  16
GLY A  64
MET A 134
ASN A 298
ADN  A 401 (-4.7A)
ADN  A 401 (-3.7A)
ADN  A 401 ( 4.0A)
ADN  A 401 (-3.7A)
1.13A 3uq6B-3vasA:
58.8
3uq6B-3vasA:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cqm CARBONYL REDUCTASE
FAMILY MEMBER 4


(Homo sapiens)
PF13561
(adh_short_C2)
4 LEU B 113
GLY B 110
PHE B  67
ASN B 132
None
1.17A 3uq6B-4cqmB:
6.2
3uq6B-4cqmB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)


(Clostridioides
difficile)
PF00112
(Peptidase_C1)
4 LEU A 315
GLY A 236
PHE A 306
ASN A 261
None
1.15A 3uq6B-4d59A:
undetectable
3uq6B-4d59A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Synechococcus
elongatus)
PF13561
(adh_short_C2)
4 LEU A 123
GLY A 120
PHE A  77
ASN A 142
None
1.31A 3uq6B-4dmmA:
7.0
3uq6B-4dmmA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Sinorhizobium
meliloti)
PF00106
(adh_short)
4 LEU A 126
GLY A 123
PHE A  79
ASN A 147
None
1.32A 3uq6B-4dryA:
5.9
3uq6B-4dryA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
4 LEU A 120
GLY A 117
PHE A  73
ASN A 142
None
1.27A 3uq6B-4e3zA:
6.8
3uq6B-4e3zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE


(Streptomyces
atroolivaceus)
no annotation 4 LEU A  34
GLY A  35
PHE A 227
ASN A 139
None
1.09A 3uq6B-4hzpA:
undetectable
3uq6B-4hzpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Polaromonas sp.
JS666)
no annotation 4 LEU C 118
GLY C 115
MET C  70
ASN C  32
None
None
None
NAP  C 304 (-3.6A)
1.21A 3uq6B-4iqgC:
2.9
3uq6B-4iqgC:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jig DEHYDROGENASE

(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
4 LEU A 123
GLY A 120
MET A  75
ASN A  37
None
1.16A 3uq6B-4jigA:
6.6
3uq6B-4jigA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 LEU A 319
GLY A 320
MET A 353
PHE A 384
None
1.23A 3uq6B-4k3yA:
undetectable
3uq6B-4k3yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE


(Aspergillus
fischeri)
PF11991
(Trp_DMAT)
4 LEU A  87
GLY A  88
PHE A 103
ASN A 142
None
1.15A 3uq6B-4ld7A:
undetectable
3uq6B-4ld7A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
4 LEU A1137
GLY A1138
PHE A1290
ASN A1132
None
1.03A 3uq6B-4ll8A:
undetectable
3uq6B-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozs ALPHA SOLENOID
PROTEIN


(synthetic
construct)
PF12854
(PPR_1)
PF13041
(PPR_2)
4 LEU A 152
GLY A 151
PHE A 130
ASN A 146
None
1.24A 3uq6B-4ozsA:
undetectable
3uq6B-4ozsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppr PENICILLIN-BINDING
PROTEIN DACB1


(Mycobacterium
tuberculosis)
PF00768
(Peptidase_S11)
4 LEU A 172
GLY A 171
PHE A 243
ASN A 267
None
1.07A 3uq6B-4pprA:
undetectable
3uq6B-4pprA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Streptococcus
pneumoniae)
PF01832
(Glucosaminidase)
4 LEU A 230
GLY A 231
PHE A 169
ASN A 203
None
0.95A 3uq6B-4q2wA:
undetectable
3uq6B-4q2wA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE


(Leishmania
major)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 LEU A 394
GLY A 403
MET A 379
PHE A 332
None
1.24A 3uq6B-4qg5A:
undetectable
3uq6B-4qg5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2


(Erythrobacter
litoralis)
PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2)
4 LEU A  20
GLY A 116
PHE A  18
ASN A  97
None
RBF  A 402 ( 3.8A)
None
RBF  A 402 (-4.0A)
1.25A 3uq6B-4r3aA:
undetectable
3uq6B-4r3aA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Mycobacterium
tuberculosis)
PF00768
(Peptidase_S11)
4 LEU A 120
GLY A 119
PHE A 193
ASN A 215
None
1.18A 3uq6B-4ryeA:
undetectable
3uq6B-4ryeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF13200
(DUF4015)
4 LEU A 287
GLY A 284
PHE A 240
ASN A 263
None
1.29A 3uq6B-4s1aA:
undetectable
3uq6B-4s1aA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE


(Shigella sonnei)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
4 LEU A 597
GLY A 598
PHE A 435
ASN A 573
None
1.14A 3uq6B-4umvA:
undetectable
3uq6B-4umvA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE


(Homo sapiens)
PF03414
(Glyco_transf_6)
4 LEU A 118
GLY A 117
MET A 142
PHE A 269
None
1.24A 3uq6B-4y63A:
undetectable
3uq6B-4y63A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 LEU A 530
GLY A 531
PHE A 552
ASN A 581
None
1.01A 3uq6B-4z64A:
undetectable
3uq6B-4z64A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH


(Synechocystis
sp. PCC 6803)
PF02514
(CobN-Mg_chel)
PF11965
(DUF3479)
4 LEU A 624
GLY A 469
PHE A 626
ASN A 657
None
1.21A 3uq6B-4zhjA:
2.8
3uq6B-4zhjA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 LEU A 150
GLY A 151
PHE A 157
ASN A 380
None
None
DGT  A 702 (-3.5A)
None
1.06A 3uq6B-4zweA:
undetectable
3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 LEU A 150
GLY A 152
PHE A 157
ASN A 380
None
None
DGT  A 702 (-3.5A)
None
1.29A 3uq6B-4zweA:
undetectable
3uq6B-4zweA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 LEU A 150
GLY A 151
PHE A 157
ASN A 380
None
None
None
DG3  A2001 (-3.2A)
1.01A 3uq6B-5ao0A:
undetectable
3uq6B-5ao0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1


(Homo sapiens)
PF01966
(HD)
4 LEU A 150
GLY A 152
PHE A 157
ASN A 380
None
None
None
DG3  A2001 (-3.2A)
1.24A 3uq6B-5ao0A:
undetectable
3uq6B-5ao0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON


(Schizosaccharomyces
pombe)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
4 LEU I 256
GLY I 250
MET I 155
PHE I 234
None
1.23A 3uq6B-5b04I:
2.3
3uq6B-5b04I:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans)
PF05879
(RHD3)
4 LEU A 269
GLY A 270
PHE A 262
ASN A  80
None
1.31A 3uq6B-5cb2A:
undetectable
3uq6B-5cb2A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
PF01740
(STAS)
4 LEU A 345
GLY A 343
MET A 359
ASN A 133
None
1.28A 3uq6B-5da0A:
undetectable
3uq6B-5da0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
4 LEU A 780
GLY A 783
MET A 802
ASN A 823
None
1.24A 3uq6B-5dllA:
undetectable
3uq6B-5dllA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16


(Homo sapiens)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
4 LEU A 381
GLY A 382
MET A 330
PHE A 304
None
1.30A 3uq6B-5e5bA:
undetectable
3uq6B-5e5bA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehd NUCLEOPHOSMIN

(Homo sapiens)
PF03066
(Nucleoplasmin)
4 LEU A  44
GLY A 113
PHE A  31
ASN A  16
None
1.16A 3uq6B-5ehdA:
undetectable
3uq6B-5ehdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 LEU A 466
GLY A 467
PHE A 488
ASN A 516
None
0.99A 3uq6B-5gr8A:
undetectable
3uq6B-5gr8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
4 LEU A 345
GLY A 343
MET A 359
ASN A 133
None
1.28A 3uq6B-5iofA:
undetectable
3uq6B-5iofA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwh ENDORIBONUCLEASE
HIGB


(Proteus
vulgaris)
PF05015
(HigB-like_toxin)
4 LEU A  12
GLY A  17
PHE A   5
ASN A  31
None
1.20A 3uq6B-5iwhA:
undetectable
3uq6B-5iwhA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP2
CAPSID PROTEIN VP3


(Rhinovirus C)
PF00073
(Rhv)
4 LEU C 183
GLY C 184
MET B  67
PHE C 176
None
1.31A 3uq6B-5k0uC:
undetectable
3uq6B-5k0uC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH


(Aspergillus
japonicus)
PF05721
(PhyH)
4 LEU A  99
GLY A  98
MET A 228
PHE A  38
None
1.16A 3uq6B-5m0tA:
undetectable
3uq6B-5m0tA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE


(Pyrococcus
furiosus)
PF00535
(Glycos_transf_2)
PF04138
(GtrA)
4 LEU A 242
GLY A 244
PHE A 338
ASN A 281
None
LDA  A 408 (-4.6A)
None
None
1.20A 3uq6B-5mlzA:
undetectable
3uq6B-5mlzA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE


(Bacteroides
thetaiotaomicron)
PF13088
(BNR_2)
4 LEU A1030
GLY A1029
PHE A1055
ASN A1044
None
1.10A 3uq6B-5mqsA:
undetectable
3uq6B-5mqsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
TAP TRANSPORTER
INHIBITOR ICP47


(Homo sapiens;
Human
alphaherpesvirus
1)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF05363
(Herpes_US12)
4 LEU A 422
GLY A 419
PHE A 339
ASN X  14
None
0.93A 3uq6B-5u1dA:
undetectable
3uq6B-5u1dA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE


(Leishmania
donovani)
PF00579
(tRNA-synt_1b)
4 LEU A 181
GLY A 182
PHE A  39
ASN A  56
YSA  A 701 (-3.6A)
YSA  A 701 (-3.3A)
YSA  A 701 (-4.6A)
None
1.22A 3uq6B-5usfA:
undetectable
3uq6B-5usfA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans)
PF00225
(Kinesin)
4 LEU A 326
GLY A 328
PHE A 419
ASN A 349
None
1.24A 3uq6B-5x3eA:
undetectable
3uq6B-5x3eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1

(Escherichia
virus N4)
no annotation 4 LEU A 124
GLY A 245
PHE A 229
ASN A 256
None
1.09A 3uq6B-6c2jA:
undetectable
3uq6B-6c2jA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2


(Saccharomyces
cerevisiae)
no annotation 4 LEU B 961
GLY B 964
PHE B1019
ASN B 754
None
1.24A 3uq6B-6f42B:
undetectable
3uq6B-6f42B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens)
no annotation 4 LEU B 145
GLY B 144
PHE B  90
ASN B 101
None
1.31A 3uq6B-6faeB:
undetectable
3uq6B-6faeB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)


(Homo sapiens)
no annotation 4 LEU A 883
GLY A 880
MET A 191
PHE A 941
None
1.03A 3uq6B-6fn1A:
undetectable
3uq6B-6fn1A:
12.57