SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ7_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 LEU B 105
GLY B 125
ILE B 511
ARG B 430
ALA B 434
 None
 1.12A 3uj7A-1a6dB:
0.0		 3uj7A-1a6dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		5 LEU A 161
ILE A 115
ILE A 111
ARG A 151
ALA A 154
 None
 1.21A 3uj7A-1c9kA:
0.0		 3uj7A-1c9kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 LEU A 297
TYR A 289
ILE A 301
ASP A 258
ALA A 259
 None
 1.24A 3uj7A-1dk5A:
0.0		 3uj7A-1dk5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		5 LEU A 225
TYR A 287
ILE A 285
ILE A  35
ALA A  11
 None
 1.35A 3uj7A-1qfcA:
0.4		 3uj7A-1qfcA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgv FERREDOXIN

(Thauera
aromatica) 		PF00037
(Fer4) 		5 TYR A  30
ILE A  23
CYH A   8
ILE A   4
ALA A  13
 SF4  A 101 ( 3.8A)
None
SF4  A 101 (-2.4A)
SF4  A 101 ( 4.1A)
SF4  A 101 ( 4.1A)
 0.89A 3uj7A-1rgvA:
undetectable		 3uj7A-1rgvA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 LEU A  12
ILE A   3
ILE A  99
CYH A  58
ILE A 145
 NAI  A 300 (-4.5A)
None
NAI  A 300 (-4.2A)
None
None
 1.13A 3uj7A-1vl0A:
0.9		 3uj7A-1vl0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		5 ILE A 246
ILE A 266
ILE A 232
ASP A 239
ALA A 238
 None
 1.18A 3uj7A-1vluA:
0.0		 3uj7A-1vluA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN

(Bacillus
subtilis) 		PF01812
(5-FTHF_cyc-lig) 		5 LEU A  35
ILE A 120
ILE A 182
ILE A 183
ARG A 132
 None
None
None
None
SO4  A 301 (-2.6A)
 1.03A 3uj7A-1ydmA:
2.3		 3uj7A-1ydmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		5 ILE A 147
ILE A 166
ILE A 113
ARG A 181
ALA A 183
 None
 0.92A 3uj7A-1z9aA:
0.4		 3uj7A-1z9aA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		5 LEU A 251
ILE A  27
ARG A  37
ASP A 255
ALA A 256
 None
 1.35A 3uj7A-2aazA:
undetectable		 3uj7A-2aazA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		5 LEU B 221
TYR B 200
ILE B  70
ILE B 160
ILE B 279
 None
 1.03A 3uj7A-2f9iB:
undetectable		 3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		5 LEU B 221
TYR B 200
ILE B  70
ILE B 219
ILE B 160
 None
 1.11A 3uj7A-2f9iB:
undetectable		 3uj7A-2f9iB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Sulfurisphaera
tokodaii) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		5 LEU A 163
ILE A 144
GLY A 159
ILE A  95
ILE A  96
 None
 0.99A 3uj7A-2ggqA:
undetectable		 3uj7A-2ggqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 167
ILE A  34
ILE A 236
ASP A 226
ALA A 223
 None
 1.38A 3uj7A-2hk3A:
undetectable		 3uj7A-2hk3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus) 		PF02585
(PIG-L) 		5 LEU A  39
ILE A  36
ILE A  89
ILE A 124
ALA A 103
 None
 1.26A 3uj7A-2ixdA:
undetectable		 3uj7A-2ixdA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfg DIHYDRODIPICOLINATE
SYNTHASE

(Hahella
chejuensis) 		PF00701
(DHDPS) 		5 ILE A 202
GLY A 158
ILE A 129
ILE A  73
ASP A 161
 None
 0.85A 3uj7A-2rfgA:
undetectable		 3uj7A-2rfgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		5 LEU A  11
ILE A  79
GLY A  57
ILE A  65
ALA A 112
 KDG  A1313 ( 4.7A)
None
None
None
None
 0.97A 3uj7A-2varA:
undetectable		 3uj7A-2varA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 LEU A 295
ILE A 344
ILE A 314
ILE A 353
HIS A 351
 None
 1.03A 3uj7A-2vk9A:
undetectable		 3uj7A-2vk9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		5 LEU G 219
ILE G 133
ARG G  30
ASP G 136
ALA G 137
 None
 1.31A 3uj7A-2xokG:
undetectable		 3uj7A-2xokG:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 285
GLY A 301
ILE A 168
ASP A 164
ALA A 165
 None
 1.38A 3uj7A-2z1uA:
undetectable		 3uj7A-2z1uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A  81
GLY A  73
ARG A 115
ASP A 119
ALA A 117
 None
 1.12A 3uj7A-2zauA:
undetectable		 3uj7A-2zauA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG

(Escherichia
coli) 		PF05368
(NmrA) 		5 LEU A  71
TYR A 101
ILE A  88
ALA A  81
HIS A  84
 None
 1.08A 3uj7A-2zcvA:
5.2		 3uj7A-2zcvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 ILE A 250
ILE A 238
ILE A 194
ASP A 248
ALA A 245
 None
 1.29A 3uj7A-3b1fA:
4.9		 3uj7A-3b1fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		5 LEU A 138
ILE A  63
ILE A 100
ILE A 113
ASP A 119
 None
 0.97A 3uj7A-3bf0A:
undetectable		 3uj7A-3bf0A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		5 ILE A 315
ILE A 260
CYH A 256
ILE A 255
ALA A 308
 None
 0.99A 3uj7A-3bg2A:
undetectable		 3uj7A-3bg2A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		5 LEU A  81
ILE A  25
GLY A  12
ILE A   8
ALA A  47
 None
 0.85A 3uj7A-3dniA:
undetectable		 3uj7A-3dniA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4p C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB

(Sinorhizobium
meliloti) 		no annotation 5 ILE A 194
ILE A 180
ILE A 126
ASP A 161
ALA A 158
 None
 0.95A 3uj7A-3e4pA:
undetectable		 3uj7A-3e4pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		5 LEU A 159
ILE A 411
GLY A  91
ILE A  95
ALA A  65
 None
None
EDO  A 474 (-3.3A)
None
EDO  A 474 (-3.6A)
 1.37A 3uj7A-3eu8A:
undetectable		 3uj7A-3eu8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis) 		PF04493
(Endonuclease_5) 		5 ILE A 143
GLY A  44
ILE A  65
ASP A 223
ALA A 222
 None
 1.19A 3uj7A-3ga2A:
undetectable		 3uj7A-3ga2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 916
GLY A 866
ILE A 823
ASP A 925
ALA A 924
 None
 1.22A 3uj7A-3hmjA:
undetectable		 3uj7A-3hmjA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 LEU A  69
GLY A 324
ILE A 322
ILE A 339
ALA A 327
 None
 1.21A 3uj7A-3iauA:
2.3		 3uj7A-3iauA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ILE A 246
GLY A 254
CYH A 229
ILE A 231
ARG A 251
 None
 1.36A 3uj7A-3k30A:
undetectable		 3uj7A-3k30A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nav TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Vibrio cholerae) 		PF00290
(Trp_syntA) 		5 ILE A 241
GLY A  26
ILE A  36
ILE A  80
ALA A  71
 None
 1.20A 3uj7A-3navA:
undetectable		 3uj7A-3navA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 5 LEU B  75
ILE B 109
ILE B  20
ASP B  85
ALA B  84
 None
 1.38A 3uj7A-3nndB:
undetectable		 3uj7A-3nndB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 LEU A 112
ILE A  61
ILE A  58
ARG A 259
HIS A 115
 FMT  A 500 ( 4.8A)
None
None
None
None
 1.36A 3uj7A-3nnmA:
undetectable		 3uj7A-3nnmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 LEU A 250
ILE A  18
GLY A 663
ILE A 660
ARG A  46
 None
 0.91A 3uj7A-3nz4A:
undetectable		 3uj7A-3nz4A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  28
ILE A   7
ILE A  41
ILE A  40
ALA A  14
 None
 1.28A 3uj7A-3oa2A:
undetectable		 3uj7A-3oa2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 LEU A 191
ILE A  13
ILE A  99
ILE A  47
ALA A  16
 None
 1.15A 3uj7A-3peaA:
undetectable		 3uj7A-3peaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		5 LEU A  44
ILE A  76
GLY A  79
ILE A  27
ALA A  88
 None
 0.82A 3uj7A-3r2hA:
undetectable		 3uj7A-3r2hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru8 EPITOPE SCAFFOLD
2BODX43

(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		PF01341
(Glyco_hydro_6) 		5 LEU X 244
ILE X 105
ILE X 141
ARG X 100
ALA X 102
 None
 1.18A 3uj7A-3ru8X:
undetectable		 3uj7A-3ru8X:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 LEU A 213
ILE A 164
ILE A 242
ILE A 263
ASP A 235
 None
 1.23A 3uj7A-3t1iA:
undetectable		 3uj7A-3t1iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum) 		PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11) 		5 GLY A 119
ILE A 117
ILE A  98
ASP A 133
ALA A 134
 None
 1.21A 3uj7A-3vtxA:
undetectable		 3uj7A-3vtxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 317
ILE A  60
ILE A 349
ASP A 340
ALA A 337
 None
 0.96A 3uj7A-3wxyA:
undetectable		 3uj7A-3wxyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A 175
TYR A 178
ILE A 165
ASP A 134
ALA A 135
 None
 1.17A 3uj7A-3wywA:
undetectable		 3uj7A-3wywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atq 4-AMINOBUTYRATE
TRANSAMINASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A  69
ILE A 389
ILE A 442
ARG A 363
ALA A 358
 None
 1.36A 3uj7A-4atqA:
undetectable		 3uj7A-4atqA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A  81
ILE A  25
GLY A  12
ILE A   8
ALA A  47
 None
 0.81A 3uj7A-4awnA:
undetectable		 3uj7A-4awnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6y CITRATE SYNTHASE

(Vibrio
vulnificus) 		PF00285
(Citrate_synt) 		5 LEU A 165
ILE A 118
GLY A 140
ILE A 253
ALA A 143
 None
 1.01A 3uj7A-4e6yA:
undetectable		 3uj7A-4e6yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		5 LEU A 355
GLY A 305
ILE A  67
ILE A 127
ALA A 276
 None
 1.11A 3uj7A-4f0sA:
undetectable		 3uj7A-4f0sA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0o PROTEIN ARGONAUTE 5

(Arabidopsis
thaliana) 		PF02171
(Piwi) 		5 LEU A 639
ILE A 622
ILE A 663
CYH A 657
ILE A 656
 None
 1.30A 3uj7A-4g0oA:
undetectable		 3uj7A-4g0oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		5 ILE A 176
GLY A  32
ILE A  39
ILE A 107
ARG A 185
 None
 1.28A 3uj7A-4g8dA:
undetectable		 3uj7A-4g8dA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 LEU A 542
ILE A 672
GLY A 536
ILE A 638
ILE A 534
 None
 1.37A 3uj7A-4gfhA:
undetectable		 3uj7A-4gfhA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 TYR A  60
ILE A 264
ILE A  63
ASP A 254
ALA A 257
 None
 1.27A 3uj7A-4gx8A:
undetectable		 3uj7A-4gx8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		5 LEU A  11
TYR A   7
ILE A 181
ILE A  37
ALA A 171
 None
None
None
None
UMP  A 301 ( 4.9A)
 1.09A 3uj7A-4h0uA:
undetectable		 3uj7A-4h0uA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 LEU A 182
TYR A 187
GLY A 232
ARG A 298
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.64A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ARG A 298
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
 1.16A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ASP A 299
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
 1.20A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		6 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ASP A 299
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.74A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		7 GLY A  61
ILE A  84
ILE A 109
ARG A 125
ASP A 126
ALA A 127
HIS A 130
 SAM  A 301 (-3.5A)
SAM  A 301 (-3.8A)
SAM  A 301 (-4.1A)
None
None
SAM  A 301 (-3.4A)
SAM  A 301 (-3.9A)
 0.34A 3uj7A-4iv8A:
35.3		 3uj7A-4iv8A:
59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 336
ILE A 307
ILE A 312
ASP A 304
ALA A 301
 None
 1.02A 3uj7A-4jgaA:
undetectable		 3uj7A-4jgaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 LEU A 178
TYR A 183
GLY A 228
ARG A 294
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.62A 3uj7A-4kriA:
38.4		 3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		6 LEU A 178
TYR A 183
ILE A 200
GLY A 228
ASP A 295
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.2A)
SAH  A 701 ( 4.5A)
SAH  A 701 (-3.5A)
None
SAH  A 701 (-4.2A)
 0.62A 3uj7A-4kriA:
38.4		 3uj7A-4kriA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		5 LEU A  65
GLY A  17
ILE A  19
ASP A  74
ALA A  73
 None
 1.33A 3uj7A-4lhbA:
undetectable		 3uj7A-4lhbA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		7 TYR A  16
ILE A  33
GLY A  60
CYH A  84
ILE A 108
ARG A 124
ASP A 125
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
BME  A 303 (-1.9A)
SAM  A 301 (-4.0A)
None
None
 0.72A 3uj7A-4mwzA:
41.5		 3uj7A-4mwzA:
63.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		8 TYR A  16
ILE A  33
GLY A  60
ILE A  83
ILE A 108
ARG A 124
ASP A 125
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 (-4.3A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.0A)
None
None
SAM  A 301 (-3.9A)
 0.18A 3uj7A-4mwzA:
41.5		 3uj7A-4mwzA:
63.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxe N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13880
(Acetyltransf_13) 		5 GLY A 768
ILE A 766
ILE A 806
ARG A 771
ALA A 724
 None
 1.09A 3uj7A-4mxeA:
undetectable		 3uj7A-4mxeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		5 LEU A 108
GLY A 138
ILE A 128
ALA A 101
HIS A 104
 None
 1.28A 3uj7A-4n30A:
undetectable		 3uj7A-4n30A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		5 LEU A 224
ILE A 132
GLY A 178
ILE A 204
ALA A 135
 None
 1.18A 3uj7A-4o6vA:
undetectable		 3uj7A-4o6vA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyd APOPTOSIS REGULATOR
BHRF1

(Human
gammaherpesvirus
4) 		PF00452
(Bcl-2) 		5 LEU A  54
ILE A 154
GLY A  99
ILE A  57
ALA A 101
 None
 1.20A 3uj7A-4oydA:
undetectable		 3uj7A-4oydA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 LEU A 198
ILE A  84
ILE A 203
ILE A  19
ALA A 152
 None
 0.98A 3uj7A-4p9nA:
3.5		 3uj7A-4p9nA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		7 LEU A  14
TYR A  19
GLY A  63
ILE A  86
CYH A  87
ILE A  84
ARG A 127
 None
SAH  A 302 ( 4.1A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
None
 1.34A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		10 LEU A  14
TYR A  19
ILE A  36
GLY A  63
ILE A  86
CYH A  87
ILE A 111
ARG A 127
ALA A 129
HIS A 132
 None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.3A)
SAH  A 302 (-4.3A)
 0.27A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		9 LEU A  14
TYR A  19
ILE A  36
ILE A  86
CYH A  87
ILE A  90
ILE A 111
ARG A 127
HIS A 132
 None
SAH  A 302 ( 4.1A)
SAH  A 302 ( 3.9A)
SAH  A 302 (-3.7A)
SAH  A 302 (-3.4A)
None
SAH  A 302 (-4.1A)
None
SAH  A 302 (-4.3A)
 0.47A 3uj7A-4r6wA:
46.3		 3uj7A-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		5 LEU B 177
ILE B 276
ILE B 204
ILE B 223
ALA B 237
 None
 1.20A 3uj7A-4s1iB:
undetectable		 3uj7A-4s1iB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens) 		PF02191
(OLF) 		5 TYR A 392
GLY A 399
ILE A 401
ASP A 396
ALA A 397
 None
 1.03A 3uj7A-4wxuA:
undetectable		 3uj7A-4wxuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		no annotation 5 LEU A  73
ILE A  38
ILE A 128
ILE A  24
ALA A 135
 None
 1.08A 3uj7A-4xe7A:
undetectable		 3uj7A-4xe7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 173
ILE A 161
CYH A 162
ILE A 119
ARG A 141
 None
 1.32A 3uj7A-4xriA:
undetectable		 3uj7A-4xriA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		5 LEU A  80
ILE A  18
ILE A  78
ILE A 124
ALA A  27
 None
 0.94A 3uj7A-4yxmA:
undetectable		 3uj7A-4yxmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 LEU A 157
ILE A 216
ILE A 237
CYH A 234
ALA A 107
 None
None
HEM  A 401 (-4.5A)
None
None
 1.26A 3uj7A-4z5qA:
undetectable		 3uj7A-4z5qA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 ILE E 374
ILE E 400
ILE E 379
ILE E 430
ARG E 407
 None
 1.12A 3uj7A-5b04E:
undetectable		 3uj7A-5b04E:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		5 ILE A 676
GLY A   8
ILE A  21
ILE A  20
ALA A 705
 None
 0.93A 3uj7A-5czzA:
undetectable		 3uj7A-5czzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 LEU A 199
ILE A 311
CYH A 345
ILE A 337
ILE A 192
 None
 1.37A 3uj7A-5e02A:
undetectable		 3uj7A-5e02A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 ILE M 206
GLY M  38
CYH M 165
ILE M  41
ARG M  56
 None
 1.12A 3uj7A-5fmgM:
undetectable		 3uj7A-5fmgM:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 604
ILE A 449
ILE A 532
ASP A 538
ALA A 542
 None
 1.22A 3uj7A-5hdtA:
undetectable		 3uj7A-5hdtA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A 237
ILE A 210
ILE A 187
ILE A 214
ASP A 204
 None
 1.26A 3uj7A-5hwsA:
4.6		 3uj7A-5hwsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 394
GLY A 351
ILE A 383
ILE A 348
ARG A 431
 None
 1.18A 3uj7A-5i2gA:
undetectable		 3uj7A-5i2gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 LEU L 432
GLY L 246
ILE L 426
ILE L 159
ALA L 165
 None
None
None
None
FAD  L 503 (-3.6A)
 1.15A 3uj7A-5jfcL:
undetectable		 3uj7A-5jfcL:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		5 ILE B1151
ILE B1153
ARG B1134
ASP B1137
ALA B1138
 None
 1.26A 3uj7A-5m5xB:
undetectable		 3uj7A-5m5xB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz6 SEPARASE

(Caenorhabditis
elegans) 		PF03568
(Peptidase_C50) 		5 LEU 1 819
ILE 1 828
GLY 1 841
ILE 1 744
ALA 1 843
 None
 1.34A 3uj7A-5mz61:
undetectable		 3uj7A-5mz61:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4s PUTATIVE SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 LEU A  26
GLY A  18
ILE A  77
ARG A  15
ALA A  13
 None
None
None
NAP  A 300 (-4.2A)
None
 1.28A 3uj7A-5u4sA:
5.5		 3uj7A-5u4sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 LEU A 433
GLY A 246
ILE A 427
ILE A 159
ALA A 165
 None
None
None
None
FAD  A 503 (-3.8A)
 1.15A 3uj7A-5vj7A:
undetectable		 3uj7A-5vj7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 6 LEU A 241
TYR A 246
GLY A 290
ARG A 355
ASP A 356
HIS A 360
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
PC  A 702 ( 4.6A)
SAH  A 703 (-4.0A)
 0.43A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 LEU A 241
TYR A 246
GLY A 290
ILE A 311
ARG A 355
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
SAH  A 703 (-4.0A)
None
None
 1.08A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 LEU A 241
TYR A 246
ILE A 251
ARG A 355
ASP A 356
 SAH  A 703 (-4.0A)
SAH  A 703 ( 4.0A)
None
None
PC  A 702 ( 4.6A)
 1.15A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
 None
 1.29A 3uj7A-5wp4A:
40.0		 3uj7A-5wp4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 LEU A 375
ILE A 352
ILE A 383
ASP A 425
ALA A 488
 None
 1.37A 3uj7A-5wp5A:
33.2		 3uj7A-5wp5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 LEU A  91
ILE A  82
GLY A 301
CYH A  57
ALA A  73
 None
None
PLP  A 504 (-3.4A)
None
PLP  A 504 ( 3.8A)
 1.22A 3uj7A-5x7nA:
undetectable		 3uj7A-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 5 LEU S 143
ILE S 100
ILE S 114
ILE S 115
ALA S 121
 None
 1.22A 3uj7A-5xvdS:
undetectable		 3uj7A-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6t ENDO-1,4-BETA-MANNAN
ASE

(Eisenia fetida) 		no annotation 5 LEU A 124
ILE A  67
GLY A  75
ILE A 374
ILE A 372
 None
 1.21A 3uj7A-5y6tA:
undetectable		 3uj7A-5y6tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  51
ILE A   5
ILE A  31
ASP A 390
ALA A 391
 None
 0.88A 3uj7A-5ykdA:
undetectable		 3uj7A-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 LEU A 181
GLY A 201
ILE A 199
ILE A 203
ALA A 209
 None
 1.14A 3uj7A-6at7A:
undetectable		 3uj7A-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 168
ASP A 251
ASP A  29
 None
 0.86A 3uj7A-1b8uA:
5.8		 3uj7A-1b8uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 SER A  29
ASP A  83
ASP A  49
 None
FEO  A 404 (-2.2A)
None
 0.79A 3uj7A-1e5dA:
undetectable		 3uj7A-1e5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)

(Drosophila
melanogaster) 		PF00035
(dsrm) 		3 SER A  11
ASP A   5
ASP A   2
 None
 0.86A 3uj7A-1ekzA:
undetectable		 3uj7A-1ekzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		3 SER A 143
ASP A 147
ASP A 153
 None
 0.91A 3uj7A-1gjuA:
undetectable		 3uj7A-1gjuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		3 SER A 118
ASP A  67
ASP A  33
 None
 0.72A 3uj7A-1h1yA:
undetectable		 3uj7A-1h1yA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 SER A 281
ASP A 331
ASP A 324
 None
 0.69A 3uj7A-1hlgA:
undetectable		 3uj7A-1hlgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		3 SER A 281
ASP A 331
ASP A 324
 None
 0.75A 3uj7A-1k8qA:
2.9		 3uj7A-1k8qA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 SER A 282
ASP A  71
ASP A 106
 None
 0.88A 3uj7A-1kcxA:
undetectable		 3uj7A-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		3 SER A  59
ASP A 109
ASP A 141
 SAH  A 300 (-3.7A)
SAH  A 300 (-2.9A)
SAH  A 300 (-3.7A)
 0.66A 3uj7A-1kr5A:
9.5		 3uj7A-1kr5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		3 SER A 159
ASP A 376
ASP A 373
 None
 0.92A 3uj7A-1lrzA:
undetectable		 3uj7A-1lrzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		3 SER A 561
ASP A 422
ASP A 333
 None
 0.90A 3uj7A-1nbwA:
undetectable		 3uj7A-1nbwA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		3 SER A 301
ASP A 288
ASP A 327
 None
 0.87A 3uj7A-1nhcA:
undetectable		 3uj7A-1nhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8b RIBOSE 5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  30
ASP A  84
ASP A 170
 ABF  A1269 (-2.5A)
ABF  A1269 (-2.6A)
None
 0.91A 3uj7A-1o8bA:
undetectable		 3uj7A-1o8bA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		3 SER A 216
ASP A 175
ASP A  84
 None
 0.91A 3uj7A-1o9gA:
10.3		 3uj7A-1o9gA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opo COAT PROTEIN

(Carnation
mottle virus) 		PF00729
(Viral_coat)
PF08462
(Carmo_coat_C) 		3 SER A 257
ASP A 210
ASP A 158
 None
 0.91A 3uj7A-1opoA:
undetectable		 3uj7A-1opoA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		3 SER E 210
ASP E  65
ASP E  97
 None
 0.73A 3uj7A-1pekE:
2.3		 3uj7A-1pekE:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		3 SER E  43
ASP E 102
ASP E 175
 None
 0.90A 3uj7A-1sgqE:
undetectable		 3uj7A-1sgqE:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ss6 NSFL1 COFACTOR P47

(Homo sapiens) 		PF08059
(SEP) 		3 SER A   2
ASP A  26
ASP A  66
 None
 0.78A 3uj7A-1ss6A:
undetectable		 3uj7A-1ss6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 SER A 540
ASP A 553
ASP A 560
 None
 0.66A 3uj7A-1sxjA:
undetectable		 3uj7A-1sxjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 SER B 210
ASP B 174
ASP B 170
 NAG  A 900 (-3.6A)
None
None
 0.92A 3uj7A-1ta3B:
undetectable		 3uj7A-1ta3B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		3 SER A 151
ASP A  99
ASP A 106
 None
 0.90A 3uj7A-1uuoA:
undetectable		 3uj7A-1uuoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		3 SER A 245
ASP A 417
ASP A 346
 None
 0.87A 3uj7A-1vpbA:
undetectable		 3uj7A-1vpbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		3 SER A 343
ASP A 307
ASP A 259
 None
None
GOL  A1651 (-2.8A)
 0.90A 3uj7A-1w8oA:
undetectable		 3uj7A-1w8oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A 356
ASP A 270
ASP A 293
 SER  A 356 ( 0.0A)
ASP  A 270 ( 0.6A)
ASP  A 293 ( 0.6A)
 0.84A 3uj7A-1wqaA:
undetectable		 3uj7A-1wqaA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxq GTP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF08438
(MMR_HSR1_C) 		3 SER A 228
ASP A 110
ASP A 116
 None
 0.91A 3uj7A-1wxqA:
undetectable		 3uj7A-1wxqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A 367
ASP A 112
ASP A 140
 None
 0.92A 3uj7A-1xmbA:
undetectable		 3uj7A-1xmbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 SER A 247
ASP A 295
ASP A 340
 None
 0.79A 3uj7A-1xogA:
undetectable		 3uj7A-1xogA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 SER A 165
ASP A  34
ASP A  32
 None
 0.83A 3uj7A-1yd9A:
undetectable		 3uj7A-1yd9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		3 SER A 392
ASP A  39
ASP A   5
 None
 0.90A 3uj7A-1z3zA:
undetectable		 3uj7A-1z3zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 SER A  89
ASP A 195
ASP A 221
 None
 0.59A 3uj7A-1z6rA:
undetectable		 3uj7A-1z6rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 SER A 264
ASP A 221
ASP A 196
 None
EDO  A 556 ( 4.7A)
None
 0.92A 3uj7A-1zy9A:
undetectable		 3uj7A-1zy9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 SER A 278
ASP A 239
ASP A 232
 None
 0.76A 3uj7A-2aaaA:
undetectable		 3uj7A-2aaaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 SER A  97
ASP A 126
ASP A 211
 None
 0.84A 3uj7A-2d3tA:
5.8		 3uj7A-2d3tA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4) 		no annotation 3 SER A 274
ASP A  53
ASP A  46
 None
 0.87A 3uj7A-2ddxA:
undetectable		 3uj7A-2ddxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 SER A 157
ASP A 298
ASP A 711
 None
 0.84A 3uj7A-2e7zA:
undetectable		 3uj7A-2e7zA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eaa 7S GLOBULIN-3

(Vigna angularis) 		PF00190
(Cupin_1) 		3 SER A 100
ASP A 230
ASP A 262
 None
 0.91A 3uj7A-2eaaA:
undetectable		 3uj7A-2eaaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 SER A 960
ASP A 967
ASP A 974
 None
 0.83A 3uj7A-2ec5A:
undetectable		 3uj7A-2ec5A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f53 T-CELL RECEPTOR,
ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 SER D  84
ASP D 164
ASP D 169
 None
 0.82A 3uj7A-2f53D:
undetectable		 3uj7A-2f53D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 139
ASP A  53
ASP A  54
 None
 0.83A 3uj7A-2hlpA:
3.6		 3uj7A-2hlpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		3 SER A 298
ASP A  76
ASP A 181
 None
 0.91A 3uj7A-2hz6A:
undetectable		 3uj7A-2hz6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		3 SER A 202
ASP A 209
ASP A 504
 None
MN  A1001 (-3.9A)
None
 0.79A 3uj7A-2id0A:
undetectable		 3uj7A-2id0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		3 SER A 350
ASP A 291
ASP A 262
 None
 0.76A 3uj7A-2ie8A:
3.0		 3uj7A-2ie8A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)

(Homo sapiens) 		no annotation 3 SER A 359
ASP A 305
ASP A 254
 None
 0.92A 3uj7A-2jdxA:
undetectable		 3uj7A-2jdxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mah PROTEIN SMOOTHENED

(Drosophila
melanogaster) 		PF01392
(Fz) 		3 SER A  12
ASP A  50
ASP A  53
 None
 0.79A 3uj7A-2mahA:
undetectable		 3uj7A-2mahA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 327
ASP A 127
ASP A 103
 None
 0.87A 3uj7A-2nqlA:
undetectable		 3uj7A-2nqlA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY

(Campylobacter
jejuni) 		PF03309
(Pan_kinase) 		3 SER A   9
ASP A  89
ASP A  97
 SO4  A 218 (-4.5A)
None
None
 0.81A 3uj7A-2nrhA:
undetectable		 3uj7A-2nrhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		3 SER A 235
ASP A 178
ASP A 151
 None
 0.68A 3uj7A-2ntbA:
undetectable		 3uj7A-2ntbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 SER A 746
ASP A 726
ASP A 720
 None
 0.84A 3uj7A-2nztA:
undetectable		 3uj7A-2nztA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		3 SER A 211
ASP A 161
ASP A  63
 None
 0.80A 3uj7A-2o04A:
undetectable		 3uj7A-2o04A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 SER A 261
ASP A 232
ASP A 176
 None
 0.86A 3uj7A-2ocaA:
undetectable		 3uj7A-2ocaA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE

(Shewanella
frigidimarina) 		PF04820
(Trp_halogenase) 		3 SER A 430
ASP A 405
ASP A 451
 None
 0.86A 3uj7A-2pyxA:
2.6		 3uj7A-2pyxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qom SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 SER A1179
ASP A1243
ASP A1058
 None
 0.83A 3uj7A-2qomA:
undetectable		 3uj7A-2qomA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4n MULTIFUNCTIONAL
PROTEIN SUR E

(Salmonella
enterica) 		PF01975
(SurE) 		3 SER A 104
ASP A 213
ASP A 218
 PO4  A1257 ( 3.9A)
None
None
 0.87A 3uj7A-2v4nA:
undetectable		 3uj7A-2v4nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		3 SER A 684
ASP A 620
ASP A 624
 None
SAH  A1846 (-2.6A)
None
 0.83A 3uj7A-2vdwA:
16.5		 3uj7A-2vdwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 SER A 273
ASP A 178
ASP A 162
 None
FE2  A 401 (-2.5A)
None
 0.91A 3uj7A-2vw8A:
undetectable		 3uj7A-2vw8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 SER B 530
ASP B 660
ASP B 714
 XAX  B1778 (-4.9A)
None
None
 0.90A 3uj7A-2w55B:
undetectable		 3uj7A-2w55B:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		3 SER A 181
ASP A 469
ASP A 487
 None
 0.92A 3uj7A-2wokA:
undetectable		 3uj7A-2wokA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 SER A 217
ASP A 108
ASP A 103
 None
 0.90A 3uj7A-2xn8A:
undetectable		 3uj7A-2xn8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		3 SER A 294
ASP A 148
ASP A 131
 None
 0.82A 3uj7A-2yheA:
undetectable		 3uj7A-2yheA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Escherichia
coli;
Escherichia
coli) 		PF13360
(PQQ_2)
PF13360
(PQQ_2) 		3 SER A  96
ASP D 303
ASP D 288
 None
 0.70A 3uj7A-2ymsA:
undetectable		 3uj7A-2ymsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 SER A 310
ASP A 149
ASP A 186
 None
 0.80A 3uj7A-2z2zA:
2.6		 3uj7A-2z2zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 SER A  34
ASP A 146
ASP A 196
 SAH  A 801 (-3.6A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.86A 3uj7A-2zwaA:
12.8		 3uj7A-2zwaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 766
ASP A 563
ASP A 568
 None
 0.90A 3uj7A-3b2rA:
undetectable		 3uj7A-3b2rA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq0 PUTATIVE
TRANSALDOLASE
YGR043C

(Saccharomyces
cerevisiae) 		PF00923
(TAL_FSA) 		3 SER A 319
ASP A 313
ASP A 197
 GOL  A 356 (-4.9A)
None
None
 0.92A 3uj7A-3cq0A:
undetectable		 3uj7A-3cq0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A 166
ASP A 249
ASP A  29
 None
 0.69A 3uj7A-3d5tA:
5.8		 3uj7A-3d5tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE

(Mycolicibacterium
smegmatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 244
ASP A 191
ASP A 171
 None
MG  A2001 ( 2.6A)
None
 0.91A 3uj7A-3dg7A:
undetectable		 3uj7A-3dg7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dul O-METHYLTRANSFERASE,
PUTATIVE

(Bacillus cereus) 		PF01596
(Methyltransf_3) 		3 SER A  43
ASP A 140
ASP A 142
 None
 0.81A 3uj7A-3dulA:
12.3		 3uj7A-3dulA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		3 SER A  30
ASP A  84
ASP A 170
 None
 0.67A 3uj7A-3enqA:
2.1		 3uj7A-3enqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 SER A  70
ASP A 270
ASP A 235
 None
 0.89A 3uj7A-3gfvA:
undetectable		 3uj7A-3gfvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 SER A1407
ASP A 853
ASP A 868
 None
 0.52A 3uj7A-3h0gA:
undetectable		 3uj7A-3h0gA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE

(Vibrio cholerae) 		PF00342
(PGI) 		3 SER A 333
ASP A 403
ASP A  53
 None
 0.79A 3uj7A-3hjbA:
undetectable		 3uj7A-3hjbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 SER A  75
ASP A 134
ASP A 193
 None
 0.81A 3uj7A-3hsyA:
undetectable		 3uj7A-3hsyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE

(Bacillus
anthracis) 		PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A  25
ASP A 314
ASP A 321
 None
 0.80A 3uj7A-3icsA:
3.6		 3uj7A-3icsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd6 CARBOHYDRATE KINASE,
PFKB FAMILY

(Chlorobaculum
tepidum) 		PF00294
(PfkB) 		3 SER A  29
ASP A  12
ASP A  98
 None
AMP  A 509 (-2.8A)
None
 0.80A 3uj7A-3kd6A:
2.9		 3uj7A-3kd6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 SER A 152
ASP A 169
ASP A 175
 None
 0.87A 3uj7A-3ladA:
2.5		 3uj7A-3ladA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		3 SER A 356
ASP A  90
ASP A  83
 None
 0.84A 3uj7A-3mdoA:
undetectable		 3uj7A-3mdoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		3 SER A  55
ASP A  61
ASP A 438
 None
MG  A 601 ( 2.4A)
None
 0.85A 3uj7A-3mx3A:
undetectable		 3uj7A-3mx3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		3 SER A 455
ASP A 538
ASP A 531
 None
 0.82A 3uj7A-3nowA:
undetectable		 3uj7A-3nowA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		3 SER A 221
ASP A 215
ASP A  27
 None
 0.88A 3uj7A-3o82A:
undetectable		 3uj7A-3o82A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 SER B 254
ASP B 135
ASP B  22
 None
 0.86A 3uj7A-3p8cB:
undetectable		 3uj7A-3p8cB:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H

(Human
gammaherpesvirus
4) 		no annotation 3 SER A  51
ASP A 206
ASP A 203
 None
 0.82A 3uj7A-3phfA:
undetectable		 3uj7A-3phfA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 SER A1117
ASP A1226
ASP A1168
 None
MG  A   1 ( 3.2A)
ANP  A1358 (-4.1A)
 0.80A 3uj7A-3plsA:
undetectable		 3uj7A-3plsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		3 SER A 179
ASP A  70
ASP A 100
 None
 0.88A 3uj7A-3q4iA:
undetectable		 3uj7A-3q4iA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF09711
(Cas_Csn2) 		3 SER A 159
ASP A  82
ASP A  89
 None
 0.73A 3uj7A-3s5uA:
undetectable		 3uj7A-3s5uA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 SER A  53
ASP A  98
ASP A 268
 None
 0.76A 3uj7A-3swoA:
undetectable		 3uj7A-3swoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0a ACYL-COA
THIOESTERASE II
TESB2

(Mycobacterium
marinum) 		PF13622
(4HBT_3) 		3 SER A 166
ASP A 236
ASP A 117
 None
 0.80A 3uj7A-3u0aA:
undetectable		 3uj7A-3u0aA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		3 SER A  57
ASP A  84
ASP A 107
 None
 0.79A 3uj7A-3uboA:
3.8		 3uj7A-3uboA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw0 PECTINESTERASE

(Yersinia
enterocolitica) 		PF01095
(Pectinesterase) 		3 SER A 233
ASP A 177
ASP A 150
 None
 0.68A 3uj7A-3uw0A:
undetectable		 3uj7A-3uw0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 SER A 320
ASP A  19
ASP A 162
 None
 0.84A 3uj7A-3va8A:
undetectable		 3uj7A-3va8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 3 SER A 438
ASP A 263
ASP A 298
 None
 0.85A 3uj7A-3wevA:
undetectable		 3uj7A-3wevA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 3 SER A 895
ASP A 782
ASP A 878
 None
 0.79A 3uj7A-4a7kA:
undetectable		 3uj7A-4a7kA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 SER A1094
ASP A1170
ASP A1146
 None
 0.82A 3uj7A-4amcA:
undetectable		 3uj7A-4amcA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axz PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 SER A 150
ASP A 239
ASP A 246
 None
 0.66A 3uj7A-4axzA:
undetectable		 3uj7A-4axzA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2f PUTATIVE ANTIGEN P35

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		3 SER A 150
ASP A 239
ASP A 246
 None
 0.72A 3uj7A-4b2fA:
undetectable		 3uj7A-4b2fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 SER A  69
ASP A 146
ASP A 128
 None
 0.58A 3uj7A-4b9dA:
undetectable		 3uj7A-4b9dA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		3 SER A 291
ASP A 298
ASP A 110
 NDP  A1313 (-2.9A)
None
None
 0.90A 3uj7A-4bvaA:
5.5		 3uj7A-4bvaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		3 SER A 140
ASP A 264
ASP A 324
 None
 0.92A 3uj7A-4c3sA:
4.2		 3uj7A-4c3sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 SER A 282
ASP A  71
ASP A 106
 None
 0.91A 3uj7A-4cntA:
undetectable		 3uj7A-4cntA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6y BACTERIAL
REGULATORY, FIS
FAMILY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg) 		3 SER A  59
ASP A   9
ASP A  16
 None
MG  A1126 ( 4.1A)
None
 0.91A 3uj7A-4d6yA:
3.0		 3uj7A-4d6yA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 SER A 436
ASP A 439
ASP A 442
 None
 0.90A 3uj7A-4dweA:
undetectable		 3uj7A-4dweA:
20.77