SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ7_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 168
ASP A 251
ASP A  29
 None
 0.86A 3uj7A-1b8uA:
5.8		 3uj7A-1b8uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 SER A  29
ASP A  83
ASP A  49
 None
FEO  A 404 (-2.2A)
None
 0.79A 3uj7A-1e5dA:
undetectable		 3uj7A-1e5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)

(Drosophila
melanogaster) 		PF00035
(dsrm) 		3 SER A  11
ASP A   5
ASP A   2
 None
 0.86A 3uj7A-1ekzA:
undetectable		 3uj7A-1ekzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		3 SER A 143
ASP A 147
ASP A 153
 None
 0.91A 3uj7A-1gjuA:
undetectable		 3uj7A-1gjuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 SER A 118
ASP A  67
ASP A  33
 None
 0.72A 3uj7A-1h1yA:
undetectable		 3uj7A-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 SER A 281
ASP A 331
ASP A 324
 None
 0.69A 3uj7A-1hlgA:
undetectable		 3uj7A-1hlgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		3 SER A 281
ASP A 331
ASP A 324
 None
 0.75A 3uj7A-1k8qA:
2.9		 3uj7A-1k8qA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 SER A 282
ASP A  71
ASP A 106
 None
 0.88A 3uj7A-1kcxA:
undetectable		 3uj7A-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		3 SER A  59
ASP A 109
ASP A 141
 SAH  A 300 (-3.7A)
SAH  A 300 (-2.9A)
SAH  A 300 (-3.7A)
 0.66A 3uj7A-1kr5A:
9.5		 3uj7A-1kr5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		3 SER A 159
ASP A 376
ASP A 373
 None
 0.92A 3uj7A-1lrzA:
undetectable		 3uj7A-1lrzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		3 SER A 561
ASP A 422
ASP A 333
 None
 0.90A 3uj7A-1nbwA:
undetectable		 3uj7A-1nbwA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 SER A 301
ASP A 288
ASP A 327
 None
 0.87A 3uj7A-1nhcA:
undetectable		 3uj7A-1nhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  30
ASP A  84
ASP A 170
 ABF  A1269 (-2.5A)
ABF  A1269 (-2.6A)
None
 0.91A 3uj7A-1o8bA:
undetectable		 3uj7A-1o8bA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		3 SER A 216
ASP A 175
ASP A  84
 None
 0.91A 3uj7A-1o9gA:
10.3		 3uj7A-1o9gA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opo COAT PROTEIN

(Carnation
mottle virus) 		PF00729
(Viral_coat)
PF08462
(Carmo_coat_C) 		3 SER A 257
ASP A 210
ASP A 158
 None
 0.91A 3uj7A-1opoA:
undetectable		 3uj7A-1opoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		3 SER E 210
ASP E  65
ASP E  97
 None
 0.73A 3uj7A-1pekE:
2.3		 3uj7A-1pekE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 SER E  43
ASP E 102
ASP E 175
 None
 0.90A 3uj7A-1sgqE:
undetectable		 3uj7A-1sgqE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ss6 NSFL1 COFACTOR P47

(Homo sapiens) 		PF08059
(SEP) 		3 SER A   2
ASP A  26
ASP A  66
 None
 0.78A 3uj7A-1ss6A:
undetectable		 3uj7A-1ss6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 SER A 540
ASP A 553
ASP A 560
 None
 0.66A 3uj7A-1sxjA:
undetectable		 3uj7A-1sxjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 SER B 210
ASP B 174
ASP B 170
 NAG  A 900 (-3.6A)
None
None
 0.92A 3uj7A-1ta3B:
undetectable		 3uj7A-1ta3B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		3 SER A 151
ASP A  99
ASP A 106
 None
 0.90A 3uj7A-1uuoA:
undetectable		 3uj7A-1uuoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		3 SER A 245
ASP A 417
ASP A 346
 None
 0.87A 3uj7A-1vpbA:
undetectable		 3uj7A-1vpbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 SER A 343
ASP A 307
ASP A 259
 None
None
GOL  A1651 (-2.8A)
 0.90A 3uj7A-1w8oA:
undetectable		 3uj7A-1w8oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A 356
ASP A 270
ASP A 293
 SER  A 356 ( 0.0A)
ASP  A 270 ( 0.6A)
ASP  A 293 ( 0.6A)
 0.84A 3uj7A-1wqaA:
undetectable		 3uj7A-1wqaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		3 SER A 228
ASP A 110
ASP A 116
 None
 0.91A 3uj7A-1wxqA:
undetectable		 3uj7A-1wxqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A 367
ASP A 112
ASP A 140
 None
 0.92A 3uj7A-1xmbA:
undetectable		 3uj7A-1xmbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 SER A 247
ASP A 295
ASP A 340
 None
 0.79A 3uj7A-1xogA:
undetectable		 3uj7A-1xogA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 SER A 165
ASP A  34
ASP A  32
 None
 0.83A 3uj7A-1yd9A:
undetectable		 3uj7A-1yd9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		3 SER A 392
ASP A  39
ASP A   5
 None
 0.90A 3uj7A-1z3zA:
undetectable		 3uj7A-1z3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 SER A  89
ASP A 195
ASP A 221
 None
 0.59A 3uj7A-1z6rA:
undetectable		 3uj7A-1z6rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 SER A 264
ASP A 221
ASP A 196
 None
EDO  A 556 ( 4.7A)
None
 0.92A 3uj7A-1zy9A:
undetectable		 3uj7A-1zy9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 SER A 278
ASP A 239
ASP A 232
 None
 0.76A 3uj7A-2aaaA:
undetectable		 3uj7A-2aaaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 SER A  97
ASP A 126
ASP A 211
 None
 0.84A 3uj7A-2d3tA:
5.8		 3uj7A-2d3tA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 3 SER A 274
ASP A  53
ASP A  46
 None
 0.87A 3uj7A-2ddxA:
undetectable		 3uj7A-2ddxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 SER A 157
ASP A 298
ASP A 711
 None
 0.84A 3uj7A-2e7zA:
undetectable		 3uj7A-2e7zA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 SER A 100
ASP A 230
ASP A 262
 None
 0.91A 3uj7A-2eaaA:
undetectable		 3uj7A-2eaaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 SER A 960
ASP A 967
ASP A 974
 None
 0.83A 3uj7A-2ec5A:
undetectable		 3uj7A-2ec5A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f53 T-CELL RECEPTOR,
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 SER D  84
ASP D 164
ASP D 169
 None
 0.82A 3uj7A-2f53D:
undetectable		 3uj7A-2f53D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 139
ASP A  53
ASP A  54
 None
 0.83A 3uj7A-2hlpA:
3.6		 3uj7A-2hlpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		3 SER A 298
ASP A  76
ASP A 181
 None
 0.91A 3uj7A-2hz6A:
undetectable		 3uj7A-2hz6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		3 SER A 202
ASP A 209
ASP A 504
 None
MN  A1001 (-3.9A)
None
 0.79A 3uj7A-2id0A:
undetectable		 3uj7A-2id0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		3 SER A 350
ASP A 291
ASP A 262
 None
 0.76A 3uj7A-2ie8A:
3.0		 3uj7A-2ie8A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 3 SER A 359
ASP A 305
ASP A 254
 None
 0.92A 3uj7A-2jdxA:
undetectable		 3uj7A-2jdxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mah PROTEIN SMOOTHENED

(Drosophila
melanogaster) 		PF01392
(Fz) 		3 SER A  12
ASP A  50
ASP A  53
 None
 0.79A 3uj7A-2mahA:
undetectable		 3uj7A-2mahA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 327
ASP A 127
ASP A 103
 None
 0.87A 3uj7A-2nqlA:
undetectable		 3uj7A-2nqlA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY

(Campylobacter
jejuni) 		PF03309
(Pan_kinase) 		3 SER A   9
ASP A  89
ASP A  97
 SO4  A 218 (-4.5A)
None
None
 0.81A 3uj7A-2nrhA:
undetectable		 3uj7A-2nrhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		3 SER A 235
ASP A 178
ASP A 151
 None
 0.68A 3uj7A-2ntbA:
undetectable		 3uj7A-2ntbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 SER A 746
ASP A 726
ASP A 720
 None
 0.84A 3uj7A-2nztA:
undetectable		 3uj7A-2nztA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		3 SER A 211
ASP A 161
ASP A  63
 None
 0.80A 3uj7A-2o04A:
undetectable		 3uj7A-2o04A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 SER A 261
ASP A 232
ASP A 176
 None
 0.86A 3uj7A-2ocaA:
undetectable		 3uj7A-2ocaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 430
ASP A 405
ASP A 451
 None
 0.86A 3uj7A-2pyxA:
2.6		 3uj7A-2pyxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qom SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 SER A1179
ASP A1243
ASP A1058
 None
 0.83A 3uj7A-2qomA:
undetectable		 3uj7A-2qomA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		3 SER A 104
ASP A 213
ASP A 218
 PO4  A1257 ( 3.9A)
None
None
 0.87A 3uj7A-2v4nA:
undetectable		 3uj7A-2v4nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		3 SER A 684
ASP A 620
ASP A 624
 None
SAH  A1846 (-2.6A)
None
 0.83A 3uj7A-2vdwA:
16.5		 3uj7A-2vdwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 SER A 273
ASP A 178
ASP A 162
 None
FE2  A 401 (-2.5A)
None
 0.91A 3uj7A-2vw8A:
undetectable		 3uj7A-2vw8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 SER B 530
ASP B 660
ASP B 714
 XAX  B1778 (-4.9A)
None
None
 0.90A 3uj7A-2w55B:
undetectable		 3uj7A-2w55B:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		3 SER A 181
ASP A 469
ASP A 487
 None
 0.92A 3uj7A-2wokA:
undetectable		 3uj7A-2wokA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 SER A 217
ASP A 108
ASP A 103
 None
 0.90A 3uj7A-2xn8A:
undetectable		 3uj7A-2xn8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 SER A 294
ASP A 148
ASP A 131
 None
 0.82A 3uj7A-2yheA:
undetectable		 3uj7A-2yheA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli;
Escherichia
coli) 		PF13360
(PQQ_2)
PF13360
(PQQ_2) 		3 SER A  96
ASP D 303
ASP D 288
 None
 0.70A 3uj7A-2ymsA:
undetectable		 3uj7A-2ymsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 SER A 310
ASP A 149
ASP A 186
 None
 0.80A 3uj7A-2z2zA:
2.6		 3uj7A-2z2zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 SER A  34
ASP A 146
ASP A 196
 SAH  A 801 (-3.6A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.86A 3uj7A-2zwaA:
12.8		 3uj7A-2zwaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 766
ASP A 563
ASP A 568
 None
 0.90A 3uj7A-3b2rA:
undetectable		 3uj7A-3b2rA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		3 SER A 319
ASP A 313
ASP A 197
 GOL  A 356 (-4.9A)
None
None
 0.92A 3uj7A-3cq0A:
undetectable		 3uj7A-3cq0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 166
ASP A 249
ASP A  29
 None
 0.69A 3uj7A-3d5tA:
5.8		 3uj7A-3d5tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 244
ASP A 191
ASP A 171
 None
MG  A2001 ( 2.6A)
None
 0.91A 3uj7A-3dg7A:
undetectable		 3uj7A-3dg7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		3 SER A  43
ASP A 140
ASP A 142
 None
 0.81A 3uj7A-3dulA:
12.3		 3uj7A-3dulA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  30
ASP A  84
ASP A 170
 None
 0.67A 3uj7A-3enqA:
2.1		 3uj7A-3enqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 SER A  70
ASP A 270
ASP A 235
 None
 0.89A 3uj7A-3gfvA:
undetectable		 3uj7A-3gfvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 SER A1407
ASP A 853
ASP A 868
 None
 0.52A 3uj7A-3h0gA:
undetectable		 3uj7A-3h0gA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		3 SER A 333
ASP A 403
ASP A  53
 None
 0.79A 3uj7A-3hjbA:
undetectable		 3uj7A-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 SER A  75
ASP A 134
ASP A 193
 None
 0.81A 3uj7A-3hsyA:
undetectable		 3uj7A-3hsyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A  25
ASP A 314
ASP A 321
 None
 0.80A 3uj7A-3icsA:
3.6		 3uj7A-3icsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		3 SER A  29
ASP A  12
ASP A  98
 None
AMP  A 509 (-2.8A)
None
 0.80A 3uj7A-3kd6A:
2.9		 3uj7A-3kd6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 152
ASP A 169
ASP A 175
 None
 0.87A 3uj7A-3ladA:
2.5		 3uj7A-3ladA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		3 SER A 356
ASP A  90
ASP A  83
 None
 0.84A 3uj7A-3mdoA:
undetectable		 3uj7A-3mdoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		3 SER A  55
ASP A  61
ASP A 438
 None
MG  A 601 ( 2.4A)
None
 0.85A 3uj7A-3mx3A:
undetectable		 3uj7A-3mx3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		3 SER A 455
ASP A 538
ASP A 531
 None
 0.82A 3uj7A-3nowA:
undetectable		 3uj7A-3nowA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 SER A 221
ASP A 215
ASP A  27
 None
 0.88A 3uj7A-3o82A:
undetectable		 3uj7A-3o82A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 SER B 254
ASP B 135
ASP B  22
 None
 0.86A 3uj7A-3p8cB:
undetectable		 3uj7A-3p8cB:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 SER A  51
ASP A 206
ASP A 203
 None
 0.82A 3uj7A-3phfA:
undetectable		 3uj7A-3phfA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 SER A1117
ASP A1226
ASP A1168
 None
MG  A   1 ( 3.2A)
ANP  A1358 (-4.1A)
 0.80A 3uj7A-3plsA:
undetectable		 3uj7A-3plsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		3 SER A 179
ASP A  70
ASP A 100
 None
 0.88A 3uj7A-3q4iA:
undetectable		 3uj7A-3q4iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF09711
(Cas_Csn2) 		3 SER A 159
ASP A  82
ASP A  89
 None
 0.73A 3uj7A-3s5uA:
undetectable		 3uj7A-3s5uA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 SER A  53
ASP A  98
ASP A 268
 None
 0.76A 3uj7A-3swoA:
undetectable		 3uj7A-3swoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0a ACYL-COA
THIOESTERASE II
TESB2

(Mycobacterium
marinum) 		PF13622
(4HBT_3) 		3 SER A 166
ASP A 236
ASP A 117
 None
 0.80A 3uj7A-3u0aA:
undetectable		 3uj7A-3u0aA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		3 SER A  57
ASP A  84
ASP A 107
 None
 0.79A 3uj7A-3uboA:
3.8		 3uj7A-3uboA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		3 SER A 233
ASP A 177
ASP A 150
 None
 0.68A 3uj7A-3uw0A:
undetectable		 3uj7A-3uw0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 SER A 320
ASP A  19
ASP A 162
 None
 0.84A 3uj7A-3va8A:
undetectable		 3uj7A-3va8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 SER A 438
ASP A 263
ASP A 298
 None
 0.85A 3uj7A-3wevA:
undetectable		 3uj7A-3wevA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 3 SER A 895
ASP A 782
ASP A 878
 None
 0.79A 3uj7A-4a7kA:
undetectable		 3uj7A-4a7kA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 SER A1094
ASP A1170
ASP A1146
 None
 0.82A 3uj7A-4amcA:
undetectable		 3uj7A-4amcA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axz PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 SER A 150
ASP A 239
ASP A 246
 None
 0.66A 3uj7A-4axzA:
undetectable		 3uj7A-4axzA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2f PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 SER A 150
ASP A 239
ASP A 246
 None
 0.72A 3uj7A-4b2fA:
undetectable		 3uj7A-4b2fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A  69
ASP A 146
ASP A 128
 None
 0.58A 3uj7A-4b9dA:
undetectable		 3uj7A-4b9dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		3 SER A 291
ASP A 298
ASP A 110
 NDP  A1313 (-2.9A)
None
None
 0.90A 3uj7A-4bvaA:
5.5		 3uj7A-4bvaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		3 SER A 140
ASP A 264
ASP A 324
 None
 0.92A 3uj7A-4c3sA:
4.2		 3uj7A-4c3sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 SER A 282
ASP A  71
ASP A 106
 None
 0.91A 3uj7A-4cntA:
undetectable		 3uj7A-4cntA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6y BACTERIAL
REGULATORY, FIS
FAMILY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg) 		3 SER A  59
ASP A   9
ASP A  16
 None
MG  A1126 ( 4.1A)
None
 0.91A 3uj7A-4d6yA:
3.0		 3uj7A-4d6yA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 SER A 436
ASP A 439
ASP A 442
 None
 0.90A 3uj7A-4dweA:
undetectable		 3uj7A-4dweA:
20.77