SIMILAR PATTERNS OF AMINO ACIDS FOR 3UNC_B_SALB1338

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 LEU A  18
PHE A  45
VAL A  24
LEU A  37
ALA A  42
 None
 1.04A 3uncB-1dj2A:
0.0		 3uncB-1dj2A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		5 LEU A  17
PHE A  44
VAL A  23
LEU A  36
ALA A  41
 None
 1.03A 3uncB-1dj3A:
0.0		 3uncB-1dj3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehx SCAFFOLDIN PROTEIN

([Clostridium]
cellulolyticum) 		PF03442
(CBM_X2) 		5 GLU A  37
LEU A  68
THR A  84
VAL A  85
LEU A  60
 None
 1.42A 3uncB-1ehxA:
undetectable		 3uncB-1ehxA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		5 LEU A 366
PHE A  29
VAL A  89
LEU A  91
ALA A  31
 None
 1.47A 3uncB-1f6dA:
0.3		 3uncB-1f6dA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		5 GLU A 166
LEU A 169
SER A 162
VAL A 148
LEU A  76
 None
 1.48A 3uncB-1n4oA:
undetectable		 3uncB-1n4oA:
12.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		9 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.29A 3uncB-1n5xA:
46.8		 3uncB-1n5xA:
99.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.15A 3uncB-1n5xA:
46.8		 3uncB-1n5xA:
99.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2) 		5 LEU A 191
SER A 188
VAL A 178
LEU A 118
ALA A 122
 None
 1.49A 3uncB-1zcmA:
undetectable		 3uncB-1zcmA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 LEU A 386
THR A 324
VAL A 323
LEU A 339
ALA A 382
 None
 1.18A 3uncB-2eceA:
0.0		 3uncB-2eceA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 296
ARG A 305
PHE A 111
THR A  61
VAL A 271
 None
MLR  A2913 (-3.0A)
None
None
None
 1.31A 3uncB-2gh9A:
0.0		 3uncB-2gh9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.40A 3uncB-2iwgB:
undetectable		 3uncB-2iwgB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4m UPF0146 PROTEIN
MTH_1000

(Methanothermobacter
thermautotrophicus) 		PF03686
(UPF0146) 		5 LEU A  92
SER A  33
VAL A  60
LEU A  62
ALA A  26
 None
 1.30A 3uncB-2k4mA:
undetectable		 3uncB-2k4mA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 3uncB-2w55B:
47.0		 3uncB-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.36A 3uncB-2x8xX:
undetectable		 3uncB-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		5 LEU A 167
PHE A  81
THR A  63
VAL A  66
LEU A  71
 None
 1.11A 3uncB-3bujA:
1.4		 3uncB-3bujA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU B  39
ARG B  97
PHE B  41
THR B  48
LEU B  50
 None
FLC  B 292 (-2.8A)
None
FLC  B 292 (-4.1A)
None
 1.40A 3uncB-3d6nB:
undetectable		 3uncB-3d6nB:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		5 SER A  86
ARG A  82
THR A  91
VAL A  92
ALA A  72
 None
 1.42A 3uncB-3hj9A:
undetectable		 3uncB-3hj9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 435
SER A 433
PHE A1129
VAL A 844
LEU A 860
 None
 1.46A 3uncB-3ikmA:
0.6		 3uncB-3ikmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oee ATP SYNTHASE SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 LEU A 283
SER A 284
ARG A 281
LEU A 303
ALA A 277
 None
 1.41A 3uncB-3oeeA:
undetectable		 3uncB-3oeeA:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.22A 3uncB-3sr6C:
56.8		 3uncB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
 None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
 1.16A 3uncB-3sr6C:
56.8		 3uncB-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 234
PHE A 277
THR A 245
VAL A 247
LEU A 255
 None
 1.46A 3uncB-3tqiA:
1.2		 3uncB-3tqiA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo0 E3 UBIQUITIN-PROTEIN
LIGASE TRIM21

(Mus musculus) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 164
THR B  17
VAL B  53
LEU B  13
ALA B  56
 None
 1.46A 3uncB-3zo0B:
undetectable		 3uncB-3zo0B:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		5 LEU A 265
SER A 266
THR A 100
LEU A 105
ALA A 418
 None
 1.32A 3uncB-4m8jA:
undetectable		 3uncB-4m8jA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A  49
LEU A  13
VAL A 358
LEU A 359
ALA A 331
 None
 1.45A 3uncB-4mggA:
0.7		 3uncB-4mggA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 LEU A 187
SER A 200
PHE A 215
VAL A 202
ALA A 212
 None
 1.37A 3uncB-4muoA:
undetectable		 3uncB-4muoA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		5 LEU B  22
SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.08A 3uncB-4nfuB:
undetectable		 3uncB-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 351
THR A 219
VAL A 250
LEU A 226
ALA A 217
 None
 1.39A 3uncB-4pxqA:
2.2		 3uncB-4pxqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.11A 3uncB-4rlvA:
undetectable		 3uncB-4rlvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		5 LEU A2336
THR A2381
VAL A2380
LEU A2383
ALA A2389
 None
 1.37A 3uncB-4rlvA:
undetectable		 3uncB-4rlvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.40A 3uncB-4tn5A:
undetectable		 3uncB-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udn PERIPLASMIC SOLUTE
BINDING PROTEIN

(Candidatus
Liberibacter
asiaticus) 		PF01297
(ZnuA) 		5 LEU A  58
SER A   9
THR A  29
VAL A  28
ALA A  54
 None
None
SO4  A1276 (-4.0A)
None
None
 1.28A 3uncB-4udnA:
undetectable		 3uncB-4udnA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 LEU A1213
PHE A1223
VAL A1396
LEU A1400
ALA A1408
 None
 1.32A 3uncB-4xqkA:
undetectable		 3uncB-4xqkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		5 LEU A 358
ARG A  39
THR A 275
VAL A 272
LEU A 287
 None
 1.35A 3uncB-4y5rA:
undetectable		 3uncB-4y5rA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.35A 3uncB-4yswA:
46.0		 3uncB-4yswA:
86.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT BETA

(Yersinia
enterocolitica) 		PF00699
(Urease_beta) 		5 LEU B  83
PHE B  85
VAL B 113
LEU B  95
ALA B  90
 None
 1.48A 3uncB-4z42B:
undetectable		 3uncB-4z42B:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Streptomyces
viridosporus;
Sulfolobus
solfataricus) 		no annotation 5 LEU A  32
THR A  13
VAL A  16
LEU A  25
ALA A  27
 None
 1.21A 3uncB-5b0lA:
1.0		 3uncB-5b0lA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp2 CURF

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 216
ARG A 214
VAL A 222
LEU A 158
ALA A 210
 None
 1.25A 3uncB-5dp2A:
undetectable		 3uncB-5dp2A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 LEU A  72
SER A  71
VAL A  65
LEU A 107
ALA A 127
 None
SAH  A 400 ( 4.8A)
None
None
None
 1.40A 3uncB-5f2oA:
undetectable		 3uncB-5f2oA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		5 LEU A 493
THR A 541
VAL A 540
LEU A 543
ALA A 549
 None
 1.40A 3uncB-5jhqA:
undetectable		 3uncB-5jhqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		5 LEU A 635
PHE A 664
VAL A 705
LEU A 712
ALA A 716
 None
 1.21A 3uncB-5kqiA:
undetectable		 3uncB-5kqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 5 GLU A 651
LEU A 341
VAL A 266
LEU A 333
ALA A 313
 None
 1.27A 3uncB-5no8A:
undetectable		 3uncB-5no8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT B

(Methanothermococcus
thermolithotrophicus) 		PF02754
(CCG) 		5 LEU B 260
SER B 261
PHE B 122
VAL B  25
LEU B  29
 None
 1.46A 3uncB-5odrB:
undetectable		 3uncB-5odrB:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 201
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.45A 3uncB-5vyeA:
undetectable		 3uncB-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 217
PHE A 219
THR A  54
LEU A  51
ALA A 190
 None
 1.40A 3uncB-5vyeA:
undetectable		 3uncB-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 5 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.44A 3uncB-5wzkA:
undetectable		 3uncB-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A2270
SER A2274
VAL A2314
LEU A2317
ALA A2323
 None
 1.11A 3uncB-5y4dA:
undetectable		 3uncB-5y4dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4e ANKYRIN-2,ANKYRIN-2

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU A1270
SER A1274
VAL A1314
LEU A1317
ALA A1323
 None
None
SO4  A1507 (-4.7A)
None
None
 1.18A 3uncB-5y4eA:
undetectable		 3uncB-5y4eA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 LEU A 483
SER A 498
PHE A 500
THR A 370
LEU A 375
 None
 1.28A 3uncB-5ykbA:
undetectable		 3uncB-5ykbA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 5 LEU A  20
PHE A  52
THR A 317
VAL A 316
LEU A 268
 None
 1.46A 3uncB-6fhfA:
undetectable		 3uncB-6fhfA:
undetectable