SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ7_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)


(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
5 LEU B 105
GLY B 125
ILE B 511
ARG B 430
ALA B 434
None
1.12A 3uj7A-1a6dB:
0.0
3uj7A-1a6dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE


(Salmonella
enterica)
PF02283
(CobU)
5 LEU A 161
ILE A 115
ILE A 111
ARG A 151
ALA A 154
None
1.21A 3uj7A-1c9kA:
0.0
3uj7A-1c9kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum)
PF00191
(Annexin)
5 LEU A 297
TYR A 289
ILE A 301
ASP A 258
ALA A 259
None
1.24A 3uj7A-1dk5A:
0.0
3uj7A-1dk5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)


(Rattus
norvegicus)
PF00149
(Metallophos)
5 LEU A 225
TYR A 287
ILE A 285
ILE A  35
ALA A  11
None
1.35A 3uj7A-1qfcA:
0.4
3uj7A-1qfcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgv FERREDOXIN

(Thauera
aromatica)
PF00037
(Fer4)
5 TYR A  30
ILE A  23
CYH A   8
ILE A   4
ALA A  13
SF4  A 101 ( 3.8A)
None
SF4  A 101 (-2.4A)
SF4  A 101 ( 4.1A)
SF4  A 101 ( 4.1A)
0.89A 3uj7A-1rgvA:
undetectable
3uj7A-1rgvA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG


(Clostridium
acetobutylicum)
PF04321
(RmlD_sub_bind)
5 LEU A  12
ILE A   3
ILE A  99
CYH A  58
ILE A 145
NAI  A 300 (-4.5A)
None
NAI  A 300 (-4.2A)
None
None
1.13A 3uj7A-1vl0A:
0.9
3uj7A-1vl0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Saccharomyces
cerevisiae)
PF00171
(Aldedh)
5 ILE A 246
ILE A 266
ILE A 232
ASP A 239
ALA A 238
None
1.18A 3uj7A-1vluA:
0.0
3uj7A-1vluA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN


(Bacillus
subtilis)
PF01812
(5-FTHF_cyc-lig)
5 LEU A  35
ILE A 120
ILE A 182
ILE A 183
ARG A 132
None
None
None
None
SO4  A 301 (-2.6A)
1.03A 3uj7A-1ydmA:
2.3
3uj7A-1ydmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE


([Candida]
tenuis)
PF00248
(Aldo_ket_red)
5 ILE A 147
ILE A 166
ILE A 113
ARG A 181
ALA A 183
None
0.92A 3uj7A-1z9aA:
0.4
3uj7A-1z9aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans)
PF00303
(Thymidylat_synt)
5 LEU A 251
ILE A  27
ARG A  37
ASP A 255
ALA A 256
None
1.35A 3uj7A-2aazA:
undetectable
3uj7A-2aazA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Staphylococcus
aureus)
PF01039
(Carboxyl_trans)
5 LEU B 221
TYR B 200
ILE B  70
ILE B 160
ILE B 279
None
1.03A 3uj7A-2f9iB:
undetectable
3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Staphylococcus
aureus)
PF01039
(Carboxyl_trans)
5 LEU B 221
TYR B 200
ILE B  70
ILE B 219
ILE B 160
None
1.11A 3uj7A-2f9iB:
undetectable
3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 LEU A 163
ILE A 144
GLY A 159
ILE A  95
ILE A  96
None
0.99A 3uj7A-2ggqA:
undetectable
3uj7A-2ggqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE


(Staphylococcus
aureus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A 167
ILE A  34
ILE A 236
ASP A 226
ALA A 223
None
1.38A 3uj7A-2hk3A:
undetectable
3uj7A-2hk3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus)
PF02585
(PIG-L)
5 LEU A  39
ILE A  36
ILE A  89
ILE A 124
ALA A 103
None
1.26A 3uj7A-2ixdA:
undetectable
3uj7A-2ixdA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE


(Hahella
chejuensis)
PF00701
(DHDPS)
5 ILE A 202
GLY A 158
ILE A 129
ILE A  73
ASP A 161
None
0.85A 3uj7A-2rfgA:
undetectable
3uj7A-2rfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus)
PF00294
(PfkB)
5 LEU A  11
ILE A  79
GLY A  57
ILE A  65
ALA A 112
KDG  A1313 ( 4.7A)
None
None
None
None
0.97A 3uj7A-2varA:
undetectable
3uj7A-2varA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
5 LEU A 295
ILE A 344
ILE A 314
ILE A 353
HIS A 351
None
1.03A 3uj7A-2vk9A:
undetectable
3uj7A-2vk9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00231
(ATP-synt)
5 LEU G 219
ILE G 133
ARG G  30
ASP G 136
ALA G 137
None
1.31A 3uj7A-2xokG:
undetectable
3uj7A-2xokG:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE


(Desulfovibrio
vulgaris)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 LEU A 285
GLY A 301
ILE A 168
ASP A 164
ALA A 165
None
1.38A 3uj7A-2z1uA:
undetectable
3uj7A-2z1uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE


(Aquifex
aeolicus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 LEU A  81
GLY A  73
ARG A 115
ASP A 119
ALA A 117
None
1.12A 3uj7A-2zauA:
undetectable
3uj7A-2zauA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG


(Escherichia
coli)
PF05368
(NmrA)
5 LEU A  71
TYR A 101
ILE A  88
ALA A  81
HIS A  84
None
1.08A 3uj7A-2zcvA:
5.2
3uj7A-2zcvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE


(Streptococcus
mutans)
PF02153
(PDH)
5 ILE A 250
ILE A 238
ILE A 194
ASP A 248
ALA A 245
None
1.29A 3uj7A-3b1fA:
4.9
3uj7A-3b1fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli)
PF01343
(Peptidase_S49)
5 LEU A 138
ILE A  63
ILE A 100
ILE A 113
ASP A 119
None
0.97A 3uj7A-3bf0A:
undetectable
3uj7A-3bf0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE


(Leeuwenhoekiella
blandensis)
PF01966
(HD)
5 ILE A 315
ILE A 260
CYH A 256
ILE A 255
ALA A 308
None
0.99A 3uj7A-3bg2A:
undetectable
3uj7A-3bg2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus)
PF03372
(Exo_endo_phos)
5 LEU A  81
ILE A  25
GLY A  12
ILE A   8
ALA A  47
None
0.85A 3uj7A-3dniA:
undetectable
3uj7A-3dniA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB


(Sinorhizobium
meliloti)
no annotation 5 ILE A 194
ILE A 180
ILE A 126
ASP A 161
ALA A 158
None
0.95A 3uj7A-3e4pA:
undetectable
3uj7A-3e4pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE


(Bacteroides
fragilis)
PF10091
(Glycoamylase)
PF11329
(DUF3131)
5 LEU A 159
ILE A 411
GLY A  91
ILE A  95
ALA A  65
None
None
EDO  A 474 (-3.3A)
None
EDO  A 474 (-3.6A)
1.37A 3uj7A-3eu8A:
undetectable
3uj7A-3eu8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis)
PF04493
(Endonuclease_5)
5 ILE A 143
GLY A  44
ILE A  65
ASP A 223
ALA A 222
None
1.19A 3uj7A-3ga2A:
undetectable
3uj7A-3ga2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 LEU A 916
GLY A 866
ILE A 823
ASP A 925
ALA A 924
None
1.22A 3uj7A-3hmjA:
undetectable
3uj7A-3hmjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum)
PF00291
(PALP)
5 LEU A  69
GLY A 324
ILE A 322
ILE A 339
ALA A 327
None
1.21A 3uj7A-3iauA:
2.3
3uj7A-3iauA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE


(Pimelobacter
simplex)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
5 ILE A 246
GLY A 254
CYH A 229
ILE A 231
ARG A 251
None
1.36A 3uj7A-3k30A:
undetectable
3uj7A-3k30A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Vibrio cholerae)
PF00290
(Trp_syntA)
5 ILE A 241
GLY A  26
ILE A  36
ILE A  80
ALA A  71
None
1.20A 3uj7A-3navA:
undetectable
3uj7A-3navA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM


(Rhodopseudomonas
palustris)
no annotation 5 LEU B  75
ILE B 109
ILE B  20
ASP B  85
ALA B  84
None
1.38A 3uj7A-3nndB:
undetectable
3uj7A-3nndB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula)
PF05721
(PhyH)
5 LEU A 112
ILE A  61
ILE A  58
ARG A 259
HIS A 115
FMT  A 500 ( 4.8A)
None
None
None
None
1.36A 3uj7A-3nnmA:
undetectable
3uj7A-3nnmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
5 LEU A 250
ILE A  18
GLY A 663
ILE A 660
ARG A  46
None
0.91A 3uj7A-3nz4A:
undetectable
3uj7A-3nz4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 LEU A  28
ILE A   7
ILE A  41
ILE A  40
ALA A  14
None
1.28A 3uj7A-3oa2A:
undetectable
3uj7A-3oa2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Bacillus
anthracis)
PF00378
(ECH_1)
5 LEU A 191
ILE A  13
ILE A  99
ILE A  47
ALA A  16
None
1.15A 3uj7A-3peaA:
undetectable
3uj7A-3peaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa)
PF00210
(Ferritin)
5 LEU A  44
ILE A  76
GLY A  79
ILE A  27
ALA A  88
None
0.82A 3uj7A-3r2hA:
undetectable
3uj7A-3r2hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43


(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct)
PF01341
(Glyco_hydro_6)
5 LEU X 244
ILE X 105
ILE X 141
ARG X 100
ALA X 102
None
1.18A 3uj7A-3ru8X:
undetectable
3uj7A-3ru8X:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A


(Homo sapiens)
PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind)
5 LEU A 213
ILE A 164
ILE A 242
ILE A 263
ASP A 235
None
1.23A 3uj7A-3t1iA:
undetectable
3uj7A-3t1iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum)
PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11)
5 GLY A 119
ILE A 117
ILE A  98
ASP A 133
ALA A 134
None
1.21A 3uj7A-3vtxA:
undetectable
3uj7A-3vtxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB


(Aspergillus
oryzae)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 LEU A 317
ILE A  60
ILE A 349
ASP A 340
ALA A 337
None
0.96A 3uj7A-3wxyA:
undetectable
3uj7A-3wxyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE


(Nilaparvata
lugens)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 LEU A 175
TYR A 178
ILE A 165
ASP A 134
ALA A 135
None
1.17A 3uj7A-3wywA:
undetectable
3uj7A-3wywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE


(Paenarthrobacter
aurescens)
PF00202
(Aminotran_3)
5 LEU A  69
ILE A 389
ILE A 442
ARG A 363
ALA A 358
None
1.36A 3uj7A-4atqA:
undetectable
3uj7A-4atqA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens)
PF03372
(Exo_endo_phos)
5 LEU A  81
ILE A  25
GLY A  12
ILE A   8
ALA A  47
None
0.81A 3uj7A-4awnA:
undetectable
3uj7A-4awnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus)
PF00285
(Citrate_synt)
5 LEU A 165
ILE A 118
GLY A 140
ILE A 253
ALA A 143
None
1.01A 3uj7A-4e6yA:
undetectable
3uj7A-4e6yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE


(Chromobacterium
violaceum)
PF01979
(Amidohydro_1)
5 LEU A 355
GLY A 305
ILE A  67
ILE A 127
ALA A 276
None
1.11A 3uj7A-4f0sA:
undetectable
3uj7A-4f0sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0o PROTEIN ARGONAUTE 5

(Arabidopsis
thaliana)
PF02171
(Piwi)
5 LEU A 639
ILE A 622
ILE A 663
CYH A 657
ILE A 656
None
1.30A 3uj7A-4g0oA:
undetectable
3uj7A-4g0oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Ochrobactrum
sp. T63)
PF00561
(Abhydrolase_1)
5 ILE A 176
GLY A  32
ILE A  39
ILE A 107
ARG A 185
None
1.28A 3uj7A-4g8dA:
undetectable
3uj7A-4g8dA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae)
PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C)
5 LEU A 542
ILE A 672
GLY A 536
ILE A 638
ILE A 534
None
1.37A 3uj7A-4gfhA:
undetectable
3uj7A-4gfhA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA


(Escherichia
coli)
PF02811
(PHP)
5 TYR A  60
ILE A 264
ILE A  63
ASP A 254
ALA A 257
None
1.27A 3uj7A-4gx8A:
undetectable
3uj7A-4gx8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum)
PF00303
(Thymidylat_synt)
5 LEU A  11
TYR A   7
ILE A 181
ILE A  37
ALA A 171
None
None
None
None
UMP  A 301 ( 4.9A)
1.09A 3uj7A-4h0uA:
undetectable
3uj7A-4h0uA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 LEU A 182
TYR A 187
GLY A 232
ARG A 298
HIS A 303
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
0.64A 3uj7A-4ineA:
38.4
3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ARG A 298
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
1.16A 3uj7A-4ineA:
38.4
3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ASP A 299
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
1.20A 3uj7A-4ineA:
38.4
3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
6 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ASP A 299
HIS A 303
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
0.74A 3uj7A-4ineA:
38.4
3uj7A-4ineA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
knowlesi)
PF08241
(Methyltransf_11)
7 GLY A  61
ILE A  84
ILE A 109
ARG A 125
ASP A 126
ALA A 127
HIS A 130
SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.1A)
None
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
0.34A 3uj7A-4iv8A:
35.3
3uj7A-4iv8A:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Rickettsia
rickettsii)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A 336
ILE A 307
ILE A 312
ASP A 304
ALA A 301
None
1.02A 3uj7A-4jgaA:
undetectable
3uj7A-4jgaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
5 LEU A 178
TYR A 183
GLY A 228
ARG A 294
HIS A 299
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
0.62A 3uj7A-4kriA:
38.4
3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
6 LEU A 178
TYR A 183
ILE A 200
GLY A 228
ASP A 295
HIS A 299
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
0.62A 3uj7A-4kriA:
38.4
3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE


(Pyrococcus
furiosus)
PF00994
(MoCF_biosynth)
5 LEU A  65
GLY A  17
ILE A  19
ASP A  74
ALA A  73
None
1.33A 3uj7A-4lhbA:
undetectable
3uj7A-4lhbA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
7 TYR A  16
ILE A  33
GLY A  60
CYH A  84
ILE A 108
ARG A 124
ASP A 125
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
None
0.72A 3uj7A-4mwzA:
41.5
3uj7A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE


(Plasmodium
vivax)
PF13649
(Methyltransf_25)
8 TYR A  16
ILE A  33
GLY A  60
ILE A  83
ILE A 108
ARG A 124
ASP A 125
HIS A 129
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.0A)
None
None
SAM  A 301 (-3.9A)
0.18A 3uj7A-4mwzA:
41.5
3uj7A-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxe N-ACETYLTRANSFERASE
ESCO1


(Homo sapiens)
PF13880
(Acetyltransf_13)
5 GLY A 768
ILE A 766
ILE A 806
ARG A 771
ALA A 724
None
1.09A 3uj7A-4mxeA:
undetectable
3uj7A-4mxeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE


(Pseudomonas
aeruginosa)
PF13462
(Thioredoxin_4)
5 LEU A 108
GLY A 138
ILE A 128
ALA A 101
HIS A 104
None
1.28A 3uj7A-4n30A:
undetectable
3uj7A-4n30A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY


(Brucella suis)
PF13561
(adh_short_C2)
5 LEU A 224
ILE A 132
GLY A 178
ILE A 204
ALA A 135
None
1.18A 3uj7A-4o6vA:
undetectable
3uj7A-4o6vA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyd APOPTOSIS REGULATOR
BHRF1


(Human
gammaherpesvirus
4)
PF00452
(Bcl-2)
5 LEU A  54
ILE A 154
GLY A  99
ILE A  57
ALA A 101
None
1.20A 3uj7A-4oydA:
undetectable
3uj7A-4oydA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae)
PF07859
(Abhydrolase_3)
5 LEU A 198
ILE A  84
ILE A 203
ILE A  19
ALA A 152
None
0.98A 3uj7A-4p9nA:
3.5
3uj7A-4p9nA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
7 LEU A  14
TYR A  19
GLY A  63
ILE A  86
CYH A  87
ILE A  84
ARG A 127
None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
1.34A 3uj7A-4r6wA:
46.3
3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
10 LEU A  14
TYR A  19
ILE A  36
GLY A  63
ILE A  86
CYH A  87
ILE A 111
ARG A 127
ALA A 129
HIS A 132
None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
0.27A 3uj7A-4r6wA:
46.3
3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE


(Plasmodium
falciparum)
PF13649
(Methyltransf_25)
9 LEU A  14
TYR A  19
ILE A  36
ILE A  86
CYH A  87
ILE A  90
ILE A 111
ARG A 127
HIS A 132
None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
0.47A 3uj7A-4r6wA:
46.3
3uj7A-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica)
PF08543
(Phos_pyr_kin)
5 LEU B 177
ILE B 276
ILE B 204
ILE B 223
ALA B 237
None
1.20A 3uj7A-4s1iB:
undetectable
3uj7A-4s1iB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens)
PF02191
(OLF)
5 TYR A 392
GLY A 399
ILE A 401
ASP A 396
ALA A 397
None
1.03A 3uj7A-4wxuA:
undetectable
3uj7A-4wxuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN


(Bacillus
thuringiensis)
no annotation 5 LEU A  73
ILE A  38
ILE A 128
ILE A  24
ALA A 135
None
1.08A 3uj7A-4xe7A:
undetectable
3uj7A-4xe7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 LEU A 173
ILE A 161
CYH A 162
ILE A 119
ARG A 141
None
1.32A 3uj7A-4xriA:
undetectable
3uj7A-4xriA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA


(Thermotoga
maritima)
PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker)
5 LEU A  80
ILE A  18
ILE A  78
ILE A 124
ALA A  27
None
0.94A 3uj7A-4yxmA:
undetectable
3uj7A-4yxmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE


(Streptomyces
atroolivaceus)
PF00067
(p450)
5 LEU A 157
ILE A 216
ILE A 237
CYH A 234
ALA A 107
None
None
HEM  A 401 (-4.5A)
None
None
1.26A 3uj7A-4z5qA:
undetectable
3uj7A-4z5qA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA


(Schizosaccharomyces
pombe)
PF00483
(NTP_transferase)
5 ILE E 374
ILE E 400
ILE E 379
ILE E 430
ARG E 407
None
1.12A 3uj7A-5b04E:
undetectable
3uj7A-5b04E:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Staphylococcus
aureus)
PF13395
(HNH_4)
PF16592
(Cas9_REC)
5 ILE A 676
GLY A   8
ILE A  21
ILE A  20
ALA A 705
None
0.93A 3uj7A-5czzA:
undetectable
3uj7A-5czzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
5 LEU A 199
ILE A 311
CYH A 345
ILE A 337
ILE A 192
None
1.37A 3uj7A-5e02A:
undetectable
3uj7A-5e02A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE


(Plasmodium
falciparum)
PF00227
(Proteasome)
5 ILE M 206
GLY M  38
CYH M 165
ILE M  41
ARG M  56
None
1.12A 3uj7A-5fmgM:
undetectable
3uj7A-5fmgM:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 5 LEU A 604
ILE A 449
ILE A 532
ASP A 538
ALA A 542
None
1.22A 3uj7A-5hdtA:
undetectable
3uj7A-5hdtA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE


(Thermococcus
kodakarensis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 LEU A 237
ILE A 210
ILE A 187
ILE A 214
ASP A 204
None
1.26A 3uj7A-5hwsA:
4.6
3uj7A-5hwsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 LEU A 394
GLY A 351
ILE A 383
ILE A 348
ARG A 431
None
1.18A 3uj7A-5i2gA:
undetectable
3uj7A-5i2gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA


(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
5 LEU L 432
GLY L 246
ILE L 426
ILE L 159
ALA L 165
None
None
None
None
FAD  L 503 (-3.6A)
1.15A 3uj7A-5jfcL:
undetectable
3uj7A-5jfcL:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4)
5 ILE B1151
ILE B1153
ARG B1134
ASP B1137
ALA B1138
None
1.26A 3uj7A-5m5xB:
undetectable
3uj7A-5m5xB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans)
PF03568
(Peptidase_C50)
5 LEU 1 819
ILE 1 828
GLY 1 841
ILE 1 744
ALA 1 843
None
1.34A 3uj7A-5mz61:
undetectable
3uj7A-5mz61:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00106
(adh_short)
5 LEU A  26
GLY A  18
ILE A  77
ARG A  15
ALA A  13
None
None
None
NAP  A 300 (-4.2A)
None
1.28A 3uj7A-5u4sA:
5.5
3uj7A-5u4sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
5 LEU A 433
GLY A 246
ILE A 427
ILE A 159
ALA A 165
None
None
None
None
FAD  A 503 (-3.8A)
1.15A 3uj7A-5vj7A:
undetectable
3uj7A-5vj7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 6 LEU A 241
TYR A 246
GLY A 290
ARG A 355
ASP A 356
HIS A 360
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
0.43A 3uj7A-5wp4A:
40.0
3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 LEU A 241
TYR A 246
GLY A 290
ILE A 311
ARG A 355
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
None
1.08A 3uj7A-5wp4A:
40.0
3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 LEU A 241
TYR A 246
ILE A 251
ARG A 355
ASP A 356
SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
None
None
PC  A 702 ( 4.6A)
1.15A 3uj7A-5wp4A:
40.0
3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
None
1.29A 3uj7A-5wp4A:
40.0
3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2


(Arabidopsis
thaliana)
no annotation 5 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
None
1.37A 3uj7A-5wp5A:
33.2
3uj7A-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE


(Corynebacterium
glutamicum)
no annotation 5 LEU A  91
ILE A  82
GLY A 301
CYH A  57
ALA A  73
None
None
PLP  A 504 (-3.4A)
None
PLP  A 504 ( 3.8A)
1.22A 3uj7A-5x7nA:
undetectable
3uj7A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN


(Citrobacter sp.
MGH106)
no annotation 5 LEU S 143
ILE S 100
ILE S 114
ILE S 115
ALA S 121
None
1.22A 3uj7A-5xvdS:
undetectable
3uj7A-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE


(Eisenia fetida)
no annotation 5 LEU A 124
ILE A  67
GLY A  75
ILE A 374
ILE A 372
None
1.21A 3uj7A-5y6tA:
undetectable
3uj7A-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE


(Pseudomonas
aeruginosa)
no annotation 5 LEU A  51
ILE A   5
ILE A  31
ASP A 390
ALA A 391
None
0.88A 3uj7A-5ykdA:
undetectable
3uj7A-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE


(Sorghum bicolor)
no annotation 5 LEU A 181
GLY A 201
ILE A 199
ILE A 203
ALA A 209
None
1.14A 3uj7A-6at7A:
undetectable
3uj7A-6at7A:
undetectable