SIMILAR PATTERNS OF AMINO ACIDS FOR 3UJ6_A_SAMA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 SER A 129
ASP A  34
ASP A  31
ALA A  28
 DFP  A 300 ( 1.5A)
None
None
None
 1.36A 3uj6A-1at3A:
undetectable		 3uj6A-1at3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A 186
ASP A  86
ASP A  81
ALA A 224
 None
 1.28A 3uj6A-1cliA:
undetectable		 3uj6A-1cliA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 SER A 333
ASP A 357
ASP A  47
ALA A 375
 None
 1.27A 3uj6A-1hjvA:
undetectable		 3uj6A-1hjvA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		4 SER A  59
ASP A 109
ASP A 141
ALA A 159
 SAH  A 300 (-3.7A)
SAH  A 300 (-2.9A)
SAH  A 300 (-3.7A)
SAH  A 300 ( 3.8A)
 1.04A 3uj6A-1kr5A:
9.4		 3uj6A-1kr5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 SER A 146
ASP A 116
ASP A 214
ALA A 209
 None
None
ZN  A 400 (-2.2A)
None
 1.22A 3uj6A-1qwyA:
undetectable		 3uj6A-1qwyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 SER A 170
ASP A 197
ASP A 217
ALA A 210
 None
 1.45A 3uj6A-1vecA:
3.5		 3uj6A-1vecA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 SER A 266
ASP A 626
ASP A 507
ALA A 262
 None
 1.42A 3uj6A-1w99A:
undetectable		 3uj6A-1w99A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 SER A 351
ASP A 408
ASP A 368
ALA A 365
 None
 1.22A 3uj6A-1wd3A:
undetectable		 3uj6A-1wd3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		4 SER A 100
ASP A  50
ASP A  44
ALA A  77
 None
None
None
SO4  A 403 ( 4.3A)
 1.49A 3uj6A-2a0uA:
3.4		 3uj6A-2a0uA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY

(Campylobacter
jejuni) 		PF03309
(Pan_kinase) 		4 SER A   9
ASP A  89
ASP A  97
ALA A  93
 SO4  A 218 (-4.5A)
None
None
None
 1.31A 3uj6A-2nrhA:
undetectable		 3uj6A-2nrhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 SER A 224
ASP A 293
ASP A 290
ALA A 227
 None
 1.29A 3uj6A-2piaA:
3.1		 3uj6A-2piaA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 SER A 555
ASP A 517
ASP A 496
ALA A 523
 None
 1.33A 3uj6A-2wk2A:
undetectable		 3uj6A-2wk2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 SER A  25
ASP A 214
ASP A 242
ALA A 160
 None
MG  A 501 (-2.8A)
None
GOL  A 503 ( 4.9A)
 1.37A 3uj6A-2x4dA:
undetectable		 3uj6A-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 SER A 150
ASP A 202
ASP A 204
ALA A 171
 ACA  A 601 ( 2.7A)
ACA  A 601 ( 4.7A)
None
ACA  A 602 ( 3.3A)
 1.31A 3uj6A-3a2qA:
undetectable		 3uj6A-3a2qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 SER A 652
ASP A 530
ASP A 527
ALA A 577
 None
 1.34A 3uj6A-3aibA:
undetectable		 3uj6A-3aibA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		4 SER A 174
ASP A 283
ASP A 321
ALA A 143
 LLP  A 284 ( 2.7A)
LLP  A 284 ( 3.2A)
None
LLP  A 284 ( 3.3A)
 1.33A 3uj6A-3bc8A:
3.2		 3uj6A-3bc8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 4 SER A 129
ASP A  27
ASP A  25
ALA A 122
 None
 1.24A 3uj6A-3dadA:
undetectable		 3uj6A-3dadA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		4 SER A  33
ASP A  48
ASP A  73
ALA A 114
 None
 1.22A 3uj6A-3dtnA:
18.8		 3uj6A-3dtnA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8h PUTATIVE POLYKETIDE
CYCLASE

(Ruegeria sp.
TM1040) 		PF12680
(SnoaL_2) 		4 SER A 104
ASP A 107
ASP A  69
ALA A  73
 MPD  A 133 (-3.6A)
None
None
None
 1.43A 3uj6A-3f8hA:
undetectable		 3uj6A-3f8hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 SER A 293
ASP A 205
ASP A 150
ALA A 190
 None
 1.44A 3uj6A-3gp0A:
undetectable		 3uj6A-3gp0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER A 347
ASP A  86
ASP A  93
ALA A 308
 None
 1.30A 3uj6A-3hrdA:
undetectable		 3uj6A-3hrdA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 SER A 275
ASP A 339
ASP A  58
ALA A 304
 None
 1.27A 3uj6A-3i09A:
undetectable		 3uj6A-3i09A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF12838
(Fer4_7) 		4 SER 9  57
ASP 3 123
ASP 3 237
ALA 3 244
 None
 1.30A 3uj6A-3i9v9:
undetectable		 3uj6A-3i9v9:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 SER B 464
ASP B 235
ASP B 139
ALA B 457
 None
 1.42A 3uj6A-3jb9B:
undetectable		 3uj6A-3jb9B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 SER E 303
ASP E 198
ASP E 161
ALA E 298
 None
 1.32A 3uj6A-3kfuE:
undetectable		 3uj6A-3kfuE:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 SER A 303
ASP A 242
ASP A 184
ALA A 229
 None
 1.50A 3uj6A-3lijA:
undetectable		 3uj6A-3lijA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 SER A 275
ASP A 339
ASP A  57
ALA A 304
 None
 1.32A 3uj6A-3n0wA:
undetectable		 3uj6A-3n0wA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 SER A 728
ASP A 432
ASP A 437
ALA A 730
 None
 1.15A 3uj6A-3nafA:
5.0		 3uj6A-3nafA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o81 BETA-2-MICROGLOBULIN

(Gallus gallus) 		PF07654
(C1-set) 		4 SER A  55
ASP A  59
ASP A   2
ALA A  28
 None
 1.33A 3uj6A-3o81A:
undetectable		 3uj6A-3o81A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A 187
ASP A  87
ASP A  82
ALA A 224
 None
 1.36A 3uj6A-3p4eA:
undetectable		 3uj6A-3p4eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 SER B 258
ASP B 272
ASP B 349
ALA B 354
 None
 1.42A 3uj6A-3v0aB:
undetectable		 3uj6A-3v0aB:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 SER A 519
ASP A 527
ASP A 507
ALA A 513
 None
None
MG  A1768 (-2.5A)
None
 1.19A 3uj6A-4a01A:
undetectable		 3uj6A-4a01A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euk HISTIDINE KINASE 5
HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF00072
(Response_reg)
PF01627
(Hpt) 		4 SER B  86
ASP A 828
ASP A 835
ALA A 885
 None
MG  A1001 (-2.5A)
None
None
 1.21A 3uj6A-4eukB:
undetectable		 3uj6A-4eukB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 SER A 517
ASP A 499
ASP A 462
ALA A 512
 None
 1.33A 3uj6A-4kvoA:
undetectable		 3uj6A-4kvoA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 SER H 227
ASP H 319
ASP H 323
ALA H 356
 ADP  H 801 ( 3.7A)
None
None
None
 1.32A 3uj6A-4nl4H:
2.2		 3uj6A-4nl4H:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		4 SER A  37
ASP A  85
ASP A 110
ALA A 129
 SAH  A 302 (-2.5A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
SAH  A 302 (-3.3A)
 0.21A 3uj6A-4r6wA:
46.3		 3uj6A-4r6wA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 SER B  56
ASP B 168
ASP B 112
ALA B  34
 None
39G  B 401 (-3.5A)
None
None
 1.37A 3uj6A-4tyhB:
undetectable		 3uj6A-4tyhB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 SER A 279
ASP A 151
ASP A 545
ALA A 537
 None
 1.30A 3uj6A-4xqkA:
undetectable		 3uj6A-4xqkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		4 SER A 174
ASP A 283
ASP A 321
ALA A 143
 PLR  A1001 (-2.7A)
None
None
PLR  A1001 (-3.0A)
 1.32A 3uj6A-4zdlA:
3.4		 3uj6A-4zdlA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00071
(Ras)
PF00620
(RhoGAP) 		4 SER A  85
ASP A 249
ASP A  65
ALA A  15
 None
None
None
GDP  A 503 ( 4.2A)
 1.48A 3uj6A-5c2kA:
undetectable		 3uj6A-5c2kA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 SER A 282
ASP A 290
ASP A 321
ALA A 296
 None
None
SO4  A 505 ( 4.7A)
None
 1.43A 3uj6A-5huqA:
2.1		 3uj6A-5huqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 SER A 255
ASP A  90
ASP A  67
ALA A 170
 None
None
GPE  A 402 ( 4.5A)
GPE  A 402 (-3.6A)
 1.40A 3uj6A-5t1pA:
undetectable		 3uj6A-5t1pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 SER A 184
ASP A  84
ASP A  79
ALA A 222
 None
 1.39A 3uj6A-5vk4A:
undetectable		 3uj6A-5vk4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdy HEAT SHOCK PROTEIN
HTRA

(Mycobacterium
tuberculosis) 		no annotation 4 SER A 450
ASP A 491
ASP A 374
ALA A 488
 None
 1.36A 3uj6A-5xdyA:
undetectable		 3uj6A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium) 		no annotation 4 SER A  10
ASP A  51
ASP A  46
ALA A 214
 None
 1.43A 3uj6A-5z6oA:
2.4		 3uj6A-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 SER A 557
ASP A 519
ASP A 498
ALA A 525
 None
GOL  A 701 (-4.3A)
None
None
 1.21A 3uj6A-5zl9A:
undetectable		 3uj6A-5zl9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 SER A 105
ASP A 136
ASP A  24
ALA A  31
 None
None
PO4  A 306 (-3.2A)
None
 1.41A 3uj6A-6bmaA:
undetectable		 3uj6A-6bmaA:
22.67