SIMILAR PATTERNS OF AMINO ACIDS FOR 3UNI_B_SALB1345_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 LEU B 200
PHE B  13
VAL B  20
LEU B  21
 None
 0.77A 3uniB-1ccwB:
0.5		 3uniB-1ccwB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 LEU E1253
VAL E1243
LEU E1240
ALA E1233
 None
 0.92A 3uniB-1f51E:
undetectable		 3uniB-1f51E:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 177
VAL A 134
LEU A   8
ALA A 458
 None
 0.94A 3uniB-1i7qA:
0.0		 3uniB-1i7qA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.95A 3uniB-1idmA:
3.7		 3uniB-1idmA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A  78
VAL A  68
LEU A  64
ALA A   9
 None
 0.93A 3uniB-1iq0A:
0.0		 3uniB-1iq0A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 291
THR A 243
VAL A 242
ALA A 276
 None
 0.89A 3uniB-1iwaA:
0.0		 3uniB-1iwaA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		4 LEU C  28
THR C 140
LEU C  41
ALA C  55
 None
 0.84A 3uniB-1ixrC:
undetectable		 3uniB-1ixrC:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3m THE CONSERVED
HYPOTHETICAL PROTEIN
TT1751

(Thermus
thermophilus) 		PF03625
(DUF302) 		4 LEU A  82
THR A   7
LEU A 129
ALA A  10
 None
 0.81A 3uniB-1j3mA:
undetectable		 3uniB-1j3mA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 137
VAL A 199
LEU A 195
ALA A 175
 None
 0.89A 3uniB-1m3uA:
undetectable		 3uniB-1m3uA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0r 4 ANKYRIN REPEATS

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 LEU A  39
VAL A  83
LEU A  86
ALA A  92
 None
 0.82A 3uniB-1n0rA:
undetectable		 3uniB-1n0rA:
7.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.28A 3uniB-1n5xA:
46.7		 3uniB-1n5xA:
99.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6x PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF02244
(Propep_M14) 		4 LEU A  26
PHE A  39
VAL A  54
LEU A  13
 None
 0.90A 3uniB-1o6xA:
undetectable		 3uniB-1o6xA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 LEU A 241
VAL A 164
LEU A  53
ALA A 171
 None
 0.85A 3uniB-1q1rA:
undetectable		 3uniB-1q1rA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		4 LEU A  20
PHE A 181
VAL A 191
LEU A 174
 None
 0.89A 3uniB-1qyrA:
undetectable		 3uniB-1qyrA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 291
THR A 243
VAL A 242
ALA A 276
 None
 0.93A 3uniB-1rblA:
undetectable		 3uniB-1rblA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 284
THR A 236
VAL A 235
ALA A 269
 None
 0.94A 3uniB-1svdA:
undetectable		 3uniB-1svdA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 LEU A 145
PHE A 162
LEU A 129
ALA A 165
 None
 0.81A 3uniB-1td6A:
undetectable		 3uniB-1td6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		4 LEU A  85
VAL A  12
LEU A   6
ALA A  92
 None
XE  A1118 ( 3.9A)
None
None
 0.83A 3uniB-1uvyA:
undetectable		 3uniB-1uvyA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 LEU A  68
VAL A 102
LEU A 106
ALA A  28
 None
 0.89A 3uniB-1vfnA:
undetectable		 3uniB-1vfnA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 LEU A 223
ARG A 227
VAL A  29
LEU A  36
 None
 0.76A 3uniB-1xs5A:
undetectable		 3uniB-1xs5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		4 LEU A  51
THR A  96
VAL A  95
ALA A  40
 None
 0.91A 3uniB-2bv8A:
undetectable		 3uniB-2bv8A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 LEU A 819
VAL A 288
LEU A 578
ALA A 294
 None
FAD  A1001 (-4.9A)
None
None
 0.71A 3uniB-2dw4A:
2.5		 3uniB-2dw4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffj CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01937
(DUF89) 		4 LEU A 171
VAL A 155
LEU A 240
ALA A 243
 None
 0.91A 3uniB-2ffjA:
undetectable		 3uniB-2ffjA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		4 LEU A  59
PHE A  29
LEU A  93
ALA A  28
 None
 0.92A 3uniB-2hi0A:
undetectable		 3uniB-2hi0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.84A 3uniB-2iyfA:
undetectable		 3uniB-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lst THIOREDOXIN

(Thermus
thermophilus) 		PF13899
(Thioredoxin_7) 		4 LEU A  70
VAL A  83
LEU A  85
ALA A  58
 None
 0.93A 3uniB-2lstA:
2.2		 3uniB-2lstA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		4 LEU A  51
THR A  96
VAL A  95
ALA A  40
 None
 0.88A 3uniB-2uunA:
undetectable		 3uniB-2uunA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE

(Homo sapiens) 		PF00378
(ECH_1) 		4 LEU A 152
PHE A  88
VAL A  44
LEU A  32
 None
 0.84A 3uniB-2vreA:
undetectable		 3uniB-2vreA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 3uniB-2w55B:
56.6		 3uniB-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 409
VAL A 405
LEU A 277
ALA A 279
 None
None
None
DMS  A 999 ( 4.6A)
 0.94A 3uniB-2yneA:
undetectable		 3uniB-2yneA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv4 HYPOTHETICAL PROTEIN
PH0435

(Pyrococcus
horikoshii) 		PF03481
(SUA5) 		4 LEU A 329
VAL A 292
LEU A 285
ALA A 299
 None
 0.68A 3uniB-2yv4A:
2.7		 3uniB-2yv4A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 LEU A 681
VAL A 654
LEU A 651
ALA A 694
 None
 0.80A 3uniB-2zj8A:
undetectable		 3uniB-2zj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU A 193
THR A 150
VAL A 153
ALA A 226
 None
 0.87A 3uniB-3a6pA:
undetectable		 3uniB-3a6pA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.69A 3uniB-3c8fA:
undetectable		 3uniB-3c8fA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 GLU A  67
LEU A 159
VAL A  50
ALA A  78
 None
 0.90A 3uniB-3citA:
undetectable		 3uniB-3citA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl3 ORF K13

(Human
gammaherpesvirus
8) 		PF01335
(DED) 		4 LEU A   7
VAL A  22
LEU A  26
ALA A  41
 None
 0.83A 3uniB-3cl3A:
undetectable		 3uniB-3cl3A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		4 LEU A 260
VAL A 111
LEU A 113
ALA A 253
 None
 0.91A 3uniB-3fd9A:
2.3		 3uniB-3fd9A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 THR A  17
VAL A  18
LEU A  14
ALA A 343
 None
 0.95A 3uniB-3ffrA:
undetectable		 3uniB-3ffrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 LEU A 116
VAL A  77
LEU A  81
ALA A  88
 None
 0.75A 3uniB-3fmyA:
undetectable		 3uniB-3fmyA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 225
THR A 152
VAL A 153
ALA A  47
 None
 0.84A 3uniB-3gtdA:
undetectable		 3uniB-3gtdA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		4 LEU A  93
PHE A 109
VAL A 206
ALA A 209
 None
 0.89A 3uniB-3gzjA:
undetectable		 3uniB-3gzjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		4 LEU A 113
VAL A  95
LEU A 138
ALA A  98
 None
 0.92A 3uniB-3hj9A:
undetectable		 3uniB-3hj9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa) 		PF00182
(Glyco_hydro_19) 		4 LEU A 102
ARG A 100
VAL A  93
ALA A 312
 None
 0.83A 3uniB-3iwrA:
undetectable		 3uniB-3iwrA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H 170
THR H 168
VAL H 167
LEU H 191
 None
 0.94A 3uniB-3m8oH:
undetectable		 3uniB-3m8oH:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054

(Leptospirillum
rubarum) 		PF06335
(DUF1054) 		4 LEU A 143
PHE A 183
THR A 200
LEU A 204
 None
GOL  A 218 (-3.3A)
GOL  A 218 (-2.6A)
None
 0.70A 3uniB-3mqzA:
undetectable		 3uniB-3mqzA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		4 LEU A 128
VAL A  94
LEU A  66
ALA A 101
 None
 0.84A 3uniB-3o82A:
undetectable		 3uniB-3o82A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		4 LEU A1264
PHE A1155
VAL A1580
LEU A1584
 None
None
SAH  A1601 (-4.4A)
None
 0.84A 3uniB-3ptaA:
undetectable		 3uniB-3ptaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbn DNA MISMATCH REPAIR
PROTEIN MLH1

(Homo sapiens) 		PF16413
(Mlh1_C) 		4 LEU A 186
PHE A 216
VAL A 180
LEU A 107
 None
 0.88A 3uniB-3rbnA:
undetectable		 3uniB-3rbnA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  66
VAL A  98
LEU A  93
ALA A  62
 None
 0.82A 3uniB-3rg2A:
undetectable		 3uniB-3rg2A:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		8 GLU C 802
LEU C 873
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.24A 3uniB-3sr6C:
69.6		 3uniB-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU X1981
PHE X1955
VAL X2049
LEU X1941
 None
 0.85A 3uniB-3su8X:
3.1		 3uniB-3su8X:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 0.89A 3uniB-3sucA:
undetectable		 3uniB-3sucA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 338
THR A 350
VAL A 351
LEU A 348
 None
 0.81A 3uniB-3tqpA:
undetectable		 3uniB-3tqpA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v42 FOLLICULIN

(Homo sapiens) 		PF16692
(Folliculin_C) 		4 LEU A 349
PHE A 361
VAL A 368
LEU A 369
 None
 0.90A 3uniB-3v42A:
undetectable		 3uniB-3v42A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		4 LEU A 249
VAL A 198
LEU A 195
ALA A 180
 None
 0.91A 3uniB-3w53A:
undetectable		 3uniB-3w53A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a25 FERRITIN DPS FAMILY
PROTEIN

(Kineococcus
radiotolerans) 		PF00210
(Ferritin) 		4 LEU A 145
VAL A  33
LEU A  37
ALA A  78
 None
 0.87A 3uniB-4a25A:
undetectable		 3uniB-4a25A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcn ARFAPTIN-2

(Homo sapiens) 		PF06456
(Arfaptin) 		4 LEU C 286
THR C 224
VAL C 225
LEU C 222
 None
 0.67A 3uniB-4dcnC:
undetectable		 3uniB-4dcnC:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  35
LEU A  45
VAL A 354
LEU A 384
 None
 0.90A 3uniB-4dhgA:
undetectable		 3uniB-4dhgA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2o ALPHA-AMYLASE

(Geobacillus
thermoleovorans) 		PF00128
(Alpha-amylase) 		4 LEU A 122
THR A  74
VAL A  73
ALA A 129
 None
 0.88A 3uniB-4e2oA:
undetectable		 3uniB-4e2oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e72 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF11738
(DUF3298) 		4 LEU A 155
VAL A 239
LEU A 235
ALA A 166
 None
 0.91A 3uniB-4e72A:
undetectable		 3uniB-4e72A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLU A 310
LEU A 308
VAL A   9
ALA A 281
 None
 0.94A 3uniB-4ictA:
undetectable		 3uniB-4ictA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  81
VAL A  90
LEU A 117
ALA A 113
 None
 0.83A 3uniB-4koaA:
undetectable		 3uniB-4koaA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		4 LEU A 222
VAL A 237
LEU A 238
ALA A 100
 None
 0.92A 3uniB-4l4xA:
undetectable		 3uniB-4l4xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 LEU A 265
THR A 100
LEU A 105
ALA A 418
 None
 0.88A 3uniB-4m8jA:
undetectable		 3uniB-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 109
PHE A  11
THR A  34
VAL A  35
 None
 0.92A 3uniB-4mmoA:
undetectable		 3uniB-4mmoA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onu ACETYLTRANSFERASE
PAT

(Mycolicibacterium
smegmatis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 LEU A 256
PHE A 268
VAL A 263
ALA A 233
 None
 0.93A 3uniB-4onuA:
undetectable		 3uniB-4onuA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 LEU A 156
VAL A 168
LEU A 169
ALA A  97
 None
None
None
BRU  A 302 (-3.6A)
 0.95A 3uniB-4p5bA:
0.8		 3uniB-4p5bA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens) 		PF08242
(Methyltransf_12)
PF08659
(KR) 		4 LEU A1342
ARG A1405
VAL A1384
ALA A1334
 None
 0.94A 3uniB-4pivA:
undetectable		 3uniB-4pivA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 LEU A1213
VAL A1396
LEU A1400
ALA A1408
 None
 0.82A 3uniB-4xqkA:
undetectable		 3uniB-4xqkA:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		7 GLU A 802
LEU A 873
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.0A)
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.36A 3uniB-4yswA:
40.0		 3uniB-4yswA:
86.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 352
THR A 359
VAL A 358
LEU A 334
 None
 0.69A 3uniB-4z0cA:
undetectable		 3uniB-4z0cA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 546
ARG A 538
VAL A 484
LEU A 462
 None
CL  A 807 (-4.0A)
None
None
 0.90A 3uniB-4zlgA:
undetectable		 3uniB-4zlgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zva DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF11563
(Protoglobin) 		4 LEU A 115
VAL A  76
LEU A  77
ALA A  35
 None
 0.92A 3uniB-4zvaA:
undetectable		 3uniB-4zvaA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvb DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF11563
(Protoglobin) 		4 LEU A 115
VAL A  76
LEU A  77
ALA A  35
 None
 0.87A 3uniB-4zvbA:
undetectable		 3uniB-4zvbA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		4 LEU A  46
VAL A 138
LEU A 100
ALA A 145
 None
 0.90A 3uniB-5bmoA:
undetectable		 3uniB-5bmoA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 LEU B 149
THR B 543
VAL B 542
LEU B 132
 None
 0.64A 3uniB-5cyrB:
undetectable		 3uniB-5cyrB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eid ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 2

(Arabidopsis
thaliana) 		PF13637
(Ank_4) 		4 LEU A 288
VAL A 332
LEU A 335
ALA A 340
 None
 0.88A 3uniB-5eidA:
undetectable		 3uniB-5eidA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU B 688
PHE B 657
VAL B 598
ALA B 660
 None
 0.53A 3uniB-5gztB:
undetectable		 3uniB-5gztB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU B1174
PHE B1143
VAL B1085
ALA B1146
 None
 0.52A 3uniB-5gztB:
undetectable		 3uniB-5gztB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU A 688
PHE A 657
VAL A 598
ALA A 660
 None
 0.56A 3uniB-5gzuA:
undetectable		 3uniB-5gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU A1174
PHE A1143
VAL A1085
ALA A1146
 None
 0.51A 3uniB-5gzuA:
undetectable		 3uniB-5gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 231
PHE A 218
VAL A 240
LEU A 214
 None
 0.78A 3uniB-5ilqA:
undetectable		 3uniB-5ilqA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		4 LEU A 406
VAL A 450
LEU A 453
ALA A 459
 None
 0.76A 3uniB-5jhqA:
undetectable		 3uniB-5jhqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 LEU A 819
VAL A 288
LEU A 578
ALA A 294
 None
FAD  A 901 (-4.8A)
None
None
 0.71A 3uniB-5l3dA:
undetectable		 3uniB-5l3dA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000906: PREDICTED
PERMEASE
FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		4 LEU G 329
THR F  45
VAL F  48
LEU F  49
 None
 0.90A 3uniB-5l75G:
undetectable		 3uniB-5l75G:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lde IMMUNOGLOBULIN
G-BINDING PROTEIN
G,VIRAL FLICE
PROTEIN

(Human
gammaherpesvirus
8;
Streptococcus
sp. 'group G') 		PF01335
(DED)
PF01378
(IgG_binding_B) 		4 LEU A 107
VAL A 122
LEU A 126
ALA A 141
 None
 0.82A 3uniB-5ldeA:
undetectable		 3uniB-5ldeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 LEU A  15
VAL A   5
LEU A   8
ALA A  44
 None
 0.84A 3uniB-5lhvA:
undetectable		 3uniB-5lhvA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnt PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.1

(Arabidopsis
thaliana) 		PF01680
(SOR_SNZ) 		4 LEU A 124
VAL A 118
LEU A 110
ALA A  61
 None
 0.91A 3uniB-5lntA:
undetectable		 3uniB-5lntA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 GLU A 651
LEU A 341
VAL A 266
LEU A 333
 None
 0.70A 3uniB-5no8A:
undetectable		 3uniB-5no8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 LEU A 341
VAL A 266
LEU A 333
ALA A 313
 None
 0.94A 3uniB-5no8A:
undetectable		 3uniB-5no8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 LEU A 237
PHE A 218
VAL A 230
LEU A 214
 None
 0.86A 3uniB-5oenA:
undetectable		 3uniB-5oenA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 LEU A 198
VAL A 112
LEU A 146
ALA A 119
 None
 0.90A 3uniB-5tvtA:
undetectable		 3uniB-5tvtA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  88
PHE A  83
VAL A 189
ALA A  64
 None
 0.57A 3uniB-5u1oA:
undetectable		 3uniB-5u1oA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 GLU A1440
LEU A1290
VAL A1303
LEU A1304
 None
 0.91A 3uniB-5u89A:
undetectable		 3uniB-5u89A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5  91
THR 5  62
VAL 5  63
LEU 5 139
 None
 0.86A 3uniB-5udb5:
undetectable		 3uniB-5udb5:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  94
PHE A  89
VAL A 195
ALA A  70
 None
 0.80A 3uniB-5vdnA:
undetectable		 3uniB-5vdnA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yi4 DISRUPTED IN
SCHIZOPHRENIA 1
HOMOLOG,NUCLEAR
DISTRIBUTION PROTEIN
NUDE-LIKE 1

(Mus musculus) 		no annotation 4 LEU A  32
THR A  57
VAL A  58
LEU A  55
 None
 0.87A 3uniB-5yi4A:
undetectable		 3uniB-5yi4A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 GLU A1165
LEU A 666
THR A 678
ALA A 608
 None
 0.85A 3uniB-6co7A:
undetectable		 3uniB-6co7A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 LEU A 235
THR A 109
VAL A 110
LEU A 107
 None
 0.94A 3uniB-6d8wA:
undetectable		 3uniB-6d8wA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
1

(Eremothecium
gossypii) 		no annotation 4 LEU A  23
PHE A  46
VAL A 143
ALA A  42
 None
 0.90A 3uniB-6dexA:
undetectable		 3uniB-6dexA:
5.25