SIMILAR PATTERNS OF AMINO ACIDS FOR 3UQ6_A_ADNA401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a59 | CITRATE SYNTHASE (AntarcticbacteriumDS2-3R) |
PF00285(Citrate_synt) | 4 | LEU A 340ALA A 343MET A 94PHE A 130 | None | 1.49A | 3uq6A-1a59A:undetectable | 3uq6A-1a59A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bsl | BACTERIAL LUCIFERASE (Vibrio harveyi) |
PF00296(Bac_luciferase) | 4 | LEU A 5ALA A 40MET A 24ASN A 9 | None | 1.47A | 3uq6A-1bslA:undetectable | 3uq6A-1bslA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6i | TRANSCRIPTIONALACTIVATOR GCN5 (Saccharomycescerevisiae) |
PF00439(Bromodomain) | 4 | LEU A 420ALA A 396PHE A 424ASN A 401 | None | 1.47A | 3uq6A-1e6iA:undetectable | 3uq6A-1e6iA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ef9 | METHYLMALONYL COADECARBOXYLASE (Escherichiacoli) |
PF00378(ECH_1) | 4 | LEU A 160ALA A 172MET A 116PHE A 129 | None | 1.23A | 3uq6A-1ef9A:undetectable | 3uq6A-1ef9A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1geg | ACETOIN REDUCTASE (Klebsiellapneumoniae) |
PF00106(adh_short) | 4 | LEU A 170ALA A 121PHE A 125ASN A 136 | None | 1.45A | 3uq6A-1gegA:6.6 | 3uq6A-1gegA:24.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js6 | DOPA DECARBOXYLASE (Sus scrofa) |
PF00282(Pyridoxal_deC) | 4 | LEU A 153ALA A 155PHE A 238ASN A 298 | None | 1.42A | 3uq6A-1js6A:undetectable | 3uq6A-1js6A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1msk | COBALAMIN-DEPENDENTMETHIONINE SYNTHASE (Escherichiacoli) |
PF02965(Met_synt_B12) | 4 | ALA A1090MET A 983PHE A 950ASN A1084 | None | 1.43A | 3uq6A-1mskA:undetectable | 3uq6A-1mskA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1npe | NIDOGEN (Mus musculus) |
PF00058(Ldl_recept_b) | 4 | LEU A1117ALA A1149MET A1154ASN A1132 | None | 1.38A | 3uq6A-1npeA:undetectable | 3uq6A-1npeA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o8u | 6-OXO CAMPHORHYDROLASE (Rhodococcuserythropolis) |
PF00378(ECH_1) | 4 | LEU A 164ALA A 184PHE A 140ASN A 191 | None | 0.97A | 3uq6A-1o8uA:undetectable | 3uq6A-1o8uA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oh9 | ACETYLGLUTAMATEKINASE (Escherichiacoli) |
PF00696(AA_kinase) | 4 | LEU A 142ALA A 92PHE A 24ASN A 85 | None | 1.24A | 3uq6A-1oh9A:undetectable | 3uq6A-1oh9A:23.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pq4 | PERIPLASMIC BINDINGPROTEIN COMPONENT OFAN ABC TYPE ZINCUPTAKE TRANSPORTER (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | LEU A 312ALA A 327PHE A 249ASN A 334 | None | 1.48A | 3uq6A-1pq4A:4.3 | 3uq6A-1pq4A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r30 | BIOTIN SYNTHASE (Escherichiacoli) |
PF04055(Radical_SAM)PF06968(BATS) | 4 | LEU A 291ALA A 263PHE A 285ASN A 153 | DTB A 502 ( 3.3A)DTB A 502 (-3.4A)DTB A 502 (-4.5A)DTB A 502 ( 3.7A) | 1.40A | 3uq6A-1r30A:2.2 | 3uq6A-1r30A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjy | SUGAR TRANSPORTPROTEIN (Salmonellaenterica) |
PF13407(Peripla_BP_4) | 4 | LEU A 225ALA A 227PHE A 158ASN A 195 | None | 1.47A | 3uq6A-1tjyA:4.7 | 3uq6A-1tjyA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ttx | ONCOMODULIN (Homo sapiens) |
PF13499(EF-hand_7) | 4 | LEU A 59ALA A 100PHE A 48ASN A 92 | None | 1.28A | 3uq6A-1ttxA:undetectable | 3uq6A-1ttxA:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyp | BETA-FRUCTOSIDASE (Thermotogamaritima) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | LEU A 60ALA A 63PHE A 31ASN A 112 | None | 1.45A | 3uq6A-1uypA:undetectable | 3uq6A-1uypA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vb3 | THREONINE SYNTHASE (Escherichiacoli) |
PF00291(PALP)PF14821(Thr_synth_N) | 4 | ALA A 18MET A 114PHE A 15ASN A 209 | None | 1.48A | 3uq6A-1vb3A:undetectable | 3uq6A-1vb3A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbj | PROSTAGLANDIN FSYNTHASE (Trypanosomabrucei) |
PF00248(Aldo_ket_red) | 4 | LEU A 7MET A 158PHE A 73ASN A 11 | None | 1.46A | 3uq6A-1vbjA:3.2 | 3uq6A-1vbjA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdk | FUMARATE HYDRATASECLASS II (Thermusthermophilus) |
PF00206(Lyase_1)PF10415(FumaraseC_C) | 4 | LEU A 66ALA A 56PHE A 242ASN A 108 | None | 1.44A | 3uq6A-1vdkA:undetectable | 3uq6A-1vdkA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vki | HYPOTHETICAL PROTEINATU3699 (Agrobacteriumfabrum) |
PF04073(tRNA_edit) | 4 | LEU A 138ALA A 111PHE A 154ASN A 51 | None | 1.46A | 3uq6A-1vkiA:undetectable | 3uq6A-1vkiA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 4 | LEU A 388ALA A 392MET A 171ASN A 143 | None | 1.36A | 3uq6A-1vpeA:5.8 | 3uq6A-1vpeA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zpv | ACT DOMAIN PROTEIN (Streptococcuspneumoniae) |
PF13740(ACT_6) | 4 | LEU A 28ALA A 3PHE A 56ASN A -2 | None | 1.43A | 3uq6A-1zpvA:undetectable | 3uq6A-1zpvA:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bjs | ISOPENICILLIN NSYNTHETASE (Aspergillusnidulans) |
PF03171(2OG-FeII_Oxy)PF14226(DIOX_N) | 4 | LEU A 157ALA A 161MET A 257PHE A 170 | None | 1.22A | 3uq6A-2bjsA:undetectable | 3uq6A-2bjsA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dj6 | HYPOTHETICAL PROTEINPH0634 (Pyrococcushorikoshii) |
PF01242(PTPS) | 4 | LEU A 63ALA A 13PHE A 31ASN A 69 | LEU A 63 ( 0.5A)ALA A 13 ( 0.0A)PHE A 31 ( 1.3A)ASN A 69 ( 0.6A) | 1.44A | 3uq6A-2dj6A:undetectable | 3uq6A-2dj6A:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fo1 | LIN-12 PROTEIN (Caenorhabditiselegans) |
PF00023(Ank)PF12796(Ank_2) | 4 | LEU E1131ALA E1136MET E1099ASN E1124 | None | 1.31A | 3uq6A-2fo1E:undetectable | 3uq6A-2fo1E:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hh9 | THIAMINPYROPHOSPHOKINASE (Candidaalbicans) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 4 | LEU A 54ALA A 199PHE A 228ASN A 141 | None | 1.27A | 3uq6A-2hh9A:undetectable | 3uq6A-2hh9A:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i80 | D-ALANINE-D-ALANINELIGASE (Staphylococcusaureus) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | LEU A 22ALA A 315PHE A 316ASN A 29 | None | 1.40A | 3uq6A-2i80A:undetectable | 3uq6A-2i80A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o2q | FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Rattusnorvegicus) |
PF00171(Aldedh) | 4 | LEU A 680ALA A 835PHE A 859ASN A 706 | NoneNoneNoneGOL A 1 (-3.3A) | 1.17A | 3uq6A-2o2qA:3.7 | 3uq6A-2o2qA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3e | NEUROLYSIN (Rattusnorvegicus) |
PF01432(Peptidase_M3) | 4 | LEU A 449ALA A 427PHE A 429ASN A 452 | None | 1.44A | 3uq6A-2o3eA:undetectable | 3uq6A-2o3eA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | LEU A 314ALA A 317MET A 308PHE A 343 | None | 1.28A | 3uq6A-2pq6A:5.8 | 3uq6A-2pq6A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy1 | PECTATE LYASE II (Xanthomonascampestris) |
PF00544(Pec_lyase_C) | 4 | LEU A 130ALA A 107PHE A 109ASN A 157 | None | 1.41A | 3uq6A-2qy1A:undetectable | 3uq6A-2qy1A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7y | RIBONUCLEASE H (Bacillushalodurans) |
no annotation | 4 | LEU A 117ALA A 165PHE A 110ASN A 170 | None | 1.24A | 3uq6A-2r7yA:undetectable | 3uq6A-2r7yA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjn | RESPONSE REGULATORRECEIVER:METAL-DEPENDENTPHOSPHOHYDROLASE, HDSUBDOMAIN (Neptuniibactercaesariensis) |
PF00072(Response_reg) | 4 | LEU A 41ALA A 43MET A 61PHE A 69 | None | 1.50A | 3uq6A-2rjnA:5.5 | 3uq6A-2rjnA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v5i | SALMONELLATYPHIMURIUM DB7155BACTERIOPHAGE DET7TAILSPIKE (unidentifiedphage) |
PF09251(PhageP22-tail) | 4 | LEU A 486ALA A 510PHE A 517ASN A 469 | None | 1.35A | 3uq6A-2v5iA:undetectable | 3uq6A-2v5iA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xu2 | UPF0271 PROTEINPA4511 (Pseudomonasaeruginosa) |
PF03746(LamB_YcsF) | 4 | LEU A 229MET A 148PHE A 174ASN A 38 | NoneNoneCIT A1249 (-3.9A)None | 1.42A | 3uq6A-2xu2A:2.4 | 3uq6A-2xu2A:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3k | LEUCYL/PHENYLALANYL-TRNA-PROTEINTRANSFERASE (Escherichiacoli) |
PF03588(Leu_Phe_trans) | 4 | LEU A 219ALA A 148PHE A 153ASN A 92 | None | 1.24A | 3uq6A-2z3kA:undetectable | 3uq6A-2z3kA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a28 | L-2.3-BUTANEDIOLDEHYDROGENASE (Corynebacteriumglutamicum) |
no annotation | 4 | LEU C 172ALA C 123PHE C 127ASN C 138 | None | 1.38A | 3uq6A-3a28C:6.6 | 3uq6A-3a28C:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1n | POU DOMAIN, CLASS 6,TRANSCRIPTION FACTOR1 (Homo sapiens) |
PF00046(Homeobox)PF00157(Pou) | 4 | LEU I 163ALA I 212MET I 172PHE I 226 | None | 1.33A | 3uq6A-3d1nI:undetectable | 3uq6A-3d1nI:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3esh | PROTEIN SIMILAR TOMETAL-DEPENDENTHYDROLASE (Staphylococcusaureus) |
PF00753(Lactamase_B) | 4 | LEU A 11ALA A 64PHE A 126ASN A 68 | None | 1.28A | 3uq6A-3eshA:undetectable | 3uq6A-3eshA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk9 | MUTATOR MUTT PROTEIN (Bacillushalodurans) |
PF00293(NUDIX) | 4 | LEU A 144ALA A 115MET A 66PHE A 142 | None | 1.33A | 3uq6A-3fk9A:undetectable | 3uq6A-3fk9A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcf | TERMINAL OXYGENASECOMPONENT OFCARBAZOLE1,9A-DIOXYGENASE (Nocardioidesaromaticivorans) |
PF00355(Rieske)PF11723(Aromatic_hydrox) | 4 | LEU A 55ALA A 27PHE A 31ASN A 176 | None | 1.28A | 3uq6A-3gcfA:undetectable | 3uq6A-3gcfA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3git | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT ALPHA (Moorellathermoacetica) |
PF03598(CdhC) | 4 | LEU A 587ALA A 603MET A 729PHE A 644 | None | 1.35A | 3uq6A-3gitA:undetectable | 3uq6A-3gitA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h09 | IMMUNOGLOBULIN A1PROTEASE (Haemophilusinfluenzae) |
PF02395(Peptidase_S6)PF03212(Pertactin) | 4 | LEU A 279ALA A 244MET A 74ASN A 43 | None | 1.50A | 3uq6A-3h09A:undetectable | 3uq6A-3h09A:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kwr | PUTATIVE RNA-BINDINGPROTEIN (Lactobacillusplantarum) |
no annotation | 4 | LEU A 53ALA A 31PHE A 25ASN A 47 | None | 1.08A | 3uq6A-3kwrA:undetectable | 3uq6A-3kwrA:15.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lfl | GLUTATHIONES-TRANSFERASEOMEGA-1 (Homo sapiens) |
PF13417(GST_N_3)PF14497(GST_C_3) | 4 | LEU A 56ALA A 235PHE A 224ASN A 231 | GSH A 241 (-3.7A)NoneNoneNone | 1.36A | 3uq6A-3lflA:undetectable | 3uq6A-3lflA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lo0 | INORGANICPYROPHOSPHATASE (Ehrlichiachaffeensis) |
PF00719(Pyrophosphatase) | 4 | LEU A 73ALA A 75PHE A 131ASN A 25 | None | 1.48A | 3uq6A-3lo0A:undetectable | 3uq6A-3lo0A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lst | CALO1METHYLTRANSFERASE (Micromonosporaechinospora) |
PF00891(Methyltransf_2) | 4 | LEU A 144ALA A 305PHE A 118ASN A 256 | None | 1.01A | 3uq6A-3lstA:undetectable | 3uq6A-3lstA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7n | PROBABLE EXOSOMECOMPLEX EXONUCLEASE1 (Archaeoglobusfulgidus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 4 | LEU D 173ALA D 163MET D 47ASN D 142 | None | 1.49A | 3uq6A-3m7nD:undetectable | 3uq6A-3m7nD:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qna | 6-CARBOXY-5,6,7,8-TETRAHYDROPTERINSYNTHASE (Escherichiacoli) |
PF01242(PTPS) | 4 | LEU A 68ALA A 13PHE A 34ASN A 74 | None | 1.23A | 3uq6A-3qnaA:undetectable | 3uq6A-3qnaA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0o | CARNITINYL-COADEHYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | LEU A 159ALA A 179PHE A 136ASN A 186 | None | 1.34A | 3uq6A-3r0oA:undetectable | 3uq6A-3r0oA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9s | CARNITINYL-COADEHYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | LEU A 153ALA A 173PHE A 130ASN A 180 | None | 1.35A | 3uq6A-3r9sA:2.8 | 3uq6A-3r9sA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk1 | TRANSKETOLASE (Burkholderiathailandensis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | LEU A 201MET A 53PHE A 80ASN A 84 | NoneNoneNoneOCS A 177 ( 4.2A) | 1.29A | 3uq6A-3uk1A:undetectable | 3uq6A-3uk1A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up9 | PUTATIVEUNCHARACTERIZEDPROTEIN (Actinomycesodontolyticus) |
PF03180(Lipoprotein_9) | 4 | LEU A 100ALA A 103MET A 300ASN A 149 | None | 1.25A | 3uq6A-3up9A:undetectable | 3uq6A-3up9A:21.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 5 | LEU A 16ALA A 65MET A 134PHE A 169ASN A 298 | ADN A 401 (-4.7A)ADN A 401 (-3.8A)ADN A 401 ( 4.0A)ADN A 401 (-3.7A)ADN A 401 (-3.7A) | 0.19A | 3uq6A-3vasA:62.7 | 3uq6A-3vasA:99.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvd | AMINO ACID ABCTRANSPORTER, BINDINGPROTEIN (Thermusthermophilus) |
PF00497(SBP_bac_3) | 4 | LEU A 205ALA A 196PHE A 91ASN A 68 | None | 0.95A | 3uq6A-3vvdA:undetectable | 3uq6A-3vvdA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w6x | MPR1 PROTEIN (Saccharomycescerevisiae) |
no annotation | 4 | LEU A 153ALA A 44MET A 228ASN A 159 | None | 1.44A | 3uq6A-3w6xA:undetectable | 3uq6A-3w6xA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2x | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE 2 (Homo sapiens) |
PF01233(NMT)PF02799(NMT_C) | 4 | ALA A 452MET A 435PHE A 467ASN A 424 | None | 1.44A | 3uq6A-4c2xA:undetectable | 3uq6A-4c2xA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 4 | LEU A 254ALA A 183MET A 100ASN A 205 | None | 1.33A | 3uq6A-4c9mA:undetectable | 3uq6A-4c9mA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 4 | LEU A 67ALA A 129MET A 141ASN A 124 | None | 1.12A | 3uq6A-4eziA:undetectable | 3uq6A-4eziA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jwv | SHORT CHAINENOYL-COA HYDRATASE (Novosphingobiumaromaticivorans) |
PF00378(ECH_1) | 4 | LEU A 150ALA A 170PHE A 127ASN A 177 | None | 1.11A | 3uq6A-4jwvA:undetectable | 3uq6A-4jwvA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mrp | ABC TRANSPORTERRELATED PROTEIN (Novosphingobiumaromaticivorans) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 4 | LEU A 311MET A 280PHE A 176ASN A 305 | None | 1.39A | 3uq6A-4mrpA:undetectable | 3uq6A-4mrpA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntm | 6-CARBOXY-5,6,7,8-TETRAHYDROPTERINSYNTHASE (Escherichiacoli) |
PF01242(PTPS) | 4 | LEU A 69ALA A 14PHE A 35ASN A 75 | None | 1.24A | 3uq6A-4ntmA:undetectable | 3uq6A-4ntmA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe6 | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00171(Aldedh) | 4 | LEU A 220ALA A 215PHE A 169ASN A 212 | None | 1.40A | 3uq6A-4oe6A:undetectable | 3uq6A-4oe6A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ww3 | RHODOPSIN (Todarodespacificus) |
PF00001(7tm_1) | 4 | LEU A 165ALA A 167PHE A 120ASN A 200 | NoneNoneRET A 401 (-4.0A)None | 1.42A | 3uq6A-4ww3A:undetectable | 3uq6A-4ww3A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeu | TRANSKETOLASE (Pseudomonasaeruginosa) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ALA A 151MET A 33PHE A 60ASN A 64 | None | 1.47A | 3uq6A-4xeuA:undetectable | 3uq6A-4xeuA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ycr | TELLURITE RESISTANCEPROTEIN TEHA HOMOLOG (Haemophilusinfluenzae) |
PF03595(SLAC1) | 4 | LEU A 298ALA A 259PHE A 260ASN A 254 | NoneBOG A 401 (-4.0A)NoneNone | 1.22A | 3uq6A-4ycrA:undetectable | 3uq6A-4ycrA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zgs | PUTATIVE D-LACTATEDEHYDROGENASE (Chlamydomonasreinhardtii) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | LEU A 331ALA A 145MET A 262ASN A 151 | None | 1.45A | 3uq6A-4zgsA:4.2 | 3uq6A-4zgsA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2r | ANGIOTENSIN-CONVERTING ENZYME (Drosophilamelanogaster) |
PF01401(Peptidase_M2) | 4 | LEU A 556ALA A 567PHE A 393ASN A 572 | None | 1.25A | 3uq6A-5a2rA:undetectable | 3uq6A-5a2rA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITGAMMAMETHYL-COENZYME MREDUCTASE II,SUBUNIT BETA (Methanothermobactermarburgensis) |
PF02240(MCR_gamma)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | LEU B 332ALA B 328MET C 109ASN B 317 | None | 1.42A | 3uq6A-5a8rB:undetectable | 3uq6A-5a8rB:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cs4 | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | LEU A1086ALA A1102MET A1264ASN A1223 | None | 1.49A | 3uq6A-5cs4A:undetectable | 3uq6A-5cs4A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6k | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | LEU A 492ALA A 440MET A 498PHE A 442 | None | 1.45A | 3uq6A-5e6kA:undetectable | 3uq6A-5e6kA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ei0 | SERPIN A12 (Homo sapiens) |
PF00079(Serpin) | 4 | LEU A 74ALA A 356PHE A 404ASN A 206 | None | 1.48A | 3uq6A-5ei0A:undetectable | 3uq6A-5ei0A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fif | CARBOXYLASE (Deinococcusradiodurans) |
PF01039(Carboxyl_trans) | 4 | LEU A 377ALA A 416PHE A 414ASN A 345 | None | 1.45A | 3uq6A-5fifA:3.0 | 3uq6A-5fifA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fis | EXD1 (Bombyx mori) |
PF01612(DNA_pol_A_exo1) | 4 | LEU B 135ALA B 105PHE B 102ASN B 110 | None | 1.40A | 3uq6A-5fisB:undetectable | 3uq6A-5fisB:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT CSL4 (Saccharomycescerevisiae) |
PF10447(EXOSC1) | 4 | LEU I 156ALA I 193PHE I 201ASN I 126 | None | 1.41A | 3uq6A-5g06I:undetectable | 3uq6A-5g06I:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g3z | ADENYLATE KINSE (syntheticconstruct) |
PF00406(ADK)PF05191(ADK_lid) | 4 | LEU A 107ALA A 93PHE A 185ASN A 98 | None | 1.48A | 3uq6A-5g3zA:2.2 | 3uq6A-5g3zA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdm | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE1, CHLOROPLASTIC (Arabidopsisthaliana) |
PF00202(Aminotran_3) | 4 | LEU A 44ALA A 20PHE A 17ASN A 29 | None | 1.42A | 3uq6A-5hdmA:undetectable | 3uq6A-5hdmA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6e | ACETYL-COACARBOXYLASE (Saccharomycescerevisiae) |
PF08326(ACC_central) | 4 | LEU A1086ALA A1102MET A1264ASN A1223 | None | 1.45A | 3uq6A-5i6eA:undetectable | 3uq6A-5i6eA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j78 | ACETALDEHYDEDEHYDROGENASE(ACETYLATING) (Parageobacillusthermoglucosidasius) |
PF00171(Aldedh) | 4 | LEU A 346ALA A 348PHE A 359ASN A 302 | None | 1.36A | 3uq6A-5j78A:undetectable | 3uq6A-5j78A:26.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lw6 | DDB_G0293866 (Dictyosteliumdiscoideum) |
no annotation | 4 | LEU A 51ALA A 46MET A 64PHE A 215 | None | 1.44A | 3uq6A-5lw6A:undetectable | 3uq6A-5lw6A:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg3 | PROTEIN TRANSLOCASESUBUNIT SECD (Escherichiacoli) |
PF02355(SecD_SecF)PF07549(Sec_GG)PF13721(SecD-TM1) | 4 | LEU D 483ALA D 520MET D 468ASN D 525 | None | 1.14A | 3uq6A-5mg3D:undetectable | 3uq6A-5mg3D:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1q | METHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT BETAMETHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT GAMMA (Methanothermococcusthermolithotrophicus) |
PF02240(MCR_gamma)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | LEU B 332ALA B 328MET C 109ASN B 317 | None | 1.35A | 3uq6A-5n1qB:undetectable | 3uq6A-5n1qB:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n28 | METHYL-COENZYME MREDUCTASE, BETASUBUNITMETHYL-COENZYME MREDUCTASE, GAMMASUBUNIT (Methanotorrisformicicus) |
PF02240(MCR_gamma)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | LEU B 333ALA B 329MET C 109ASN B 318 | None | 1.30A | 3uq6A-5n28B:undetectable | 3uq6A-5n28B:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ndf | POLYPEPTIDEN-ACETYLGALACTOSAMINYLTRANSFERASE 2 (Homo sapiens) |
no annotation | 4 | LEU A 278ALA A 384MET A 305ASN A 335 | NoneNoneNoneEDO A 604 ( 4.3A) | 1.39A | 3uq6A-5ndfA:undetectable | 3uq6A-5ndfA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vai | UNCHARACTERIZEDPROTEIN (Oryctolaguscuniculus) |
PF00002(7tm_2)PF02793(HRM) | 4 | LEU R 359ALA R 399PHE R 184ASN R 406 | None | 1.16A | 3uq6A-5vaiR:undetectable | 3uq6A-5vaiR:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbf | NAD-DEPENDENTSUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiavietnamiensis) |
PF00171(Aldedh) | 4 | LEU A 415ALA A 261MET A 446ASN A 440 | None | 1.24A | 3uq6A-5vbfA:undetectable | 3uq6A-5vbfA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wai | POLYCOMB PROTEINSUZ12 (Homo sapiens) |
no annotation | 4 | LEU B 87ALA B 89PHE B 90ASN B 435 | None | 1.25A | 3uq6A-5waiB:undetectable | 3uq6A-5waiB:11.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7r | IRON/ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ASQJ (Aspergillusnidulans) |
no annotation | 4 | LEU B 226ALA B 202PHE B 38ASN B 157 | NoneNoneNone58K B 403 ( 3.7A) | 1.37A | 3uq6A-5y7rB:undetectable | 3uq6A-5y7rB:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ys9 | ACYL-COENZYME AOXIDASE 3 (Yarrowialipolytica) |
no annotation | 4 | LEU A 233ALA A 212PHE A 129ASN A 275 | None | 1.27A | 3uq6A-5ys9A:undetectable | 3uq6A-5ys9A:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z0y | SERINEHYDROXYMETHYLTRANSFERASE (Komagataellaphaffii) |
no annotation | 4 | LEU A 93ALA A 95MET A 258PHE A 96 | None | 1.01A | 3uq6A-5z0yA:undetectable | 3uq6A-5z0yA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byi | BETA-MANNOSIDASE (Xanthomonascitri) |
no annotation | 4 | LEU A 166ALA A 68MET A 143ASN A 211 | None | 1.25A | 3uq6A-6byiA:undetectable | 3uq6A-6byiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c4m | YERSINOPINEDEHYDROGENASE (Yersinia pestis) |
no annotation | 4 | LEU C 147ALA C 232MET C 209ASN C 199 | None | 1.36A | 3uq6A-6c4mC:3.4 | 3uq6A-6c4mC:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 4 | LEU A 68ALA A 66PHE A 377ASN A 235 | None | 1.44A | 3uq6A-6c66A:undetectable | 3uq6A-6c66A:13.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cc4 | SOLUBLE CYTOCHROMEB562, LIPID IIFLIPPASE MURJCHIMERA (Escherichiacoli) |
no annotation | 4 | LEU A 91ALA A 94MET A 233PHE A 55 | None | 1.41A | 3uq6A-6cc4A:undetectable | 3uq6A-6cc4A:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccz | SERINEHYDROXYMETHYLTRANSFERASE (Medicagotruncatula) |
no annotation | 4 | LEU A 162ALA A 164MET A 327PHE A 165 | None | 1.05A | 3uq6A-6cczA:undetectable | 3uq6A-6cczA:13.91 |