SIMILAR PATTERNS OF AMINO ACIDS FOR 3UNI_A_SALA1344

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 PHE A 106
THR A 117
LEU A 115
ALA A 109
 None
 0.96A 3uniA-1dy2A:
0.1		 3uniA-1dy2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 GLU B 266
THR B 273
VAL B 274
LEU B 271
 None
 1.02A 3uniA-1mhyB:
0.0		 3uniA-1mhyB:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		7 GLU A 802
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.29A 3uniA-1n5xA:
46.7		 3uniA-1n5xA:
99.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ARG A 171
VAL A  62
LEU A  66
ALA A 162
 None
 0.99A 3uniA-1oa1A:
0.0		 3uniA-1oa1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 0.98A 3uniA-1qwjA:
0.8		 3uniA-1qwjA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 GLU C 194
ARG C 176
VAL C 181
LEU C 182
 None
 1.02A 3uniA-1sxjC:
0.0		 3uniA-1sxjC:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		4 PHE A 168
VAL A 253
LEU A 160
ALA A 165
 None
 0.98A 3uniA-1t98A:
0.0		 3uniA-1t98A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 PHE A 642
VAL A 683
LEU A 690
ALA A 694
 None
 0.97A 3uniA-1u2lA:
0.0		 3uniA-1u2lA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 1.00A 3uniA-1ug3A:
1.1		 3uniA-1ug3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
VAL A 134
LEU A 129
ALA A 121
 None
 1.02A 3uniA-1us4A:
undetectable		 3uniA-1us4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE A  64
VAL A  57
LEU A  22
ALA A  63
 None
 1.02A 3uniA-1v6hA:
undetectable		 3uniA-1v6hA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 205
 None
 1.01A 3uniA-1v9pA:
undetectable		 3uniA-1v9pA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 1.00A 3uniA-1wytA:
undetectable		 3uniA-1wytA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL

(Homo sapiens) 		PF02817
(E3_binding)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.92A 3uniA-1zy8A:
undetectable		 3uniA-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.95A 3uniA-2d1gA:
undetectable		 3uniA-2d1gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 GLU A 246
VAL A  43
LEU A  21
ALA A 250
 None
 1.02A 3uniA-2dbyA:
undetectable		 3uniA-2dbyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.40A 3uniA-2iwgB:
undetectable		 3uniA-2iwgB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.88A 3uniA-2iyfA:
undetectable		 3uniA-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 THR A  40
VAL A  41
LEU A  38
ALA A  35
 None
 1.01A 3uniA-2n57A:
undetectable		 3uniA-2n57A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8t HYPOTHETICAL PROTEIN
PH0730

(Pyrococcus
horikoshii) 		PF14544
(DUF4443) 		4 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 1.01A 3uniA-2p8tA:
undetectable		 3uniA-2p8tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 1.00A 3uniA-2p8uA:
undetectable		 3uniA-2p8uA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 0.99A 3uniA-2q6uA:
undetectable		 3uniA-2q6uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1

(Homo sapiens) 		PF13238
(AAA_18) 		4 ARG A 129
PHE A 143
THR A  12
VAL A  11
 TIZ  A 302 ( 2.8A)
None
TIZ  A 302 ( 4.2A)
None
 1.00A 3uniA-2ql6A:
undetectable		 3uniA-2ql6A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 0.99A 3uniA-2qnrA:
undetectable		 3uniA-2qnrA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.01A 3uniA-2rgjA:
undetectable		 3uniA-2rgjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.39A 3uniA-2w55B:
51.7		 3uniA-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.34A 3uniA-2x8xX:
undetectable		 3uniA-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 0.98A 3uniA-3aizA:
undetectable		 3uniA-3aizA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF00551
(Formyl_trans_N) 		4 THR A 180
VAL A 181
LEU A 182
ALA A  21
 None
 0.91A 3uniA-3av3A:
undetectable		 3uniA-3av3A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 PHE A  81
THR A  63
VAL A  66
LEU A  71
 None
 1.00A 3uniA-3bujA:
undetectable		 3uniA-3bujA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.71A 3uniA-3c8fA:
undetectable		 3uniA-3c8fA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 1.01A 3uniA-3chlA:
undetectable		 3uniA-3chlA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  71
THR A  75
VAL A  76
LEU A  77
 None
 1.02A 3uniA-3ddmA:
undetectable		 3uniA-3ddmA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 140
THR A 138
VAL A 137
LEU A 150
 None
 0.98A 3uniA-3ecqA:
undetectable		 3uniA-3ecqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 GLU A 288
THR A  47
VAL A  48
LEU A  49
 None
 0.92A 3uniA-3ez1A:
undetectable		 3uniA-3ez1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 THR A  17
VAL A  18
LEU A  14
ALA A 343
 None
 0.95A 3uniA-3ffrA:
undetectable		 3uniA-3ffrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		4 PHE A 189
VAL A 152
LEU A 125
ALA A 149
 None
None
None
HG  A 800 (-2.4A)
 0.93A 3uniA-3gfhA:
undetectable		 3uniA-3gfhA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 1.02A 3uniA-3gq9A:
undetectable		 3uniA-3gq9A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		4 GLU A 633
VAL A 626
LEU A 599
ALA A 629
 None
 1.01A 3uniA-3grcA:
undetectable		 3uniA-3grcA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG C 185
THR C 164
LEU C 152
ALA C 162
 None
 1.01A 3uniA-3gzdC:
undetectable		 3uniA-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 GLU A  91
VAL A 340
LEU A 258
ALA A   5
 None
 1.00A 3uniA-3hxwA:
undetectable		 3uniA-3hxwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF1A

(Saccharomyces
cerevisiae) 		PF01201
(Ribosomal_S8e) 		4 GLU i  34
VAL i  92
LEU i  78
ALA i  36
 None
 0.87A 3uniA-3japi:
undetectable		 3uniA-3japi:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 ARG A 315
THR A  51
LEU A  42
ALA A 136
 LEU  A 400 (-2.7A)
LEU  A 400 ( 4.1A)
None
LEU  A 400 ( 4.3A)
 1.02A 3uniA-3lopA:
1.5		 3uniA-3lopA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H 170
THR H 168
VAL H 167
LEU H 191
 None
 0.91A 3uniA-3m8oH:
undetectable		 3uniA-3m8oH:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 THR A 374
VAL A 373
LEU A 313
ALA A 360
 None
 0.92A 3uniA-3memA:
undetectable		 3uniA-3memA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 ARG A 156
VAL A 209
LEU A 149
ALA A 153
 None
 0.98A 3uniA-3oqbA:
undetectable		 3uniA-3oqbA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		4 GLU A  80
VAL A 226
LEU A 185
ALA A 152
 None
CL  A 705 ( 4.0A)
None
None
 0.94A 3uniA-3oyzA:
undetectable		 3uniA-3oyzA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.96A 3uniA-3pblA:
undetectable		 3uniA-3pblA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.00A 3uniA-3pdsA:
undetectable		 3uniA-3pdsA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 THR A 189
VAL A 190
LEU A 191
ALA A  53
 None
 0.85A 3uniA-3qp9A:
undetectable		 3uniA-3qp9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  66
VAL A  98
LEU A  93
ALA A  62
 None
 0.80A 3uniA-3rg2A:
undetectable		 3uniA-3rg2A:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		7 GLU C 802
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 RMO  C1317 (-4.4A)
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.23A 3uniA-3sr6C:
61.3		 3uniA-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 0.88A 3uniA-3sucA:
undetectable		 3uniA-3sucA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t58 SULFHYDRYL OXIDASE 1

(Mus musculus) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 GLU A 115
THR A  56
VAL A  57
LEU A  58
 None
 0.97A 3uniA-3t58A:
undetectable		 3uniA-3t58A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 PHE A 699
VAL A 740
LEU A 747
ALA A 751
 None
 0.94A 3uniA-3ut2A:
undetectable		 3uniA-3ut2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.01A 3uniA-3v2yA:
undetectable		 3uniA-3v2yA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 164
THR B  17
VAL B  53
LEU B  13
ALA B  56
 None
 1.47A 3uniA-3zo0B:
undetectable		 3uniA-3zo0B:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 1.01A 3uniA-4a4zA:
undetectable		 3uniA-4a4zA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.80A 3uniA-4by6B:
undetectable		 3uniA-4by6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		4 THR B 276
VAL B 277
LEU B 213
ALA B 250
 None
 0.98A 3uniA-4c1nB:
undetectable		 3uniA-4c1nB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		4 PHE A 264
VAL A 189
LEU A 190
ALA A  47
 None
 0.99A 3uniA-4d2oA:
undetectable		 3uniA-4d2oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.83A 3uniA-4d3yA:
undetectable		 3uniA-4d3yA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		4 GLU A  56
VAL A 131
LEU A 129
ALA A 172
 None
 0.93A 3uniA-4hhqA:
undetectable		 3uniA-4hhqA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 GLU A 412
THR A 466
VAL A 467
LEU A 437
 None
 0.98A 3uniA-4jcmA:
undetectable		 3uniA-4jcmA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg9 LIPOPROTEIN

(Bacillus
anthracis) 		PF16167
(DUF4871) 		4 THR A 115
VAL A 114
LEU A  47
ALA A  41
 None
 1.01A 3uniA-4jg9A:
undetectable		 3uniA-4jg9A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		4 GLU A1049
VAL A1208
LEU A1179
ALA A1053
 None
None
None
ADP  A1301 (-3.9A)
 1.01A 3uniA-4jlvA:
undetectable		 3uniA-4jlvA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ons CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		4 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.89A 3uniA-4onsA:
2.0		 3uniA-4onsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.03A 3uniA-4r85A:
undetectable		 3uniA-4r85A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7l TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 ARG A 880
THR A1104
VAL A1105
LEU A 875
ALA A 877
 None
 1.42A 3uniA-4y7lA:
undetectable		 3uniA-4y7lA:
10.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 802
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.0A)
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.36A 3uniA-4yswA:
45.4		 3uniA-4yswA:
86.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 3uniA-4yxcA:
undetectable		 3uniA-4yxcA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ARG A 355
VAL A 330
LEU A 334
ALA A 359
 None
 0.94A 3uniA-4yyfA:
undetectable		 3uniA-4yyfA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk7 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE M  64
VAL M  57
LEU M  22
ALA M  63
 None
 1.00A 3uniA-4zk7M:
undetectable		 3uniA-4zk7M:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 3uniA-5bz6A:
undetectable		 3uniA-5bz6A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		4 GLU A 279
THR A  81
VAL A  82
LEU A  83
 PLP  A 401 ( 4.0A)
None
None
None
 1.00A 3uniA-5c3uA:
undetectable		 3uniA-5c3uA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		4 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.81A 3uniA-5c6uA:
undetectable		 3uniA-5c6uA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 ARG A 160
THR A 158
VAL A 157
LEU A 131
 None
 0.93A 3uniA-5ccxA:
undetectable		 3uniA-5ccxA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 0.99A 3uniA-5dsgA:
undetectable		 3uniA-5dsgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG B 176
THR B 174
VAL B 173
LEU B 197
 None
 0.94A 3uniA-5e8eB:
undetectable		 3uniA-5e8eB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 GLU A  28
THR A  62
VAL A  63
ALA A  38
 None
 0.84A 3uniA-5eo6A:
undetectable		 3uniA-5eo6A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.01A 3uniA-5et1A:
undetectable		 3uniA-5et1A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gli ENDOTHELIN RECEPTOR
SUBTYPE-B

(Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.01A 3uniA-5gliA:
undetectable		 3uniA-5gliA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.97A 3uniA-5i14A:
undetectable		 3uniA-5i14A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.03A 3uniA-5if3A:
undetectable		 3uniA-5if3A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 PHE A 664
VAL A 705
LEU A 712
ALA A 716
 None
 0.95A 3uniA-5kqiA:
2.1		 3uniA-5kqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR B 234
VAL B 235
LEU B 236
ALA B 275
 None
 1.03A 3uniA-5l3rB:
1.5		 3uniA-5l3rB:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 PHE A 392
VAL A 451
LEU A 455
ALA A 389
 None
 0.99A 3uniA-5mjuA:
undetectable		 3uniA-5mjuA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpg HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		PF00076
(RRM_1) 		5 ARG A  14
THR A  61
VAL A  60
LEU A  40
ALA A  63
 None
 1.28A 3uniA-5mpgA:
undetectable		 3uniA-5mpgA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ARG A 304
THR A 142
VAL A 141
LEU A 249
ALA A 272
 None
 1.49A 3uniA-5mscA:
undetectable		 3uniA-5mscA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		4 THR A 220
VAL A 221
LEU A 225
ALA A 212
 7P7  A4000 ( 4.1A)
None
None
7P7  A4000 ( 3.8A)
 1.01A 3uniA-5twxA:
2.1		 3uniA-5twxA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5  91
THR 5  62
VAL 5  63
LEU 5 139
 None
 0.87A 3uniA-5udb5:
undetectable		 3uniA-5udb5:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdd BCL-2-RELATED
OVARIAN KILLER
PROTEIN

(Gallus gallus) 		no annotation 4 PHE A 115
VAL A 158
LEU A 154
ALA A 111
 None
 0.83A 3uniA-5wddA:
undetectable		 3uniA-5wddA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 THR A 219
VAL A 131
LEU A 136
ALA A 216
 None
 0.96A 3uniA-5wypA:
undetectable		 3uniA-5wypA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US4

(Toxoplasma
gondii) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 GLU J  33
THR J 100
VAL J 101
LEU J 105
 None
 0.86A 3uniA-5xxuJ:
undetectable		 3uniA-5xxuJ:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 3uniA-5yqrA:
undetectable		 3uniA-5yqrA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 GLU A 259
THR A 237
VAL A 238
ALA A 263
 None
 0.99A 3uniA-6ap6A:
undetectable		 3uniA-6ap6A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 4 GLU A 286
THR A 468
VAL A 446
LEU A 445
 None
 1.03A 3uniA-6b5iA:
undetectable		 3uniA-6b5iA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 0.93A 3uniA-6eicC:
undetectable		 3uniA-6eicC:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B

(Homo sapiens) 		no annotation 4 THR A 650
VAL A 651
LEU A 748
ALA A 752
 None
 0.89A 3uniA-6ek6A:
undetectable		 3uniA-6ek6A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 3uniA-6fwhA:
3.0		 3uniA-6fwhA:
undetectable